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Research Article

Improved Bioavailability of a Micronized Megestrol Acetate Tablet Formulation in Humans

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Pages 567-570 | Published online: 04 Oct 2000

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Read on this site (3)

Young Dai Seo, Su-Eon Jin, Daehyun Kim, Don Haeng Lee & Su-Geun Yang. (2018) Fabrication of Eudragit polymeric nanoparticles using ultrasonic nebulization method for enhanced oral absorption of megestrol acetate. Pharmaceutical Development and Technology 23:4, pages 407-413.
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Kyungho Jang, Seonghae Yoon, Sung-Eun Kim, Joo-Youn Cho, Seo Hyun Yoon, Kyoung Soo Lim, Kyung-Sang Yu, In-Jin Jang & Howard Lee. (2014) Novel nanocrystal formulation of megestrol acetate has improved bioavailability compared with the conventional micronized formulation in the fasting state. Drug Design, Development and Therapy 8, pages 851-858.
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Julie K. Spence, Shobha N. Bhattachar, James A. Wesley, Peter J. Martin & Suresh R. Babu. (2005) Increased Dissolution Rate and Bioavailability Through Comicronization with Microcrystalline Cellulose. Pharmaceutical Development and Technology 10:4, pages 451-460.
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Articles from other publishers (20)

Hossieny Ibrahim, Mohamed Ibrahim & Yassien Temerk. (2019) A novel megestrol acetate electrochemical sensor based on conducting functionalized acetylene black–CeO2NPs nanohybrids decorated glassy carbon microspheres. Talanta 200, pages 324-332.
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R. Bose, S Dan, P. Mandal, P. Sarkar, B Ghosh, L. K. Ghosh & T. K. Pal. (2018) BIOANALYTICAL METHOD DEVELOPMENT AND VALIDATION OF MICRONIZED GLICLAZIDE IN HUMAN PLASMA BY LC-MS/MS AND ITS PHARMACOKINETIC STUDIES. INDIAN DRUGS 55:09, pages 24-33.
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Samia E. Etewa, Dalia A. Abo El-Maaty, Rania S. Hamza, Ashraf S. Metwaly, Mohamed H. Sarhan, Sara A. Abdel-Rahman, Ghada M. Fathy & Mahmoud A. El-Shafey. (2017) Assessment of spiramycin-loaded chitosan nanoparticles treatment on acute and chronic toxoplasmosis in mice. Journal of Parasitic Diseases 42:1, pages 102-113.
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Alaa H. Salama, Mona Basha & Sally El Awdan. (2018) Experimentally designed lyophilized dry emulsion tablets for enhancing the antihyperlipidemic activity of atorvastatin calcium: Preparation, in-vitro evaluation and in-vivo assessment. European Journal of Pharmaceutical Sciences 112, pages 52-62.
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Aminu Ishaka, Maznah Ismail, Mustapha Umar Imam, Rozi Mahmud, Ismaila Muhammad Sani & Zuki Abu Bakar Zakaria. (2017) Toxicity Evaluation, HET-CAM Irritation, and Anti-Irritant Potential of Rice Bran Wax Policosanol Nanoemulsion. Journal of Nano Research 49, pages 44-55.
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Jinju Guk, Hankil Son, Dong Woo Chae & Kyungsoo Park. (2016) Quantitative Assessment of Food Effect on the Pharmacokinetics of Nano‐Crystallized Megestrol Acetate. Basic & Clinical Pharmacology & Toxicology 120:3, pages 270-277.
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Xiaonan Zhang, Xia Wu, Fengying Xie, Zhongjiang Wang, Xiuling Zhang & Lianzhou Jiang. (2016) Physicochemical Properties and In Vitro Dissolution of Spiramycin Microparticles Using the Homogenate-Antisolvent Precipitation Process. Applied Sciences 7:1, pages 10.
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Yixian Li, Chung Kil Song, Min-Kyoung Kim, Hyosang Lim, Qingbo Shen, Don Haeng Lee & Su-Geun Yang. (2015) Nanomemulsion of megestrol acetate for improved oral bioavailability and reduced food effect. Archives of Pharmacal Research 38:10, pages 1850-1856.
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Ying-Yuan Lu, Xin Wang, Xiao-Wei Wang, Jun-Yi Liu, Pu Li, Hong Ren, Ya-Qing Lou, Chuang Lu & Guo-Liang Zhang. (2015) Development and validation of a high performance liquid chromatography method for determination of 6-benzyl-1-benzyloxymethyl-5-iodouracil (W-1), a novel non-nucleoside reverse transcriptase inhibitor and its application to a pharmacokinetic study in rats. Biomedical Chromatography 29:10, pages 1548-1552.
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Katharina Maisel, Laura Ensign, Mihika Reddy, Richard Cone & Justin Hanes. (2015) Effect of surface chemistry on nanoparticle interaction with gastrointestinal mucus and distribution in the gastrointestinal tract following oral and rectal administration in the mouse. Journal of Controlled Release 197, pages 48-57.
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Frank Z. StanczykJanet P. Hapgood, Sharon Winer & Daniel R. MishellJr.Jr.. (2013) Progestogens Used in Postmenopausal Hormone Therapy: Differences in Their Pharmacological Properties, Intracellular Actions, and Clinical Effects. Endocrine Reviews 34:2, pages 171-208.
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Ji-Hyung Seo, Ji-Sun Park, Min-Ho Jo, Mi-Sun Park, Ju-Hee Ryu, Young-Wuk Cho, Wang-Sup Shim, Gyu-Jeong Noh & Kyung-Tae Lee. (2013) Rapid and sensitive LC-MS/MS method for determination of megestrol acetate in human plasma: application to a human pharmacokinetic study. Biomedical Chromatography 27:4, pages 409-415.
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Sateesh Kumar Sathigari, Courtney A. Ober, Ganesh P. Sanganwar, Ram B. Gupta & R. Jayachandra Babu. (2011) Single-Step Preparation and Deagglomeration of Itraconazole Microflakes by Supercritical Antisolvent Method for Dissolution Enhancement. Journal of Pharmaceutical Sciences 100:7, pages 2952-2965.
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Valery Alakhov, Grzegorz Pietrzynski, Kishore Patel, Alexander Kabanov, Lev Bromberg & T Alan Hatton. (2004) Pluronic block copolymers and Pluronic poly(acrylic acid) microgels in oral delivery of megestrol acetate. Journal of Pharmacy and Pharmacology 56:10, pages 1233-1241.
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Koji Shiraki, Noriyuki Takata, Ryusuke Takano, Yoshiki Hayashi & Katsuhide Terada. (2008) Dissolution Improvement and the Mechanism of the Improvement from Cocrystallization of Poorly Water-soluble Compounds. Pharmaceutical Research 25:11, pages 2581-2592.
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Jeong-Soo Kim, Min-Soo Kim, Hee Jun Park, Shun-Ji Jin, Sibeum Lee & Sung-Joo Hwang. (2008) Physicochemical properties and oral bioavailability of amorphous atorvastatin hemi-calcium using spray-drying and SAS process. International Journal of Pharmaceutics 359:1-2, pages 211-219.
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Shaoling Li, Rong (Ron) Liu & Nuo (Nolan) Wang. 2008. Water-Insoluble Drug Formulation, Second Edition. Water-Insoluble Drug Formulation, Second Edition 609 636 .
Y.F. LI, S. FU, W. HU, J.H. LIU, K.W. FINKEL, D.M. GERSHENSON & J.J. KAVANAGH. (2007) Systemic anticancer therapy in gynecological cancer patients with renal dysfunction. International Journal of Gynecological Cancer 17:4, pages 739-763.
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Robert A Femia & Richert E Goyette. (2005) The Science of Megestrol Acetate Delivery. BioDrugs 19:3, pages 179-187.
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Chong-Kook Kim & Jeong-Sook Park. (2004) Solubility Enhancers for Oral Drug Delivery. American Journal of Drug Delivery 2:2, pages 113-130.
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