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Drug Development and Industrial Pharmacy Volume 27, 2001 - Issue 4
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Research Article

Preformulation Studies on the S-Isomer of Oxybutynin Hydrochloride, an Improved Chemical Entity (ICE™)

Paul E. Luner Pharmaceutics Division, College of Pharmacy, University of Iowa, Iowa City, IA, 52242, U.S.A.
,
Lee E. Kirsch Pharmaceutics Division, College of Pharmacy, University of Iowa, Iowa City, IA, 52242, U.S.A.
,
Shingai Majuru Pharmaceutics Division, College of Pharmacy, University of Iowa, Iowa City, IA, 52242, U.S.A.
,
Euichaul Oh Pharmaceutics Division, College of Pharmacy, University of Iowa, Iowa City, IA, 52242, U.S.A.
,
Anjali B. Joshi Pharmaceutics Division, College of Pharmacy, University of Iowa, Iowa City, IA, 52242, U.S.A.
,
Dale Eric Wurster Pharmaceutics Division, College of Pharmacy, University of Iowa, Iowa City, IA, 52242, U.S.A.
&
Martin P. Redmon Sepracor Inc., 111 Locke Drive, Marlborough, MA, 01752, U.S.A.
 show all
Pages 321-329 | Published online: 30 Apr 2001

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Wael Gamal, Rania H. Fahmy & Magdy I. Mohamed. (2017) Development of novel amisulpride-loaded solid self-nanoemulsifying tablets: preparation and pharmacokinetic evaluation in rabbits. Drug Development and Industrial Pharmacy 43:9, pages 1539-1547.
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Christianne Mounir Zaki Rizkalla, Randa latif Aziz & Iman Ibrahim Soliman. (2013) Microencapsulation of hydroxyzine HCl by thermal phase separation: in vitro release enhancement and in vivo pharmacodynamic evaluation. Pharmaceutical Development and Technology 18:1, pages 196-209.
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A. Abd-Elbary, M. Haider & S. Sayed. (2012) In vitro characterization and release study of Ambroxol hydrochloride matrix tablets prepared by direct compression. Pharmaceutical Development and Technology 17:5, pages 562-573.
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Articles from other publishers (14)

Nihal Farid Younes, Abd El-Halim I. El Assasy & Amal I.A. Makhlouf. (2020) Microenvironmental pH-modified Amisulpride-Labrasol matrix tablets: development, optimization and in vivo pharmacokinetic study. Drug Delivery and Translational Research 11:1, pages 103-117.
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Vivek Verma, Kevin M. Ryan & Luis Padrela. (2021) Pharmaceutical nanoparticle isolation using CO2-assisted dynamic bed coating. International Journal of Pharmaceutics 592, pages 120032.
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James A. Kaduk, Nicholas C. Boaz, Amy M. Gindhart & Thomas N. Blanton. (2019) Crystal structure of oxybutynin hydrochloride hemihydrate, C 22 H 32 NO 3 Cl(H 2 O) 0.5 . Powder Diffraction 34:1, pages 50-58.
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N.R. Jadhav, P.V. Irny & U.S. Patil. (2017) Solid state behavior of progesterone and its release from Neusilin US2 based liquisolid compacts. Journal of Drug Delivery Science and Technology 38, pages 97-106.
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Samia A. Nour, Nevine Shawky Abdelmalak & Marianne J. Naguib. (2016) Novel chewable colon targeted tablets of bumadizone calcium for treatment of ulcerative colitis: Formulation and optimization. Journal of Drug Delivery Science and Technology 35, pages 172-183.
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Kewen Tang, Yaqiong Wang, Panliang Zhang, Yan Huang & Guilin Dai. (2015) Process optimization of continuous liquid–liquid extraction in centrifugal contactor separators for separation of oxybutynin enantiomers. Separation and Purification Technology 150, pages 170-178.
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Nermeen Adel ElKasabgy, Ibrahim Elsayed & Ahmed Hassen Elshafeey. (2014) Design of lipotomes as a novel dual functioning nanocarrier for bioavailability enhancement of lacidipine: In-vitro and in-vivo characterization. International Journal of Pharmaceutics 472:1-2, pages 369-379.
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Sami Ahmed, Doaa Ahmed El-Setouhy, Alia Abd El-Latif Badawi & Mohamed Ahmed El-Nabarawi. (2014) Provesicular granisetron hydrochloride buccal formulations: In vitro evaluation and preliminary investigation of in vivo performance. European Journal of Pharmaceutical Sciences 60, pages 10-23.
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Kadria A. Elkhodairy, Hanna A. Elsaghir & Amal M. Al-Subayiel. (2014) Formulation of Indomethacin Colon Targeted Delivery Systems Using Polysaccharides as Carriers by Applying Liquisolid Technique. BioMed Research International 2014, pages 1-17.
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Achyut Khire & Pradeep Vavia. (2014) Electron capture detection of oxybutynin in plasma: precolumn derivatization approach and application to a pharmacokinetic study. Analytical Methods 6:5, pages 1455.
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Yuan Gao, Li Li, Jianjun Zhang, Feng Su, Zhenhua Gong, Yisheng Lai & Yihua Zhang. (2012) Physicochemical characterization and an injection formulation study of water insoluble ZCVI4-2, a novel NO-donor anticancer compound. Archives of Pharmacal Research 35:7, pages 1177-1186.
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Asish Kumar Dutta, Steven P. Stodghill & Christy M. Wyandt. (2010) Physicochemical Characterization of NPC 1161C, A Novel Antimalarial 8-Aminoquinoline, in Solution and Solid State. AAPS PharmSciTech 12:1, pages 177-191.
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M Reus-Medina, M Lanz, V Kumar & H Leuenberger. (2004) Comparative evaluation of the powder properties and compression behaviour of a new cellulose-based direct compression excipient and Avicel PH-102. Journal of Pharmacy and Pharmacology 56:8, pages 951-956.
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Soad A. Yehia, Ahmed H. Elshafeey, Ibrahim Sayed & Ahmed H. Shehata. (2009) Optimization of Budesonide Compression-Coated Tablets for Colonic Delivery. AAPS PharmSciTech 10:1, pages 147-157.
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