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Original

Scale-up Feasibility in High-Shear Mixers: Determination Through Statistical Procedures

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Pages 651-657 | Published online: 02 Jul 2010

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Pathi Suresh, Vikranth Kumar Surasani & Inkollu Sreedhar. (2018) Investigations at an industrial scale on granule and tablet attributes in high shear rapid mixer granulator. Particulate Science and Technology 36:4, pages 457-463.
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Preetanshu Pandey & Sherif Badawy. (2016) A quality by design approach to scale-up of high-shear wet granulation process. Drug Development and Industrial Pharmacy 42:2, pages 175-189.
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Articles from other publishers (21)

Vinod V. Kenekar, Suhas B. Ghugare & Veena Patil-Shinde. (2023) Multi-objective optimization of high-shear wet granulation process for better granule properties and fluidized bed drying characteristics. Powder Technology, pages 118373.
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Binbin Liu, Jiamiao Wang, Qin Zhou, Lijie Zhao, Youjie Wang, Lan Shen, Yi Feng & Ruofei Du. (2022) High shear wet granulation: Improved understanding of the effects of process variables on granule and tablet properties of a high-dose, high-hydrophobicity API based on quality by design and multivariate analysis approaches. Advanced Powder Technology 33:1, pages 103369.
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Binbin Liu, Jiamiao Wang, Jia Zeng, Lijie Zhao, Youjie Wang, Yi Feng & Ruofei Du. (2021) A review of high shear wet granulation for better process understanding, control and product development. Powder Technology 381, pages 204-223.
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Krista Taipale-Kovalainen, Jarkko Ketolainen, Ossi Korhonen & Tuomas Ervasti. (2020) Converting a batch based high-shear granulation process to a continuous dry granulation process; a demonstration with ketoprofen tablets. European Journal of Pharmaceutical Sciences 151, pages 105381.
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Prakash Thapa, Du Hyung Choi, Min Soo Kim & Seong Hoon Jeong. (2019) Effects of granulation process variables on the physical properties of dosage forms by combination of experimental design and principal component analysis. Asian Journal of Pharmaceutical Sciences 14:3, pages 287-304.
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Sherif I.F. Badawy, Ajit S. Narang, Keirnan R. LaMarche, Ganeshkumar A. Subramanian & Sailesh A. Varia. 2019. Handbook of Pharmaceutical Wet Granulation. Handbook of Pharmaceutical Wet Granulation 89 118 .
Ajit S. Narang & Sherif I.F. Badawy. 2019. Handbook of Pharmaceutical Wet Granulation. Handbook of Pharmaceutical Wet Granulation 825 840 .
Preetanshu Pandey & Sherif I.F. Badawy. 2019. Handbook of Pharmaceutical Wet Granulation. Handbook of Pharmaceutical Wet Granulation 615 650 .
Zheng Yan, Ying-ying Gong, Liang-shan Ming & Yi-hui Xie. (2018) Multivariate modeling to evaluate effect of fabricating process on product profile of high shear granulation. Chinese Herbal Medicines 10:4, pages 396-404.
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S. Badawy & P. Pandey. 2017. Developing Solid Oral Dosage Forms. Developing Solid Oral Dosage Forms 749 776 .
. 2016. How to Scale-Up a Wet Granulation End Point Scientifically. How to Scale-Up a Wet Granulation End Point Scientifically 67 72 .
Jing Tao, Preetanshu Pandey, Dilbir S. Bindra, Julia Z. Gao & Ajit S. Narang. (2015) Evaluating Scale-Up Rules of a High-Shear Wet Granulation Process. Journal of Pharmaceutical Sciences 104:7, pages 2323-2333.
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Jumpei UchiyamaShigeru AokiYoshifumi Uemoto. (2015) New Approach to Evaluate the Lubrication Process in Various Granule Filling Levels and Rotating Mixer Sizes Using a Thermal Effusivity Sensor. CHEMICAL & PHARMACEUTICAL BULLETIN Chemical and Pharmaceutical Bulletin 63:3, pages 164-179.
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Sherif I.F. Badawy, Ajit S. Narang, Keirnan LaMarche, Ganeshkumar Subramanian & Sailesh A. Varia. (2012) Mechanistic basis for the effects of process parameters on quality attributes in high shear wet granulation. International Journal of Pharmaceutics 439:1-2, pages 324-333.
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Rung-Kai Tan, Werner Eberhard & Jochen Büchs. (2011) Measurement and characterization of mixing time in shake flasks. Chemical Engineering Science 66:3, pages 440-447.
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Xiaorong He, Keith A. Lunday, Liang‐chi Li & Mark J. Sacchetti. (2008) Formulation Development and Process Scale Up of a High Shear Wet Granulation Formulation Containing a Poorly Wettable Drug. Journal of Pharmaceutical Sciences 97:12, pages 5274-5289.
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N Anthony Armstrong. 2006. Pharmaceutical Experimental Design and Interpretation, 2nd Edition. Pharmaceutical Experimental Design and Interpretation, 2nd Edition 135 156 .
N Anthony Armstrong. 2006. Pharmaceutical Experimental Design and Interpretation, 2nd Edition. Pharmaceutical Experimental Design and Interpretation, 2nd Edition 83 133 .
S.L. Rough, D.I. Wilson, A.E. Bayly & D.W. York. (2005) Mechanisms in high-viscosity immersion–granulation. Chemical Engineering Science 60:14, pages 3777-3793.
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S.L. Rough, D.I. Wilson, A.E. Bayly & D.W. York. (2005) Influence of Process Parameters on the Tapping Characteristics of High Shear Mixer Agglomerates Made with Ultra-High Viscosity Binders. Chemical Engineering Research and Design 83:1, pages 7-23.
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Hidaka Abe, Tetsuya Suzuki, Ayako Ootsuki, Kazuhiko Ozaki, Hirofumi Samemoto & Satoru Watano. (2004) Rheological Analysis and Quantitative Evaluation of Wet Kneaded Wax Matrix. CHEMICAL & PHARMACEUTICAL BULLETIN 52:5, pages 510-516.
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