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Research Article

Study of the Influence of the pH Media Dissolution, Degree of Polymerization, and Degree of Swelling of the Polymers on the Mechanism of Release of Diltiazem from Matrices Based on Mixtures of Chitosan/Alginate

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Pages 217-224 | Published online: 04 Aug 2002

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K. Sudhakar, K. Madhusudana Rao, M.C.S. Subha, K. Chowdoji Rao & E. Rotimi Sadiku. (2015) Temperature-responsive poly(N-vinylcaprolactam-co-hydroxyethyl methacrylate) nanogels for controlled release studies of curcumin. Designed Monomers and Polymers 18:8, pages 705-713.
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Tin Wui Wong & Harjoh Nurulaini. (2012) Sustained-release alginate-chitosan pellets prepared by melt pelletization technique. Drug Development and Industrial Pharmacy 38:12, pages 1417-1427.
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Srinivas Lankalapalli & Ramana Murthy Kolapalli. (2012) Biopharmaceutical evaluation of diclofenac sodium controlled release tablets prepared from gum karaya − chitosan polyelectrolyte complexes. Drug Development and Industrial Pharmacy 38:7, pages 815-824.
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Poushpi Dwivedi, ShahidS. Narvi & RaviP. Tewari. (2012) Rudraksha Assisted Generation of Silver Nanoparticles for Integrated Application in the Biomedical Landscape. International Journal of Green Nanotechnology 4:3, pages 248-261.
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Cristián Tapia, Víctor Ormazabal, Edda Costa & Mehrdad Yazdani-Pedram. (2007) Study of Dissolution Behavior of Matrices Tablets Based on Alginate—Gelatin Mixtures as Prolonged Diltiazem Hydrochloride Release Systems. Drug Development and Industrial Pharmacy 33:6, pages 585-593.
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A. Iruín, M. Fernández-Arévalo, J. Álvarez-Fuéntes, A. Fini & M. A. Holgado. (2005) Elaboration and “In Vitro” Characterization of 5-ASA Beads. Drug Development and Industrial Pharmacy 31:2, pages 231-239.
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Articles from other publishers (30)

Katarzyna Adamiak & Alina Sionkowska. (2023) State of Innovation in Alginate-Based Materials. Marine Drugs 21:6, pages 353.
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Jiaoyang Li, Hui Jin, Md. Abdur Razzak, Eun Ji Kim & Shin Sik Choi. (2022) Crosslinker-free Bovine Serum Albumin-loaded Chitosan/alginate Nanocomplex for pH-responsive Bursting Release of Oral-administered Protein. Biotechnology and Bioprocess Engineering 27:1, pages 40-50.
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Ahmed A. H. Abdellatif, Mohamed A. Ibrahim, Mohammed A. Amin, Hamzah Maswadeh, Muhammed N. Alwehaibi, Sultan N. Al-Harbi, Zayed A. Alharbi, Hamdoon A. Mohammed, Ahmed B. M. Mehany & Imran Saleem. (2020) Cetuximab Conjugated with Octreotide and Entrapped Calcium Alginate-beads for Targeting Somatostatin Receptors. Scientific Reports 10:1.
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Dorsaf Cheikh, Fátima García-Villén, Hatem Majdoub, César Viseras & Memia Benna Zayani. (2019) Chitosan/beidellite nanocomposite as diclofenac carrier. International Journal of Biological Macromolecules 126, pages 44-53.
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Xiaofei Zhang, Xiangqin Gu, Xiaodan Wang, Huimin Wang & Shirui Mao. (2018) Tunable and sustained-release characteristics of venlafaxine hydrochloride from chitosan–carbomer matrix tablets based on in situ formed polyelectrolyte complex film coating. Asian Journal of Pharmaceutical Sciences 13:6, pages 566-574.
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May S. Freag, Wedad M. Saleh & Ossama Y. Abdallah. (2018) Exploiting polymer blending approach for fabrication of buccal chitosan-based composite sponges with augmented mucoadhesive characteristics. European Journal of Pharmaceutical Sciences 120, pages 10-19.
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Jianwen Li, Chunli Luo, Dong Zhang, Mo Li, Qiang Fu & Zhonggui He. (2016) Formulation and development of ternary hybrid matrix tablets of diltiazem hydrochloride. Powder Technology 294, pages 66-70.
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Bing Xue, Veronika Kozlovskaya, Fei Liu, Jun Chen, J. Fox Williams, Javier Campos-Gomez, Mohammad Saeed & Eugenia Kharlampieva. (2015) Intracellular Degradable Hydrogel Cubes and Spheres for Anti-Cancer Drug Delivery. ACS Applied Materials & Interfaces 7:24, pages 13633-13644.
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Sameer Nadaf, Petra Nnamani & Namdeo Jadhav. (2014) Evaluation of Prosopis africana Seed Gum as an Extended Release Polymer for Tablet Formulation. AAPS PharmSciTech 16:3, pages 716-729.
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Sonia Lefnaoui & Nadji Moulai-Mostefa. (2015) Polyelectrolyte complex based on carboxymethyl-kappa-carrageenan and Eudragit RL 30D as prospective carriers for sustained drug delivery. Chemical Engineering Research and Design 97, pages 165-174.
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Liang Li, Linlin Wang, Jinfeng Li, Shan Jiang, Yitong Wang, Xin Zhang, Jiaojiao Ding, Tongya Yu & Shirui Mao. (2014) Insights into the mechanisms of chitosan–anionic polymers-based matrix tablets for extended drug release. International Journal of Pharmaceutics 476:1-2, pages 253-265.
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Rakesh Singh, Siddhartha Maity & Biswanath Sa. (2014) Effect of ionic crosslink on the release of metronidazole from partially carboxymethylated guar gum tablet. Carbohydrate Polymers 106, pages 414-421.
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Dina Maciel, Priscilla Figueira, Shili Xiao, Dengmai Hu, Xiangyang Shi, João Rodrigues, Helena Tomás & Yulin Li. (2013) Redox-Responsive Alginate Nanogels with Enhanced Anticancer Cytotoxicity. Biomacromolecules 14:9, pages 3140-3146.
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Se-Kwon KimHéctor Prado, María Matulewicz, Pablo Bonelli & Ana Cukierman. 2013. Marine Biomaterials. Marine Biomaterials 603 632 .
Carolina Valenzuela, Lilian Abugoch & Cristian Tapia. (2013) Quinoa protein–chitosan–sunflower oil edible film: Mechanical, barrier and structural properties. LWT - Food Science and Technology 50:2, pages 531-537.
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Pinaki Ghosh, Kiran S. Bhise, Anant R. Paradkar, S. L. Bodhankar & Shivajirao S. Kadam. (2012) Reduced Ulcerogenic Potential and Antiarthritic Effect of Chitosan–Naproxen Sodium Complexes. AAPS PharmSciTech 13:3, pages 896-902.
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Héctor J. Prado, María C. Matulewicz, Pablo R. Bonelli & Ana L. Cukierman. (2012) Preparation and characterization of controlled release matrices based on novel seaweed interpolyelectrolyte complexes. International Journal of Pharmaceutics 429:1-2, pages 12-21.
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Rajat Ray, Siddhartha Maity, Sanchita Mandal, Tapan Kumar Chatterjee & Biswanath Sa. (2011) Studies on the release of ibuprofen from Al3+ ion cross-linked homopolymeric and interpenetrating network hydrogel beads of carboxymethyl xanthan and sodium alginate. Advances in Polymer Technology 30:1, pages 1-11.
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Tingting Zhang, Shirui Mao & Wei Sun. (2010) Design and In Vitro Evaluation of a Film-Controlled Dosage Form Self-Converted from Monolithic Tablet in Gastrointestinal Environment. Journal of Pharmaceutical Sciences 99:11, pages 4678-4690.
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Sanchita Mandal, Sanat Kumar Basu & Biswanath Sa. (2010) Ca2+ ion cross-linked interpenetrating network matrix tablets of polyacrylamide-grafted-sodium alginate and sodium alginate for sustained release of diltiazem hydrochloride. Carbohydrate Polymers 82:3, pages 867-873.
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Cristián Tapia, Sergio Molina, Alvaro Diaz, Lilian Abugoch, Mario Diaz-Dosque, Fernando Valenzuela & Mehrdad Yazdani-Pedram. (2010) The Effect of Chitosan as Internal or External Coating on the 5-ASA Release from Calcium Alginate Microparticles. AAPS PharmSciTech 11:3, pages 1294-1305.
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Kiran S. Bhise, Ravindra S. Dhumal, Biradar Shailesh, Anant R. Paradkar & Shivajirao S. Kadam. (2010) Effect of Oppositely Charged Polymer and Dissolution Media on Rheology of Spray-Dried Ionic Complexes. AAPS PharmSciTech 11:1, pages 226-232.
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Sanchita Mandal, Sanat Kumar Basu & Biswanath Sa. (2009) Sustained Release of a Water-Soluble Drug from Alginate Matrix Tablets Prepared by Wet Granulation Method. AAPS PharmSciTech 10:4.
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Nirmala Devi & T. K. Maji. (2009) A novel microencapsulation of neem ( Azadirachta Indica A. Juss .) seed oil (NSO) in polyelectrolyte complex of κ‐carrageenan and chitosan . Journal of Applied Polymer Science 113:3, pages 1576-1583.
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Arthur F.T. Mak & Shan Sun. 2007. Intelligent Materials. Intelligent Materials 447 463 .
Kiran S. Bhise, Ravindra S. Dhumal, Bhaskar Chauhan, Anant Paradkar & Shivajirao S. Kadam. (2007) Effect of oppositely charged polymer and dissolution medium on swelling, erosion, and drug release from chitosan matrices. AAPS PharmSciTech 8:2, pages E110-E118.
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Mayur G. Sankalia, Rajashree C. Mashru, Jolly M. Sankalia & Vijay B. Sutariya. (2007) Reversed chitosan–alginate polyelectrolyte complex for stability improvement of alpha-amylase: Optimization and physicochemical characterization. European Journal of Pharmaceutics and Biopharmaceutics 65:2, pages 215-232.
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Jeanny S. Maciel, Haroldo C. B. Paula, Marcus A. R. Miranda, Jose M. Sasaki & Regina C. M. de Paula. (2005) Reacetylated chitosan/cashew gum gel: Preliminary study for potential utilization as drug release matrix. Journal of Applied Polymer Science 99:1, pages 326-334.
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C. Tapia, V. Corbalán, E. Costa, M. N. Gai & M. Yazdani-Pedram. (2005) Study of the Release Mechanism of Diltiazem Hydrochloride from Matrices Based on Chitosan−Alginate and Chitosan−Carrageenan Mixtures. Biomacromolecules 6:5, pages 2389-2395.
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Cristián Tapia, Zunilda Escobar, Edda Costa, Jaime Sapag-Hagar, Fernando Valenzuela, Carlos Basualto, Marı́a Nella Gai & Mehrdad Yazdani-Pedram. (2004) Comparative studies on polyelectrolyte complexes and mixtures of chitosan–alginate and chitosan–carrageenan as prolonged diltiazem clorhydrate release systems. European Journal of Pharmaceutics and Biopharmaceutics 57:1, pages 65-75.
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