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Drug Development and Industrial Pharmacy Volume 28, 2002 - Issue 5
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Research Article

19F Solid-State NMR Spectroscopic Investigation of Crystalline and Amorphous Forms of a Selective Muscarinic M3 Receptor Antagonist, in Both Bulk and Pharmaceutical Dosage Form Samples

Robert M. Wenslow Merck Research Laboratories, Merck & Co., Rahway, New Jersey, 07065-0900, U.S.A.
Pages 555-561 | Published online: 30 May 2002

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Jodi Liu, Karthik Nagapudi, Y.-H. Kiang, Ezequiel Martinez & Janan Jona. (2009) Quantification of compaction-induced crystallinity reduction of a pharmaceutical solid using 19F solid-state NMR and powder X-ray diffraction. Drug Development and Industrial Pharmacy 35:8, pages 969-975.
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Marco Geppi, Giulia Mollica, Silvia Borsacchi & Carlo Alberto Veracini. (2008) Solid‐State NMR Studies of Pharmaceutical Systems. Applied Spectroscopy Reviews 43:3, pages 202-302.
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Ilma Nugrahani, Emy Susanti, Tazkia Adawiyah, Safira Santosa & Agnesya Namira Laksana. (2022) Non-Covalent Reactions Supporting Antiviral Development. Molecules 27:24, pages 9051.
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Y. T. Angel Wong, Ruud L. E. G. Aspers, Marketta Uusi-Penttilä & Arno P. M. Kentgens. (2022) Rapid Quantification of Pharmaceuticals via 1 H Solid-State NMR Spectroscopy . Analytical Chemistry 94:48, pages 16667-16674.
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Tyson Chasse, Stephen L. Conway, Gerald D. Danzer, Lili Feng, Anthony M. Leone, Michael McNevin, John Smoliga, Paul A. Stroud & Holger van Lishaut. (2022) Industry White Paper: Contemporary Opportunities and Challenges in Characterizing Crystallinity in Amorphous Solid Dispersions. Journal of Pharmaceutical Sciences 111:6, pages 1543-1555.
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Ilma Nugrahani. (2021) Sustainable Pharmaceutical Preparation Methods and Solid-state Analysis Supporting Green Pharmacy. Current Pharmaceutical Analysis 17:8, pages 969-982.
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Xingyu Lu, Chengbin Huang, Mingyue Li, Daniel Skomski, Wei Xu, Lian Yu, Stephen R. Byrn, Allen C. Templeton & Yongchao Su. (2020) Molecular Mechanism of Crystalline-to-Amorphous Conversion of Pharmaceutical Solids from 19 F Magic Angle Spinning NMR . The Journal of Physical Chemistry B 124:25, pages 5271-5283.
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You-lee Hong, G.N. Manjunatha Reddy & Yusuke Nishiyama. (2020) Selective detection of active pharmaceutical ingredients in tablet formulations using solid-state NMR spectroscopy. Solid State Nuclear Magnetic Resonance 106, pages 101651.
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David A. Hirsh, Anuradha V. Wijesekara, Scott L. Carnahan, Ivan Hung, Joseph W. Lubach, Karthik Nagapudi & Aaron J. Rossini. (2019) Rapid Characterization of Formulated Pharmaceuticals Using Fast MAS 1 H Solid-State NMR Spectroscopy . Molecular Pharmaceutics 16:7, pages 3121-3132.
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Xingyu Lu, Daniel Skomski, Karen C. Thompson, Michael J. McNevin, Wei Xu & Yongchao Su. (2019) Three-Dimensional NMR Spectroscopy of Fluorinated Pharmaceutical Solids under Ultrafast Magic Angle Spinning. Analytical Chemistry 91:9, pages 6217-6224.
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Ann Newman & Robert Wenslow. 2018. Pharmaceutical Crystals. Pharmaceutical Crystals 89 121 .
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Stanislav L. Veinberg, Karen E. Johnston, Michael J. Jaroszewicz, Brianna M. Kispal, Christopher R. Mireault, Takeshi Kobayashi, Marek Pruski & Robert W. Schurko. (2016) Natural abundance 14 N and 15 N solid-state NMR of pharmaceuticals and their polymorphs . Physical Chemistry Chemical Physics 18:26, pages 17713-17730.
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Andrew M. Namespetra, David A. Hirsh, Marcel P. Hildebrand, Anthony R. Sandre, Hiyam Hamaed, Jeremy M. Rawson & Robert W. Schurko. (2016) 35 Cl solid-state NMR spectroscopy of HCl pharmaceuticals and their polymorphs in bulk and dosage forms . CrystEngComm 18:33, pages 6213-6232.
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Y.-H. Kiang, Karthik Nagapudi, Tian Wu, Matthew L. Peterson, Janan Jona, Richard J. Staples & Peter W. Stephens. (2015) Conformational Isomerism in Solid State of AMG 853—Structure Studies Using Solid-State Nuclear Magnetic Resonance and X-ray Diffraction. Journal of Pharmaceutical Sciences 104:7, pages 2161-2168.
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Frederick G. Vogt. 2007. eMagRes. eMagRes 255 268 .
Grace Ilevbare, Patrick Marsac & Amitava Mitra. 2015. Discovering and Developing Molecules with Optimal Drug-Like Properties. Discovering and Developing Molecules with Optimal Drug-Like Properties 287 343 .
Aaron J. Rossini, Cory M. Widdifield, Alexandre Zagdoun, Moreno Lelli, Martin Schwarzwälder, Christophe Copéret, Anne Lesage & Lyndon Emsley. (2014) Dynamic Nuclear Polarization Enhanced NMR Spectroscopy for Pharmaceutical Formulations. Journal of the American Chemical Society 136:6, pages 2324-2334.
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Marcel Hildebrand, Hiyam Hamaed, Andrew M. Namespetra, John M. Donohue, Riqiang Fu, Ivan Hung, Zhehong Gan & Robert W. Schurko. (2014) 35 Cl solid-state NMR of HCl salts of active pharmaceutical ingredients: structural prediction, spectral fingerprinting and polymorph recognition . CrystEngComm 16:31, pages 7334-7356.
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Michael M. Leane, John F. Gamble, Jonathan Brown, Helen Hughes, George Crull, Josh Engstrom, Qi Gao, Matt Bunker, Sandra Rutherford, Andrew Parker, Clive J. Roberts & Mike Tobyn. (2013) Imaging Dehydration Kinetics of a Channel Hydrate Form of the HIV-1 Attachment Inhibitor Prodrug BMS-663068. Journal of Pharmaceutical Sciences 102:12, pages 4375-4383.
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Shayne Cox GadFrederick G. Vogt, Jacalyn S. Clawson, Mark Strohmeier, Tran N. Pham, Simon A. Watson & Andrew J. Edwards. 2010. Pharmaceutical Sciences Encyclopedia. Pharmaceutical Sciences Encyclopedia.
Frederick G. Vogt. 2006. Encyclopedia of Analytical Chemistry. Encyclopedia of Analytical Chemistry.
Frederick G Vogt. (2010) Evolution of solid-state NMR in pharmaceutical analysis. Future Medicinal Chemistry 2:6, pages 915-921.
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Lee M. Katrincic, Yan T. Sun, Robert A. Carlton, Ann M. Diederich, Ronald L. Mueller & Frederick G. Vogt. (2009) Characterization, selection, and development of an orally dosed drug polymorph from an enantiotropically related system. International Journal of Pharmaceutics 366:1-2, pages 1-13.
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Hiyam Hamaed, Jenna M. Pawlowski, Benjamin F.T. Cooper, Riqiang Fu, S. Holger Eichhorn & Robert W. Schurko. (2008) Application of Solid-State 35 Cl NMR to the Structural Characterization of Hydrochloride Pharmaceuticals and their Polymorphs . Journal of the American Chemical Society 130:33, pages 11056-11065.
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Brian T. Farrer, Andrey Peresypkin & Robert M. Wenslow. (2007) Quantitation of Crystalline Material within a Liquid Vehicle using 1H/19F CP/MAS NMR. Journal of Pharmaceutical Sciences 96:2, pages 264-267.
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Robin K. Harris. (2006) NMR studies of organic polymorphs & solvates. The Analyst 131:3, pages 351.
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Patrick A. Tishmack, David E. Bugay & Stephen R. Byrn. (2003) Solid-State Nuclear Magnetic Resonance Spectroscopy-Pharmaceutical Applications. Journal of Pharmaceutical Sciences 92:3, pages 441-474.
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Joseph W. Lubach & Eric J. Munson. 2006. Encyclopedia of Analytical Chemistry. Encyclopedia of Analytical Chemistry 1 18 .

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