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Research Article

Mixing of Cohesive Pharmaceutical Formulations in Tote (Bin) Blenders

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Pages 905-918 | Published online: 28 Aug 2002

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Read on this site (3)

Bader B. Alsulays, Mohamed H. Fayed, Ahmed Alalaiwe, Saad M. Alshahrani, Abdullah S. Alshetaili, Sultan M. Alshehri & Fars K. Alanazi. (2018) Mixing of low-dose cohesive drug and overcoming of pre-blending step using a new gentle-wing high-shear mixer granulator. Drug Development and Industrial Pharmacy 44:9, pages 1520-1527.
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Marcos Llusá, Kalyana Pingali & Fernando J. Muzzio. (2013) Method to study the effect of blend flowability on the homogeneity of acetaminophen. Drug Development and Industrial Pharmacy 39:2, pages 252-258.
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Zhen Xu, HeidiM. Mansour & AnthonyJ. Hickey. (2011) Particle Interactions in Dry Powder Inhaler Unit Processes: A Review. Journal of Adhesion Science and Technology 25:4-5, pages 451-482.
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Articles from other publishers (20)

Qi Shi & Mikio Sakai. (2023) Numerical study on the elucidation of powder mixing mechanism in a container blender. Advanced Powder Technology 34:11, pages 104231.
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F. Mostafaei, C. Davies, M. Wong, R. Turki, P. Liu, A. Sarkar, P. Doshi, J.G. Khinast & D. Jajcevic. (2023) Analysis of powder behaviour in bin blending processes at different scales using DEM. Advanced Powder Technology 34:10, pages 104166.
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Yan Zhou, Feng Li, Constantijn Sanders, Sophie Samain & Agba Salman. (2023) Online monitoring of dry powder mixing in a bin mixer. Powder Technology 415, pages 118081.
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Mohamed H. Fayed, Sayed I. Abdel-Rahman, Fars K. Alanazi, Mahrous O. Ahmed & Hesham M. Tawfeek. (2020) An investigation into the impact of key process variables on the uniformity of powder blends containing a low-dose drug in a gentle-wing high shear mixer. Journal of Drug Delivery Science and Technology 60, pages 102036.
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Liang Zhong, Lele Gao, Lian Li & Hengchang Zang. (2020) Trends-process analytical technology in solid oral dosage manufacturing. European Journal of Pharmaceutics and Biopharmaceutics 153, pages 187-199.
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Koyel Sen, Natasha Velez, Carl Anderson, James K. Drennen III, Ahmed S. Zidan & Bodhisattwa Chaudhuri. (2020) Multicomponent granular mixing in a Bohle bin Blender-Experiments and simulation. International Journal of Pharmaceutics 578, pages 119131.
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Waseem Kaialy. (2016) On the effects of blending, physicochemical properties, and their interactions on the performance of carrier-based dry powders for inhalation — A review. Advances in Colloid and Interface Science 235, pages 70-89.
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Barbara Bakri, Marco Weimer, Gerrit Hauck & Gabriele Reich. (2015) Assessment of powder blend uniformity: Comparison of real-time NIR blend monitoring with stratified sampling in combination with HPLC and at-line NIR Chemical Imaging. European Journal of Pharmaceutics and Biopharmaceutics 97, pages 78-89.
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Magnus Hoffmann, Patrick S. Wray, John F. Gamble & Mike Tobyn. (2015) Investigation into process-induced de-aggregation of cohesive micronised API particles. International Journal of Pharmaceutics 493:1-2, pages 341-346.
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Takehiko Horio, Masatoshi Yasuda & Shuji Matsusaka. (2014) Effect of particle shape on powder flowability of microcrystalline cellulose as determined using the vibration shear tube method. International Journal of Pharmaceutics 473:1-2, pages 572-578.
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Ebrahim Alizadeh, Habibollah Hajhashemi, François Bertrand & Jamal Chaouki. (2013) Experimental investigation of solid mixing and segregation in a tetrapodal blender. Chemical Engineering Science 97, pages 354-365.
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A.D. Karande, C.V. Liew & P.W.S. Heng. (2010) Calibration sampling paradox in near infrared spectroscopy: A case study of multi-component powder blend. International Journal of Pharmaceutics 395:1-2, pages 91-97.
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M. Perrault, F. Bertrand & J. Chaouki. (2010) An investigation of magnesium stearate mixing in a V-blender through gamma-ray detection. Powder Technology 200:3, pages 234-245.
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Ganesh P. Sanganwar & Ram B. Gupta. (2009) Nano-mixing of dipyridamole drug and excipient nanoparticles by sonication in liquid CO2. Powder Technology 196:1, pages 36-49.
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Fernando J. Muzzio, Marcos Llusa, Christopher L. Goodridge, Nhat-Hang Duong & Elizabeth Shen. (2008) Evaluating the mixing performance of a ribbon blender. Powder Technology 186:3, pages 247-254.
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Thomas Garcia & James Prescott. 2008. Pharmaceutical Dosage Forms - Tablets. Pharmaceutical Dosage Forms - Tablets 111 174 .
Thomas Garcia & James Prescott. 2008. Pharmaceutical Dosage Forms - Tablets, Third Edition. Pharmaceutical Dosage Forms - Tablets, Third Edition 111 174 .
M. Lemieux, F. Bertrand, J. Chaouki & P. Gosselin. (2007) Comparative study of the mixing of free-flowing particles in a V-blender and a bin-blender. Chemical Engineering Science 62:6, pages 1783-1802.
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P.E. Arratia, Nhat-hang Duong, F.J. Muzzio, P. Godbole & S. Reynolds. (2006) A study of the mixing and segregation mechanisms in the Bohle Tote blender via DEM simulations. Powder Technology 164:1, pages 50-57.
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O.S Sudah, D Coffin-Beach & F.J Muzzio. (2002) Effects of blender rotational speed and discharge on the homogeneity of cohesive and free-flowing mixtures. International Journal of Pharmaceutics 247:1-2, pages 57-68.
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