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Research Article

The Role of Lymphatic Transport in Enhancing Oral Protein and Peptide Drug Delivery

Pages 1047-1058 | Published online: 10 Aug 2002

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Read on this site (4)

Verica Risovic, Mike Rosland, Olena Sivak, Kishor M. Wasan & Karen Bartlett. (2007) Assessing the Antifungal Activity of a New Oral Lipid-Based Amphotericin B Formulation Following Administration to Rats Infected with Aspergillus Fumigatus. Drug Development and Industrial Pharmacy 33:7, pages 703-707.
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Corina Borghouts, Christian Kunz & Bernd Groner. (2005) Peptide aptamers: recent developments for cancer therapy. Expert Opinion on Biological Therapy 5:6, pages 783-797.
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Verica Risovic, Kristina Sachs‐Barrable, Michael Boyd & Kishor M. Wasan. (2004) Potential Mechanisms by Which Peceol® Increases the Gastrointestinal Absorption of Amphotericin B. Drug Development and Industrial Pharmacy 30:7, pages 767-774.
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Ramaswamy Subramanian & Kishor M. Wasan. (2003) Effect of Lipid Excipients on In Vitro Pancreatic Lipase Activity. Drug Development and Industrial Pharmacy 29:8, pages 885-890.
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Articles from other publishers (32)

Ding Wang, Qi Jiang, Zhefan Dong, Tingting Meng, Fuqiang Hu, Jianwei Wang & Hong Yuan. (2023) Nanocarriers transport across the gastrointestinal barriers: The contribution to oral bioavailability via blood circulation and lymphatic pathway. Advanced Drug Delivery Reviews 203, pages 115130.
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Yang‐Bao Miao, Yu‐Jung Lin, Kuan‐Hung Chen, Po‐Kai Luo, Shun‐Hao Chuang, Yu‐Tzu Yu, Hsien‐Meng Tai, Chiung‐Tong Chen, Kun‐Ju Lin & Hsing‐Wen Sung. (2021) Engineering Nano‐ and Microparticles as Oral Delivery Vehicles to Promote Intestinal Lymphatic Drug Transport. Advanced Materials 33:51, pages 2104139.
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Pavel Ryšánek, Tomáš Grus, Martin Šíma & Ondřej Slanař. (2020) Lymphatic Transport of Drugs after Intestinal Absorption: Impact of Drug Formulation and Physicochemical Properties. Pharmaceutical Research 37:9.
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Felix Stader, Melissa A. Penny, Marco Siccardi & Catia Marzolini. (2019) A Comprehensive Framework for Physiologically‐Based Pharmacokinetic Modeling in Matlab. CPT: Pharmacometrics & Systems Pharmacology.
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Elena Maestri, Marta Marmiroli & Nelson Marmiroli. (2016) Bioactive peptides in plant-derived foodstuffs. Journal of Proteomics 147, pages 140-155.
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Sarwar Beg, Kaisar Raza, Rajendra Kumar, Renu Chadha, O. P. Katare & Bhupinder Singh. (2016) Improved intestinal lymphatic drug targeting via phospholipid complex-loaded nanolipospheres of rosuvastatin calcium. RSC Advances 6:10, pages 8173-8187.
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Fernanda O. Lemos, Maria Imaculada C. Villalba, Carlos A. Tagliati, Valbert N. Cardoso, Carlos E. Salas & Miriam T.P. Lopes. (2016) Biodistribution, pharmacokinetics and toxicity of a Vasconcellea cundinamarcensis proteinase fraction with pharmacological activity. Revista Brasileira de Farmacognosia 26:1, pages 94-101.
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S Sajeesh & Chandra Sharma. 2015. Handbook of Encapsulation and Controlled Release. Handbook of Encapsulation and Controlled Release 1359 1380 .
Yi Lu, Yiting Qiu, Jianping Qi, Meiqing Feng, Dianwen Ju & Wei Wu. (2015) Biomimetic reassembled chylomicrons as novel association model for the prediction of lymphatic transportation of highly lipophilic drugs via the oral route. International Journal of Pharmaceutics 483:1-2, pages 69-76.
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Sami Saadi, Nazamid Saari, Farooq Anwar, Azizah Abdul Hamid & Hasanah Mohd Ghazali. (2015) Recent advances in food biopeptides: Production, biological functionalities and therapeutic applications. Biotechnology Advances 33:1, pages 80-116.
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Fereidoon Shahidi & Quanqaun Li. 2014. Applied Food Protein Chemistry. Applied Food Protein Chemistry 75 98 .
Jeffrey D. Miller. (2014) An evolutionary perspective on intestinal lymphatic fat absorption, the industrialization of food, and allergy. Annals of Allergy, Asthma & Immunology 113:4, pages 339-342.
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Raphael Johnson, Thomas Nawroth, Pooneh Khoshakhlagh, Peter Langguth, Lars Schmueser, Nadja Hellmann, Heinz Decker & Noemi Kinga Szekely. (2014) Amphotericin B microparticles ‘AmbiShell’ from phospholipid and gelatin: Development and investigation by combined DLS and SANS resolves the core‐shell structure. European Journal of Lipid Science and Technology 116:9, pages 1167-1173.
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Martin H. Bolli, Jörg Velker, Claus Müller, Boris Mathys, Magdalena Birker, Roberto Bravo, Daniel Bur, Ruben de Kanter, Patrick Hess, Christopher Kohl, David Lehmann, Solange Meyer, Oliver Nayler, Markus Rey, Michael Scherz & Beat Steiner. (2013) Novel S1P 1 Receptor Agonists - Part 2: From Bicyclo[3.1.0]hexane-Fused Thiophenes to Isobutyl Substituted Thiophenes . Journal of Medicinal Chemistry 57:1, pages 78-97.
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Indu Singh, Rajan Swami, Wahid Khan & Ramakrishna Sistla. 2014. Focal Controlled Drug Delivery. Focal Controlled Drug Delivery 429 458 .
T.T.H. Pham, P.M. Loiseau & G. Barratt. (2013) Strategies for the design of orally bioavailable antileishmanial treatments. International Journal of Pharmaceutics 454:1, pages 539-552.
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Marshall Grant & Andrea Leone-Bay. (2012) Peptide therapeutics: it’s all in the delivery. Therapeutic Delivery 3:8, pages 981-996.
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Werner Siegmund, Joachim Siegert, Klaus Richter, Frieder Schnabel, Cornelia Feustel & Wilhelm Kirch. (2013) Influence of a Fat‐Rich Meal on Bioavailability of Extended‐Release and Immediate‐Release Propiverine. The Journal of Clinical Pharmacology 52:5, pages 681-690.
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Jürgen Wagner, Peter von Matt, Bernard Faller, Nigel G. Cooke, Rainer Albert, Richard Sedrani, Hansjörg Wiegand, Christian Jean, Christian Beerli, Gisbert Weckbecker, Jean-Pierre Evenou, Gerhard Zenke & Sylvain Cottens. (2011) Structure–Activity Relationship and Pharmacokinetic Studies of Sotrastaurin (AEB071), a Promising Novel Medicine for Prevention of Graft Rejection and Treatment of Psoriasis. Journal of Medicinal Chemistry 54:17, pages 6028-6039.
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Stephen R. Dueker, Le T. Vuong, Peter N. Lohstroh, Jason A. Giacomo & John S. Vogel. (2011) Quantifying exploratory low dose compounds in humans with AMS. Advanced Drug Delivery Reviews 63:7, pages 518-531.
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Bahareh H. Sarmadi & Amin Ismail. (2010) Antioxidative peptides from food proteins: A review. Peptides 31:10, pages 1949-1956.
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Abu Bakar Abdul Majeed, Rosa E. V. Pereira, Tommy B. Julianto & Kah H. Yuen. (2010) Enhanced oral cefotaxime sodium bioavailability after administration of cefotaxime-loaded Eudragit S100 nanoparticles and its influence on the lymphatic transport. Enhanced oral cefotaxime sodium bioavailability after administration of cefotaxime-loaded Eudragit S100 nanoparticles and its influence on the lymphatic transport.
Pavel Gershkovich, Joseph Fanous, Bashir Qadri, Avihai Yacovan, Shimon Amselem & Amnon Hoffman. (2009) The role of molecular physicochemical properties and apolipoproteins in association of drugs with triglyceride-rich lipoproteins: in-silico prediction of uptake by chylomicrons. Journal of Pharmacy and Pharmacology 61:1, pages 31-39.
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Andrew C. Miller, Anna Bershteyn, Wuisiew Tan, Paula T. Hammond, Robert E. Cohen & Darrell J. Irvine. (2009) Block Copolymer Micelles as Nanocontainers for Controlled Release of Proteins from Biocompatible Oil Phases. Biomacromolecules 10:4, pages 732-741.
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Sajeesh S.Chandra Sharma. 2008. Biomaterials Fabrication and Processing Handbook. Biomaterials Fabrication and Processing Handbook 171 192 .
Mei-Ling Chen. (2008) Lipid excipients and delivery systems for pharmaceutical development: A regulatory perspective. Advanced Drug Delivery Reviews 60:6, pages 768-777.
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Pavel Gershkovich & Amnon Hoffman. (2005) Uptake of lipophilic drugs by plasma derived isolated chylomicrons: Linear correlation with intestinal lymphatic bioavailability. European Journal of Pharmaceutical Sciences 26:5, pages 394-404.
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Ching-Jou Lim & Wei-Chiang Shen. (2005) Comparison of monomeric and oligomeric transferrin as potential carrier in oral delivery of protein drugs. Journal of Controlled Release 106:3, pages 273-286.
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Werner Weitschies, Annika Bernsdorf, Thomas Giessmann, Michael Zschiesche, Christiane Modess, Vera Hartmann, Claudia Mrazek, Danilo Wegner, Stefan Nagel & Werner Siegmund. (2005) The Talinolol Double-Peak Phenomenon Is Likely Caused by Presystemic Processing After Uptake from Gut Lumen. Pharmaceutical Research 22:5, pages 728-735.
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Michael Boyd, Verica Risovic, Philip Jull, Eugene Choo & Kishor M Wasan. (2004) A stepwise surgical procedure to investigate the lymphatic transport of lipid-based oral drug formulations: Cannulation of the mesenteric and thoracic lymph ducts within the rat. Journal of Pharmacological and Toxicological Methods 49:2, pages 115-120.
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Verica Risovic, Michael Boyd, Eugene Choo & Kishor M. Wasan. (2003) Effects of Lipid-Based Oral Formulations on Plasma and Tissue Amphotericin B Concentrations and Renal Toxicity in Male Rats. Antimicrobial Agents and Chemotherapy 47:10, pages 3339-3342.
Crossref
M.S. Pepper. (2003) Literature Watch. Lymphatic Research and Biology 1:3, pages 245-249.
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