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Drug Development and Industrial Pharmacy Volume 29, 2003 - Issue 5
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Research Article

Highly Stabilized Amorphous 3-bis(4-Methoxyphenyl)methylene-2-indolinone (TAS-301) in Melt-Adsorbed Products with Silicate Compounds

Masahiro Kinoshita Pharmaceutical Research Laboratory, Taiho Pharmaceutical Co., Ltd., Hiraishi, Kawauchi-cho, Tokushima, Japan
,
Kazuhiko Baba Pharmaceutical Research Laboratory, Taiho Pharmaceutical Co., Ltd., Hiraishi, Kawauchi-cho, Tokushima, Japan
,
Atsushi Nagayasu Pharmaceutical Research Laboratory, Taiho Pharmaceutical Co., Ltd., Hiraishi, Kawauchi-cho, Tokushima, Japan
,
Kanoo Yamabe Pharmaceutical Research Laboratory, Taiho Pharmaceutical Co., Ltd., Hiraishi, Kawauchi-cho, Tokushima, Japan
,
Mami Azuma Department of Pharmacy, The Tokushima University Hospital, Kuramoto, Tokushima, Japan
,
Hitoshi Houchi Department of Pharmacy, The Tokushima University Hospital, Kuramoto, Tokushima, Japan
&
Kazuo Minakuchi Department of Pharmacy, The Tokushima University Hospital, Kuramoto, Tokushima, Japan
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Pages 523-529 | Published online: 05 Dec 2003

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Read on this site (2)

Orsolya Jójárt-Laczkovich & Piroska Szabó-Révész. (2011) Formulation of tablets containing an ‘in-process’ amorphized active pharmaceutical ingredient. Drug Development and Industrial Pharmacy 37:11, pages 1272-1281.
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Deepak Bahl, John Hudak & Robin H. Bogner. (2008) Comparison of the Ability of Various Pharmaceutical Silicates to Amorphize and Enhance Dissolution of Indomethacin Upon Co-grinding. Pharmaceutical Development and Technology 13:3, pages 255-269.
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Articles from other publishers (6)

Sayan Pramanik, Pinaki Saha, Prasanta Ghosh & Chhanda Mukhopadhyay. (2023) Steric-Hindrance-Induced Diastereoselective Radical Nitration of 3-Alkylidene-2-oxindoles Followed by Tosylhydrazine-Mediated Sulfonation. The Journal of Organic Chemistry.
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Hyun Ju Lee, Ko Hoon Kim, Se Hee Kim & Jae Nyoung Kim. (2013) Palladium-catalyzed oxidative arylation of trisubstituted olefin: an efficient synthesis of 3-(disubstituted)alkylidene-oxindoles. Tetrahedron Letters 54:2, pages 170-175.
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Shumet A. Hailu & Robin H. Bogner. (2011) Complex Effects of Drug/Silicate Ratio, Solid-State Equivalent pH, and Moisture on Chemical Stability of Amorphous Quinapril Hydrochloride Coground with Silicates. Journal of Pharmaceutical Sciences 100:4, pages 1503-1515.
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Bernard Van Eerdenbrugh, Michiel Van Speybroeck, Raf Mols, Kristof Houthoofd, Johan A. Martens, Ludo Froyen, Jan Van Humbeeck, Patrick Augustijns & Guy Van den Mooter. (2009) Itraconazole/TPGS/Aerosil®200 solid dispersions. European Journal of Pharmaceutical Sciences 38:3, pages 270-278.
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Deepak Bahl & Robin H. Bogner. (2008) Amorphization Alone Does Not Account for the Enhancement of Solubility of Drug Co-ground with Silicate: The Case of Indomethacin. AAPS PharmSciTech 9:1, pages 146-153.
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Sameer Sharma, Praveen Sher, Shraddha Badve & Atmaram P. Pawar. (2005) Adsorption of meloxicam on porous calcium silicate: Characterization and tablet formulation. AAPS PharmSciTech 6:4, pages E618-E625.
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