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Research Article

Multivariate Methods in the Development of a New Tablet Formulation

, M.Sc., , Ph.D., , M.Sc., , Ph.D., , Ph.D. & , Ph.D.
Pages 1053-1075 | Published online: 17 Nov 2003

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Nika Jordan, Jure Zakrajšek, Simona Bohanec, Robert Roškar & Iztok Grabnar. (2020) Prediction of saxagliptin stability using a new approach based on Partial Least Squares and Design of Experiments. Pharmaceutical Development and Technology 25:10, pages 1260-1270.
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Nika Jordan, Jure Zakrajšek, Simona Bohanec, Robert Roškar & Iztok Grabnar. (2018) Applying the methodology of Design of Experiments to stability studies: a Partial Least Squares approach for evaluation of drug stability. Drug Development and Industrial Pharmacy 44:5, pages 778-786.
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Stavros N. Politis, Paolo Colombo, Gaia Colombo & Dimitrios M. Rekkas. (2017) Design of experiments (DoE) in pharmaceutical development. Drug Development and Industrial Pharmacy 43:6, pages 889-901.
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Martin Kuentz, Nicole Wyttenbach & Olaf Kuhlmann. (2007) Application of a Statistical Method to the Absorption of a New Model Drug from Micellar and Lipid Formulations—Evaluation of Qualitative Excipient Effects. Pharmaceutical Development and Technology 12:3, pages 275-283.
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Jon Gabrielsson, Michael Sjöström, Nils-Olof Lindberg, Ann-Christin Pihl & Torbjörn Lundstedt. (2006) Robustness Testing of a Tablet Formulation Using Multivariate Design. Drug Development and Industrial Pharmacy 32:3, pages 297-307.
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Jon Gabrielsson, Michael Sjöström, Nils-Olof Lindberg, Ann-Christin Pihl & Torbjörn Lundstedt. (2006) Multivariate Methods in the Development of a New Tablet Formulation: Excipient Mixtures and Principal Properties. Drug Development and Industrial Pharmacy 32:1, pages 7-20.
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Jon Gabrielsson, Nils‐Olof Lindberg, Magnus Pålsson, Fredrik Nicklasson, Michael Sjöström & Torbjörn Lundstedt. (2004) Multivariate Methods in the Development of a New Tablet Formulation: Optimization and Validation. Drug Development and Industrial Pharmacy 30:10, pages 1037-1049.
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Emanuele Tomba, Massimiliano Barolo & Salvador García-Muñoz. (2014) In-silico product formulation design through latent variable model inversion. Chemical Engineering Research and Design 92:3, pages 534-544.
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Emanuele Tomba, Pierantonio Facco, Fabrizio Bezzo & Massimiliano Barolo. (2013) Latent variable modeling to assist the implementation of Quality-by-Design paradigms in pharmaceutical development and manufacturing: A review. International Journal of Pharmaceutics 457:1, pages 283-297.
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Rabab Kamel. (2013) Study of the influence of selected variables on the preparation of prolonged release bioadhesive vaginal carbohydrate microspheres using experimental design. Journal of Drug Delivery Science and Technology 23:3, pages 247-254.
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N. Mennini, S. Furlanetto, M. Cirri & P. Mura. (2012) Quality by design approach for developing chitosan-Ca-alginate microspheres for colon delivery of celecoxib-hydroxypropyl-β-cyclodextrin-PVP complex. European Journal of Pharmaceutics and Biopharmaceutics 80:1, pages 67-75.
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Ana Teresa Ochoa Andrade. (2011) Application of multivariate techniques in the evaluation of melt granulation products. Brazilian Journal of Pharmaceutical Sciences 47:4, pages 733-741.
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Simeone Zomer, Manish Gupta & Andy Scott. (2010) Application of Multivariate Tools in Pharmaceutical Product Development to Bridge Risk Assessment to Continuous Verification in a Quality by Design Environment. Journal of Pharmaceutical Innovation 5:3, pages 109-118.
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Shailesh K. Singh, Thirunellai G. Venkateshwaran & Stephen P. Simmons. 2010. Oral Controlled Release Formulation Design and Drug Delivery. Oral Controlled Release Formulation Design and Drug Delivery 279 303 .
Charles Solvason, Nishanth Chemmangattuvalappil & Mario Eden. 2009. Design for Energy and the Environment. Design for Energy and the Environment 861 869 .
Charles C. Solvason, Nishanth G. Chemmangattuvalappil, Susilpa Bommareddy & Mario R. Eden. 2009. 10th International Symposium on Process Systems Engineering: Part A. 10th International Symposium on Process Systems Engineering: Part A 1089 1094 .
Charles C. Solvason, Nishanth G. Chemmangattuvalappil & Mario R. Eden. 2009. 19th European Symposium on Computer Aided Process Engineering. 19th European Symposium on Computer Aided Process Engineering 153 158 .
N Anthony Armstrong. 2006. Pharmaceutical Experimental Design and Interpretation, 2nd Edition. Pharmaceutical Experimental Design and Interpretation, 2nd Edition 55 81 .
Nils‐Olof Lindberg & Jon Gabrielsson. (2004) Use of software to facilitate pharmaceutical formulation—experiences from a tablet formulation. Journal of Chemometrics 18:3-4, pages 133-138.
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