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Research Article

Wet Spheronization by Rotary Processing—A Multistage Single‐Pot Process for Producing Spheroids

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Pages 111-123 | Published online: 03 Nov 2004

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Ian C. Kemp, Lewis Iler, Michael Waldron & Neil Turnbull. (2019) Modeling, experimental trials, and design space determination for the GEA ConsiGma™ coater. Drying Technology 37:4, pages 475-485.
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A. A. Karatzas, S. N. Politis & D. M. Rekkas. (2017) Development of rapidly dissolving pellets within the Quality by Design approach. Drug Development and Industrial Pharmacy 43:5, pages 770-779.
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Stavros N. Politis & Dimitrios M. Rekkas. (2017) Development of a fast, lean and agile direct pelletization process using experimental design techniques. Drug Development and Industrial Pharmacy 43:4, pages 545-557.
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Florian Priese, Toni Frisch & Bertram Wolf. (2015) Comparison of film-coated retarded release pellets manufactured by layering technique or by bed rotor pelletization. Pharmaceutical Development and Technology 20:4, pages 417-425.
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Zhi Hui Loh, Dawn ZL Er, Lai Wah Chan, Celine V Liew & Paul WS Heng. (2011) Spray granulation for drug formulation. Expert Opinion on Drug Delivery 8:12, pages 1645-1661.
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Dali Shukla, Subhashis Chakraborty, Sanjay Singh & Brahmeshwar Mishra. (2011) Lipid-based oral multiparticulate formulations – advantages, technological advances and industrial applications. Expert Opinion on Drug Delivery 8:2, pages 207-224.
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L. Gu, C.V. Liew, J.L.P. Soh & P.W.S. Heng. (2006) Feasibility of Eliminating Premixing for the Production of Pellets in a Rotary Processor. Pharmaceutical Development and Technology 11:2, pages 159-165.
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Articles from other publishers (17)

Philipp Grohn, Stefan Heinrich & Sergiy Antonyuk. (2023) Numerical Investigation of the Particle Dynamics in a Rotorgranulator Depending on the Properties of the Coating Liquid. Pharmaceutics 15:2, pages 469.
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Akshay Parihar, Bhupendra Gopalbhai Prajapati, Kiran Patel & Himanshu Paliwal. (2023) Formulation, evaluation, and optimization of the omeprazole magnesium multi-unit particulate controlled release tablets using different concentrations of polymers. IP International Journal of Comprehensive and Advanced Pharmacology 7:4, pages 211-217.
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Philipp Grohn, Tobias Oesau, Stefan Heinrich & Sergiy Antonyuk. (2022) Investigation of the influence of wetting on the particle dynamics in a fluidized bed rotor granulator by MPT measurements and CFD-DEM simulations. Powder Technology 408, pages 117736.
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Gaia Colombo, Stavros Politis & Alessandra Rossi. 2022. Oral Drug Delivery for Modified Release Formulations. Oral Drug Delivery for Modified Release Formulations 119 136 .
Yousif H-E.Y. Ibrahim, Patience Wobuoma, Katalin Kristó, Ferenc Lajkó, Gábor Klivényi, Béla Jancsik, Géza Regdon jr, Klára Pintye-Hódi & Tamás Sovány. (2021) Effect of processing conditions and material attributes on the design space of lysozyme pellets prepared by extrusion/spheronization. Journal of Drug Delivery Science and Technology 66, pages 102714.
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Ramy N. Elsergany, Lai Wah Chan & Paul Wan Sia Heng. (2019) Application of the Modified Tangential Spray-Fluidized Bed to Produce Nonpareils from Primary Crystals. AAPS PharmSciTech 20:3.
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Qi Lin, Lumin Chen, Ansheng Feng, Yihao Li & Xinjie Wang. (2016) Study of orientation and morphology of elliptical particles in drum granulation by dynamic simulation. Particuology 25, pages 159-166.
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Olav Lyngberg, Lieve Bijnens, Jeroen Geens, Alex Marchut, Steve Mehrman & Elisabeth Schafer. 2016. Process Simulation and Data Modeling in Solid Oral Drug Development and Manufacture. Process Simulation and Data Modeling in Solid Oral Drug Development and Manufacture 1 42 .
Johannes Neuwirth, Sergiy Antonyuk, Stefan Heinrich & Michael Jacob. (2013) CFD–DEM study and direct measurement of the granular flow in a rotor granulator. Chemical Engineering Science 86, pages 151-163.
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Anneleen Burggraeve, Tinne Monteyne, Chris Vervaet, Jean Paul Remon & Thomas De Beer. (2013) Process analytical tools for monitoring, understanding, and control of pharmaceutical fluidized bed granulation: A review. European Journal of Pharmaceutics and Biopharmaceutics 83:1, pages 2-15.
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Lucia Zema, Luca Palugan, Alessandra Maroni, Anastasia Foppoli, Maria Edvige Sangalli & Andrea Gazzaniga. (2008) The Use of ß-Cyclodextrin in the Manufacturing of Disintegrating Pellets with Improved Dissolution Performances. AAPS PharmSciTech 9:2.
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L. Zema, L. Palugan, M. Cerea, A. Foppoli, A. Maroni & M.E. Sangalli. (2008) Pelletization of a β-cyclodextrin-acetaminophen interaction compound in a rotary fluid bed granulator: an optimization study. Journal of Drug Delivery Science and Technology 18:3, pages 197-202.
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J. Bouffard, H. Dumont, F. Bertrand & R. Legros. (2007) Optimization and scale-up of a fluid bed tangential spray rotogranulation process. International Journal of Pharmaceutics 335:1-2, pages 54-62.
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Peter Kleinebudde & Klaus Knop. 2007. Granulation. Granulation 779 811 .
Jakob Kristensen. (2014) Investigation of a 2-step agglomeration process performed in a rotary processor using polyethylene glycol solutions as the primary binder liquid. AAPS PharmSciTech 7:4, pages E46-E53.
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Jakob Kristensen & Vibeke Wallaert Hansen. (2017) Wet granulation in rotary processor and fluid bed: Comparison of granule and tablet properties. AAPS PharmSciTech 7:1, pages E153-E162.
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Jakob Kristensen. (2005) Direct pelletization in a rotary processor controlled by torque measurements. III. Investigation of microcrystalline cellulose and lactose grade. AAPS PharmSciTech 6:3, pages E495-E503.
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