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Research Article

In Vitro Transungual Permeation of Ciclopirox from a Hydroxypropyl Chitosan-Based, Water-Soluble Nail Lacquer

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Pages 11-17 | Published online: 20 Oct 2008

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Read on this site (9)

Eman Yahya Gaballah, Thanaa Mohammed Borg & Elham Abdelmonem Mohamed. (2022) Hydroxypropyl chitosan nail lacquer of ciclopirox-PLGA nanocapsules for augmented in vitro nail plate absorption and onychomycosis treatment. Drug Delivery 29:1, pages 3304-3316.
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Hiep X. Nguyen, Yujin Kim, Tejas D. Kekatpure, Emily Lesica & Ajay K. Banga. (2021) A novel technique to evaluate nail softening effects of different urea formulations. Pharmaceutical Development and Technology 26:4, pages 403-411.
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Aditya K. Gupta & Nadia Stec. (2019) Emerging drugs for the treatment of onychomycosis. Expert Opinion on Emerging Drugs 24:4, pages 213-220.
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Purnima Kataria, Gajanand Sharma, Kanika Thakur, Vikas Bansal, Sunil Dogra & Om Prakash Katare. (2016) Emergence of nail lacquers as potential transungual delivery system in the management of onchomycosis. Expert Opinion on Drug Delivery 13:7, pages 937-952.
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Rania Elkeeb, Xiaoying Hui, Narasimha Murthy & Howard I Maibach. (2014) Emerging Topical Onychomycosis Therapies – Quo Vadis?. Expert Opinion on Emerging Drugs 19:4, pages 489-495.
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Manish V. Saner, Abhijeet D. Kulkarni & Chandrakantsing V. Pardeshi. (2014) Insights into drug delivery across the nail plate barrier. Journal of Drug Targeting 22:9, pages 769-789.
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Sandeep Kumar & Alexa B Kimball. (2009) New antifungal therapies for the treatment of onychomycosis. Expert Opinion on Investigational Drugs 18:6, pages 727-734.
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Martin Schaller, Claudia Borelli, Ursula Berger, Birgit Walker, Sybille Schmidt, Günther Weindl & Andreas Jäckel. (2009) Susceptibility testing of amorolfine, bifonazole and ciclopiroxolamine against Trichophyton rubrum in an in vitro model of dermatophyte nail infection. Medical Mycology 47:7, pages 753-758.
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Sudaxshina Murdan. (2008) Enhancing the nail permeability of topically applied drugs. Expert Opinion on Drug Delivery 5:11, pages 1267-1282.
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Alexandre Rolim Mineto, Sheila Porto de Matos, Isabella Morel Bordignon, Rayssa Ribeiro, Miriam Anders Apel, Valdir Florêncio da Veiga-Junior & Letícia Scherer Koester. (2024) Development by design of experiment and validation of a HPLC-UV method for simultaneous quantification of 1-nitro-2-phenylethane and methyleugenol: Application to nail permeation/retention studies. Journal of Pharmaceutical and Biomedical Analysis 239, pages 115889.
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Dorota Dobler, Mona Gerber, Thomas M. Schmidts, Frank Runkel & Peggy Schlupp. (2022) Comparative Ungual Drug Uptake Studies: Equine Hoof Membrane vs. Human Nail Plate. Pharmaceutics 14:12, pages 2552.
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Tom Bellmann, Ruth Luber, Lisa Kischio, Berit Karl, Yvette Pötzinger, Uwe Beekmann, Dana Kralisch, Cornelia Wiegand & Dagmar Fischer. (2022) Bacterial nanocellulose patches as a carrier for hydrating formulations to improve the topical treatment of nail diseases. International Journal of Pharmaceutics 628, pages 122267.
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Atiya Rahman, Mohd. Aqil, Abdul Ahad, Syed Sarim Imam, Abdul Qadir & Asgar Ali. (2021) Application of central composite design for the optimization of itraconazole loaded nail lacquer formulation. 3 Biotech 11:7.
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Rohan Aggarwal, Monika Targhotra, Bhumika Kumar, P.K Sahoo & Meenakshi K. Chauhan. (2021) Novel Polypseudorotaxanes Hydrogel based Nail Lacquer of Efinaconazole for Transungual Drug Delivery. Drug Delivery Letters 11:1, pages 52-61.
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Aditya K. Gupta, Maanasa Venkataraman & Emma M. Quinlan. 2021. Dermatophytes and Dermatophytoses. Dermatophytes and Dermatophytoses 433 471 .
Már Másson. 2021. Chitosan for Biomaterials III. Chitosan for Biomaterials III 131 168 .
Bianca Maria Piraccini, Matilde Iorizzo, André Lencastre, Pietro Nenoff & Dimitris Rigopoulos. (2020) Ciclopirox Hydroxypropyl Chitosan (HPCH) Nail Lacquer: A Review of Its Use in Onychomycosis. Dermatology and Therapy 10:5, pages 917-929.
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Silvia Tampucci, Eleonora Terreni, Erica Zucchetti, Susi Burgalassi, Patrizia Chetoni & Daniela Monti. (2020) Formulations Based on Natural Ingredients for the Treatment of Nail Diseases. Current Pharmaceutical Design 26:5, pages 556-565.
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Elena Cutrín-Gómez, Andrea Conde-Penedo, Soledad Anguiano-Igea, José Luis Gómez-Amoza & Francisco J. Otero-Espinar. (2020) Optimization of Drug Permeation from 8% Ciclopirox Cyclodextrin/Poloxamer-Soluble Polypseudorotaxane-Based Nail Lacquers. Pharmaceutics 12:3, pages 231.
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Agrawal Vikas, Patel Rashmin, Patel Mrunali, Rahul B. Chavan & Thanki Kaushik. (2020) Mechanistic Insights of Formulation Approaches for the Treatment of Nail Infection: Conventional and Novel Drug Delivery Approaches. AAPS PharmSciTech 21:2.
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Corinne Granger, Michela Starace, Aurora Alessandrini, Sonia Aladren, Francesca Bruni, Mridvika Narda, Paola Perugini & Bianca Maria Piraccini. (2020) Efficacy and Acceptability of a New Water-Soluble Nail Strengthener Containing <b><i>Pistacia lentiscus</i></b> and Hyaluronic Acid to Improve the Appearance of Brittle Nails versus Untreated Nails: In vitro and Clinical Evidence. Skin Appendage Disorders 6:2, pages 108-114.
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Daniela Monti, Diletta Mazzantini, Silvia Tampucci, Alessandra Vecchione, Francesco Celandroni, Susi Burgalassi & Emilia Ghelardi. (2019) Ciclopirox and Efinaconazole Transungual Permeation, Antifungal Activity, and Proficiency To Induce Resistance in Trichophyton rubrum. Antimicrobial Agents and Chemotherapy 63:10.
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Florian Laubé, Andy Poupon, Philippe Zinck, Christel Müller-Goymann, Stephan Reichl & Véronique Nardello-Rataj. (2019) Physicochemical investigations of native nails and synthetic models for a better understanding of surface adhesion of nail lacquers. European Journal of Pharmaceutical Sciences 131, pages 208-217.
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Elena Cutrín-Gómez, Soledad Anguiano-Igea, M. Delgado-Charro, José Gómez-Amoza & Francisco Otero-Espinar. (2018) Effect on Nail Structure and Transungual Permeability of the Ethanol and Poloxamer Ratio from Cyclodextrin-Soluble Polypseudorotaxanes Based Nail Lacquer. Pharmaceutics 10:3, pages 156.
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Alina Kline‐Schoder, Zung Le & Vesna Zderic. (2017) Ultrasound‐Enhanced Drug Delivery for Treatment of Onychomycosis. Journal of Ultrasound in Medicine 37:7, pages 1743-1752.
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Abeer Khattab & Samia Shalaby. (2017) Optimized Ciclopirox-Based Eudragit RLPO Nail Lacquer: Effect of Endopeptidase Enzyme as Permeation Enhancer on Transungual Drug Delivery and Efficiency Against Onychomycosis. AAPS PharmSciTech 19:3, pages 1048-1060.
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Purva Thatai & Bharti Sapra. (2018) Terbinafine hydrochloride nail lacquer for the management of onychomycosis: formulation, characterization and in vitro evaluation . Therapeutic Delivery 9:2, pages 99-119.
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Sudaxshina Murdan, Laxmi Kerai & Basma Hossin. (2015) To what extent do in vitro tests correctly predict the in vivo residence of nail lacquers on the nail plate?. Journal of Drug Delivery Science and Technology 25, pages 23-28.
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