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Drug Development and Industrial Pharmacy Volume 31, 2005 - Issue 4-5
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Research Article

Competitive Displacement of Clozapine from Plasma Proteins in Normolipidemic and Hyperlipidemic Plasma Samples: Clinical Implications

Dr. Ric M. Procyshyn Division of Pharmaceutics and Biopharmaceutics, Faculty of Pharmaceutical Sciences, The University of British Columbia, Vancouver, British Columbia, Canada; Division of Medical Services, Riverview Hospital, Port Coquitlam, British Columbia, Canada
, Ph.D.,
Tiffany Ho Division of Pharmaceutics and Biopharmaceutics, Faculty of Pharmaceutical Sciences, The University of British Columbia, Vancouver, British Columbia, Canada
&
Kishor M. Wasan Division of Pharmaceutics and Biopharmaceutics, Faculty of Pharmaceutical Sciences, The University of British Columbia, Vancouver, British Columbia, Canada
, Ph.D.
Pages 331-337 | Published online: 26 Sep 2008

Citations (8)

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Read on this site (2)

Micheal Rosland, Priscilla Szeto, Ric Procyshyn, Alasdair M. Barr & Kishor M. Wasan. (2007) Determination of Clozapine and its Metabolite, Norclozapine in Various Biological Matrices Using High-Performance Liquid Chromatography. Drug Development and Industrial Pharmacy 33:10, pages 1158-1166.
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Ric M. Procyshyn, Tiffany Ho & Kishor M. Wasan. (2005) The Effects of Competitive Displacement on Haloperidol's Plasma Distribution in Normolipidemic and Hyperlipidemic Plasma. Drug Development and Industrial Pharmacy 31:9, pages 901-905.
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Articles from other publishers (6)

Jose de Leon, Can-Jun Ruan, Georgios Schoretsanitis & Carlos De las Cuevas. (2020) A Rational Use of Clozapine Based on Adverse Drug Reactions, Pharmacokinetics, and Clinical Pharmacopsychology. Psychotherapy and Psychosomatics 89:4, pages 200-214.
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Trond T. SerklandJan Schjøtt, Jon A. BergLars HerfindalBettina Riedel & Silje Skrede. (2019) Distribution of Psychotropic Drugs Into Lipoproteins. Therapeutic Drug Monitoring 41:6, pages 766-771.
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Francisco J. Diaz, Richard C. Josiassen & Jose de Leon. (2018) The Effect of Body Weight Changes on Total Plasma Clozapine Concentrations Determined by Applying a Statistical Model to the Data From a Double-Blind Trial. Journal of Clinical Psychopharmacology 38:5, pages 442-446.
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Hideaki Yamamoto, Tappei Takada, Yoshihide Yamanashi, Masatsune Ogura, Yusuke Masuo, Mariko Harada-Shiba & Hiroshi Suzuki. (2017) VLDL/LDL acts as a drug carrier and regulates the transport and metabolism of drugs in the body. Scientific Reports 7:1.
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Kishor M. Wasan, Dion R. Brocks, Stephen D. Lee, Kristina Sachs-Barrable & Sheila J. Thornton. (2008) Impact of lipoproteins on the biological activity and disposition of hydrophobic drugs: implications for drug discovery. Nature Reviews Drug Discovery 7:1, pages 84-99.
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Anooshirvan Shayeganpour, Stephen D. Lee, Kishor M. Wasan & Dion R. Brocks. (2007) The Influence of Hyperlipoproteinemia on in Vitro Distribution of Amiodarone and Desethylamiodarone in Human and Rat Plasma. Pharmaceutical Research 24:4, pages 672-678.
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