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Research Article

A COMMENTARY ON THE USE OF HEPATOCYTES IN DRUG METABOLISM STUDIES DURING DRUG DISCOVERY AND DEVELOPMENT*

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Pages 219-240 | Published online: 04 Jun 2000

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Chibuzor Uchea, Sunil Sarda, Timothy Schulz-Utermoehl, Stewart Owen & Kevin J. Chipman. (2013) In vitro models of xenobiotic metabolism in trout for use in environmental bioaccumulation studies. Xenobiotica 43:5, pages 421-431.
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Ines A Pieper & Martin Bertau. (2010) Predictive tools for the evaluation of microbial effects on drugs during gastrointestinal passage. Expert Opinion on Drug Metabolism & Toxicology 6:6, pages 747-760.
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A.-K. Sohlenius-Sternbeck & S. Schmidt. (2005) Impaired glutathione-conjugating capacity by cryopreserved human and rat hepatocytes. Xenobiotica 35:7, pages 727-736.
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Marc Vermeir, Pieter Annaert, Rao NVS Mamidi, Dirk Roymans, Willem Meuldermans & Geert Mannens. (2005) Cell-based models to study hepatic drug metabolism and enzyme induction in humans. Expert Opinion on Drug Metabolism & Toxicology 1:1, pages 75-90.
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E. Floby, S. Briem, Y. Terelius & A.-K. Sohlenius-Sternbeck. (2004) Use of a cocktail of probe substrates for drug-metabolizing enzymes for the assessment of the metabolic capacity of hepatocyte preparations. Xenobiotica 34:11-12, pages 949-959.
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Slobodan Rendic. (2002) Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metabolism Reviews 34:1-2, pages 83-448.
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