176
Views
67
CrossRef citations to date
0
Altmetric
Research Article

GENETIC EPIDEMIOLOGY OF ENVIRONMENTAL TOXICITY AND CANCER SUSCEPTIBILITY: HUMAN ALLELIC POLYMORPHISMS IN DRUG-METABOLIZING ENZYME GENES, THEIR FUNCTIONAL IMPORTANCE, AND NOMENCLATURE ISSUES

, &
Pages 467-487 | Published online: 05 Dec 1999

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (3)

Daniel W. Nebert, Ge Zhang & Elliot S. Vesell. (2008) From Human Genetics and Genomics to Pharmacogenetics and Pharmacogenomics: Past Lessons, Future Directions. Drug Metabolism Reviews 40:2, pages 187-224.
Read now
Joel A Lefferts, Claudine L Bartels & Gregory J Tsongalis. (2007) Pharmacogenetics: where are we with respect to personalized medicine?. Expert Opinion on Medical Diagnostics 1:1, pages 117-128.
Read now
Hiroshi Miyakawa, Eriko Kitazawa, Kentaro Kikuchi, Hirotoshi Fujikawa, Naomi Kawaguchi, Kazuhiro Abe, Masanao Matsushita, Hiroshi Matsushima, Toshiko Igarashi, Raleigh W. Hankins & Makoto Kako. (2001) Immunoreactivity to Various Human Cytochrome P450 Proteins of Sera from Patients with Autoimmune Hepatitis, Chronic Hepatitis B, and Chronic Hepatitis C. Autoimmunity 33:1, pages 23-32.
Read now

Articles from other publishers (64)

Judes Poirier, Nathalie Nilsson, Marina Tedeschi Dauar, Justin Miron & Cynthia Picard. 2020. Rosenberg's Molecular and Genetic Basis of Neurological and Psychiatric Disease. Rosenberg's Molecular and Genetic Basis of Neurological and Psychiatric Disease 81 94 .
Robert D. Nerenz. 2020. Essential Concepts in Molecular Pathology. Essential Concepts in Molecular Pathology 579 589 .
Robert D. Nerenz. 2018. Molecular Pathology. Molecular Pathology 731 743 .
Lana Ganoci, Tamara Božina, Nikica Mirošević Skvrce, Mila Lovrić, Petar Mas & Nada Božina. (2017) Genetic polymorphisms of cytochrome P450 enzymes: CYP2C9 , CYP2C19 , CYP2D6 , CYP3A4 , and CYP3A5 in the Croatian population . Drug Metabolism and Personalized Therapy 32:1, pages 11-21.
Crossref
Tugba Boyunegmez Tumer, Seda Savranoglu, Pelin Atmaca, Gulsum Terzioglu, Alaattin Sen & Sevki Arslan. (2016) Modulatory role of GSTM1 null genotype on the frequency of micronuclei in pesticide-exposed agricultural workers . Toxicology and Industrial Health 32:12, pages 1942-1951.
Crossref
Jac M. M. J. G. Aarts, Gerrit M. Alink, Fulco Scherjon, Katharine MacDonald, Alison C. Smith, Harm Nijveen & Wil Roebroeks. (2016) Fire Usage and Ancient Hominin Detoxification Genes: Protective Ancestral Variants Dominate While Additional Derived Risk Variants Appear in Modern Humans. PLOS ONE 11:9, pages e0161102.
Crossref
Yan Zeng, Jian Bai, Li-Cong Deng, Yu-Ping Xie, Fen Zhao & Ying Huang. (2016) Association of the Glutathione S-transferase T1 Null Genotype with Risk of Gastric Cancer: a Meta-analysis in Asian Populations. Asian Pacific Journal of Cancer Prevention 17:3, pages 1141-1148.
Crossref
Yasunobu Aoki. 2016. Thresholds of Genotoxic Carcinogens. Thresholds of Genotoxic Carcinogens 155 170 .
Judes Poirier, Justin Miron & Cynthia Picard. 2015. Rosenberg's Molecular and Genetic Basis of Neurological and Psychiatric Disease. Rosenberg's Molecular and Genetic Basis of Neurological and Psychiatric Disease 51 62 .
A. P. Mikhalenko, E. V. Krupnova, N. N. Chakova, N. V. Chebotareva & Yu. E. Demidchik. (2014) Assessment of the relationship between combinations of polymorphic variants of xenobiotic-metabolizing enzyme genes and predisposition to lung cancer. Cytology and Genetics 48:2, pages 111-116.
Crossref
Ray Greek. (2014) The Ethical Implications for Humans in Light of the Poor Predictive Value of Animal Models. International Journal of Clinical Medicine 05:16, pages 966-1005.
Crossref
Shiv Kumar Giri, Anita Yadav, Anil Kumar, Kapil Dev, Sachin Gulati, Ranjan Gupta, Neeraj Aggarwal & Sanjeev Kumar Gautam. (2013) Polymorphic Variation of CYP1A1 and CYP1B1 Genes in a Haryana Population. Biochemical Genetics 51:11-12, pages 853-864.
Crossref
Ray Greek & Lawrence A. Hansen. (2013) Questions regarding the predictive value of one evolved complex adaptive system for a second: Exemplified by the SOD1 mouse. Progress in Biophysics and Molecular Biology 113:2, pages 231-253.
Crossref
Ashwini V. TilakSandhya N. IyerManjari S. MukherjeeRekha S. SinghalSmita S. Lele. (2013) Full-Gene-Sequencing Analysis of N -Acetyltransferase-2 in an Adult Indian Population . Genetic Testing and Molecular Biomarkers 17:3, pages 188-194.
Crossref
Daniel W. Nebert & Elliot S. Vesell. 2013. Emery and Rimoin's Principles and Practice of Medical Genetics. Emery and Rimoin's Principles and Practice of Medical Genetics 1 27 .
Vita Dolžan. 2012. Pharmacogenetics and Individualized Therapy. Pharmacogenetics and Individualized Therapy 13 80 .
N. Cardenas-Rodriguez, E. Lara-Padilla, C. Bandala, J. Lopez-Cruz, C. Uscanga-Carmona, P.F. Lucio-Monter & E. Floriano-Sanchez. (2012) CYP2W1, CYP4F11 and CYP8A1 Polymorphisms and Interaction of CYP2W1 Genotypes with Risk Factors in Mexican Women with Breast Cancer. Asian Pacific Journal of Cancer Prevention 13:3, pages 837-846.
Crossref
Tugba Boyunegmez Tumer, Gurses Sahin & Emel Arinç. (2011) Association between polymorphisms of EPHX1 and XRCC1 genes and the risk of childhood acute lymphoblastic leukemia. Archives of Toxicology 86:3, pages 431-439.
Crossref
Miriam Hernando‐Rodriguez, Natalia Rey‐Barja, Xabier Marichalar‐Mendia, Maria J. Rodriguez‐Tojo, Amelia Acha‐Sagredo & Jose M. Aguirre‐Urizar. (2011) Role of cytochrome P‐450 genetic polymorphisms in oral carcinogenesis. Journal of Oral Pathology & Medicine 41:1, pages 1-8.
Crossref
Qiang Zheng, Xianyi Sha, Jiansheng Liu, Elisabeth Heath, Patricia LoRusso & Jing Li. (2010) Association of Human Cytochrome P450 1A1 ( CYP1A1 ) and Sulfotransferase 1A1 ( SULT1A1 ) Polymorphisms with Differential Metabolism and Cytotoxicity of Aminoflavone . Molecular Cancer Therapeutics 9:10, pages 2803-2813.
Crossref
Vivek Kumar, Satyender Singh, Rafat Sultana Ahmed, Basu Dev Banerjee, Tanzeel Ahmed & Syed Tazeen Pasha. (2009) Frequency of common CYP1B1 polymorphic variations in Delhi population of Northern India. Environmental Toxicology and Pharmacology 28:3, pages 392-396.
Crossref
Nada Božina, Vlasta Bradamante & Mila Lovrić. (2009) Genetic Polymorphism of Metabolic Enzymes P450 (CYP) as a Susceptibility Factor for Drug Response, Toxicity, and Cancer Risk. Archives of Industrial Hygiene and Toxicology 60:2, pages 217-242.
Crossref
Hong Kee Lee & Gregory J. Tsongalis. 2009. Molecular Pathology. Molecular Pathology 613 622 .
Tsutomu ShimadaNorie MurayamaKatsuhiro TanakaShigeo TakenakaYoshio ImaiNancy E. HopkinsMaryam K. ForoozeshWillam L. AlworthHiroshi YamazakiF. Peter GuengerichMasayuki Komori. (2008) Interaction of Polycyclic Aromatic Hydrocarbons with Human Cytochrome P450 1B1 in Inhibiting Catalytic Activity. Chemical Research in Toxicology 21:12, pages 2313-2323.
Crossref
Michelle Cotterchio, Beatrice A. Boucher, Michael Manno, Steven Gallinger, Allan B. Okey & Patricia A. Harper. (2008) Red Meat Intake, Doneness, Polymorphisms in Genes that Encode Carcinogen-Metabolizing Enzymes, and Colorectal Cancer Risk. Cancer Epidemiology, Biomarkers & Prevention 17:11, pages 3098-3107.
Crossref
I. V. Goldenkova-Pavlova, S. A. Brouskin, R. M. Abdeev, E. V. Markarova, S. G. Bigvava, L. A. Radkevich, H. A. Kurdanov, Zh. M. Kozhekbaeva, A. S. Glotov, O. A. Gra, A. S. Zasedatelev, T. V. Nasedkina & E. S. Piruzyan. (2006) Comparative analysis of N-acetylation polymorphism in humans as determined by phenotyping and genotyping. Russian Journal of Genetics 42:8, pages 947-953.
Crossref
Tsutomu Shimada. (2006) Xenobiotic-Metabolizing Enzymes Involved in Activation and Detoxification of Carcinogenic Polycyclic Aromatic Hydrocarbons. Drug Metabolism and Pharmacokinetics 21:4, pages 257-276.
Crossref
L. F. Masson, L. Sharp, S. C. Cotton & J. Little. (2005) Cytochrome P-450 1A1 Gene Polymorphisms and Risk of Breast Cancer: A HuGE Review. American Journal of Epidemiology 161:10, pages 901-915.
Crossref
Tsutomu Shimada, Raymond L. Mernaugh & F. Peter Guengerich. (2005) Interactions of mammalian cytochrome P450, NADPH-cytochrome P450 reductase, and cytochrome b5 enzymes. Archives of Biochemistry and Biophysics 435:1, pages 207-216.
Crossref
May-Jen Huang. (2005) Polymorphisms of uridine-diphosphoglucuronosyltransferase 1A7 gene in Taiwan Chinese. World Journal of Gastroenterology 11:6, pages 797.
Crossref
Mark J. Roth, Christian C. Abnet, Laura Lee Johnson, Steven D. Mark, Zhi Wei Dong, Philip R. Taylor, Sanford M. Dawsey & You-Lin Qiao. (2004) Polymorphic variation of CYP1A1 is associated with the risk of gastric cardia cancer: a prospective case?cohort study of cytochrome P-450 1A1 and GST enzymes. Cancer Causes and Control 15:10, pages 1077-1083.
Crossref
Mark E Hahn, Sibel I Karchner, Diana G Franks & Rebeka R Merson. (2004) Aryl hydrocarbon receptor polymorphisms and dioxin resistance in Atlantic killifish (Fundulus heteroclitus). Pharmacogenetics 14:2, pages 131-143.
Crossref
Tsutomu Shimada & Yoshiaki Fujii‐Kuriyama. (2005) Metabolic activation of polycyclic aromatic hydrocarbons to carcinogens by cytochromes P450 1A1 and1B1. Cancer Science 95:1, pages 1-6.
Crossref
Rhydian Hapgood. (2003) The potential and limitations of personalized medicine in the doctor–patient relationship. Pharmacogenomics 4:6, pages 685-687.
Crossref
Christoph Köhle, Bernd Möhrle, Peter A. Münzel, Matthias Schwab, Dorothee Wernet, Osama A. Badary & Karl Walter Bock. (2003) Frequent co-occurrence of the TATA box mutation associated with Gilbert’s syndrome (UGT1A1*28) with other polymorphisms of the UDP-glucuronosyltransferase-1 locus (UGT1A6*2 and UGT1A7*3) in Caucasians and Egyptians. Biochemical Pharmacology 65:9, pages 1521-1527.
Crossref
Alexey Chernogolov, Joachim Behlke, Wolf-Hagen Schunck, Ivar Roots & Dieter Schwarz. (2003) Human CYP1A1 allelic variants: baculovirus expression and purification, hydrodynamic, spectral, and catalytical properties and their potency in the formation of all-trans-retinoic acid. Protein Expression and Purification 28:2, pages 259-269.
Crossref
Devendra K Amre & Ernest G Seidman. (2003) Etiopathogenesis of pediatric Crohn’s disease. Biologic pathways based on interactions between genetic and environmental factors. Medical Hypotheses 60:3, pages 344-350.
Crossref
K.R. MERIKANGAS. (2003) Implications of Genomics for Public Health: The Role of Genetic Epidemiology. Cold Spring Harbor Symposia on Quantitative Biology 68:0, pages 359-364.
Crossref
A Rautio. (2003) Polymorphic CYP2A6 and its clinical and toxicological significance. The Pharmacogenomics Journal 3:1, pages 6-7.
Crossref
Patricia A Harper, Judy M.Y Wong, Maria S.M Lam & Allan B Okey. (2002) Polymorphisms in the human AH receptor. Chemico-Biological Interactions 141:1-2, pages 161-187.
Crossref
Eun-Young Kim & Mark E Hahn. (2002) cDNA cloning and characterization of an aryl hydrocarbon receptor from the harbor seal (Phoca vitulina): a biomarker of dioxin susceptibility?. Aquatic Toxicology 58:1-2, pages 57-73.
Crossref
Daniel W Nebert, Amy L Roe, Susan E Vandale, Eula Bingham & Gregory G Oakley. (2002) NAD(P)H:quinone oxidoreductase (NQO1) polymorphism, exposure to benzene, and predisposition to disease: A HuGE review. Genetics in Medicine 4:2, pages 62-70.
Crossref
Ulrike Brockstedt, Maja Krajinovic, Chantal Richer, Geraldine Mathonnet, Daniel Sinnett, Wolfgang Pfau & Damian Labuda. (2002) Analyses of bulky DNA adduct levels in human breast tissue and genetic polymorphisms of cytochromes P450 (CYPs), myeloperoxidase (MPO), quinone oxidoreductase (NQO1), and glutathione S-transferases (GSTs). Mutation Research/Genetic Toxicology and Environmental Mutagenesis 516:1-2, pages 41-47.
Crossref
David O Carpenter, Kathleen Arcaro & David C Spink. (2002) Understanding the human health effects of chemical mixtures.. Environmental Health Perspectives 110:suppl 1, pages 25-42.
Crossref
Magnus Ingelman-Sundberg & Mikael Oscarson. 2002. Cytochrome P450 Part C. Cytochrome P450 Part C 28 36 .
Sambasivarao Damaraju, Michael Sawyer & Brent Zanke. 2002. Clinically Relevant Resistance in Cancer Chemotherapy. Clinically Relevant Resistance in Cancer Chemotherapy 347 372 .
Pothur R Srinivas, Barnett S Kramer & Sudhir Srivastava. (2001) Trends in biomarker research for cancer detection. The Lancet Oncology 2:11, pages 698-704.
Crossref
Hannu Raunio, Arja Rautio, Harriet Gullstén & Olavi Pelkonen. (2001) Polymorphisms of CYP2A6 and its practical consequences. British Journal of Clinical Pharmacology 52:4, pages 357-363.
Crossref
Catherine Gallou, Sandrine Longuemaux, Claudine Deloménie, Arnaud Méjean, Natacha Martin, Stéphane Martinet, Gaël Palais, Raymonde Bouvier, Dominique Droz, Rajagopal Krishnamoorthy, Claudine Junien, Christophe Béroud & Jean-Marie Dupret. (2001) Association of GSTT1 non-null and NAT1 slow/rapid genotypes with von Hippel-Lindau tumour suppressor gene transversions in sporadic renal cell carcinoma. Pharmacogenetics 11:6, pages 521-535.
Crossref
Stacey J Wieczorek & Gregory J Tsongalis. (2001) Pharmacogenomics: will it change the field of medicine?. Clinica Chimica Acta 308:1-2, pages 1-8.
Crossref
Daniel W. Nebert & Amy L. Roe. 2001. Patty's Toxicology. Patty's Toxicology.
Judy Wong, Patricia Harper, Urs Meyer, Karl Bock, Klaus Morike, Jean Lagueux, Pierre Ayotte, Rachel Tyndale, Edward Sellers, David Manchester & Allan Okey. (2001) Pharmacogenetics 11:1, pages 85-94.
Crossref
Graeme I. Murray. (2000) The role of cytochrome P450 in tumour development and progression and its potential in therapy. The Journal of Pathology 192:4, pages 419-426.
Crossref
Katherine J. Aitchison, Frank J. Gonzalez, Linda C. Quattrochi, Andrea Sapone, Jing H. Zhao, Hani Zaher, Guillermo Elizondo, Catherine Bryant, Janet Munro, David A. Collier, Andrew J. Makoff & Robert W Kerwin. (2000) Identification of novel polymorphisms in the 5’ flanking region of CYP1A2, characterization of interethnic variability, and investigation of their functional significance. Pharmacogenetics 10:8, pages 695-704.
Crossref
Chantal Guillemette, Joseph K. Ritter, Diana J. Auyeung, Fay K. Kessler & David E. Housman. (2000) Structural heterogeneity at the UDP-glucuronosyltransferase 1 locus: functional consequences of three novel missense mutations in the human UGT1A7 gene. Pharmacogenetics 10:7, pages 629-644.
Crossref
DANIEL W. NEBERT, TIMOTHY P. DALTON, GARY W. STUART & MICHAEL J. CARVANIIIIII. (2006) “Gene-Swap Knock-in” Cassette in Mice to Study Allelic Differences in Human Genes. Annals of the New York Academy of Sciences 919:1, pages 148-170.
Crossref
Dieter Schwarz, Pyotr Kisselev, Wolf-Hagen Schunck, Alexey Chernogolov, Werner Boidol, Ingolf Cascorbi & Ivar Roots. (2000) Allelic variants of human cytochrome P450 1A1 (CYP1A1): effect of T461N and I462V substitutions on steroid hydroxylase specificity. Pharmacogenetics 10:6, pages 519-530.
Crossref
David W. Hein, Denis M. Grant & Edith Sim. (2000) Update on consensus arylamine N-acetyltransferase gene nomenclature. Pharmacogenetics 10:4, pages 291-292.
Crossref
Daniel W. Nebert. (2000) Suggestions for the nomenclature of human alleles: relevance to ecogenetics, pharmacogenetics and molecular epidemiology. Pharmacogenetics 10:4, pages 279-290.
Crossref
Sherif Z. Abdel-Rahman, Salama A. Salama, William W. Au & Farid A. Hamada. (2000) Role of polymorphic CYP2E1 and CYP2D6 genes in NNK-induced chromosome aberrations in cultured human lymphocytes. Pharmacogenetics 10:3, pages 239-249.
Crossref
Ruth March. (2000) Pharmacogenomics: The Genomics of Drug Response. Yeast 1:1, pages 16-21.
Crossref
N. Caporaso, N. Rothman & S. Wacholder. (1999) Case-Control Studies of Common Alleles and Environmental Factors. JNCI Monographs 1999:26, pages 25-30.
Crossref
Daniel W Nebert. (2001) Pharmacogenetics and pharmacogenomics: why is this relevant to the clinical geneticist?. Clinical Genetics 56:4, pages 247-258.
Crossref
Ann K Daly, Karen S Fairbrother & Joanne Smart. (1998) Recent advances in understanding the molecular basis of polymorphisms in genes encoding cytochrome P450 enzymes. Toxicology Letters 102-103, pages 143-147.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.