192
Views
62
CrossRef citations to date
0
Altmetric
Research Article

FK506 AND THE ROLE OF THE IMMUNOPHILIN FKBP-52 IN NERVE REGENERATION*

Pages 649-663 | Published online: 16 Aug 1999

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (6)

Feng Zheng, Biao Zhang, Yanan Sun, Mingfeng Qiu & Jing Su. (2015) Evaluation of WO2011045166A1, Fkbp52–tau interaction as a novel therapeutical target for treating the neurological disorders involving tau dysfunction. Expert Opinion on Therapeutic Patents 25:7, pages 831-835.
Read now
Robert E Babine, J Ernest Villafranca & Bruce G Gold. (2005) FKBP immunophilin patents for neurological disorders. Expert Opinion on Therapeutic Patents 15:5, pages 555-573.
Read now
JosephC. Banis, JohnH. Barker, Michael Cunningham, CedricG. Francois, Allen Furr, Federico Grossi, Moshe Kon, Claudio Maldonado, Serge Martinez, Gustavo Perez-Abadia, Marieke Vossen & OsborneP. Wiggins. (2004) Response to Selected Commentaries on the AJOB Target Article “On the Ethics of Facial Transplantation Research”. The American Journal of Bioethics 4:3, pages W23-W31.
Read now
Bruce G. Gold, Esther Udina, Dennis Bourdette & Xavier Navarro. (2004) Neuroregenerative and neuroprotective actions of neuroimmunophilin compounds in traumatic and inflammatory neuropathies. Neurological Research 26:4, pages 371-380.
Read now
Terence M. Myckatyn & Susan E. MacKinnon. (2004) A review of research endeavors to optimize peripheral nerve reconstruction. Neurological Research 26:2, pages 124-138.
Read now
Bruce G Gold. (2000) Neuroimmunophilin ligands: evaluation of their therapeutic potential for the treatment of neurological disorders. Expert Opinion on Investigational Drugs 9:10, pages 2331-2342.
Read now

Articles from other publishers (56)

Mohammed Barham, Michael Streppel, Orlando Guntinas-Lichius, Nicole Fulgham-Scott, Johannes Vogt & Wolfram F. Neiss. (2022) Treatment With Nimodipine or FK506 After Facial Nerve Repair Neither Improves Accuracy of Reinnervation Nor Recovery of Mimetic Function in Rats. Frontiers in Neuroscience 16.
Crossref
Krishika Sambyal & Rahul Vikram Singh. (2020) Bioprocess and genetic engineering aspects of ascomycin production: a review. Journal of Genetic Engineering and Biotechnology 18:1.
Crossref
Sally Jo, Deng Pan, Alexandra E. Halevi, Joseph Roh, Lauren Schellhardt, Daniel A. Hunter RA, Alison K. Snyder‐Warwick, Amy M. Moore, Susan E. Mackinnon & Matthew D. Wood. (2019) Comparing electrical stimulation and tacrolimus (FK506) to enhance treating nerve injuries. Muscle & Nerve 60:5, pages 629-636.
Crossref
Brandon J. Peiffer, Le Qi, Ali R. Ahmadi, Yuefan Wang, Zufeng Guo, Hanjing Peng, Zhaoli Sun & Jun O. Liu. (2019) Activation of BMP Signaling by FKBP12 Ligands Synergizes with Inhibition of CXCR4 to Accelerate Wound Healing. Cell Chemical Biology 26:5, pages 652-661.e4.
Crossref
Qiaoli Wu, Guodong Liu, Lixia Xu, Xiaochang Wen, Ying Cai, Weijia Fan, Xiuhua Yao, Huiling Huang & Qingguo Li. (2016) Repair of Neurological Function in Response to FK506 Through CaN/NFATc1 Pathway Following Traumatic Brain Injury in Rats. Neurochemical Research 41:10, pages 2810-2818.
Crossref
Cillian Byrne, Morkos A. Henen, Mathilde Belnou, François-Xavier Cantrelle, Amina Kamah, Haoling Qi, Julien Giustiniani, Béatrice Chambraud, Etienne-Emile Baulieu, Guy Lippens, Isabelle Landrieu & Yves Jacquot. (2016) A β-Turn Motif in the Steroid Hormone Receptor’s Ligand-Binding Domains Interacts with the Peptidyl-prolyl Isomerase (PPIase) Catalytic Site of the Immunophilin FKBP52. Biochemistry 55:38, pages 5366-5376.
Crossref
Terry D. Hinds, Kezia John, Lucien McBeth, Christopher J. Trabbic & Edwin R. Sanchez. (2016) Timcodar (VX-853) Is a Non-FKBP12 Binding Macrolide Derivative That Inhibits PPAR γ and Suppresses Adipogenesis . PPAR Research 2016, pages 1-10.
Crossref
Pierfausto Seneci. 2015. Chemical Modulators of Protein Misfolding and Neurodegenerative Disease. Chemical Modulators of Protein Misfolding and Neurodegenerative Disease 25 71 .
P. J. Johnson, M. D. Wood, A. M . Moore & S. E. Mackinnon. (2013) Tissue engineered constructs for peripheral nerve surgery. European Surgery 45:3, pages 122-135.
Crossref
H.H. Sun, M. Saheb-Al-Zamani, Y. Yan, D.A. Hunter, S.E. Mackinnon & P.J. Johnson. (2012) Geldanamycin accelerated peripheral nerve regeneration in comparison to FK-506 in vivo. Neuroscience 223, pages 114-123.
Crossref
Ying Yan, Hank H. Sun, Susan E. Mackinnon & Philip J. Johnson. (2011) Evaluation of peripheral nerve regeneration via in vivo serial transcutaneous imaging using transgenic Thy1-YFP mice. Experimental Neurology 232:1, pages 7-14.
Crossref
Melanie Gerard, Angélique Deleersnijder, Jonas Demeulemeester, Zeger Debyser & Veerle Baekelandt. (2011) Unraveling the Role of Peptidyl-Prolyl Isomerases in Neurodegeneration. Molecular Neurobiology 44:1, pages 13-27.
Crossref
Maria Siemionow, Bahar Bassiri Gharb & Antonio Rampazzo. (2011) Pathways of Sensory Recovery after Face Transplantation. Plastic and Reconstructive Surgery 127:5, pages 1875-1889.
Crossref
Magdalena Zak, Andreas Bress, Markus Pfister & Nikolaus Blin. (2011) Temporal Expression Pattern of Fkbp8 in Rodent Cochlea. Cellular Physiology and Biochemistry 28:5, pages 1023-1030.
Crossref
Bahar Bassiri Gharb, Antonio Rampazzo & Maria Z. Siemionow. 2011. The Know-How of Face Transplantation. The Know-How of Face Transplantation 375 387 .
Héctor R. Quintá, Darío Maschi, Celso Gomez‐Sanchez, Graciela Piwien‐Pilipuk & Mario D. Galigniana. (2010) Subcellular rearrangement of hsp90‐binding immunophilins accompanies neuronal differentiation and neurite outgrowth. Journal of Neurochemistry 115:3, pages 716-734.
Crossref
Daniela Fusco, Manuela Vargiolu, Michele Vidone, Elisa Mariani, Lucia Fiammetta Pennisi, Elena Bonora, Sabina Capellari, Dietmar Dirnberger, Ralf Baumeister, Paolo Martinelli & Giovanni Romeo. (2010) The RET51/FKBP52 complex and its involvement in Parkinson disease. Human Molecular Genetics 19:14, pages 2804-2816.
Crossref
Amala Soumyanath, Yong-Ping Zhong, Xiaolin Yu, Dennis Bourdette, Dennis R Koop, Sandra A Gold & Bruce G Gold. (2005) Centella asiatica accelerates nerve regeneration upon oral administration and contains multiple active fractions increasing neurite elongation in-vitro . Journal of Pharmacy and Pharmacology 57:9, pages 1221-1229.
Crossref
Gwen Lagoda, Sena F. Sezen & Arthur L. Burnett. (2009) FK506 and Rapamycin Neuroprotect Erection and Involve Different Immunophilins in a Rat Model of Cavernous Nerve Injury. The Journal of Sexual Medicine 6:7, pages 1914-1923.
Crossref
Radoslav Savić, Tony Azzam, Adi Eisenberg, Hinyu Nedev, Lawrence Rosenberg & Dusica Maysinger. (2009) Block-copolymer micelles as carriers of cell signaling modulators for the inhibition of JNK in human islets of Langerhans. Biomaterials 30:21, pages 3597-3604.
Crossref
Christian Kozany, Andreas März, Christoph Kress & Felix Hausch. (2009) Fluorescent Probes to Characterise FK506-Binding Proteins. ChemBioChem 10:8, pages 1402-1410.
Crossref
H. Piza-Katzer. 2009. Plastische Chirurgie. Plastische Chirurgie 475 488 .
Ayato Hayashi, Arash Moradzadeh, Alice Tong, Cindy Wei, Sami H. Tuffaha, Daniel A. Hunter, Thomas H. Tung, Alexander Parsadanian, Susan E. Mackinnon & Terence M. Myckatyn. (2008) Treatment modality affects allograft-derived Schwann cell phenotype and myelinating capacity. Experimental Neurology 212:2, pages 324-336.
Crossref
John H. Barker, Charles S. Brown, Michael Cunningham, Osborne Wiggins, Allen Furr, Claudio Maldonado & Joseph C. Banis. (2008) Ethical Considerations in Human Facial Tissue Allotransplantation. Annals of Plastic Surgery 60:1, pages 103-109.
Crossref
Matthew L. Maddess, Miles N. Tackett & Steven V. Ley. 2008. Natural Compounds as Drugs. Natural Compounds as Drugs 13 186 .
Michael J. Brenner, Arash Moradzadeh, Terence M. Myckatyn, Thomas H. H. Tung, Allen B. Mendez, Daniel A. Hunter & Susan E. Mackinnon. (2008) Role of timing in assessment of nerve regeneration. Microsurgery 28:4, pages 265-272.
Crossref
Charles S. Brown, Brian Gander, Michael Cunningham, Allen Furr, Dalibor Vasilic, Osborne Wiggins, Joseph C. BanisJr.Jr., Marieke Vossen, Claudio Maldonado, Gustavo Perez-Abadia & John H. Barker. (2007) Ethical considerations in face transplantation. International Journal of Surgery 5:5, pages 353-364.
Crossref
Ulrich W. Thomale, Marcel Bender, Pablo Casalis, Stefan Rupprecht, Martin Griebenow, Konrad Neumann, Christian Woiciechowsky, Andreas W. Unterberg & John F. Stover. (2007) Tacrolimus depresses local immune cell infiltration but fails to reduce cortical contusion volume in brain-injured rats. Immunobiology 212:7, pages 567-576.
Crossref
Julio A. Clavijo-Alvarez, Giselle G. Hamad, Aurèle Taieb & W.P. Andrew Lee. (2007) Pharmacologic Approaches to Composite Tissue Allograft. The Journal of Hand Surgery 32:1, pages 104-118.
Crossref
Liqin Zhao, Hongying Liu, Lili Wang & Song Li. (2006) Modeling and synthesis of non-cyclic derivatives of GPI-1046 as potential FKBP ligands with neurotrophic properties. Bioorganic & Medicinal Chemistry Letters 16:16, pages 4385-4390.
Crossref
Jan VodaTakayuki YamajiBruce G. Gold. (2005) Neuroimmunophilin Ligands Improve Functional Recovery and Increase Axonal Growth after Spinal Cord Hemisection in Rats. Journal of Neurotrauma 22:10, pages 1150-1161.
Crossref
Bruce G. Gold, David M. Armistead & Min-Sheng Wang. (2005) Non-FK506-binding protein-12 neuroimmunophilin ligands increase neurite elongation and accelerate nerve regeneration. Journal of Neuroscience Research 80:1, pages 56-65.
Crossref
Bruce G. Gold, Jan Voda, Xiaolin Yu, Gabriel McKeon & Dennis N. Bourdette. (2004) FK506 and a nonimmunosuppressant derivative reduce axonal and myelin damage in experimental autoimmune encephalomyelitis: Neuroimmunophilin ligand-mediated neuroprotection in a model of multiple sclerosis. Journal of Neuroscience Research 77:3, pages 367-377.
Crossref
Terence M. Myckatyn, Susan E. Mackinnon & John W. McDonald. (2004) Stem cell transplantation and other novel techniques for promoting recovery from spinal cord injury. Transplant Immunology 12:3-4, pages 343-358.
Crossref
M.O. Poulter, K.B. Payne & J.P. Steiner. (2004) Neuroimmunophilins: A novel drug therapy for the reversal of neurodegenerative disease?. Neuroscience 128:1, pages 1-6.
Crossref
Roberta K. Yang, James B. LoweIII,III,, Julia B. Sobol, Subhro K. Sen, Daniel A. Hunter & Susan E. Mackinnon. (2003) Dose-Dependent Effects of FK506 on Neuroregeneration in a Rat Model. Plastic and Reconstructive Surgery 112:7, pages 1832-1840.
Crossref
Wei-Qin Zhao, Christina Feng & Daniel L Alkon. (2003) Impairment of phosphatase 2A contributes to the prolonged MAP kinase phosphorylation in Alzheimer's disease fibroblasts. Neurobiology of Disease 14:3, pages 458-469.
Crossref
Russell S. Gillon, Qi Cui, Sarah A. Dunlop & Alan R. Harvey. (2003) Effects of immunosuppression on regrowth of adult rat retinal ganglion cell axons into peripheral nerve allografts. Journal of Neuroscience Research 74:4, pages 524-532.
Crossref
S Brecht, K Schwarze, V Waetzig, C Christner, S Heiland, G Fischer, K Sartor & T Herdegen. (2003) Changes in peptidyl-prolyl cis/trans isomerase activity and fk506 binding protein expression following neuroprotection by fk506 in the ischemic rat brain. Neuroscience 120:4, pages 1037-1048.
Crossref
Esther Udina, Dolores Ceballos, Bruce G Gold & Xavier Navarro. (2003) FK506 enhances reinnervation by regeneration and by collateral sprouting of peripheral nerve fibers. Experimental Neurology 183:1, pages 220-231.
Crossref
Terence M Myckatyn, Daniel A Hunter & Susan E Mackinnon. (2003) The effects of cold preservation and subimmunosuppressive doses of FK506 on axonal regeneration in murine peripheral nerve isografts. Canadian Journal of Plastic Surgery 11:1, pages 15-22.
Crossref
Philip Rosenstiel, Peter Schramm, Stefan Isenmann, Stefan Brecht, Christian Eickmeier, Erich Bürger, Thomas Herdegen, Jobst Sievers & Ralph Lucius. (2003) Differential Effects of Immunophilin-Ligands (FK506 and V-10,367) on Survival and Regeneration of Rat Retinal Ganglion Cells In Vitro and after Optic Nerve Crush In Vivo . Journal of Neurotrauma 20:3, pages 297-307.
Crossref
Ramsay A. Ellis, Michael J. Brenner, Susan E. Mackinnon, Terence M. Myckatyn & Daniel A. Hunter. (2003) Use of mixed lymphocyte reaction to identify subimmunosuppressive FK‐506 levels in mice. Microsurgery 23:3, pages 276-282.
Crossref
Esther Udina, Dolores Ceballos, Enrique Verdú, Bruce G. Gold & Xavier Navarro. (2002) Bimodal dose-dependence of FK506 on the rate of axonal regeneration in mouse peripheral nerve. Muscle & Nerve 26:3, pages 348-355.
Crossref
H. PIZA-KATZER, M. NINKOVIC, S. PECHLANER, M. GABL, M. NINKOVIC & H. HUSSL. (2016) Double Hand Transplantation: Functional Outcome after 18 Months. Journal of Hand Surgery 27:4, pages 385-390.
Crossref
Kalju Kahn & Thomas C. Bruice. (2002) Parameterization of OPLS–AA force field for the conformational analysis of macrocyclic polyketides. Journal of Computational Chemistry 23:10, pages 977-996.
Crossref
Aaron G. Grand, Terence M. Myckatyn, Susan E. Mackinnon & Daniel A. Hunter. (2002) Axonal regeneration after cold preservation of nerve allografts and immunosuppression with tacrolimus in mice. Journal of Neurosurgery 96:5, pages 924-932.
Crossref
Martina Zuber & Josef Donnerer. (2002) Effect of FK506 on Neurotransmitter Content and Expression of GAP-43 in Neurotoxin-Lesioned Peripheral Sensory and Sympathetic Neurons. Pharmacology 66:1, pages 44-50.
Crossref
Xavier Navarro, Esther Udina, Dolores Ceballos & Bruce G. Gold. (2001) Effects of FK506 on nerve regeneration and reinnervation after graft or tube repair of long nerve gaps. Muscle & Nerve 24:7, pages 905-915.
Crossref
John G. LunzIIIIII, Sarah Contrucci, Kris Ruppert, Noriko Murase, John J. Fung, Thomas E. Starzl & Anthony J. Demetris. (2001) Replicative Senescence of Biliary Epithelial Cells Precedes Bile Duct Loss in Chronic Liver Allograft Rejection. The American Journal of Pathology 158:4, pages 1379-1390.
Crossref
Holger Neye. (2001) Mutation of FKBP associated protein 48 (FAP48) at proline 219 disrupts the interaction with FKBP12 and FKBP52. Regulatory Peptides 97:2-3, pages 147-152.
Crossref
Bruce G. Gold. (2001) Tissue Engineering of Peripheral Nerves: A Comparison of Venous and Acellular Muscle Grafts with Cultured Schwann Cells by Hisham Fansa, M.D. Gerburg Keilhoff, Ph.D., Gerald Wolf, Ph.D., Wolfgang Schneider, M.D., Ph.D.. Plastic and Reconstructive Surgery 107:2, pages 495-496.
Crossref
James Peeling, Hui-Jin Yan, Dale Corbett, M. Xue & Marc R. Del Bigio. (2001) Effect of FK-506 on Inflammation and Behavioral Outcome Following Intracerebral Hemorrhage in Rat. Experimental Neurology 167:2, pages 341-347.
Crossref
Holger Neye. (2000) Immunophiline: Vermittlung immunsuppressiver Aktivität und physiologische Funktion. Pharmazie in unserer Zeit 29:5, pages 297-302.
Crossref
Kai Wu, Loleta Chung, W.Peter Revill, Leonard Katz & Christopher D. Reeves. (2000) The FK520 gene cluster of Streptomyces hygroscopicus var. ascomyceticus (ATCC 14891) contains genes for biosynthesis of unusual polyketide extender units. Gene 251:1, pages 81-90.
Crossref
Cedric G. Francois, Warren C. Breidenbach, Claudio Maldonado, Thanos P. Kakoulidis, Anne Hodges, Jean-Michel Dubernard, Earl Owen, Guoxain Pei, Xiaoping Ren & John H. Barker. (2000) Hand transplantation: Comparisons and observations of the first four clinical cases. Microsurgery 20:8, pages 360-371.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.