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Drug Metabolism Reviews Volume 32, 2000 - Issue 3-4
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Research Article

WHAT MAKES P450s WORK? SEARCHES FOR ANSWERS WITH KNOWN AND NEW P450s*

F. PETER GUENGERICH Department of Biochemistry and Center in Molecular Toxicology, Vanderbilt University School of Medicine, Nashville, Tennessee, 37232-0146, U.S.A.; Department of Biochemistry and Center in Molecular Toxicology, Vanderbilt University School of Medicine, 638 Medical Research Building I, 23rd & Pierce Avenues, Nashville, TN, 37232-0146, U.S.A.
,
ASIT PARIKH Department of Biochemistry and Center in Molecular Toxicology, Vanderbilt University School of Medicine, Nashville, Tennessee, 37232-0146, U.S.A.
,
CHUL-HO YUN Department of Biochemistry and Center in Molecular Toxicology, Vanderbilt University School of Medicine, Nashville, Tennessee, 37232-0146, U.S.A.
,
DONGHAK KIM Department of Biochemistry and Center in Molecular Toxicology, Vanderbilt University School of Medicine, Nashville, Tennessee, 37232-0146, U.S.A.
,
KATSUNORI NAKAMURA Department of Biochemistry and Center in Molecular Toxicology, Vanderbilt University School of Medicine, Nashville, Tennessee, 37232-0146, U.S.A.
,
LISA M. NOTLEY Department of Physiology and Pharmacology, The University of Queensland, Brisbane, Queensland, 4072, Australia
&
ELIZABETH M. J. GILLAM Department of Physiology and Pharmacology, The University of Queensland, Brisbane, Queensland, 4072, Australia
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Pages 267-281 | Published online: 10 Oct 2000

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Y. W. Kim, Y. K. Kim, D.-K. Kim & Y. Y. Sheen. (2008) Identification of human cytochrome P450 enzymes involved in the metabolism of IN-1130, a novel activin receptor-like kinase-5 (ALK5) inhibitor. Xenobiotica 38:5, pages 451-464.
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D Springer, R. F Staack, L. D Paul, T Kraemer & H. H Maurer. (2005) Identification of cytochrome P450 enzymes involved in the metabolism of 3′,4′-methylenedioxy-α-pyrrolidinopropiophenone (MDPPP), a designer drug, in human liver microsomes. Xenobiotica 35:3, pages 227-237.
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D. Springer, R. F. Staack, L. D. Paul, T. Kraemer & H. H. Maurer. (2003) Identification of cytochrome P450 enzymes involved in the metabolism of 4′-methoxy-α-pyrrolidinopropiophenone (MOPPP), a designer drug, in human liver microsomes. Xenobiotica 33:10, pages 989-998.
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Slobodan Rendic. (2002) Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metabolism Reviews 34:1-2, pages 83-448.
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H.M. Chandra Mouli, Adithya Vinod, Shikha Kumari, Amit K. Tiwari, M.K. Kathiravan, V. Ravichandiran & Ramalingam Peraman. (2023) Deuterated driven new chemical entities: An optimistic way to improve therapeutic efficacy. Bioorganic Chemistry 135, pages 106490.
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Lydia Benkaidali, François André, Gautier Moroy, Bahoueddine Tangour, François Maurel & Michel Petitjean. (2019) Four Major Channels Detected in the Cytochrome P450 3A4: A Step toward Understanding Its Multispecificity. International Journal of Molecular Sciences 20:4, pages 987.
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Line Zurkinden, Dmitri Sviridov, Bruno Vogt & Geneviève Escher. (2018) Sterol 27-hydroxylase gene dosage and the antiatherosclerotic effect of Rifampicin in mice. Bioscience Reports 38:1.
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Thomas G. Gant. (2013) Using Deuterium in Drug Discovery: Leaving the Label in the Drug. Journal of Medicinal Chemistry 57:9, pages 3595-3611.
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Helena Líbalová, Kateřina Uhlířová, Jiří Kléma, Miroslav Machala, Radim J Šrám, Miroslav Ciganek & Jan Topinka. (2012) Global gene expression changes in human embryonic lung fibroblasts induced by organic extracts from respirable air particles. Particle and Fibre Toxicology 9:1.
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Sean C Gay, Arthur G Roberts & James R Halpert. (2010) Structural features of cytochromes P450 and ligands that affect drug metabolism as revealed by x-ray crystallography and NMR. Future Medicinal Chemistry 2:9, pages 1451-1468.
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Patrik Rydberg, Poongavanam Vasanthanathan, Chris Oostenbrink & Lars Olsen. (2009) Fast Prediction of Cytochrome P450 Mediated Drug Metabolism. ChemMedChem 4:12, pages 2070-2079.
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K.E. Janak. 2007. Comprehensive Organometallic Chemistry III. Comprehensive Organometallic Chemistry III 541 571 .
Ragulan Ramanathan, Swapan K. Chowdhury & Kevin B. Alton. 2005. Identification and Quantification of Drugs, Metabolites and Metabolizing Enzymes by LC-MS. Identification and Quantification of Drugs, Metabolites and Metabolizing Enzymes by LC-MS 225 276 .
Thomas Kraemer, Thomas Pflugmann, Michael Bossmann, Nicole M Kneller, Frank T Peters, Liane D Paul, Dietmar Springer, Roland F Staack & Hans H Maurer. (2004) Fenproporex N-dealkylation to amphetamine—enantioselective in vitro studies in human liver microsomes as well as enantioselective in vivo studies in Wistar and Dark Agouti rats. Biochemical Pharmacology 68:5, pages 947-957.
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Rita Bernhardt. 2004. Encyclopedia of Biological Chemistry. Encyclopedia of Biological Chemistry 544 549 .
Guang Yao, Eric B. Harstad & Christopher A. Bradfield. 2003. PAS Proteins: Regulators and Sensors of Development and Physiology. PAS Proteins: Regulators and Sensors of Development and Physiology 149 182 .
Suchitra Banerjee, Tanya Q. Shang, Angela M. Wilson, Allison L. Moore, Stuart E. Strand, Milton P. Gordon & Sharon Lafferty Doty. (2002) Expression of functional mammalian P450 2E1 in hairy root cultures. Biotechnology and Bioengineering 77:4, pages 462-466.
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