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Research Article

Prevention of carcinogenesis by tea polyphenols*

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Pages 237-253 | Published online: 04 Mar 2002

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Yonela Ntamo, Babalwa Jack, Khanyisani Ziqubu, Sithandiwe E. Mazibuko-Mbeje, Bongani B. Nkambule, Tawanda M. Nyambuya, Sihle E. Mabhida, Sidney Hanser, Patrick Orlando, Luca Tiano & Phiwayinkosi V. Dludla. (2022) Epigallocatechin gallate as a nutraceutical to potentially target the metabolic syndrome: novel insights into therapeutic effects beyond its antioxidant and anti-inflammatory properties. Critical Reviews in Food Science and Nutrition 0:0, pages 1-23.
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Noemí Yubero, Marisa Sanz-Buenhombre, Alberto Guadarrama, Sonia Villanueva, Juan M. Carrión, Eider Larrarte & Carlos Moro. (2013) LDL cholesterol-lowering effects of grape extract used as a dietary supplement on healthy volunteers. International Journal of Food Sciences and Nutrition 64:4, pages 400-406.
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Wei-Xuan Wang, Hongzong Si & Ziding Zhang. (2012) Quantitative structure–activity relationship study on antitumour activity of a series of flavonoids. Molecular Simulation 38:1, pages 38-44.
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Julie A. Baker, Susan E. McCann, Mary E. Reid, Susan Nowell, Gregory P. Beehler & Kirsten B. Moysich. (2005) Associations Between Black Tea and Coffee Consumption and Risk of Lung Cancer Among Current and Former Smokers. Nutrition and Cancer 52:1, pages 15-21.
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Elsa M. Janle, Carla Portocarrero, Yongxin Zhu & Qin Zhou. (2005) Effect of Long-Term Oral Administration of Green Tea Extract on Weight Gain and Glucose Tolerance in Zucker Diabetic (ZDF) Rats. Journal Of Herbal Pharmacotherapy 5:3, pages 55-65.
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Maria Eugenia Maciel, Gerardo Daniel Castro & Jose Alberto Castro. (2004) Inhibition of the Rat Breast Cytosolic Bioactivation of Ethanol to Acetaldehyde by Some Plant Polyphenols and Folic Acid. Nutrition and Cancer 49:1, pages 94-99.
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Y. G. Yun, H. Oh, G. S. Oh, H. O. Pae, B. M. Choi, J. W. Kwon, T. O. Kwon, S. I. Jang & Hun‐Taeg Chung. (2004) In Vitro Cytotoxicity of Mokko Lactone in Human Leukemia HL‐60 Cells: Induction of Apoptotic Cell Death by Mitochondrial Membrane Potential Collapse. Immunopharmacology and Immunotoxicology 26:3, pages 343-353.
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Vanessa Crespy, Nathalie Nancoz, Manuel Oliveira, Jörg Hau, Marie-Claude Courtet-compondu & Gary Williamson. (2004) Glucuronidation of the Green Tea Catechins, (-)-epigallocatechin-3-gallate and (-)-epicatechin-3-gallate, by Rat Hepatic and Intestinal Microsomes. Free Radical Research 38:9, pages 1025-1031.
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F. Catterall, L. J. King, M. N. Clifford & C. Ioannides. (2003) Bioavailability of dietary doses of 3H-labelled tea antioxidants (+)-catechin and (-)-epicatechin in rat. Xenobiotica 33:7, pages 743-753.
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Ho Yee Chan, Huan Wang, David S. C. Tsang, Zhen-Yu Chen & Lai K. Leung. (2003) Screening of Chemopreventive Tea Polyphenols Against PAH Genotoxicity in Breast Cancer Cells by a XRE-Luciferase ReporterConstruct. Nutrition and Cancer 46:1, pages 93-100.
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Yihuai Gao & Shufeng Zhou. (2003) Cancer Prevention and Treatment by Ganoderma, a Mushroom with Medicinal Properties. Food Reviews International 19:3, pages 275-325.
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Articles from other publishers (46)

Heng Shi, Xinhai Zhao, Qin Peng, Xianling Zhou, Sisi Liu, Chuanchuan Sun, Qiuyu Cao, Shiping Zhu & Shengyun Sun. (2023) Green Tea Polyphenols Alleviate Kidney Injury Induced by Di(2-Ethylhexyl) Phthalate in Mice. American Journal of Nephrology, pages 1-20.
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Mehmet Fuat Gülhan. (2023) A New Substrate and Nitrogen Source for Traditional Kombucha Beverage: Stevia rebaudiana Leaves. Applied Biochemistry and Biotechnology.
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Yoshimi Niwano, Hidetsugu Kohzaki, Midori Shirato, Shunichi Shishido & Keisuke Nakamura. (2022) Putative Mechanisms Underlying the Beneficial Effects of Polyphenols in Murine Models of Metabolic Disorders in Relation to Gut Microbiota. Current Issues in Molecular Biology 44:3, pages 1353-1375.
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Gökhan Akarca & Oktay TOMAR. (2018) Siyah ve Yeşil Çay İle Üretilen Kombucha Çaylarının Antimikrobiyal ve Antioksidatif Özellikleri. European Journal of Science and Technology, pages 96-101.
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Dilek Ceylan, Ahmet Aksoy, Tolga Ertekin, Arzu Hanım Yay, Mehtap Nisari, Gökçe Şeker Karatoprak & Harun Ülger. (2018) The effects of gilaburu (Viburnum opulus) juice on experimentally induced Ehrlich ascites tumor in mice. Journal of Cancer Research and Therapeutics 14:2, pages 314-320.
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Chwan-Li Shen, Gordon Brackee, Xiao Song, Michael D. Tomison, VelvetLee Finckbone, Kelly T. Mitchell, Lili Tang, Ming-Chien Chyu, Dale M. Dunn & Jia-Sheng Wang. (2017) Safety Evaluation of Green Tea Polyphenols Consumption in Middle-aged Ovariectomized Rat Model. Journal of Food Science 82:9, pages 2192-2205.
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Saumya Nigam & D. Bahadur. (2016) Dendrimerized Magnetic Nanoparticles as Carriers for the Anticancer Compound, Epigallocatechin Gallate. IEEE Transactions on Magnetics 52:6, pages 1-5.
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Mohammad Ali Esmaeili. (2015) Combination of siRNA-directed gene silencing with epigallocatechin-3-gallate (EGCG) reverses drug resistance in human breast cancer cells. Journal of Chemical Biology 9:1, pages 41-52.
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Yi Yue, Gang-Xiu Chu, Xue-Shi Liu, Xing Tang, Wei Wang, Guang-Jin Liu, Tao Yang, Tie-Jun Ling, Xiao-Gang Wang, Zheng-Zhu Zhang, Tao Xia, Xiao-Chun Wan & Guan-Hu Bao. (2014) TMDB: A literature-curated database for small molecular compounds found from tea. BMC Plant Biology 14:1.
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Szu-Chin Cheng, Wen-Hsuan Li, Yeu-Ching Shi, Pei-Ling Yen, Huan-You Lin, Vivian Hsiu-Chuan Liao & Shang-Tzen Chang. (2014) Antioxidant Activity and Delayed Aging Effects of Hot Water Extract from Chamaecyparis obtusa var. formosana Leaves . Journal of Agricultural and Food Chemistry 62:18, pages 4159-4165.
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Gerardo D. Castro, Leandro N. Quintans, María E. Maciel & José A. Castro. 2014. Polyphenols in Human Health and Disease. Polyphenols in Human Health and Disease 1181 1190 .
Thummala Srihari, Krishnamoorthy Karthikesan, Natarajan Ashokkumar & Uppala Satyanarayana. (2013) Antihyperglycaemic efficacy of kombucha in streptozotocin-induced rats. Journal of Functional Foods 5:4, pages 1794-1802.
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Andy H. Lee, Dada Su, Maria Pasalich & Colin W. Binns. (2013) Tea consumption reduces ovarian cancer risk. Cancer Epidemiology 37:1, pages 54-59.
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Yu Wu. (2013) Therapeutic potential of EGCG on acute renal damage in a rat model of obstructive nephropathy. Molecular Medicine Reports.
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Gerardo Daniel Castro & José Alberto Castro. 2013. Alcohol, Nutrition, and Health Consequences. Alcohol, Nutrition, and Health Consequences 145 154 .
Marieke GM Braem, N Charlotte Onland-Moret, Leo J Schouten, Anne Tjønneland, Louise Hansen, Christina C Dahm, Kim Overvad, Annekatrin Lukanova, Laure Dossus, Anna Floegel, Heiner Boeing, Francoise Clavel-Chapelon, Nathalie Chabbert-Buffet, Guy Fagherazzi, Antonia Trichopoulou, Vassiliki Benetou, Ioulia Goufa, Valeria Pala, Rocco Galasso, Amalia Mattiello, Carlotta Sacerdote, Domenico Palli, Rosario Tumino, Inger T Gram, Eiliv Lund, Oxana Gavrilyuk, Maria-José Sánchez, Ramón Quirós, Carlos A Gonzales, Miren Dorronsoro, José M Huerta Castaño, Aurelio Barricarte Gurrea, Annika Idahl, Nina Ohlson, Eva Lundin, Karin Jirstrom, Elisabet Wirfalt, Naomi E Allen, Konstantinos K Tsilidis, Kay-Tee Kaw, H Bas Bueno-de-Mesquita, Vincent K Dik, Sabina Rinaldi, Veronika Fedirko, Teresa Norat, Elio Riboli, Rudolf Kaaks & Petra HM Peeters. (2012) Coffee and tea consumption and the risk of ovarian cancer: a prospective cohort study and updated meta-analysis. The American Journal of Clinical Nutrition 95:5, pages 1172-1181.
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Nadi Eleya, Imran Malik, Sebastian Reimann, Kai Wittler, Martin Hein, Tamás Patonay, Alexander Villinger, Ralf Ludwig & Peter Langer. (2012) Efficient Synthesis of Arylated Flavones by Site‐Selective Suzuki–Miyaura Cross‐Coupling Reactions of the Bis(triflate) of 5,7‐ and 7,8‐Dihydroxyflavone. European Journal of Organic Chemistry 2012:8, pages 1639-1652.
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Maurizio Barontini, Roberta Bernini, Fernanda Crisante & Giancarlo Fabrizi. (2010) Selective and efficient oxidative modifications of flavonoids with 2-iodoxybenzoic acid (IBX). Tetrahedron 66:32, pages 6047-6053.
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J.M. Lee, M.-G. Chen, T.-C. Hwang & C.-Y. Yeh. (2010) Effect of cigarette taxes on the consumption of cigarettes, alcohol, tea and coffee in Taiwan. Public Health 124:8, pages 429-436.
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Recep Bıyık & Recep Tapramaz. (2009) An EPR study on tea: Identification of paramagnetic species, effect of heat and sweeteners. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 74:3, pages 767-770.
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Suresh R. Volate, Stephanie J. Muga, Ala Y. Issa, Daniela Nitcheva, Theresa Smith & Michael J. Wargovich. (2009) Epigenetic modulation of the retinoid X receptor α by green tea in the azoxymethane‐ Apc Min/+ mouse model of intestinal cancer . Molecular Carcinogenesis 48:10, pages 920-933.
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Céline Rivière, Jean-Claude Delaunay, Françoise Immel, Christophe Cullin & Jean-Pierre Monti. (2008) The Polyphenol Piceid Destabilizes Preformed Amyloid Fibrils and Oligomers In Vitro: Hypothesis on Possible Molecular Mechanisms. Neurochemical Research 34:6, pages 1120-1128.
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Daniela Weber. 2009. Physiology and Genetics. Physiology and Genetics 153 195 .
Hye-Kyung Na, Eun-Hee Kim, Joo-Hee Jung, Hyun-Hee Lee, Jin-Won Hyun & Young-Joon Surh. (2008) (?)-Epigallocatechin gallate induces Nrf2-mediated antioxidant enzyme expression via activation of PI3K and ERK in human mammary epithelial cells. Archives of Biochemistry and Biophysics 476:2, pages 171-177.
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Hye-Kyung Na & Young-Joon Surh. (2008) Modulation of Nrf2-mediated antioxidant and detoxifying enzyme induction by the green tea polyphenol EGCG. Food and Chemical Toxicology 46:4, pages 1271-1278.
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Yoon Ju Song, Alan R. Kristal, Kristine G. Wicklund, Kara L. Cushing-Haugen & Mary Anne Rossing. (2008) Coffee, Tea, Colas, and Risk of Epithelial Ovarian Cancer. Cancer Epidemiology, Biomarkers & Prevention 17:3, pages 712-716.
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Patricia M. Aron & James A. Kennedy. (2008) Flavan‐3‐ols: Nature, occurrence and biological activity. Molecular Nutrition & Food Research 52:1, pages 79-104.
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David R Foster, Kevin M Sowinski, H H Sherry Chow & Brian R Overholser. (2007) Limited Sampling Strategies to Estimate Exposure to the Green Tea Polyphenol, Epigallocatechin Gallate, in Fasting and Fed Conditions. Therapeutic Drug Monitoring 29:6, pages 835-842.
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Jung-Sook Shin & Ha-Sook Chung. (2007) Antibacterial Activities of Phenolic Components from Camellia sinensis L. on Pathogenic Microorganisms. Preventive Nutrition and Food Science 12:3, pages 135-140.
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D. I. Metelitza & E. I. Karasyova. (2007) Initiation and inhibition of free-radical processes in biochemical peroxide systems: A review. Applied Biochemistry and Microbiology 43:5, pages 481-505.
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Thomas Walle, Nga Ta, Toshihiko Kawamori, Xia Wen, Petra A. Tsuji & U. Kristina Walle. (2007) Cancer chemopreventive properties of orally bioavailable flavonoids—Methylated versus unmethylated flavones. Biochemical Pharmacology 73:9, pages 1288-1296.
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J. A. Baker, K. Boakye, S. E. Mccann, G. P. Beehler, K. J. Rodabaugh, J. A. Villella & K. B. Moysich. (2007) Consumption of black tea or coffee and risk of ovarian cancer. International Journal of Gynecologic Cancer 17:1, pages 50-54.
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R. Jayabalan, S. Marimuthu & K. Swaminathan. (2007) Changes in content of organic acids and tea polyphenols during kombucha tea fermentation. Food Chemistry 102:1, pages 392-398.
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Céline Rivière, Tristan Richard, Lysiane Quentin, Stéphanie Krisa, Jean-Michel Mérillon & Jean-Pierre Monti. (2007) Inhibitory activity of stilbenes on Alzheimer’s β-amyloid fibrils in vitro. Bioorganic & Medicinal Chemistry 15:2, pages 1160-1167.
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Emma C. Stuart, Marissa J. Scandlyn & Rhonda J. Rosengren. (2006) Role of epigallocatechin gallate (EGCG) in the treatment of breast and prostate cancer. Life Sciences 79:25, pages 2329-2336.
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Elvira González de Mejía, Sonia Chandra, MarcoVinicio Ramírez-Mares & Wenyi Wang. (2006) Catalytic inhibition of human DNA topoisomerase by phenolic compounds in Ardisia compressa extracts and their effect on human colon cancer cells. Food and Chemical Toxicology 44:8, pages 1191-1203.
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Julie A Baker, Gregory P Beehler, Abhishek C Sawant, Vijayvel Jayaprakash, Susan E McCann & Kirsten B Moysich. (2006) Consumption of Coffee, but Not Black Tea, Is Associated with Decreased Risk of Premenopausal Breast Cancer. The Journal of Nutrition 136:1, pages 166-171.
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Dong-Wook HanYoung Hwan ParkJeong Koo KimTae Gon JungKwon-Yong LeeSuong-Hyu HyonJong-Chul Park. (2005) Long-Term Preservation of Human Saphenous Vein by Green Tea Polyphenol under Physiological Conditions. Tissue Engineering 11:7-8, pages 1054-1064.
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Dong-Wook Han, Young Hwan Park, Jeong Koo Kim, Kwon-Yong Lee, Suong-Hyu Hyon, Hwal Suh & Jong-Chul Park. (2004) Effects of green tea polyphenol on preservation of human saphenous vein. Journal of Biotechnology 110:2, pages 109-117.
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Guangming Zhang, Shinichi Matsumoto, Suong-Hyu Hyon, Sabrina A. Qualley, Lisa Upshaw, D. Michael Strong & Jo-Anna Reems. (2017) Polyphenol, an Extract of Green Tea, Increases Culture Recovery Rates of Isolated Islets from Nonhuman Primate Pancreata and Marginal Grade Human Pancreata. Cell Transplantation 13:2, pages 145-152.
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David A. Kocisko, Gerald S. Baron, Richard Rubenstein, Jiancao Chen, Salomon Kuizon & Byron Caughey. (2003) New Inhibitors of Scrapie-Associated Prion Protein Formation in a Library of 2,000 Drugs and Natural Products. Journal of Virology 77:19, pages 10288-10294.
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F. Catterall, E. Copeland, M. N. Clifford & C. Ioannides. (2003) Effects of black tea theafulvins on aflatoxin B1 mutagenesis in the Ames test. Mutagenesis 18:2, pages 145-150.
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