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Research Article

Human CYPs: in vivo and clinical aspects

Pages 37-46 | Published online: 15 Apr 2002

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (8)

Haruka Nishimuta, Tetsuya Nakagawa, Naruaki Nomura & Masashi Yabuki. (2013) Species differences in hepatic and intestinal metabolic activities for 43 human cytochrome P450 substrates between humans and rats or dogs. Xenobiotica 43:11, pages 948-955.
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Chin Eng Ong, Yan Pan, Joon Wah Mak & Rusli Ismail. (2013) In vitro approaches to investigate cytochrome P450 activities: update on current status and their applicability. Expert Opinion on Drug Metabolism & Toxicology 9:9, pages 1097-1113.
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Sanna Kaivosaari, Moshe Finel & Mikko Koskinen. (2011) N-glucuronidation of drugs and other xenobiotics by human and animal UDP-glucuronosyltransferases. Xenobiotica 41:8, pages 652-669.
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M. Turpeinen, C. Ghiciuc, M. Opritoui, L. Tursas, O. Pelkonen & M. Pasanen. (2007) Predictive value of animal models for human cytochrome P450 (CYP)-mediated metabolism: A comparative study . Xenobiotica 37:12, pages 1367-1377.
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James J Cali, Dongping Ma, Mary Sobol, Daniel J Simpson, Susan Frackman, Troy D Good, William J Daily & David Liu. (2006) Luminogenic cytochrome P450 assays. Expert Opinion on Drug Metabolism & Toxicology 2:4, pages 629-645.
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Jos V Castell, Ramiro Jover, Celia P Martnez-Jimnez & Mara Jos Gmez-Lechn. (2006) Hepatocyte cell lines: their use, scope and limitations in drug metabolism studies. Expert Opinion on Drug Metabolism & Toxicology 2:2, pages 183-212.
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Shufeng Zhou, Eli Chan, Wei Duan, Min Huang & Yu-Zong Chen. (2005) Drug Bioactivation Covalent Binding to Target Proteins and Toxicity Relevance. Drug Metabolism Reviews 37:1, pages 41-213.
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Articles from other publishers (19)

Donald J. AbrahamDeepak K. Dalvie & Bernard Testa. 2003. Burger's Medicinal Chemistry and Drug Discovery. Burger's Medicinal Chemistry and Drug Discovery 1 139 .
Zhennan Zhang, Zhe Sun, Yaozhen Ye & Xianqin Wang. (2020) Determination of Main Compositions in Phyllanthus Urinaria and its Effects on Cyp450 in Rats. Current Pharmaceutical Analysis 16:5, pages 520-528.
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Yiping Lin, Yanli Wei, Xiaoxia Hu, Meilling Wu, Xiaoqian Ying & Mingxing Ding. (2018) Influences of Oldenlandia diffusa on the CYP450 Activities in Rats Using a Cocktail Method by UHPLC-MS/MS . Biochemistry Research International 2018, pages 1-6.
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Jianshe Ma, Shuanghu Wang, Meiling Zhang, Qingwei Zhang, Yunfang Zhou, Chongliang Lin, Guanyang Lin & Xianqin Wang. (2015) Simultaneous determination of bupropion, metroprolol, midazolam, phenacetin, omeprazole and tolbutamide in rat plasma by UPLC-MS/MS and its application to cytochrome P450 activity study in rats. Biomedical Chromatography 29:8, pages 1203-1212.
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Robim M. Rodrigues, Joery De Kock, Tatyana Y. Doktorova, Vera Rogiers & Tamara Vanhaecke. 2015. Protocols in In Vitro Hepatocyte Research. Protocols in In Vitro Hepatocyte Research 279 285 .
Xianqin Wang, Mengchun Chen, Xinxin Chen, Jianshe Ma, Congcong Wen, Jianchun Pan, Lufeng Hu & Guanyang Lin. (2014) The Effects of Acute Hydrogen Sulfide Poisoning on Cytochrome P450 Isoforms Activity in Rats. BioMed Research International 2014, pages 1-8.
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Robin E. Pearce, Michael Cohen-Wolkowiez, Mario R. Sampson & Gregory L. Kearns. (2013) The Role of Human Cytochrome P450 Enzymes in the Formation of 2-Hydroxymetronidazole: CYP2A6 is the High Affinity (Low K m ) Catalyst . Drug Metabolism and Disposition 41:9, pages 1686-1694.
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Tao Zhang, Qiang Zhou, Yushu Pang, Yufang Wang, Chaohui Jin, Juan Huo, Limin Angela Liu & Dongqing Wei. (2012) CYP-nsSNP: A specialized database focused on effect of non-synonymous SNPs on function of CYPs. Interdisciplinary Sciences: Computational Life Sciences 4:2, pages 83-89.
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Xin Wang & John Hok-Keung Yeung. (2012) Investigation of cytochrome P450 1A2 and 3A inhibitory properties of Danshen tincture. Phytomedicine 19:3-4, pages 348-354.
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Haruka Nishimuta, Kimihiko Sato, Yasuyuki Mizuki, Masashi Yabuki & Setsuko Komuro. (2011) Species Differences in Intestinal Metabolic Activities of Cytochrome P450 isoforms between Cynomolgus Monkeys and Humans. Drug Metabolism and Pharmacokinetics 26:3, pages 300-306.
Crossref
Donald J. AbrahamBernard Testa. 2003. Burger's Medicinal Chemistry and Drug Discovery. Burger's Medicinal Chemistry and Drug Discovery 403 454 .
Shayne Cox GadOlavi Pelkonen, Ari Tolonen, Miia Turpeinen & Jouko Uusitalo. 2010. Pharmaceutical Sciences Encyclopedia. Pharmaceutical Sciences Encyclopedia.
Bernard Testa. 2008. The Practice of Medicinal Chemistry. The Practice of Medicinal Chemistry 655 673 .
María José Gómez-Lechón, José Vicente Castell & María Teresa Donato. (2007) Hepatocytes—the choice to investigate drug metabolism and toxicity in man: In vitro variability as a reflection of in vivo. Chemico-Biological Interactions 168:1, pages 30-50.
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Bernard Testa & Stefanie D. Krämer. (2007) The Biochemistry of Drug Metabolism – An Introduction. Chemistry & Biodiversity 4:3, pages 257-405.
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Christopher E. Keefer & Nathaniel A. Woody. (2006) Rejecting unclassifiable samples with decision forests. Chemometrics and Intelligent Laboratory Systems 84:1-2, pages 40-45.
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Xiao-Xia Yang, Ze-Ping Hu, Sui Yung Chan & Shu-Feng Zhou. (2006) Monitoring drug–protein interaction. Clinica Chimica Acta 365:1-2, pages 9-29.
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M. Denise DearingWilliam J. FoleyStuart McLean. (2005) The Influence of Plant Secondary Metabolites on the Nutritional Ecology of Herbivorous Terrestrial Vertebrates. Annual Review of Ecology, Evolution, and Systematics 36:1, pages 169-189.
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Shufeng Zhou. (2003) Separation and detection methods for covalent drug–protein adducts. Journal of Chromatography B 797:1-2, pages 63-90.
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