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Drug Metabolism Reviews Volume 34, 2002 - Issue 3
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Research Article

GENETIC POLYMORPHISMS OF FLAVIN-CONTAINING MONOOXYGENASE (FMO)

Sharon K. Krueger Department of Environmental and Molecular Toxicology and The Linus Pauling Institute, Oregon State University, Corvallis, Oregon, U.S.A.
,
David E. Williams Department of Environmental and Molecular Toxicology and The Linus Pauling Institute, Oregon State University, Corvallis, Oregon, U.S.A.
,
Mei-Fei Yueh Department of Environmental and Molecular Toxicology and The Linus Pauling Institute, Oregon State University, Corvallis, Oregon, U.S.A.
,
Sarah R. Martin Department of Environmental and Molecular Toxicology and The Linus Pauling Institute, Oregon State University, Corvallis, Oregon, U.S.A.
,
Ronald N. Hines Departments of Pediatrics and Pharmacology/Toxicology, Birth Defects Research Center, Medical College of Wisconsin, Milwaukee, Wisconsin, U.S.A.
,
Judy L. Raucy La Jolla Institute for Molecular Medicine, San Diego, California, U.S.A.
,
Colin T. Dolphin Department of Molecular and Cellular Biology, University of London, Queen Mary & Westfield College, London, UK
,
Elizabeth A. Shephard Department of Biochemistry and Molecular Biology, University College London, London, UK
&
Ian R. Phillips Department of Molecular and Cellular Biology, University of London, Queen Mary & Westfield College, London, UK
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Pages 523-532 | Published online: 25 Jul 2002

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Ian R. Phillips & Elizabeth A. Shephard. (2020) Flavin-containing monooxygenase 3 (FMO3): genetic variants and their consequences for drug metabolism and disease. Xenobiotica 50:1, pages 19-33.
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S. C. Mitchell & R. L. Smith. (2010) A physiological role for flavin-containing monooxygenase (FMO3) in humans?. Xenobiotica 40:5, pages 301-305.
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Margherita Strolin Benedetti, Rhys Whomsley & Eugène Baltes. (2006) Involvement of enzymes other than CYPs in the oxidative metabolism of xenobiotics. Expert Opinion on Drug Metabolism & Toxicology 2:6, pages 895-921.
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Cristina Cereda, Elisa Gabanti, Manuel Corato, Annalisa De silvestri, Dario Alimonti, Emanuela Cova, Andrea Malaspina & Mauro Ceroni. (2006) Increased incidence of FMO1 gene single nucleotide polymorphisms in sporadic amyotrophic lateral sclerosis. Amyotrophic Lateral Sclerosis 7:4, pages 233-240.
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Sharon K. Krueger, Jonathan E. VanDyke, David E. Williams & Ronald N. Hines. (2006) The Role of Flavin-Containing Monooxygenase (FMO) in the Metabolism of Tamoxifen and Other Tertiary Amines. Drug Metabolism Reviews 38:1-2, pages 139-147.
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Articles from other publishers (35)

Longfei Wang, Hongchu Zha, Jing Huang & Lang Shi. (2023) Flavin containing monooxygenase 2 regulates renal tubular cell fibrosis and paracrine secretion via SMURF2 in AKI‑CKD transformation. International Journal of Molecular Medicine 52:5.
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Slobodan P. Rendić, Rachel D. Crouch & F. Peter Guengerich. (2022) Roles of selected non-P450 human oxidoreductase enzymes in protective and toxic effects of chemicals: review and compilation of reactions. Archives of Toxicology 96:8, pages 2145-2246.
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Tatsuki FukamiTsuyoshi Yokoi & Miki Nakajima. (2022) Non-P450 Drug-Metabolizing Enzymes: Contribution to Drug Disposition, Toxicity, and Development. Annual Review of Pharmacology and Toxicology 62:1, pages 405-425.
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Simona Alibrandi, Fabiana Nicita, Luigi Donato, Concetta Scimone, Carmela Rinaldi, Rosalia D’Angelo & Antonina Sidoti. (2021) Adaptive Modelling of Mutated FMO3 Enzyme Could Unveil Unexplored Scenarios Linking Variant Haplotypes to TMAU Phenotypes. Molecules 26:22, pages 7045.
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Beatriz Carvalho Henriques, Esther H. Yang, Diego Lapetina, Michael S. Carr, Vasyl Yavorskyy, Joshua Hague & Katherine J. Aitchison. (2020) How Can Drug Metabolism and Transporter Genetics Inform Psychotropic Prescribing?. Frontiers in Genetics 11.
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Diego L. Lapetina, Esther H. Yang, Beatriz C. Henriques & Katherine J. Aitchison. 2020. Seminars in Clinical Psychopharmacology. Seminars in Clinical Psychopharmacology 151 202 .
Callum R. Nicoll, Gautier Bailleul, Filippo Fiorentini, María Laura Mascotti, Marco W. Fraaije & Andrea Mattevi. (2019) Ancestral-sequence reconstruction unveils the structural basis of function in mammalian FMOs. Nature Structural & Molecular Biology 27:1, pages 14-24.
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A.M. Rowland & G.S. Yost. 2018. Comprehensive Toxicology. Comprehensive Toxicology 194 227 .
J.R. Cashman. 2018. Comprehensive Toxicology. Comprehensive Toxicology 87 125 .
Qingping Wang & Meng Li. 2016. Drug Delivery. Drug Delivery 164 185 .
J. Matthew Hutzler & Michael A. Zientek. 2015. New Horizons in Predictive Drug Metabolism and Pharmacokinetics. New Horizons in Predictive Drug Metabolism and Pharmacokinetics 79 130 .
Andrew J. Gow & Henry J. Forman. 2015. Comparative Biology of the Normal Lung. Comparative Biology of the Normal Lung 355 374 .
Marilyn C. Henderson, Lisbeth K. Siddens, Sharon K. Krueger, J. Fred Stevens, Karen Kedzie, Wenkui K. Fang, Todd Heidelbaugh, Phong Nguyen, Ken Chow, Michael Garst, Daniel Gil & David E. Williams. (2014) Flavin-containing monooxygenase S-oxygenation of a series of thioureas and thiones. Toxicology and Applied Pharmacology 278:2, pages 91-99.
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Teresa Esposito, Bruno Varriale, Rosalia D’Angelo, Aldo Amato & Antonina Sidoti. (2014) Regulation of flavin-containing mono-oxygenase (Fmo3) gene expression by steroids in mice and humans. Hormone Molecular Biology and Clinical Investigation 20:3.
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A. Joseph Bloom, Sharon E. Murphy, Maribel Martinez, Linda B. von Weymarn, Laura J. Bierut & Alison Goate. (2013) Effects upon in-vivo nicotine metabolism reveal functional variation in FMO3 associated with cigarette consumption. Pharmacogenetics and Genomics 23:2, pages 62-68.
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Odette A. Fahmi, Judy L. Raucy, Elsa Ponce, Saleema Hassanali & Jerome M. Lasker. (2012) Utility of DPX2 Cells for Predicting CYP3A Induction-Mediated Drug-Drug Interactions and Associated Structure-Activity Relationships. Drug Metabolism and Disposition 40:11, pages 2204-2211.
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Alexander V. LyubimovJohn R. Cashman. 2011. Encyclopedia of Drug Metabolism and Interactions. Encyclopedia of Drug Metabolism and Interactions 1 30 .
Michael Man, Mark Farmen, Carmen Dumaual, Choo Hua Teng, Brian Moser, Shin Irie, Gyu Jeong Noh, Reuben Njau, Sandra Close, Stephen Wise & Richard Hockett. (2013) Genetic Variation in Metabolizing Enzyme and Transporter Genes: Comprehensive Assessment in 3 Major East Asian Subpopulations With Comparison to Caucasians and Africans. The Journal of Clinical Pharmacology 50:8, pages 929-940.
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Rachel M. Novick, Chad M. Vezina & Adnan A. Elfarra. (2010) Isoform distinct time-, dose-, and castration-dependent alterations in flavin-containing monooxygenase expression in mouse liver after 2,3,7,8-tetrachlorodibenzo-p-dioxin treatment. Biochemical Pharmacology 79:9, pages 1345-1351.
Crossref
A.M. Rowland & G.S. Yost. 2010. Comprehensive Toxicology. Comprehensive Toxicology 511 547 .
J.R. Cashman & M.S. Motika. 2010. Comprehensive Toxicology. Comprehensive Toxicology 77 110 .
Marilyn C. Henderson, Lisbeth K. Siddens, Jeffrey T. Morré, Sharon K. Krueger & David E. Williams. (2008) Metabolism of the anti-tuberculosis drug ethionamide by mouse and human FMO1, FMO2 and FMO3 and mouse and human lung microsomes. Toxicology and Applied Pharmacology 233:3, pages 420-427.
Crossref
Lisbeth K. Siddens, Marilyn C. Henderson, Jonathan E. VanDyke, David E. Williams & Sharon K. Krueger. (2008) Characterization of mouse flavin-containing monooxygenase transcript levels in lung and liver, and activity of expressed isoforms. Biochemical Pharmacology 75:2, pages 570-579.
Crossref
David E. Williams. 2008. Advances in Bioactivation Research. Advances in Bioactivation Research 1 27 .
SANFORD P. MARKEY. 2007. Principles of Clinical Pharmacology. Principles of Clinical Pharmacology 143 162 .
John R. CashmanJun Zhang. (2006) HUMAN FLAVIN-CONTAINING MONOOXYGENASES. Annual Review of Pharmacology and Toxicology 46:1, pages 65-100.
Crossref
Sevasti B KoukouritakiRonald N Hines. (2005) Flavin-containing monooxygenase genetic polymorphism: impact on chemical metabolism and drug development. Pharmacogenomics 6:8, pages 807-822.
Crossref
John R. Cashman. (2005) Some distinctions between flavin-containing and cytochrome P450 monooxygenases. Biochemical and Biophysical Research Communications 338:1, pages 599-604.
Crossref
Sharon K. Krueger & David E. Williams. (2005) Mammalian flavin-containing monooxygenases: structure/function, genetic polymorphisms and role in drug metabolism. Pharmacology & Therapeutics 106:3, pages 357-387.
Crossref
Sharon K. Krueger, Lisbeth K. Siddens, Marilyn C. Henderson, Eric A. Andreasen, Robert L. Tanguay, Clifford B. Pereira, Erwin T. Cabacungan, Ronald N. Hines, Kristin G. Ardlie & David E. Williams. (2005) Haplotype and functional analysis of four flavin-containing monooxygenase isoform 2 (FMO2) polymorphisms in Hispanics. Pharmacogenetics and Genomics 15:4, pages 245-256.
Crossref
Irfan M. Hisamuddin, Mohammad A. Wehbi, Ann Chao, Hadley W. Wyre, Linda M. Hylind, Francis M. Giardiello & Vincent W. Yang. (2004) Genetic Polymorphisms of Human Flavin Monooxygenase 3 in Sulindac-Mediated Primary Chemoprevention of Familial Adenomatous Polyposis . Clinical Cancer Research 10:24, pages 8357-8362.
Crossref
Sharon K. Krueger, Lisbeth K. Siddens, Sarah R. Martin, Zhen Yu, Clifford B. Pereira, Erwin T. Cabacungan, Ronald N. Hines, Kristin G. Ardlie, Judy L. Raucy & David E. Williams. (2004) DIFFERENCES IN FMO2 * 1 ALLELIC FREQUENCY BETWEEN HISPANICS OF PUERTO RICAN AND MEXICAN DESCENT . Drug Metabolism and Disposition 32:12, pages 1337-1340.
Crossref
Haider Raza, Shripad V. Bhagwat & Annie John. (2004) Flavin-containing monooxygenase activity in camel tissues: comparison with rat and human liver enzymes. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology 139:4, pages 289-293.
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Marilyn C Henderson, Sharon K Krueger, Lisbeth K Siddens, Jan F Stevens & David E Williams. (2004) S-Oxygenation of the thioether organophosphate insecticides phorate and disulfoton by human lung flavin-containing monooxygenase 2. Biochemical Pharmacology 68:5, pages 959-967.
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Éva Szökő, Tamás Tábi, Tímea Borbás, Balázs Dalmadi, Károly Tihanyi & Kálmán Magyar. (2004) Assessment of theN-oxidation of deprenyl, methamphetamine, and amphetamine enantiomers by chiral capillary electrophoresis: Anin vitro metabolism study. ELECTROPHORESIS 25:16, pages 2866-2875.
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