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Research Article

“Allosterism” in the Elementary Steps of the Cytochrome P450 Reaction Cycle

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Pages 219-230 | Published online: 24 May 2004

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Baojian Wu. (2011) Substrate inhibition kinetics in drug metabolism reactions. Drug Metabolism Reviews 43:4, pages 440-456.
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Dmitri R Davydov & James R Halpert. (2008) Allosteric P450 mechanisms: multiple binding sites, multiple conformers or both?. Expert Opinion on Drug Metabolism & Toxicology 4:12, pages 1523-1535.
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William M Atkins. (2006) Current views on the fundamental mechanisms of cytochrome P450 allosterism. Expert Opinion on Drug Metabolism & Toxicology 2:4, pages 573-579.
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Articles from other publishers (21)

Zeyuan Wang, Erickson M. Paragas, Swati Nagar & Ken Korzekwa. (2021) Complex Cytochrome P450 Kinetics Due to Multisubstrate Binding and Sequential Metabolism. Part 1. Theoretical Considerations. Drug Metabolism and Disposition 49:12, pages 1090-1099.
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Edward J. Calabrese, Aristidis Tsatsakis, Evgenios Agathokleous, James Giordano & Vittorio Calabrese. (2020) Does Green Tea Induce Hormesis?. Dose-Response 18:3, pages 155932582093617.
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Jacqueline Wen Hui Leow & Eric Chun Yong Chan. (2019) Atypical Michaelis-Menten kinetics in cytochrome P450 enzymes: A focus on substrate inhibition. Biochemical Pharmacology 169, pages 113615.
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Jin Liu, Gregory J. Tawa & Anders Wallqvist. (2013) Identifying Cytochrome P450 Functional Networks and Their Allosteric Regulatory Elements. PLoS ONE 8:12, pages e81980.
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Raymond S. H. Yang, Arthur N. Mayeno, Michael A. Lyons & Brad Reisfeld. 2010. Principles and Practice of Mixtures Toxicology. Principles and Practice of Mixtures Toxicology 531 553 .
Shayne Cox GadCharles W. Locuson & Timothy S. Tracy. 2010. Pharmaceutical Sciences Encyclopedia. Pharmaceutical Sciences Encyclopedia.
Ilia G. Denisov, Daniel J. Frank & Stephen G. Sligar. (2009) Cooperative properties of cytochromes P450. Pharmacology & Therapeutics 124:2, pages 151-167.
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Emre M. Isin & F. Peter Guengerich. (2008) Substrate binding to cytochromes P450. Analytical and Bioanalytical Chemistry 392:6, pages 1019-1030.
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Dmitri R. Davydov, Nadezhda Y. Davydova, Tamara N. Tsalkova & James R. Halpert. (2008) Effect of glutathione on homo- and heterotropic cooperativity in cytochrome P450 3A4. Archives of Biochemistry and Biophysics 471:2, pages 134-145.
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Harshica Fernando, James R. Halpert & Dmitri R. Davydov. (2008) Kinetics of electron transfer in the complex of cytochrome P450 3A4 with the flavin domain of cytochrome P450BM-3 as evidence of functional heterogeneity of the heme protein. Archives of Biochemistry and Biophysics 471:1, pages 20-31.
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Hugues Ouellet, Larissa M. Podust & Paul R. Ortiz de Montellano. (2008) Mycobacterium tuberculosis CYP130. Journal of Biological Chemistry 283:8, pages 5069-5080.
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Dongmei Cheng, Danni Harris, James R. Reed & Wayne L. Backes. (2007) Inhibition of CYP2B4 by 2-ethynylnaphthalene: Evidence for the co-binding of substrate and inhibitor within the active site. Archives of Biochemistry and Biophysics 468:2, pages 174-182.
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Harshica Fernando, Dmitri R. Davydov, Christopher C. Chin & James R. Halpert. (2007) Role of subunit interactions in P450 oligomers in the loss of homotropic cooperativity in the cytochrome P450 3A4 mutant L211F/D214E/F304W. Archives of Biochemistry and Biophysics 460:1, pages 129-140.
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Peter Hlavica. (2006) Functional interaction of nitrogenous organic bases with cytochrome P450: A critical assessment and update of substrate features and predicted key active-site elements steering the access, binding, and orientation of amines. Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics 1764:4, pages 645-670.
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William M. Atkins. (2005) NON-MICHAELIS-MENTEN KINETICS IN CYTOCHROME P450-CATALYZED REACTIONS. Annual Review of Pharmacology and Toxicology 45:1, pages 291-310.
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Chaohong Sun, Jeffrey R. Huth & Philip J. Hajduk. (2005) NMR in Pharmacokinetic and Pharmacodynamic Profiling. ChemBioChem 6:9, pages 1592-1600.
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Dana L Anger, Maria-Alexandra Petre & Denis J Crankshaw. (2005) Heteroactivation of cytochrome P450 1A1 by teas and tea polyphenols. British Journal of Pharmacology 145:7, pages 926-933.
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Dmitri R. Davydov, Alexandra E. Botchkareva, Nadezhda E. Davydova & James R. Halpert. (2005) Resolution of Two Substrate-Binding Sites in an Engineered Cytochrome P450eryF Bearing a Fluorescent Probe. Biophysical Journal 89:1, pages 418-432.
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Ilia G. Denisov, Thomas M. Makris, Stephen G. Sligar & Ilme Schlichting. (2005) Structure and Chemistry of Cytochrome P450. Chemical Reviews 105:6, pages 2253-2278.
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Ann-Charlotte Egnell, J. Brian Houston & C. Scott Boyer. (2005) Predictive Models of CYP3A4 Heteroactivation: In Vitro-in Vivo Scaling and Pharmacophore Modeling. Journal of Pharmacology and Experimental Therapeutics 312:3, pages 926-937.
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J. Brian Houston & Aleksandra Galetin. (2005) Modelling atypical CYP3A4 kinetics: principles and pragmatism. Archives of Biochemistry and Biophysics 433:2, pages 351-360.
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