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Research Article

Rifampicin, A Keystone Inducer of Drug Metabolism: From Herbert Remmer's Pioneering Ideas to Modern Concepts

Pages 497-509 | Published online: 25 Oct 2004

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Qiang Su, Qiao Liu, Juan Liu, Lingyun Fu, Tao Liu, Jing Liang, Hong Peng & Xue Pan. (2021) Study on the associations between liver damage and antituberculosis drug rifampicin and relative metabolic enzyme gene polymorphisms. Bioengineered 12:2, pages 11700-11708.
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Graham H Bothamley. (2009) Management of TB during pregnancy, especially in high-risk communities. Expert Review of Obstetrics & Gynecology 4:5, pages 555-563.
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Y.-D. Gao, S. H. Olson, J. M. Balkovec, Y. Zhu, I. Royo, J. Yabut, R. Evers, E. Y. Tan, W. Tang, D. P. Hartley & R. T. Mosley. (2007) Attenuating pregnane X receptor (PXR) activation: A molecular modelling approach. Xenobiotica 37:2, pages 124-138.
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Allan Kengo, Ruth Nabisere, Kamunkhwala Gausi, Joseph Musaazi, Allan Buzibye, Denis Omali, Rob Aarnoutse, Mohammed Lamorde, Kelly E. Dooley, Derek James Sloan, Paolo Denti & Christine Sekaggya-Wiltshire. (2023) Dolutegravir pharmacokinetics in Ugandan patients with TB and HIV receiving standard- versus high-dose rifampicin. Antimicrobial Agents and Chemotherapy 67:11.
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Hyun-Eui Park, Wonsik Lee, Sangwon Choi, Myunghwan Jung, Min-Kyoung Shin & Sung Jae Shin. (2022) Modulating macrophage function to reinforce host innate resistance against Mycobacterium avium complex infection. Frontiers in Immunology 13.
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Bogdan Marian Sorohan, Gener Ismail, Dorina Tacu, Bogdan Obrișcă, Gina Ciolan, Costin Gîngu, Ioanel Sinescu & Cătălin Baston. (2022) Mycobacterium Tuberculosis Infection after Kidney Transplantation: A Comprehensive Review. Pathogens 11:9, pages 1041.
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Song Ren, Karthick Vishwanathan, Mireille Cantarini, Paul Frewer, Indira Hara, Graeme Scarfe, Wendy Burke, Stein Schalkwijk, Yan Li, David Han & Ronald Goldwater. (2021) Clinical evaluation of the potential drug–drug interactions of savolitinib: Interaction with rifampicin, itraconazole, famotidine or midazolam. British Journal of Clinical Pharmacology 88:2, pages 655-668.
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Hande Sultan Şahiner & Cavit Kum. (2020) Effects of rifampicin on plasma pharmacokinetics of tulathromycin in goats. Journal of Veterinary Pharmacology and Therapeutics 44:3, pages 374-380.
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Morgan A Wambaugh, Steven T Denham, Magali Ayala, Brianna Brammer, Miekan A Stonhill & Jessica CS Brown. (2020) Synergistic and antagonistic drug interactions in the treatment of systemic fungal infections. eLife 9.
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Raj K.S. Badhan, Rosalind Gittins & Dina Al Zabit. (2019) The optimization of methadone dosing whilst treating with rifampicin: A pharmacokinetic modeling study. Drug and Alcohol Dependence 200, pages 168-180.
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Karthick Vishwanathan, Paul A. Dickinson, Karen So, Karen Thomas, Yuh-Min Chen, Javier De Castro Carpeño, Anne-Marie C. Dingemans, Hye Ryun Kim, Joo-Hang Kim, Matthew G. Krebs, James Chih-Hsin Yang, Khanh Bui, Doris Weilert & R. Donald Harvey. (2018) The effect of itraconazole and rifampicin on the pharmacokinetics of osimertinib. British Journal of Clinical Pharmacology 84:6, pages 1156-1169.
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. 2016. Meyler's Side Effects of Drugs. Meyler's Side Effects of Drugs 132 170 .
Xin Zhou, Zhi-wei Gao, Jian Meng, Xiao-yan Chen & Da-fang Zhong. (2013) Effects of ketoconazole and rifampicin on the pharmacokinetics of GLS4, a novel anti-hepatitis B virus compound, in dogs. Acta Pharmacologica Sinica 34:11, pages 1420-1426.
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Teddy Kosoglou, Paul Statkevich, Bharath Kumar, Fengjuan Xuan, James E. Schiller, Amy O. Johnson‐Levonas, Sophia Young & David L. Cutler. (2013) The Effect of Multiple Doses of Ketoconazole or Rifampin on the Single‐ and Multiple‐Dose Pharmacokinetics of Vorapaxar. The Journal of Clinical Pharmacology 53:5, pages 540-549.
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S. Thee, H. I. Seifart, B. Rosenkranz, A. C. Hesseling, K. Magdorf, P. R. Donald & H. S. Schaaf. (2011) Pharmacokinetics of Ethionamide in Children. Antimicrobial Agents and Chemotherapy 55:10, pages 4594-4600.
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Lynn G. Dover & Geoffrey D. Coxon. (2011) Current Status and Research Strategies in Tuberculosis Drug Development. Journal of Medicinal Chemistry 54:18, pages 6157-6165.
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Paul Martin, Stuart Oliver, Jane Robertson, Sarah-Jane Kennedy, Jessica Read & Thierry Duvauchelle. (2012) Pharmacokinetic Drug Interactions with Vandetanib during Coadministration with Rifampicin or Itraconazole. Drugs in R&D 11:1, pages 37-51.
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Paul Martin, Stuart Oliver, Jane Robertson, Sarah-Jane Kennedy, Jessica Read & Thierry Duvauchelle. (2012) Pharmacokinetic Drug Interactions with Vandetanib during Coadministration with Rifampicin or Itraconazole. Drugs in R & D 11:1, pages 37-51.
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Michael D. Coleman. 2010. Human Drug Metabolism. Human Drug Metabolism 319 327 .
Connie Cheung & Frank J. Gonzalez. (2008) Humanized Mouse Lines and Their Application for Prediction of Human Drug Metabolism and Toxicological Risk Assessment. Journal of Pharmacology and Experimental Therapeutics 327:2, pages 288-299.
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Lu Luo, De-Zai Dai & Yin Dai. (2008) EFFECT OF THE ENDOTHELIN RECEPTOR ANTAGONIST CPU0213, AND ITS MODULATION BY RIFAMPIN, ON CARDIAC AND VASCULAR TISSUE FOLLOWING CHRONIC ISOPROTERENOL TREATMENT. Clinical and Experimental Pharmacology and Physiology 35:7, pages 757-765.
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Samantha Abel, Timothy M. Jenkins, Lyndsey A. Whitlock, Caroline E. Ridgway & Gary J. Muirhead. (2008) Effects of CYP3A4 inducers with and without CYP3A4 inhibitors on the pharmacokinetics of maraviroc in healthy volunteers. British Journal of Clinical Pharmacology 65:s1, pages 38-46.
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Steven D Brown. (2008) Benefit-Risk Assessment of Telithromycin in the Treatment of Community-Acquired Pneumonia. Drug Safety 31:7, pages 561-575.
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Joseph Boni, Cathie Leister, Jaime Burns, Maria Cincotta, Bruce Hug & Laurence Moore. (2007) Pharmacokinetic Profile of Temsirolimus With Concomitant Administration of Cytochrome P450-Inducing Medications 1 . The Journal of Clinical Pharmacology 47:11, pages 1430-1439.
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Wei C. Lau & Paul A. Gurbel. (2006) Antiplatelet Drug Resistance and Drug-Drug Interactions: Role of Cytochrome P450 3A4. Pharmaceutical Research 23:12, pages 2691-2708.
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Jiezhong Chen & Kenneth Raymond. (2006) Roles of rifampicin in drug-drug interactions: underlying molecular mechanisms involving the nuclear pregnane X receptor. Annals of Clinical Microbiology and Antimicrobials 5:1.
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