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Drug Metabolism Reviews Volume 36, 2004 - Issue 3-4
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Research Article

Coordinate Regulation of Drug Metabolism by Xenobiotic Nuclear Receptors: UGTs Acting Together with CYPs and Glucuronide Transporters

Karl Walter Bock Institute of Pharmacology and Toxicology, University of Tübingen, Wilhelmstrasse 56, D‐72074, Tübingen, Germany
&
Christoph Köhle Institute of Pharmacology and Toxicology, University of Tübingen, Wilhelmstrasse 56, D‐72074, Tübingen, Germany
Pages 595-615 | Published online: 25 Oct 2004

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Mélanie Verreault, Jenny Kaeding, Patrick Caron, Jocelyn Trottier, Laurent Grosse, Élise Houssin, Sophie Pâquet, Martin Perreault & Olivier Barbier. (2010) Regulation of endobiotics glucuronidation by ligand-activated transcription factors: physiological function and therapeutic potential. Drug Metabolism Reviews 42:1, pages 110-122.
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Hitoshi Ashida, Shin Nishiumi & Itsuko Fukuda. (2008) An update on the dietary ligands of the AhR. Expert Opinion on Drug Metabolism & Toxicology 4:11, pages 1429-1447.
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MistyR. Saracino & JohannaW. Lampe. (2007) Phytochemical Regulation of UDP-Glucuronosyltransferases: Implications for Cancer Prevention. Nutrition and Cancer 59:2, pages 121-141.
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Stephanie S. L. Birnbaum, David C. Rinker, Nicole M. Gerardo & Patrick Abbot. (2017) Transcriptional profile and differential fitness in a specialist milkweed insect across host plants varying in toxicity. Molecular Ecology 26:23, pages 6742-6761.
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Aysegul Cort, Tomris Ozben, Luciano Saso, Chiara De Luca & Liudmila Korkina. (2016) Redox Control of Multidrug Resistance and Its Possible Modulation by Antioxidants. Oxidative Medicine and Cellular Longevity 2016, pages 1-17.
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Michael AP Bloomfield, Fiona Pepper, Alice Egerton, Arsime Demjaha, Gianpaolo Tomasi, Elias Mouchlianitis, Levi Maximen, Mattia Veronese, Federico Turkheimer, Sudhakar Selvaraj & Oliver D Howes. (2014) Dopamine Function in Cigarette Smokers: An [18F]-DOPA PET Study. Neuropsychopharmacology 39:10, pages 2397-2404.
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Bekim Sadikovic & David I. Rodenhiser. 2012. Toxicology and Epigenetics. Toxicology and Epigenetics 111 127 .
Bunichiro Ashibe, Yu Nakajima, Yuka Fukui & Kiyoto Motojima. (2012) PPAR α as a Transcriptional Regulator for Detoxification of Plant Diet-Derived Unfavorable Compounds . PPAR Research 2012, pages 1-6.
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Michele M. Skopec & M. Denise Dearing. (2011) Differential expression and activity of catechol-O-methyl transferase (COMT) in a generalist (Neotoma albigula) and juniper specialist (Neotoma stephensi) woodrat. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology 154:4, pages 383-390.
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Halisha Aishan, Yuka Horiguchi & Kiyoto Motojima. (2010) Physiologic Roles of Hepatic Lipid Droplets and Involvement of Peroxisome Proliferator-Activated Receptor .ALPHA. in Their Dynamism. Biological and Pharmaceutical Bulletin 33:3, pages 351-354.
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S Riedmaier, K Klein, U Hofmann, J E Keskitalo, P J Neuvonen, M Schwab, M Niemi & U M Zanger. (2009) UDP-Glucuronosyltransferase (UGT) Polymorphisms Affect Atorvastatin Lactonization In Vitro and In Vivo. Clinical Pharmacology & Therapeutics 87:1, pages 65-73.
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Sylvie Fournel-Gigleux, Michael W.H. Coughtrie, Mohamed Ouzzine & Jacques Magdalou. 2010. Hepatocytes. Hepatocytes 309 326 .
Stefanie D. Krämer & Bernard Testa. (2009) The Biochemistry of Drug Metabolism – An Introduction. Chemistry & Biodiversity 6:10, pages 1477-1660.
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Mario Congiu, Maurice L Mashford, John L Slavin & Paul V Desmond. (2009) Coordinate regulation of metabolic enzymes and transporters by nuclear transcription factors in human liver disease. Journal of Gastroenterology and Hepatology 24:6, pages 1038-1044.
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Ishtiaq Qadri, Ling-Jia Hu, Mieko Iwahashi, Subhi Al-Zuabi, Linda C. Quattrochi & Francis R. Simon. (2009) Interaction of hepatocyte nuclear factors in transcriptional regulation of tissue specific hormonal expression of human multidrug resistance-associated protein 2 (abcc2). Toxicology and Applied Pharmacology 234:3, pages 281-292.
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Willem G. E. J. Schoonen, Walter M. A. Westerink & G. Jean Horbach. 2009. Molecular, Clinical and Environmental Toxicology. Molecular, Clinical and Environmental Toxicology 401 452 .
J. V. Goldstone. (2008) Environmental sensing and response genes in cnidaria: the chemical defensome in the sea anemone Nematostella vectensis. Cell Biology and Toxicology 24:6, pages 483-502.
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Hanns-Ulrich Marschall, Martin Wagner, Gernot Zollner & Michael Trauner. (2007) Clinical Hepatotoxicity. Regulation and Treatment with Inducers of Transport and Cofactors. Molecular Pharmaceutics 4:6, pages 895-910.
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Walter M.A. Westerink & Willem G.E.J. Schoonen. (2007) Phase II enzyme levels in HepG2 cells and cryopreserved primary human hepatocytes and their induction in HepG2 cells. Toxicology in Vitro 21:8, pages 1592-1602.
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Walter M.A. Westerink & Willem G.E.J. Schoonen. (2007) Cytochrome P450 enzyme levels in HepG2 cells and cryopreserved primary human hepatocytes and their induction in HepG2 cells. Toxicology in Vitro 21:8, pages 1581-1591.
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Yoshio Nishimura, Shingo Maeda, Shin-ichi Ikushiro, Peter I. Mackenzie, Yuji Ishii & Hideyuki Yamada. (2007) Inhibitory effects of adenine nucleotides and related substances on UDP-glucuronosyltransferase: Structure–effect relationships and evidence for an allosteric mechanism. Biochimica et Biophysica Acta (BBA) - General Subjects 1770:11, pages 1557-1566.
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Kuresh A. Youdim, Christine A. Tyman, Barry C. Jones & Ruth Hyland. (2007) Induction of Cytochrome P450: Assessment in an Immortalized Human Hepatocyte Cell Line (Fa2N4) Using a Novel Higher Throughput Cocktail Assay. Drug Metabolism and Disposition 35:2, pages 275-282.
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Takashi Iyanagi. 2007. 35 112 .
J.V. Goldstone, A. Hamdoun, B.J. Cole, M. Howard-Ashby, D.W. Nebert, M. Scally, M. Dean, D. Epel, M.E. Hahn & J.J. Stegeman. (2006) The chemical defensome: Environmental sensing and response genes in the Strongylocentrotus purpuratus genome. Developmental Biology 300:1, pages 366-384.
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Christoph Köhle & Karl Walter Bock. (2006) Activation of coupled Ah receptor and Nrf2 gene batteries by dietary phytochemicals in relation to chemoprevention. Biochemical Pharmacology 72:7, pages 795-805.
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Karl Walter Bock & Christoph Köhle. (2006) Ah receptor: Dioxin-mediated toxic responses as hints to deregulated physiologic functions. Biochemical Pharmacology 72:4, pages 393-404.
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Jennifer S. Sorensen, Michele M. Skopec & M. Denise Dearing. (2006) Application of Pharmacological Approaches to Plant–Mammal Interactions. Journal of Chemical Ecology 32:6, pages 1229-1246.
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Paul B. Watkins & Leonard B. Seeff. (2006) Drug-induced liver injury: Summary of a single topic clinical research conference. Hepatology 43:3, pages 618-631.
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Kiyoto Motojima & Toshitake Hirai. (2005) Peroxisome proliferator‐activated receptor α plays a vital role in inducing a detoxification system against plant compounds with crosstalk with other xenobiotic nuclear receptors. The FEBS Journal 273:2, pages 292-300.
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M. Denise DearingWilliam J. FoleyStuart McLean. (2005) The Influence of Plant Secondary Metabolites on the Nutritional Ecology of Herbivorous Terrestrial Vertebrates. Annual Review of Ecology, Evolution, and Systematics 36:1, pages 169-189.
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Moshe Finel, Xin Li, Dione Gardner-Stephen, Stacie Bratton, Peter I. Mackenzie & Anna Radominska-Pandya. (2005) Human UDP-Glucuronosyltransferase 1A5: Identification, Expression, and Activity. Journal of Pharmacology and Experimental Therapeutics 315:3, pages 1143-1149.
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Karl Walter Bock & Christoph Köhle. (2005) Ah receptor- and TCDD-mediated liver tumor promotion: clonal selection and expansion of cells evading growth arrest and apoptosis. Biochemical Pharmacology 69:10, pages 1403-1408.
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Karl Walter Bock & Christoph Köhle. 2005. Phase II Conjugation Enzymes and Transport Systems. Phase II Conjugation Enzymes and Transport Systems 57 75 .

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