Citations (46)
Keep up to date with the latest research on this topic with citation updates for this article.
Read on this site (2)
Centdrika R Dates, Tariq Fahmi, Sebastian J Pyrek, Aiwei Yao-Borengasser, Barbara Borowa-Mazgaj, Stacie M Bratton, Susan A Kadlubar, Peter I Mackenzie, Randy S Haun & Anna Radominska-Pandya. (2015) Human UDP-Glucuronosyltransferases: Effects of altered expression in breast and pancreatic cancer cell lines. Cancer Biology & Therapy 16:5, pages 714-723.
Read now
Read now
EricC. Nelson, RaymondL. Rodriguez, Kevin Dawson, AlfredoF. Galvez & ChristopherP. Evans. (2008) The Interaction of Genetic Polymorphisms With Lifestyle Factors: Implications for the Dietary Prevention of Prostate Cancer. Nutrition and Cancer 60:3, pages 301-312.
Read now
Read now
Articles from other publishers (44)
Laurent Grosse, Sarah Chouinard, Sophie Pâquet, Mélanie Verreault, Jocelyn Trottier, Alain Bélanger & Olivier Barbier. (2022) Androgen Glucuronidation in Mice: When, Where, and How. Biology 11:3, pages 403.
Crossref
Crossref
Vikki Ho, Romain Pasquet, Shaman Luo, Gang Chen, Paul Goss, Dongsheng Tu, Philip Lazarus & Harriet Richardson. (2020) Variation in the UGT2B17 genotype, exemestane metabolism and menopause-related toxicities in the CCTG MAP.3 trial. Breast Cancer Research and Treatment 183:3, pages 705-716.
Crossref
Crossref
Joanie Vaillancourt, Véronique Turcotte, Patrick Caron, Lyne Villeneuve, Louis Lacombe, Frédéric Pouliot, Éric Lévesque & Chantal Guillemette. (2020) Glucuronidation of Abiraterone and Its Pharmacologically Active Metabolites by UGT1A4, Influence of Polymorphic Variants and Their Potential as Inhibitors of Steroid Glucuronidation. Drug Metabolism and Disposition 48:2, pages 75-84.
Crossref
Crossref
Robyn Meech, Dong Gui Hu, Ross A. McKinnon, Siti Nurul Mubarokah, Alex Z. Haines, Pramod C. Nair, Andrew Rowland & Peter I. Mackenzie. (2019) The UDP-Glycosyltransferase (UGT) Superfamily: New Members, New Functions, and Novel Paradigms. Physiological Reviews 99:2, pages 1153-1222.
Crossref
Crossref
Karl-Heinz Storbeck & Elahe A. Mostaghel. 2019. Prostate Cancer. Prostate Cancer
239
277
.
Tie-Lin Yang, Ruo-Han Hao, Yan Guo, Christopher J. Papasian & Hong-Wen Deng. 2018. Genetics of Bone Biology and Skeletal Disease. Genetics of Bone Biology and Skeletal Disease
43
54
.
Delores J. Grant, Zinan Chen, Lauren E. Howard, Emily Wiggins, Amanda De Hoedt, Adriana C. Vidal, Skyla T. Carney, Jill Squires, Clara E. Magyar, Jiaoti Huang & Stephen J. Freedland. (2017) UDP-glucuronosyltransferases and biochemical recurrence in prostate cancer progression. BMC Cancer 17:1.
Crossref
Crossref
Phuong T.M. Dam, You-Jee Jang, Jae-Il Park, Bum-Chae Choi, Sang-Jin Song & Sang-Young Chun. (2017) Regulation of uridine diphosphate-glucuronosyltransferase 2B15 expression during ovulation in the rat. Endocrine Journal 64:6, pages 605-612.
Crossref
Crossref
Sandra M. Lopez, Alexander I. Agoulnik, Manqi Zhang, Leif E. Peterson, Egla Suarez, Gregory A. Gandarillas, Anna Frolov, Rile Li, Kimal Rajapakshe, Christian Coarfa, Michael M. Ittmann, Nancy L. Weigel & Irina U. Agoulnik. (2016) Nuclear Receptor Corepressor 1 Expression and Output Declines with Prostate Cancer Progression. Clinical Cancer Research 22:15, pages 3937-3949.
Crossref
Crossref
Brenna M . Zimmer, Michelle E. Howell, Qin Wei, Linlin Ma, Trevor Romsdahl, Eileen G. Loughman, Jennifer E. Markham, Javier Seravalli, Joseph J. Barycki & Melanie A. Simpson. (2016) Loss of exogenous androgen dependence by prostate tumor cells is associated with elevated glucuronidation potential. Hormones and Cancer 7:4, pages 260-271.
Crossref
Crossref
Xuan Qin, Mingyao Liu & Xin Wang. (2016) New insights into the androgen biotransformation in prostate cancer: A regulatory network among androgen, androgen receptors and UGTs. Pharmacological Research 106, pages 114-122.
Crossref
Crossref
Ailin Zhang, Jiawei Zhang, Stephen Plymate & Elahe A. Mostaghel. (2016) Classical and Non-Classical Roles for Pre-Receptor Control of DHT Metabolism in Prostate Cancer Progression. Hormones and Cancer 7:2, pages 104-113.
Crossref
Crossref
Peder Rustøen Braadland, Helene Hartvedt Grytli, Håkon Ramberg, Betina Katz, Ralf Kellman, Louis Gauthier-Landry, Ladan Fazli, Kurt Allen Krobert, Wanzhong Wang, Finn Olav Levy, Anders Bjartell, Viktor Berge, Paul S. Rennie, Gunnar Mellgren, Gunhild Mari Mælandsmo, Aud Svindland, Olivier Barbier & Kristin Austlid Taskén. (2015) Low β2-adrenergic receptor level may promote development of castration resistant prostate cancer and altered steroid metabolism. Oncotarget 7:2, pages 1878-1894.
Crossref
Crossref
Louis Gauthier-Landry, Alain Bélanger & Olivier Barbier. (2015) Multiple roles for udp-glucuronosyltransferase (UGT)2B15 and UGT2B17 enzymes in androgen metabolism and prostate cancer evolution. The Journal of Steroid Biochemistry and Molecular Biology 145, pages 187-192.
Crossref
Crossref
Laurent Grosse, Sophie Pâquet, Patrick Caron, Ladan Fazli, Paul S. Rennie, Alain Bélanger & Olivier Barbier. (2013) Androgen Glucuronidation: An Unexpected Target for Androgen Deprivation Therapy, with Prognosis and Diagnostic Implications. Cancer Research 73:23, pages 6963-6971.
Crossref
Crossref
Marce-Amara Kpoghomou, Joella Eldie Soatiana, Fatch W. Kalembo, Ghose Bishwajit & Wei Sheng. (2013) UGT2B17 Polymorphism and Risk of Prostate Cancer: A Meta-Analysis. ISRN Oncology 2013, pages 1-7.
Crossref
Crossref
Yue Wu, Alejandro Godoy, Faris Azzouni, John H. Wilton, Clement Ip & James L. Mohler. (2013) Prostate cancer cells differ in testosterone accumulation, dihydrotestosterone conversion, and androgen receptor signaling response to steroid 5α-reductase inhibitors. The Prostate 73:13, pages 1470-1482.
Crossref
Crossref
Marce-Amara Kpoghomou, Fatch W. Kalembo, Joella Eldie Soatiana, Ghose Bishwajit & Wei Sheng. (2013) UGT2B17 status and risk of prostate cancer: A meta-analysis. Open Journal of Preventive Medicine 03:04, pages 329-337.
Crossref
Crossref
Tie-Lin Yang, Yan Guo, Christopher J. Papasian & Hong-Wen Deng. 2013. Genetics of Bone Biology and Skeletal Disease. Genetics of Bone Biology and Skeletal Disease
123
132
.
Andrea D. Coviello, Robin Haring, Melissa Wellons, Dhananjay Vaidya, Terho Lehtimäki, Sarah Keildson, Kathryn L. Lunetta, Chunyan He, Myriam Fornage, Vasiliki Lagou, Massimo Mangino, N. Charlotte Onland-Moret, Brian Chen, Joel Eriksson, Melissa Garcia, Yong Mei Liu, Annemarie Koster, Kurt Lohman, Leo-Pekka Lyytikäinen, Ann-Kristin Petersen, Jennifer Prescott, Lisette Stolk, Liesbeth Vandenput, Andrew R. Wood, Wei Vivian Zhuang, Aimo Ruokonen, Anna-Liisa Hartikainen, Anneli Pouta, Stefania Bandinelli, Reiner Biffar, Georg Brabant, David G. Cox, Yuhui Chen, Steven Cummings, Luigi Ferrucci, Marc J. Gunter, Susan E. Hankinson, Hannu Martikainen, Albert Hofman, Georg Homuth, Thomas Illig, John-Olov Jansson, Andrew D. Johnson, David Karasik, Magnus Karlsson, Johannes Kettunen, Douglas P. Kiel, Peter Kraft, Jingmin Liu, Östen Ljunggren, Mattias Lorentzon, Marcello Maggio, Marcello R. P. Markus, Dan Mellström, Iva Miljkovic, Daniel Mirel, Sarah Nelson, Laure Morin Papunen, Petra H. M. Peeters, Inga Prokopenko, Leslie Raffel, Martin Reincke, Alex P. Reiner, Kathryn Rexrode, Fernando Rivadeneira, Stephen M. Schwartz, David Siscovick, Nicole Soranzo, Doris Stöckl, Shelley Tworoger, André G. Uitterlinden, Carla H. van Gils, Ramachandran S. Vasan, H.-Erich Wichmann, Guangju Zhai, Shalender Bhasin, Martin Bidlingmaier, Stephen J. Chanock, Immaculata De Vivo, Tamara B. Harris, David J. Hunter, Mika Kähönen, Simin Liu, Pamela Ouyang, Tim D. Spector, Yvonne T. van der Schouw, Jorma Viikari, Henri Wallaschofski, Mark I. McCarthy, Timothy M. Frayling, Anna Murray, Steve Franks, Marjo-Riitta Järvelin, Frank H. de Jong, Olli Raitakari, Alexander Teumer, Claes Ohlsson, Joanne M. Murabito & John R. B. Perry. (2012) A Genome-Wide Association Meta-Analysis of Circulating Sex Hormone–Binding Globulin Reveals Multiple Loci Implicated in Sex Steroid Hormone Regulation. PLoS Genetics 8:7, pages e1002805.
Crossref
Crossref
Sunit K. Chakraborty, Nikhil K. Basu, Sirsendu Jana, Mousumi Basu, Amit Raychoudhuri & Ida S. Owens. (2012) Protein Kinase Cα and Src Kinase Support Human Prostate-distributed Dihydrotestosterone-metabolizing UDP-glucuronosyltransferase 2B15 Activity. Journal of Biological Chemistry 287:29, pages 24387-24396.
Crossref
Crossref
Sophie Pâquet, Ladan Fazli, Laurent Grosse, Mélanie Verreault, Bernard Têtu, Paul S. Rennie, Alain Bélanger & Olivier Barbier. (2012) Differential Expression of the Androgen-Conjugating UGT2B15 and UGT2B17 Enzymes in Prostate Tumor Cells during Cancer Progression. The Journal of Clinical Endocrinology & Metabolism 97:3, pages E428-E432.
Crossref
Crossref
Dong Gui Hu & Peter I. Mackenzie. (2010) Forkhead Box Protein A1 Regulates UDP-Glucuronosyltransferase 2B15 Gene Transcription in LNCaP Prostate Cancer Cells. Drug Metabolism and Disposition 38:12, pages 2105-2109.
Crossref
Crossref
Dong Gui Hu, Dione Gardner-Stephen, Gianluca Severi, Philip A. Gregory, Joanna Treloar, Graham G. Giles, Dallas R. English, John L. Hopper, Wayne D. Tilley & Peter I. Mackenzie. (2010) A Novel Polymorphism in a Forkhead Box A1 (FOXA1) Binding Site of the Human UDP Glucuronosyltransferase 2B17 Gene Modulates Promoter Activity and Is Associated with Altered Levels of Circulating Androstane-3α,17β-diol Glucuronide. Molecular Pharmacology 78:4, pages 714-722.
Crossref
Crossref
Anastasios Karatzas, Eirini Giannatou, Vassilios Tzortzis, Stavros Gravas, Evangellos Aravantinos, George Moutzouris, Michael Melekos & Aspasia Tsezou. (2010) Genetic polymorphisms in the UDP-glucuronosyltransferase 1A1 (UGT1A1) gene and prostate cancer risk in Caucasian men. Cancer Epidemiology 34:3, pages 345-349.
Crossref
Crossref
Dali Huang, George P. Casale, Jun Tian, Subodh M. Lele, Vladimir M. Pisarev, Melanie A. Simpson & George P. HemstreetIIIIII. (2009) Udp‐glucose dehydrogenase as a novel field‐specific candidate biomarker of prostate cancer. International Journal of Cancer 126:2, pages 315-327.
Crossref
Crossref
Jocelyn Trottier, Diala El Husseini, Martin Perreault, Sophie Pâquet, Patrick Caron, Sylvie Bourassa, Mélanie Verreault, Ted T. Inaba, Guy G. Poirier, Alain Bélanger, Chantal Guillemette, Michael Trauner & Olivier Barbier. (2010) The Human UGT1A3 Enzyme Conjugates Norursodeoxycholic Acid into a C23-ester Glucuronide in the Liver. Journal of Biological Chemistry 285:2, pages 1113-1121.
Crossref
Crossref
Peter W. Parodi. (2009) Dairy product consumption and the risk of prostate cancer. International Dairy Journal 19:10, pages 551-565.
Crossref
Crossref
Vincent Ménard, Olivier Eap, Mario Harvey, Chantal Guillemette & Ãric Lévesque. (2009)
Copy-number variations (CNVs) of the human sex steroid metabolizing genes
UGT2B17
and
UGT2B28
and their associations with a
UGT2B15
functional polymorphism
. Human Mutation 30:9, pages 1310-1319.
Crossref
Crossref
Qin Wei, Robert Galbenus, Ashraf Raza, Ronald L. Cerny & Melanie A. Simpson. (2009) Androgen-Stimulated UDP-Glucose Dehydrogenase Expression Limits Prostate Androgen Availability without Impacting Hyaluronan Levels. Cancer Research 69:6, pages 2332-2339.
Crossref
Crossref
Steven P. Balk. 2009. Androgen Action in Prostate Cancer. Androgen Action in Prostate Cancer
123
139
.
Tie-Lin Yang, Xiang-Ding Chen, Yan Guo, Shu-Feng Lei, Jin-Tang Wang, Qi Zhou, Feng Pan, Yuan Chen, Zhi-Xin Zhang, Shan-Shan Dong, Xiang-Hong Xu, Han Yan, Xiaogang Liu, Chuan Qiu, Xue-Zhen Zhu, Teng Chen, Meng Li, Hong Zhang, Liang Zhang, Betty M. Drees, James J. Hamilton, Christopher J. Papasian, Robert R. Recker, Xiao-Ping Song, Jing Cheng & Hong-Wen Deng. (2008) Genome-wide Copy-Number-Variation Study Identified a Susceptibility Gene, UGT2B17, for Osteoporosis. The American Journal of Human Genetics 83:6, pages 663-674.
Crossref
Crossref
Lisa W Chu, Juergen KV Reichardt & Ann W Hsing. (2008) Androgens and the molecular epidemiology of prostate cancer. Current Opinion in Endocrinology, Diabetes & Obesity 15:3, pages 261-270.
Crossref
Crossref
Bo‐Ying Bao, Bin‐Fay Chuang, Qianben Wang, Oliver Sartor, Steven P. Balk, Myles Brown, Philip W. Kantoff & Gwo‐Shu Mary Lee. (2008) Androgen receptor mediates the expression of UDP‐glucuronosyltransferase 2 B15 and B17 genes. The Prostate 68:8, pages 839-848.
Crossref
Crossref
Sarah Chouinard, Mei-Fei Yueh, Robert H. Tukey, Frank Giton, Jean Fiet, Georges Pelletier, Olivier Barbier & Alain Bélanger. (2008) Inactivation by UDP-glucuronosyltransferase enzymes: The end of androgen signaling. The Journal of Steroid Biochemistry and Molecular Biology 109:3-5, pages 247-253.
Crossref
Crossref
Georges Pelletier. (2008) Expression of steroidogenic enzymes and sex-steroid receptors in human prostate. Best Practice & Research Clinical Endocrinology & Metabolism 22:2, pages 223-228.
Crossref
Crossref
Olivier Barbier & Alain Bélanger. (2008) Inactivation of androgens by UDP-glucuronosyltransferases in the human prostate. Best Practice & Research Clinical Endocrinology & Metabolism 22:2, pages 259-270.
Crossref
Crossref
Mats Olsson, Sara Lindström, Benjamin Häggkvist, Hans‐Olov Adami, Katarina Bälter, Pär Stattin, Birgitta Ask, Anders Rane, Lena Ekström & Henrik Grönberg. (2008)
The
UGT2B17
gene deletion is not associated with prostate cancer risk
. The Prostate 68:5, pages 571-575.
Crossref
Crossref
Jenny Kaeding, Emmanuel Bouchaert, Julie Bélanger, Patrick Caron, Sarah Chouinard, Mélanie Verreault, Olivier Larouche, Georges Pelletier, Bart Staels, Alain Bélanger & Olivier Barbier. (2008) Activators of the farnesoid X receptor negatively regulate androgen glucuronidation in human prostate cancer LNCAP cells. Biochemical Journal 410:2, pages 245-253.
Crossref
Crossref
Jenny Kaeding, Julie Bélanger, Patrick Caron, Mélanie Verreault, Alain Bélanger & Olivier Barbier. (2008) Calcitrol (1α,25-dihydroxyvitamin D3) inhibits androgen glucuronidation in prostate cancer cells. Molecular Cancer Therapeutics 7:2, pages 380-390.
Crossref
Crossref
Sarah Chouinard, Olivier Barbier & Alain Bélanger. (2007) UDP-glucuronosyltransferase 2B15 (UGT2B15) and UGT2B17 Enzymes Are Major Determinants of the Androgen Response in Prostate Cancer LNCaP Cells. Journal of Biological Chemistry 282:46, pages 33466-33474.
Crossref
Crossref
Bertrand Caillier, Johanie Lépine, Jelena Tojcic, Vincent Ménard, Louis Perusse, Alain Bélanger, Olivier Barbier & Chantal Guillemette. (2007) A pharmacogenomics study of the human estrogen glucuronosyltransferase UGT1A3. Pharmacogenetics and Genomics 17:7, pages 481-495.
Crossref
Crossref
Jong Park, Lan Chen, Luke Ratnashinge, Thomas A. Sellers, Jean-Paul Tanner, Ji-Hyun Lee, Nicole Dossett, Nicholas Lang, Fred F. Kadlubar, Christine B. Ambrosone, Babu Zachariah, Randy V. Heysek, Stephen Patterson & Julio Pow-Sang. (2006) Deletion Polymorphism of UDP-Glucuronosyltransferase 2B17 and Risk of Prostate Cancer in African American and Caucasian Men. Cancer Epidemiology, Biomarkers & Prevention 15:8, pages 1473-1478.
Crossref
Crossref
S Nagar & R P Remmel. (2006) Uridine diphosphoglucuronosyltransferase pharmacogenetics and cancer. Oncogene 25:11, pages 1659-1672.
Crossref
Crossref