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Original

The Effect of Sutherlandia frutescens on Steroidogenesis: Confirming Indigenous Wisdom

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Pages 745-751 | Published online: 07 Jul 2009

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Odwa Gonyela, Xolani Peter, John B. Dewar, Chris van der Westhuyzen, Paul Steenkamp & Gerda Fouche. (2021) Cycloartanol and Sutherlandioside C peracetate from Sutherlandia frutescens and their immune potentiating effects. Natural Product Research 35:12, pages 1968-1976.
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Anna-Mart Engelbrecht, Carine Smith, Ian Neethling, Mark Thomas, Beverly Ellis, Mary Mattheyse & Kathryn H. Myburgh. (2010) Daily brief restraint stress alters signaling pathways and induces atrophy and apoptosis in rat skeletal muscle. Stress 13:2, pages 132-141.
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Articles from other publishers (25)

Nontobeko Mncwangi, Alvaro Viljoen, Nduvho Mulaudzi & Gerda Fouche. 2023. The South African Herbal Pharmacopoeia. The South African Herbal Pharmacopoeia 321 344 .
Olaoluwa O. Olarewaju, Olufunke O. Fajinmi, Kuben K. Naidoo, Georgina D. Arthur & Roger M. Coopoosamy. (2022) A review of the medicinal plants with immune-boosting potential. Journal of Medicinal Plants for Economic Development 6:1.
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Moshood A. Abibu, David T. Takuwa & Kwenga Sichilongo. (2019) Quantification of eight water soluble vitamins in Sutherlandia frutescens species from Botswana using a validated reversed phase HPLC method . SEPARATION SCIENCE PLUS 2:6, pages 200-209.
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Mona H. HaronOlivia R. DaleFazila ZulfiqarYan Hong WangAmar G. ChittiboyinaIkhlas A. KhanShabana I. Khan. (2019) Effect of African Potato ( Hypoxis hemerocallidea ) Extract and Its Constituents on PXR and CYP450 Enzymes . Applied In Vitro Toxicology 5:1, pages 26-33.
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Carine Smith. (2018) Natural antioxidants in prevention of accelerated ageing: a departure from conventional paradigms required. Journal of Physiology and Biochemistry 74:4, pages 549-558.
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R. Kleynhans, M. Bulannga, L. Nenungwi, M.T. Lehlaleroa, B. Matsiliza-Mlathi & M.M. Slabbert. (2018) Preliminary investigations on germination of Sutherlandia frutescens and emergence of Ceratonia siliqua seed . Acta Horticulturae:1204, pages 153-160.
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C.A. Sergeant, D. Africander, P. Swart & A.C. Swart. (2017) Sutherlandia frutescens modulates adrenal hormone biosynthesis, acts as a selective glucocorticoid receptor agonist (SEGRA) and displays anti-mineralocorticoid properties. Journal of Ethnopharmacology 202, pages 290-301.
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Carine Smith & Amanda C. Swart. (2016) Rooibos ( Aspalathus linearis ) facilitates an anti-inflammatory state, modulating IL-6 and IL-10 while not inhibiting the acute glucocorticoid response to a mild novel stressor in vivo. Journal of Functional Foods 27, pages 42-54.
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Hui Lin, Glenn A. Jackson, Yuan Lu, Sara K. Drenkhahn, Korey J. Brownstein, Nicholas J. Starkey, William R. Lamberson, Kevin L. Fritsche, Valeri V. Mossine, Cynthia L. Besch-Williford, William R. Folk, Yong Zhang & Dennis B. Lubahn. (2016) Inhibition of Gli/hedgehog signaling in prostate cancer cells by “cancer bush” Sutherlandia frutescens extract . Cell Biology International 40:2, pages 131-142.
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Yuan Lu, Nicholas Starkey, Wei Lei, Jilong Li, Jianlin Cheng, William R. Folk & Dennis B. Lubahn. (2015) Inhibition of Hedgehog-Signaling Driven Genes in Prostate Cancer Cells by Sutherlandia frutescens Extract. PLOS ONE 10:12, pages e0145507.
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Luan Dane Africa & Carine Smith. (2015) Sutherlandia frutescens may exacerbate HIV-associated neuroinflammation. Journal of Negative Results in BioMedicine 14:1.
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G. Leisching, B. Loos, T. Nell & A.-M. Engelbrecht. (2015) Sutherlandia frutescens treatment induces apoptosis and modulates the PI3-kinase pathway in colon cancer cells. South African Journal of Botany 100, pages 20-26.
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Dennis Y. Chuang, Jiankun Cui, Agnes Simonyi, Victoria A. Engel, Shanyan Chen, Kevin L. Fritsche, Andrew L. Thomas, Wendy L. Applequist, William R. Folk, Dennis B. Lubahn, Albert Y. Sun, Grace Y. Sun & Zezong Gu. (2014) Dietary Sutherlandia and Elderberry Mitigate Cerebral Ischemia-Induced Neuronal Damage and Attenuate p47phox and Phospho-ERK1/2 Expression in Microglial Cells. ASN Neuro 6:6, pages 175909141455494.
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Bingzhao Zhang, Wei Kee Leung, Yuanfeng Zou, Wilfred Mabusela, Quinton Johnson, Terje E. Michaelsen & Berit Smestad Paulsen. (2014) Immunomodulating polysaccharides from Lessertia frutescens leaves: Isolation, characterization and structure activity relationship. Journal of Ethnopharmacology 152:2, pages 340-348.
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Jinghua Jiang, Dennis Y. Chuang, Yijia Zong, Jayleenkumar Patel, Korey Brownstein, Wei Lei, Chi-Hua Lu, Agnes Simonyi, Zezong Gu, Jiankun Cui, George E. Rottinghaus, Kevin L. Fritsche, Dennis B. Lubahn, William R. Folk & Grace Y. Sun. (2014) Sutherlandia frutescens Ethanol Extracts Inhibit Oxidative Stress and Inflammatory Responses in Neurons and Microglial Cells. PLoS ONE 9:2, pages e89748.
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Oluwaseyi M. AboyadeGustav StygerDiana GibsonGail Hughes. (2014) Sutherlandia frutescens : The Meeting of Science and Traditional Knowledge . The Journal of Alternative and Complementary Medicine 20:2, pages 71-76.
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Carine Smith & Marthinus Janse van Vuuren. (2013) Central and peripheral effects of Sutherlandia frutescens on the response to acute psychological stress . Experimental Biology and Medicine 239:1, pages 123-128.
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Pius S. Fasinu, Heike Gutmann, Hilmar Schiller, Alexander-David James, Patrick J. Bouic & Bernd Rosenkranz. (2013) The Potential of Sutherlandia frutescens for Herb-Drug Interaction . Drug Metabolism and Disposition 41:2, pages 488-497.
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Chris Vorster, Andre Stander & Annie Joubert. (2012) Differential signaling involved in Sutherlandia frutescens-induced cell death in MCF-7 and MCF-12A cells. Journal of Ethnopharmacology 140:1, pages 123-130.
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Werner Cordier & Vanessa Steenkamp. (2011) Drug interactions in African herbal remedies. Drug Metabolism and Drug Interactions 26:2.
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Janine Colling, Marietjie A. Stander & Nokwanda P. Makunga. (2010) Nitrogen supply and abiotic stress influence canavanine synthesis and the productivity of in vitro regenerated Sutherlandia frutescens microshoots. Journal of Plant Physiology 167:17, pages 1521-1524.
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B-E. van Wyk & C. Albrecht. (2008) A review of the taxonomy, ethnobotany, chemistry and pharmacology of Sutherlandia frutescens (Fabaceae). Journal of Ethnopharmacology 119:3, pages 620-629.
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B.-E. van Wyk. (2008) A broad review of commercially important southern African medicinal plants. Journal of Ethnopharmacology 119:3, pages 342-355.
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Désirée Prevoo, Pieter Swart & Amanda C. Swart. (2008) The influence of Sutherlandia frutescens on adrenal steroidogenic cytochrome P450 enzymes. Journal of Ethnopharmacology 118:1, pages 118-126.
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John A.O. Ojewole. (2008) Anticonvulsant property of Sutherlandia frutescens R. BR. (variety Incana E. MEY.) [Fabaceae] shoot aqueous extract. Brain Research Bulletin 75:1, pages 126-132.
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