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Original

ACTH Regulates Steroidogenic Gene Expression and Cortisol Biosynthesis in the Human Adrenal Cortex via Sphingolipid Metabolism

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Pages 787-794 | Published online: 07 Jul 2009

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Natasha C. Lucki, Donghui Li, Sibali Bandyopadhyay, Elaine Wang, Alfred H. Merrill & Marion B. Sewer. (2012) Acid Ceramidase (ASAH1) Represses Steroidogenic Factor 1-Dependent Gene Transcription in H295R Human Adrenocortical Cells by Binding to the Receptor. Molecular and Cellular Biology 32:21, pages 4419-4431.
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Donghui Li, Aarti N. Urs, Jeremy Allegood, Adam Leon, Alfred H. Merrill$suffix/text()$suffix/text() & Marion B. Sewer. (2007) Cyclic AMP-Stimulated Interaction between Steroidogenic Factor 1 and Diacylglycerol Kinase θ Facilitates Induction of CYP17. Molecular and Cellular Biology 27:19, pages 6669-6685.
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Marion B. Sewer, Eric B. Dammer & Srinath Jagarlapudi. (2007) Transcriptional Regulation of Adrenocortical Steroidogenic Gene Expression. Drug Metabolism Reviews 39:2-3, pages 371-388.
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Heng Sun, Chunli Wu, Biao Hu & Yuan Xiao. (2023) Interpetrosal sphingosine-1-phosphate ratio predicting Cushing’s disease tumor laterality and remission after surgery. Frontiers in Endocrinology 14.
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Defan Wang, Yedong Tang & Zhengchao Wang. (2023) Role of sphingolipid metabolites in the homeostasis of steroid hormones and the maintenance of testicular functions. Frontiers in Endocrinology 14.
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Zhirong Zhou, Tong Li, Ruijiao Du, Chengjuan Liu, Shengjie Huang, Lifeng Han, Peng Zhang, Yuefei Wang & Miaomiao Jiang. (2023) Lamiophlomis rotata attenuates rheumatoid arthritis by regulating sphingolipid and steroid hormone metabolism . Molecular Omics 19:1, pages 72-83.
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John William Honour. 2023. Steroids in the Laboratory and Clinical Practice. Steroids in the Laboratory and Clinical Practice 93 125 .
Prasanthi P Koganti, Lan N Tu & Vimal Selvaraj. (2022) Functional metabolite reserves and lipid homeostasis revealed by the MA-10 Leydig cell metabolome. PNAS Nexus.
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Shinjini C. Spaulding & Wendy B. Bollag. (2022) The role of lipid second messengers in aldosterone synthesis and secretion. Journal of Lipid Research 63:4, pages 100191.
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Sathvika Venugopal, Melanie Galano, Rachel Chan, Esha Sanyal, Leeyah Issop, Sunghoon Lee, Lorne Taylor, Pushwinder Kaur, Edward Daly & Vassilios Papadopoulos. (2021) Dynamic Remodeling of Membranes and Their Lipids during Acute Hormone-Induced Steroidogenesis in MA-10 Mouse Leydig Tumor Cells. International Journal of Molecular Sciences 22:5, pages 2554.
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Vimal Selvaraj, Douglas M Stocco & Barbara J Clark. (2018) Current knowledge on the acute regulation of steroidogenesis†. Biology of Reproduction 99:1, pages 13-26.
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Gerwyn Morris, George Anderson & Michael Maes. (2016) Hypothalamic-Pituitary-Adrenal Hypofunction in Myalgic Encephalomyelitis (ME)/Chronic Fatigue Syndrome (CFS) as a Consequence of Activated Immune-Inflammatory and Oxidative and Nitrosative Pathways. Molecular Neurobiology 54:9, pages 6806-6819.
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Adam Dinoff, Nathan Herrmann & Krista L. Lanctôt. (2017) Ceramides and depression: A systematic review. Journal of Affective Disorders 213, pages 35-43.
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Xiaodong Wang, Jun Han, Jingxi Pan & Christoph H. Borchers. (2013) Comprehensive Imaging of Porcine Adrenal Gland Lipids by MALDI-FTMS Using Quercetin as a Matrix. Analytical Chemistry 86:1, pages 638-646.
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Marion B. Sewer & Donghui Li. (2013) Regulation of adrenocortical steroid hormone production by RhoA–diaphanous 1 signaling and the cytoskeleton. Molecular and Cellular Endocrinology 371:1-2, pages 79-86.
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Natasha C. LuckiSibali BandyopadhyayElaine WangAlfred H. MerrillMarion B. Sewer. (2012) Acid Ceramidase (ASAH1) Is a Global Regulator of Steroidogenic Capacity and Adrenocortical Gene Expression. Molecular Endocrinology 26:2, pages 228-243.
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Natasha C. Lucki, Donghui Li & Marion B. Sewer. (2012) Sphingosine-1-phosphate rapidly increases cortisol biosynthesis and the expression of genes involved in cholesterol uptake and transport in H295R adrenocortical cells. Molecular and Cellular Endocrinology 348:1, pages 165-175.
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Keiichi Ikeda, Takatoshi Saito & Katsuyoshi Tojo. (2011) Efonidipine, a Ca2+-Channel Blocker, Enhances the Production of Dehydroepiandrosterone Sulfate in NCI-H295R Human Adrenocortical Carcinoma Cells. The Tohoku Journal of Experimental Medicine 224:4, pages 263-271.
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Patricia Gangoiti, Luz Camacho, Lide Arana, Alberto Ouro, Maria H. Granado, Leyre Brizuela, Josefina Casas, Gemma Fabriás, José Luis Abad, Antonio Delgado & Antonio Gómez-Muñoz. (2010) Control of metabolism and signaling of simple bioactive sphingolipids: Implications in disease. Progress in Lipid Research 49:4, pages 316-334.
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Natasha C. Lucki & Marion B. Sewer. (2010) The interplay between bioactive sphingolipids and steroid hormones. Steroids 75:6, pages 390-399.
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Natasha Lucki & Marion B. Sewer. (2009) The cAMP-responsive element binding protein (CREB) regulates the expression of acid ceramidase (ASAH1) in H295R human adrenocortical cells. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1791:8, pages 706-713.
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Marion B. Sewer & Srinath Jagarlapudi. (2009) Complex assembly on the human CYP17 promoter. Molecular and Cellular Endocrinology 300:1-2, pages 109-114.
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Natasha C. Lucki & Marion B. Sewer. 2008. Lipids in Health and Disease. Lipids in Health and Disease 387 412 .
Aarti N. Urs, Eric Dammer, Samuel Kelly, Elaine Wang, Alfred H. MerrillJr.Jr. & Marion B. Sewer. (2007) Steroidogenic factor-1 is a sphingolipid binding protein. Molecular and Cellular Endocrinology 265-266, pages 174-178.
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Aarti N. Urs, Eric Dammer & Marion B. Sewer. (2006) Sphingosine Regulates the Transcription of CYP17 by Binding to Steroidogenic Factor-1. Endocrinology 147:11, pages 5249-5258.
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