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Journal of Environmental Science and Health, Part C
Environmental Carcinogenesis and Ecotoxicology Reviews
Volume 23, 2005 - Issue 1
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Original Articles

Physiologically-Based Pharmacokinetic and Toxicokinetic Models in Cancer Risk Assessment

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Pages 31-53 | Published online: 16 Aug 2006

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Gary L. Diamond, Nicholas P. Skoulis, A. Robert Jeffcoat & J Frank Nash. (2021) A Physiological-Based Pharmacokinetic Model For The Broad Spectrum Antimicrobial Zinc Pyrithione: II. Dermal Absorption And Dosimetry In The Rat. Journal of Toxicology and Environmental Health, Part A 84:15, pages 609-631.
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Miyoung Yoon, MichaelC. Madden & HughA. Barton. (2007) Extrahepatic Metabolism by CYP2E1 in PBPK Modeling of Lipophilic Volatile Organic Chemicals: Impacts on Metabolic Parameter Estimation and Prediction of Dose Metrics. Journal of Toxicology and Environmental Health, Part A 70:18, pages 1527-1541.
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Ivan Nestorov. (2007) Whole-body physiologically based pharmacokinetic models. Expert Opinion on Drug Metabolism & Toxicology 3:2, pages 235-249.
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Tetyana Kobets, Michael J. Iatropoulos & Gary M. Williams. (2019) Mechanisms of DNA-reactive and epigenetic chemical carcinogens: applications to carcinogenicity testing and risk assessment. Toxicology Research 8:2, pages 123-145.
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Ryohji Takano, Norie Murayama, Kana Horiuchi, Masato Kitajima, Fumiaki ShonoHiroshi Yamazaki. (2010) Blood Concentrations of 1,4-Dioxane in Humans after Oral Administration Extrapolated from In Vivo Rat Pharmacokinetics, In Vitro Human Metabolism, and Physiologically Based Pharmacokinetic Modeling. Journal of Health Science 56:5, pages 557-565.
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G. Johanson. 2010. Comprehensive Toxicology. Comprehensive Toxicology 153 177 .
Weihsueh A. Chiu, Miles S. Okino & Marina V. Evans. (2009) Characterizing uncertainty and population variability in the toxicokinetics of trichloroethylene and metabolites in mice, rats, and humans using an updated database, physiologically based pharmacokinetic (PBPK) model, and Bayesian approach. Toxicology and Applied Pharmacology 241:1, pages 36-60.
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Ashley Roberts & Andrew G. Renwick. 2009. General, Applied and Systems Toxicology. General, Applied and Systems Toxicology.
Mitchell J. Small. (2008) Methods for Assessing Uncertainty in Fundamental Assumptions and Associated Models for Cancer Risk Assessment. Risk Analysis 28:5, pages 1289-1308.
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John C. Lipscomb & Torka S. Poet. (2008) In vitro measurements of metabolism for application in pharmacokinetic modeling. Pharmacology & Therapeutics 118:1, pages 82-103.
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Yasong Lu, Susan Rieth, Manupat Lohitnavy, James Dennison, Hisham El-Masri, Hugh A. Barton, James Bruckner & Raymond S.H. Yang. (2008) Application of PBPK modeling in support of the derivation of toxicity reference values for 1,1,1-trichloroethane. Regulatory Toxicology and Pharmacology 50:2, pages 249-260.
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Frank Barile. 2007. Principles of Toxicology Testing. Principles of Toxicology Testing 11 25 .
Robert De Woskin, Chadwick Thompson, Weihsueh Chiu, Paul Schlosser, Carolyn Smallwood, Jeff Swartout, Linda Teuschler & Allan Marcus. 2006. Toxicokinetics and Risk Assessment. Toxicokinetics and Risk Assessment 301 348 .

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