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Hemoglobin
international journal for hemoglobin research
Volume 26, 2002 - Issue 4
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MOLECULAR SPECTRUM OF α-THALASSEMIA IN TUNISIA: EPIDEMIOLOGY AND DETECTION AT BIRTH

Amine Zorai Hemoglobinopathies Group, Laboratory of Hematology, Pasteur Institute of Tunis, 1002 Tunis le BelvedereTunisia
,
Cornelis L. Harteveld Hemoglobinopathies Laboratory, Department of Human and Clinical Genetics, Leiden University Medical Center, Wassenaarseweg 72, 2333 AL LeidenThe Netherlands
,
Achech Bakir Hemoglobinopathies Group, Laboratory of Hematology, Pasteur Institute of Tunis, 1002 Tunis le BelvedereTunisia; Obstetrical Gynecology Service, Hôpital de Tunis, 1002 TunisTunisia
,
Peter Van Delft Hemoglobinopathies Laboratory, Department of Human and Clinical Genetics, Leiden University Medical Center, Wassenaarseweg 72, 2333 AL LeidenThe Netherlands
,
Abdelaziz Falfoul Obstetrical Gynecology Service, CHU Maamouri, 8000 NabeulTunisia
,
Koussay Dellagi Hemoglobinopathies Group, Laboratory of Hematology, Pasteur Institute of Tunis, 1002 Tunis le BelvedereTunisia
,
Salem Abbes Hemoglobinopathies Group, Laboratory of Hematology, Pasteur Institute of Tunis, 1002 Tunis le BelvedereTunisia
&
Piero C. Giordano Hemoglobinopathies Laboratory, Department of Human and Clinical Genetics, Leiden University Medical Center, Wassenaarseweg 72, 2333 AL LeidenThe Netherlands
 show all
Pages 353-362 | Received 24 May 2002, Accepted 03 Jul 2002, Published online: 07 Jul 2009

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Marcilene Rezende Silva, Shimene Mascarenhas Sendin, Fernanda Silva Pimentel, Cibele Velloso-Rodrigues, Álvaro José Romanha & Marcos Borato Viana. (2012) Hb Stanleyville-II [α78(EF7)Asn→Lys (α2); HbA2: c.237C>A]: Incidence of 1:11,500 in a Newborn Screening Program in Brazil. Hemoglobin 36:4, pages 388-394.
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Piero C. Giordano, Marjon H. Cnossen, Annemarie M.S. Joosten, Cees A.M. Jansen, Tineke E. Hakvoort, Margreet Bakker-Verweij, Sandra G.J. Arkesteijn, Peter van Delft, John S. Waye, Marelle J. Bouva & Cornelis L. Harteveld. (2010) Codon 24 (TAT>TAG) and Codon 32 (ATG>AGG) (Hb Rotterdam): Two Novel α2 Gene Mutations Associated with Mild α-Thalassemia Found in the Same Family After Newborn Screening. Hemoglobin 34:4, pages 354-365.
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Amel Haj Khelil, Sabri Denden, Nadia Leban, Houria Daimi, Ramzi Lakhdhar, Gérard Lefranc, Jemni Ben Chibani & Pascale Perrin. (2010) Hemoglobinopathies in North Africa: A Review. Hemoglobin 34:1, pages 1-23.
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Piero C. Giordano, Margaretha Bakker-Verwij & Cornelis L. Harteveld. (2009) Frequency of α-Globin Gene Triplications and Their Interaction with β-Thalassemia Mutations. Hemoglobin 33:2, pages 124-131.
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Hamida Mesbah-Amroun, Fatiha Rouabhi, Rolande Ducrocq & Jacques Elion. (2008) Molecular Basis of α-Thalassemia in Algeria. Hemoglobin 32:3, pages 273-278.
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Piero C. Giordano, Sonja Zweegman, Nicole Akkermans, Sandra G.J. Arkesteijn, Peter van Delft, Florens G.A. Versteegh, Henri Wajcman & Cornelis L. Harteveld. (2007) The First Case of Hb Groene Hart [α119(H2)Pro→Ser, CCT→TCT (α1)] Homozygosity Confirms That a Thalassemia Phenotype Is Associated with this Abnormal Hemoglobin Variant. Hemoglobin 31:2, pages 179-182.
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Imen Moumni, Amine Zorai, Bechir Ben Daoued, Ikbel Mosbahi, Souheil Omar, Neziha Kaabachi, Koussay Dellagi & Salem Abbes. (2007) Hb A2-Pasteur-Tunis [δ59(E3)Lys→Asn, AAG→AAC]: A New δ Chain Variant Detected by DNA Sequencing in a Tunisian Carrier of the Codon 39 (C→T) β0-Thalassemia Mutation. Hemoglobin 31:1, pages 23-29.
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Majid Yavarian, Mehran Karimi, Amine Zorai, Cornelis L Harteveld & Piero C Giordano. (2005) Molecular Basis of Hb H Disease in Southwest Iran. Hemoglobin 29:1, pages 43-50.
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Hajer Siala, Faida Ouali, Taieb Messaoud, Rachida Sfar & Slaheddine Fattoum. (2005) First Description in Tunisia of a Point Mutation at Codon 119 (CCT→TCT) in the α1-Globin Gene: Hb Groene Hart in Association with the − α3.7 Deletion. Hemoglobin 29:4, pages 263-268.
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Amine Zorai, Salem Abbes, Claude Préhu, Souheil Omar, Nathalie Gerard, Raouf Hafsia, Bouaziz Asma, Fethi Guemira & Kousay Dellagi. (2003) Hb H Disease Among Tunisians: Molecular Characterization of α‐Thalassemia Determinants and Hematological Findings. Hemoglobin 27:1, pages 57-61.
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Barbara J. Bain. 2020. Haemoglobinopathy Diagnosis. Haemoglobinopathy Diagnosis 85 184 .
Lilia Romdhane, Nessrine MezziYosr HamdiGhada El-Kamah, Abdelhamid Barakat & Sonia Abdelhak. (2019) Consanguinity and Inbreeding in Health and Disease in North African Populations. Annual Review of Genomics and Human Genetics 20:1, pages 155-179.
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Achraf Laghmich, Fatima Zahra Alaoui Ismaili, Amina Barakat, Naima Ghailani Nourouti, Mohamed Khattab & Mohcine Bennani Mechita. (2019) Alpha-Thalassemia in North Morocco: Prevalence and Molecular Spectrum. BioMed Research International 2019, pages 1-7.
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Kais Douzi, Imen Moumni, Amine Zorai, Maha Ben Mustapha, Ikbel Mosbahi Ben Mansour, Chaouachi Dorra & Abbes Salem. (2015) Two new β + -thalassemia mutation [ β -56 (G → C); HBBc. −106 G → C ] and [ β −83 (G → A); HBBc. −133 G → A ] described among the Tunisian population . American Journal of Human Biology 27:5, pages 716-719.
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A. Zorai, I. Moumni, I. Mosbahi, K. Douzi, D. Chaouachi, F. Guemira & S. Abbes. (2015) Rare hemoglobin variants in Tunisian population. International Journal of Laboratory Hematology 37:2, pages 148-154.
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Raffaella Origa, Maria E. Paglietti, Maria C. Sollaino, Maria F. Desogus, Susanna Barella, Daniela Loi & Renzo Galanello. (2014) Complexity of the alpha-globin genotypes identified with thalassemia screening in Sardinia. Blood Cells, Molecules, and Diseases 52:1, pages 46-49.
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Hanan A. Hamamy & Nasir A. S. Al-Allawi. (2012) Epidemiological profile of common haemoglobinopathies in Arab countries. Journal of Community Genetics 4:2, pages 147-167.
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Rinini DastidarBani GajraMadhusnata De. (2011) Molecular and Hematological Characterization of Hemoglobin H Disease in the Bengali Population of Kolkata, India. Genetic Testing and Molecular Biomarkers 15:1-2, pages 93-96.
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Cornelis L Harteveld & Douglas R Higgs. (2010) α-thalassaemia. Orphanet Journal of Rare Diseases 5:1.
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Imed Touhami, Slaheddine Fattoum, Amina Bibi, Hajer Siala, Taieb Messaoud, Donia Koubaa, Rafik Mankai, Zakia Bartagi & Daniel Le Gallais. (2009) The epidemiology of abnormal hemoglobins in Mediterranean high-level athletes. European Journal of Applied Physiology 108:6, pages 1075-1081.
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Elham Hassen & Lotfi Chouchane. 2010. Genetic Disorders Among Arab Populations. Genetic Disorders Among Arab Populations 613 638 .
Al-Hilali AkramAbu Saud Khalida, Sofi Sawsan & La Cock Charles. (2009) Birth MCV and MCH are Quite Reliable Parameters for the Prediction of Alpha Thalassemia Trait. Clinical medicine. Blood disorders 2, pages CMBD.S1927.
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H. Siala, F. Ouali, T. Messaoud, A. Bibi & S. Fattoum. (2008) α-Thalassaemia in Tunisia: some epidemiological and molecular data. Journal of Genetics 87:3, pages 229-234.
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C.L. Harteveld, M. Yavarian, A. Zorai, E.D. Quakkelaar, P. van Delft & P.C. Giordano. (2003) Molecular spectrum of α‐thalassemia in the Iranian population of Hormozgan: Three novel point mutation defects. American Journal of Hematology 74:2, pages 99-103.
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