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Hemoglobin
international journal for hemoglobin research
Volume 28, 2004 - Issue 3
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Short Communication

The β‐Globin Gene Cluster Haplotypes in Sickle Cell Anemia Patients from Northeast Brazil: A Clinical and Molecular View

Elisângela Vitória Adorno Laboratório de Patologia e Biologia Molecular, Centro de Pesquisas Gonçalo Moniz, Fundação Oswaldo Cruz (FIOCRUZ), Rua Waldemar Falcão 121, Brotas, Salvador, Bahia, CEP: 40.295‐001, Brazil; Universidade Federal da Bahia, Campus Universitário de Ondina, Salvador, Bahia, 40.000‐000, Brazil
,
Ângela Zanette Ambulatório de Hematologia, Fundação de Hematologia e Hemoterapia da Bahia (HEMOBA), Salvador, Bahia, Brazil
,
Isa Lyra Ambulatório de Hematologia, Fundação de Hematologia e Hemoterapia da Bahia (HEMOBA), Salvador, Bahia, Brazil
,
Cyntia Cajado Souza Laboratório de Patologia e Biologia Molecular, Centro de Pesquisas Gonçalo Moniz, Fundação Oswaldo Cruz (FIOCRUZ), Rua Waldemar Falcão 121, Brotas, Salvador, Bahia, CEP: 40.295‐001, Brazil
,
Leandro Ferraz Santos Laboratório de Patologia e Biologia Molecular, Centro de Pesquisas Gonçalo Moniz, Fundação Oswaldo Cruz (FIOCRUZ), Rua Waldemar Falcão 121, Brotas, Salvador, Bahia, CEP: 40.295‐001, Brazil; Universidade Federal da Bahia, Campus Universitário de Ondina, Salvador, Bahia, 40.000‐000, Brazil
,
Joelma Figueiredo Menezes Laboratório de Patologia e Biologia Molecular, Centro de Pesquisas Gonçalo Moniz, Fundação Oswaldo Cruz (FIOCRUZ), Rua Waldemar Falcão 121, Brotas, Salvador, Bahia, CEP: 40.295‐001, Brazil
,
Marie France Dupuit Universidade Federal da Bahia, Campus Universitário de Ondina, Salvador, Bahia, 40.000‐000, Brazil
,
Mari Ney Tavares Almeida Universidade Federal da Bahia, Campus Universitário de Ondina, Salvador, Bahia, 40.000‐000, Brazil
,
Mitermayer Galvão Reis Laboratório de Patologia e Biologia Molecular, Centro de Pesquisas Gonçalo Moniz, Fundação Oswaldo Cruz (FIOCRUZ), Rua Waldemar Falcão 121, Brotas, Salvador, Bahia, CEP: 40.295‐001, Brazil
&
Marilda Souza Gonçalves M.S. Laboratório de Patologia e Biologia Molecular, Centro de Pesquisas Gonçalo Moniz, Fundação Oswaldo Cruz (FIOCRUZ), Rua Waldemar Falcão 121, Brotas, Salvador, Bahia, CEP: 40.295‐001, Brazil; Universidade Federal da Bahia, Campus Universitário de Ondina, Salvador, Bahia, 40.000‐000, Brazil
, Ph.D. show all
Pages 267-271 | Received 16 Jan 2004, Accepted 08 Mar 2004, Published online: 24 Aug 2009

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Aditya N. Jha, Hrishikesh Mishra, Henu K. Verma, Isha Pandey & Bhaskar V.K.S. Lakkakula. (2018) Compound Heterozygosity of β-Thalassemia and the Sickle Cell Hemoglobin in Various Populations of Chhattisgarh State, India. Hemoglobin 42:2, pages 84-90.
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André Rolim Belisário, Cibele Velloso Rodrigues, Marina Lobato Martins, Célia Maria Silva & Marcos Borato Viana. (2010) Coinheritance of α-Thalassemia Decreases the Risk of Cerebrovascular Disease in a Cohort of Children with Sickle Cell Anemia. Hemoglobin 34:6, pages 516-529.
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Marcos André C. Bezerra, Magnun N.N. Santos, Aderson S. Araújo, Yara M. Gomes, Frederico G.C. Abath & Flavia M.G.C. Bandeira. (2007) Molecular Variations Linked to the Grouping of β- and α-Globin Genes in Neonatal Patients with Sickle Cell Disease in the State of Pernambuco, Brazil. Hemoglobin 31:1, pages 83-88.
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Justin K. Kirkham, Jeremie H. Estepp, Mitch J. Weiss & Sara R. Rashkin. (2023) Genetic Variation and Sickle Cell Disease Severity. JAMA Network Open 6:10, pages e2337484.
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Thassila N. Pitanga, Sânzio S. Santana, Dalila L. Zanette, Caroline C. Guarda, Rayra P. Santiago, Vitor V. Maffili, Jonilson B. Lima, Graziele Q. Carvalho, Jaime R. Filho, Junia R. D. Ferreira, Milena M. Aleluia, Valma M. L. Nascimento, Magda O. S. Carvalho, Isa M. Lyra, Valéria M. Borges, Ricardo R. Oliveira & Marilda S. Goncalves. (2021) Effect of lysed and non-lysed sickle red cells on the activation of NLRP3 inflammasome and LTB4 production by mononuclear cells. Inflammation Research 70:7, pages 823-834.
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Betânia Lucena Domingues Hatzlhofer, Diego Antonio Pereira-Martins, Igor de Farias Domingos, Gabriela da Silva Arcanjo, Isabel Weinhäuser, Diego Arruda Falcão, Isabela Cristina Cordeiro Farias, Jéssica Vitória Gadelha de Freitas Batista, Luana Priscilla Laranjeira Prado, Jéssica Maria Florencio Oliveira, Thais Helena Chaves Batista, Marcondes José de Vasconcelos Costa Sobreira, Rodrigo Marcionilo de Santana, Amanda Bezerra de Sá Araújo, Manuela Albuquerque de Melo, Bruna Vasconcelos de Ancântara, Juan Luiz Coelho-Silva, Ana Beatriz Lucas de Moura Rafael, Danízia Menezes de Lima Silva, Flávia Peixoto Albuquerque, Magnun Nueldo Nunes Santos, Ana Cláudia dos Anjos, Fernando Ferreira Costa, Aderson da Silva Araújo, Antonio Roberto Lucena-Araújo & Marcos André Cavalcanti Bezerra. (2021) Alpha thalassemia, but not βS-globin haplotypes, influence sickle cell anemia clinical outcome in a large, single-center Brazilian cohort. Annals of Hematology 100:4, pages 921-931.
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Narcisse Elenga, Emma Cuadro-Alvarez, Elise Martin, Falucar Njuieyon, Antoine Defo & Chimène Maniassom. (2020) Influence of beta-cluster haplotypes, alpha-gene status and UGTA1 polymorphism on clinical and hematological data in sickle-cell disease children from French Guiana. PLOS ONE 15:9, pages e0238691.
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Shahida A. Khan, Ghazi Damanhouri, Ashraf Ali, Sarah A. Khan, Aziz Khan, Ahmed Bakillah, Samy Marouf, Ghazi Al Harbi, Saeed H. Halawani & Ahmad Makki. (2016) Precipitating factors and targeted therapies in combating the perils of sickle cell disease--- A special nutritional consideration. Nutrition & Metabolism 13:1.
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Jéssika V Okumura, Danilo G H Silva, Lidiane S Torres, Edis Belini-Junior, Willian M Barberino, Renan G Oliveira, Gisele C S Carrocini, Gabriela B Gelaleti, Clarisse L C Lobo & Claudia R Bonini-Domingos. (2016) Inheritance of the Bantu/Benin haplotype causes less severe hemolytic and oxidative stress in sickle cell anemia patients treated with hydroxycarbamide. Journal of Human Genetics 61:7, pages 605-611.
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Thiago Magalhães da Silva, M R Sandhya Rani, Gustavo Nunes de Oliveira Costa, Maria A Figueiredo, Paulo S Melo, João F Nascimento, Neil D Molyneaux, Maurício L Barreto, Mitermayer G Reis, M Glória Teixeira & Ronald E Blanton. (2014) The correlation between ancestry and color in two cities of Northeast Brazil with contrasting ethnic compositions. European Journal of Human Genetics 23:7, pages 984-989.
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Elena Calvo-González. (2014) Sobre escravos e genes: “origens” e “processos” nos estudos da genética sobre a população brasileira. História, Ciências, Saúde-Manguinhos 21:4, pages 1113-1129.
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Marilda Souza Goncalves. (2014) Comment on “Molecular analysis and association with clinical and laboratory manifestations in children with sickle cell anemia”. Revista Brasileira de Hematologia e Hemoterapia 36:5, pages 315-318.
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Izabel C.J. Bandeira, Lillianne B.S. Rocha, Maritza C. Barbosa, Darcielle B.D. Elias, José A.N. Querioz, Max Vitor Carioca Freitas & Romélia P. Gonçalves. (2014) Chronic inflammatory state in sickle cell anemia patients is associated with HBB*S haplotype. Cytokine 65:2, pages 217-221.
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Aastha Aggarwal, Priyanka Khurana, Siuli Mitra, Bhavesh Raicha, K.N. Saraswathy, Yazdi M. Italia & Gautam K. Kshatriya. (2013) Distribution of beta-globin haplotypes among the tribes of southern Gujarat, India. Gene 521:2, pages 287-292.
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Lilianne Brito da Silva Rocha, Darcielle Bruna Dias Elias, Maritza Cavalcante Barbosa, Izabel Cristina Justino Bandeira & Romélia Pinheiro Gonçalves. (2012) DNA damage in leukocytes of sickle cell anemia patients is associated with hydroxyurea therapy and with HBB*S haplotype. Mutation Research/Genetic Toxicology and Environmental Mutagenesis 749:1-2, pages 48-52.
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Cynthia Hatsue Kitayama Cabral, Édvis Santos Soares Serafim, Waleska Rayane Dantas Bezerra de Medeiros, Thales Allyrio Araújo de Medeiros Fernandes, Elza Miyuki Kimura, Fernando Ferreira Costa, Maria de Fátima Sonati, Ivanise Marina Moretti Rebecchi & Tereza Maria Dantas de Medeiros. (2011) Determination of βS haplotypes in patients with sickle-cell anemia in the state of Rio Grande do Norte, Brazil. Genetics and Molecular Biology 34:3, pages 421-424.
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Wellington dos Santos Silva, Maria de Nazaré Klautau-Guimarães & Cesar Koppe Grisolia. (2010) β-globin haplotypes in normal and hemoglobinopathic individuals from Reconcavo Baiano, State of Bahia, Brazil. Genetics and Molecular Biology 33:3, pages 411-417.
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E.V. Adorno, J.P. Moura-Neto, I. Lyra, A. Zanette, L.F.O. Santos, M.O. Seixas, M.G. Reis & M.S. Goncalves. (2008) Sequence change in the HS2-LCR and Gg-globin gene promoter region of sickle cell anemia patients. Brazilian Journal of Medical and Biological Research 41:2, pages 95-98.
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Elisângela Vitória Adorno, Ângela Zanette, Isa Lyra, Magda Oliveira Seixas, Mitermayer Galvão Reis & Marilda Souza Gonçalves. (2008) Clinical and molecular characteristics of sickle cell anemia in the northeast of Brazil. Genetics and Molecular Biology 31:3, pages 621-625.
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Qiong Yang, Sekar Kathiresan, Jing-Ping Lin, Geoffrey H Tofler & Christopher J O'Donnell. (2007) Genome-wide association and linkage analyses of hemostatic factors and hematological phenotypes in the Framingham Heart Study. BMC Medical Genetics 8:S1.
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