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Immunological Investigations
A Journal of Molecular and Cellular Immunology
Volume 32, 2003 - Issue 4
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Original

Harnessing the Immunomodulatory Properties of Sertoli Cells to Enable Xenotransplantation in Type I Diabetes

Jannette M. Dufour Surgical–Medical Research Institute, 1074 Dentistry/Pharmacy Centre, University of Alberta, Edmonton, Alberta, T6G 2N8, Canada
, Ph.D.,
Ray V. Rajotte Surgical–Medical Research Institute, 1074 Dentistry/Pharmacy Centre, University of Alberta, Edmonton, Alberta, T6G 2N8, Canada
, Ph.D.,
Gregory S. Korbutt Surgical–Medical Research Institute, 1074 Dentistry/Pharmacy Centre, University of Alberta, Edmonton, Alberta, T6G 2N8, Canada
, Ph.D. &
Dwaine F. Emerich Sertoli Technologies Inc., 766 Laten Knight Rd., Cranston, Rhode Island, 02921, USA
Pages 275-297 | Published online: 10 Jul 2003

Citations (35)

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Read on this site (3)

Gurvinder Kaur, Charles R. Long & Jannette M. Dufour. (2012) Genetically engineered immune privileged Sertoli cells. Spermatogenesis 2:1, pages 23-31.
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Ina Dobrinski. (2007) De novo Morphogenesis of Functional Testis Tissue After Ectopic Transplantation of Isolated Cells. Organogenesis 3:2, pages 79-82.
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Garry M Steil & Kerstin Rebrin. (2005) Closed-loop insulin delivery – what lies between where we are and where we are going?. Expert Opinion on Drug Delivery 2:2, pages 353-362.
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Articles from other publishers (32)

N. N. Skaletskiy & G. N. Skaletskaya. (2021) Sertoli cells: immunomodulatory properties, methods of isolation and culture. Russian Journal of Transplantology and Artificial Organs 23:3, pages 142-147.
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Benjamin Smood, Rita Bottino & David K.C. Cooper. 2020. Transplantation, Bioengineering, and Regeneration of the Endocrine Pancreas. Transplantation, Bioengineering, and Regeneration of the Endocrine Pancreas 423 446 .
David K. C. Cooper, Mohamed B. Ezzelarab, Hidetaka Hara, Hayato Iwase, Whayoung Lee, Martin Wijkstrom & Rita Bottino. 2020. Clinical Xenotransplantation. Clinical Xenotransplantation 27 63 .
E.O Adegoke, Xue Wang, Hao Wang, Chen Wang, Han Zhang & Guixue Zhang. (2018) Selenium (Na2SeO3) Upregulates Expression of Immune Genes and Blood–Testis Barrier Constituent Proteins of Bovine Sertoli Cell In Vitro. Biological Trace Element Research 185:2, pages 332-343.
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David K.C. Cooper, Mohamed B. Ezzelarab, Hidetaka Hara, Hayato Iwase, Whayoung Lee, Martin Wijkstrom & Rita Bottino. (2016) The pathobiology of pig-to-primate xenotransplantation: a historical review. Xenotransplantation 23:2, pages 83-105.
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L. R. França, R. A. Hess, J. M. Dufour, M. C. Hofmann & M. D. Griswold. (2016) The Sertoli cell: one hundred fifty years of beauty and plasticity. Andrology 4:2, pages 189-212.
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Ying Guo, Yanan Hai, Chencheng Yao, Zheng Chen, Jingmei Hou, Zheng Li & Zuping He. (2015) Long-term culture and significant expansion of human Sertoli cells whilst maintaining stable global phenotype and AKT and SMAD1/5 activation. Cell Communication and Signaling 13:1.
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Georgios Michailidis, Maria Anastasiadou, Edith Guibert & Pascal Froment. (2014) Activation of innate immune system in response to lipopolysaccharide in chicken Sertoli cells. REPRODUCTION 148:3, pages 259-270.
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Naoki Tajiri, Kelsey Duncan, Mia Borlongan, Mibel Pabon, Sandra Acosta, Ike de la Pena, Diana Hernadez-Ontiveros, Diego Lozano, Daniela Aguirre, Stephanny Reyes, Paul Sanberg, David Eve, Cesar Borlongan & Yuji Kaneko. (2014) Adult Stem Cell Transplantation: Is Gender a Factor in Stemness?. International Journal of Molecular Sciences 15:9, pages 15225-15243.
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Desmond Barry Keenan & Garry M. Steil. 2014. Textbook of Organ Transplantation. Textbook of Organ Transplantation 576 583 .
Luiz R. França, Sarah A. Auharek, Rex A. Hess, Jannette M. Dufour & Barry T. Hinton. 2013. Biology and Regulation of Blood-Tissue Barriers. Biology and Regulation of Blood-Tissue Barriers 237 259 .
Qahir A. Ramji, Kevin Bayrack, Hossein Arefanian, Marcelo Marcet-Palacios, R. Chris Bleackley, Ray V. Rajotte & Gina R. Rayat. (2011) Protection of Porcine Islet Xenografts in Mice Using Sertoli Cells and Monoclonal Antibodies. Transplantation 92:12, pages 1309-1315.
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Ronald Charles, Lina Lu, Shiguang Qian & John J Fung. (2011) Stromal cell-based immunotherapy in transplantation. Immunotherapy 3:12, pages 1471-1485.
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Kitty Chui, Alpa Trivedi, C. Yan Cheng, Diana B. Cherbavaz, Paul F. Dazin, Ai Lam Thu Huynh, James B. Mitchell, Gabriel A. Rabinovich, Linda J. Noble-Haeusslein & Constance M. John. (2011) Characterization and Functionality of Proliferative Human Sertoli Cells. Cell Transplantation 20:5, pages 619-635.
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Arun Kumar, Mark Glaum, Nagwa El-Badri, Shyam Mohapatra, Edward Haller, Seungjoo Park, Leslie Patrick, Leigh Nattkemper, Dawn Vo & Don F. Cameron. (2011) Initial Observations of Cell-Mediated Drug Delivery to the Deep Lung. Cell Transplantation 20:5, pages 609-618.
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Payal Mital, Barry T. Hinton & Jannette M. Dufour. (2011) The Blood-Testis and Blood-Epididymis Barriers Are More than Just Their Tight Junctions1. Biology of Reproduction 84:5, pages 851-858.
Crossref
Gaetano Faleo & Qizhi Tang. 2011. Tissue Engineering in Regenerative Medicine. Tissue Engineering in Regenerative Medicine 335 352 .
Payal Mital, Gurvinder Kaur & Jannette M Dufour. (2010) Immunoprotective Sertoli cells: making allogeneic and xenogeneic transplantation feasible. REPRODUCTION 139:3, pages 495-504.
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Stephen A. Krawetz, Dirk G. De Rooij & Mark P. Hedger. (2009) Molecular aspects of male fertility. EMBO reports 10:10, pages 1087-1092.
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Nathan Bucay, Mayra Yebra, Vincenzo Cirulli, Ivka Afrikanova, Thomas Kaido, Alberto Hayek & Anthony M.P. Montgomery. (2009) A Novel Approach for the Derivation of Putative Primordial Germ Cells and Sertoli Cells from Human Embryonic Stem Cells. Stem Cells 27:1, pages 68-77.
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Brian T. Golat & Don F. Cameron. (2008) Sertoli Cells Enhance Formation of Capillary-Like Structures in Vitro. Cell Transplantation 17:10-11, pages 1135-1144.
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KC Caires, JA Schmidt, AP Oliver, J de Avila & DJ McLean. (2008) Endocrine Regulation of the Establishment of Spermatogenesis in Pigs. Reproduction in Domestic Animals 43, pages 280-287.
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John T. Wilson & Elliot L. Chaikof. (2008) Challenges and emerging technologies in the immunoisolation of cells and tissues. Advanced Drug Delivery Reviews 60:2, pages 124-145.
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Jannette M. Dufour, Sarah J. Lord, Tatsuya Kin, Gina R. Rayat, Doreen E. Dixon, R. Chris Bleackley, Gregory S. Korbutt & Ray V. Rajotte. (2017) Comparison of Successful and Unsuccessful Islet/Sertoli Cell Cotransplant Grafts in Streptozotocin-Induced Diabetic Mice. Cell Transplantation 16:10, pages 1029-1038.
Crossref
Giovanni LucaMario CalvittiClaudio NastruzziLuca BilancettiEnnio BecchettiGabriella AngelettiFrancesca MancusoRiccardo Calafiore. (2007) Encapsulation, In Vitro Characterization, and In Vivo Biocompatibility of Sertoli Cells in Alginate-Based Microcapsules . Tissue Engineering 13:3, pages 641-648.
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Hak-Mo LeeByoung Chol OhDong-Pyo LimDong-Sup LeeJaejin ChoGene LeeJeong Ryul Lee. (2007) Role of Complement Regulatory Proteins in the Survival of Murine Allo-transplanted Sertoli Cells. Journal of Korean Medical Science 22:2, pages 277.
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P.P.M. Rood & D.K.C. Cooper. (2006) Islet Xenotransplantation: Are We Really Ready for Clinical Trials?. American Journal of Transplantation 6:6, pages 1269-1274.
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R. Shamekh, N. S. El-Badri, S. Saporta, C. Pascual, P. R. Sanberg & D. F. Cameron. (2017) Sertoli Cells Induce Systemic Donor-Specific Tolerance in Xenogenic Transplantation Model. Cell Transplantation 15:1, pages 45-53.
Crossref
Jannette M. Dufour, Meredith Hamilton, Ray V. Rajotte & Gregory S. Korbutt. (2005) Neonatal Porcine Sertoli Cells Inhibit Human Natural Antibody-Mediated Lysis1. Biology of Reproduction 72:5, pages 1224-1231.
Crossref
Wael A. Salameh & Ronald S. Swerdloff. 2005. Sertoli Cell Biology. Sertoli Cell Biology 383 413 .
Emanuele Cozzi, Michela Seveso & Ermanno Ancona. (2004) Pathogenesis and pathology of different types of xenotransplant rejection. Current Opinion in Organ Transplantation 9:2, pages 163-169.
Crossref
Leo H. Buhler. (2004) Xenotransplantation Literature Update October-December, 2003. Xenotransplantation 11:2, pages 216-218.
Crossref

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