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Research Article

Effect of Piperine on the Inhibition of Nitric Oxide (NO) and TNF‐α Production

& , Ph.D.
Pages 337-346 | Published online: 09 Feb 2003

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Chandrasekharan Guruvayoorappan & Girija Kuttan. (2008) Methanol Extract of Biophytum sensitivum Alters the Cytokine Profile and Inhibits iNOS and COX-2 Expression in LPS/Con A Stimulated Macrophages. Drug and Chemical Toxicology 31:1, pages 175-188.
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Qoyama Noel Baito, Halmat M. Jaafar & Talar Ahmad Merza Mohammad. (2023) Piperine suppresses inflammatory fibroblast-like synoviocytes derived from rheumatoid arthritis patients Via NF-κB inhibition. Cellular Immunology 391-392, pages 104752.
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Poornima K. Gopalakrishna, Rajamma Abburu Jayaramu, Sateesha Shivally Boregowda, Shruthi Eshwar, Nikhil V. Suresh, Amr Selim Abu Lila, Afrasim Moin, Hadil Faris Alotaibi, Ahmad J. Obaidullah & El-Sayed Khafagy. (2023) Piperine-Loaded In Situ Gel: Formulation, In Vitro Characterization, and Clinical Evaluation against Periodontitis. Gels 9:7, pages 577.
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Chaowalit Monton, Thaniya Wunnakup, Jirapornchai Suksaeree, Laksana Charoenchai & Natawat Chankana. (2023) Impact of Compressional Force, Croscarmellose Sodium, and Microcrystalline Cellulose on Black Pepper Extract Tablet Properties Based on Design of Experiments Approach. Scientia Pharmaceutica 91:3, pages 30.
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Poonam Arora, Seyyed Shamsadin Athari & Lalit Mohan Nainwal. (2022) Piperine attenuates production of inflammatory biomarkers, oxidative stress and neutrophils in lungs of cigarette smoke-exposed experimental mice. Food Bioscience 49, pages 101909.
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Adil Farooq Wali, Shafat Ali, Summya Rashid, Rana M. Alsaffar, Azher Arafah, Wajhul Qamar, Ajaz Ahmad, Bilal Ahmad Paray, Sheikh Bilal Ahmad, Bashayr M. Alsuwayni & Muneeb U. Rehman. (2021) Attenuation of oxidative damage-associated hepatotoxicity by piperine in CCl4-induced liver fibrosis. Journal of King Saud University - Science 33:8, pages 101629.
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Didem Bezirci, Meltem Karşıyaka Hendek & Ebru Olgun. (2021) PERİODONTAL HASTALIK VE ANTİOKSİDAN BİTKİLER. Selcuk Dental Journal 8:1, pages 211-219.
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Ayda Hosseinkhani, Bijan Ziaian, Kamran Hessami, Ali Kashkooe & Mehdi Pasalar. (2021) An Evidence-Based Review of Antitussive Herbs Containing Essential Oils in Traditional Persian Medicine. Current Drug Discovery Technologies 18:2, pages 179-185.
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Neetu Sachan, Dilipkumar Pal & Phool Chandra. 2021. Bioactive Natural Products for Pharmaceutical Applications. Bioactive Natural Products for Pharmaceutical Applications 759 791 .
Kalyana-Chakravarthy Pentapati, Meena Anand Kukkamalla, Hanan Siddiq & Neeraja Sabnis. (2020) Effectiveness of novel herbal dentifrice in control of plaque, gingivitis, and halitosis – Randomized controlled trial. Journal of Traditional and Complementary Medicine 10:6, pages 565-569.
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Dae Woon Choi, Sun Young Jung, Dong-Hwa Shon & Hee Soon Shin. (2020) Piperine Ameliorates Trimellitic Anhydride-Induced Atopic Dermatitis-Like Symptoms by Suppressing Th2-Mediated Immune Responses via Inhibition of STAT6 Phosphorylation. Molecules 25:9, pages 2186.
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Arathyram Ramachandra Kurup Sasikala, Afeesh Rajan Unnithan, Chan Hee Park & Cheol Sang Kim. 2019. Biomimetic Nanoengineered Materials for Advanced Drug Delivery. Biomimetic Nanoengineered Materials for Advanced Drug Delivery 11 36 .
Zahra Sina, Javad Nasrollahzadeh, Sahar Shokraei, Marjan Rismanchi & Forough Foroughi. (2018) Black and red peppers attenuates plasma and lipopolysaccharide-induced splenocytes production of tumor necrosis factor-α in mice fed a high-fat, high-sucrose diet. Journal of Functional Foods 50, pages 158-163.
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Harleen Kaur, Bo He, Chenhua Zhang, Elliott Rodriguez, David S. Hage & Régis Moreau. (2018) Piperine potentiates curcumin-mediated repression of mTORC1 signaling in human intestinal epithelial cells: implications for the inhibition of protein synthesis and TNFα signaling. The Journal of Nutritional Biochemistry 57, pages 276-286.
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Shubham Jain, Sai Rama Krishna Meka & Kaushik Chatterjee. (2016) Engineering a Piperine Eluting Nanofibrous Patch for Cancer Treatment. ACS Biomaterials Science & Engineering 2:8, pages 1376-1385.
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Gemma Rodgers, Carolyn D. Doucette, David A. Soutar, Robert S. Liwski & David W. Hoskin. (2016) Piperine impairs the migration and T cell-activating function of dendritic cells. Toxicology Letters 242, pages 23-33.
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Garima Chouhan, Mohammad Islamuddin, Muzamil Y. Want, Hani A. Ozbak, Hassan A. Hemeg, Dinkar Sahal & Farhat Afrin. (2015) Leishmanicidal Activity of Piper nigrum Bioactive Fractions is Interceded via Apoptosis In Vitro and Substantiated by Th1 Immunostimulatory Potential In Vivo. Frontiers in Microbiology 6.
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Rohit A. Gupta, Meha N. Motiwala, Nitin G. Dumore, Kishor R. Danao & Anjali B. Ganjare. (2015) Effect of piperine on inhibition of FFA induced TLR4 mediated inflammation and amelioration of acetic acid induced ulcerative colitis in mice. Journal of Ethnopharmacology 164, pages 239-246.
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Yakub Ali, Mohammad Sarwar Alam, Hinna Hamid, Asif Husain, Sameena Bano, Abhijeet Dhulap, Chetna Kharbanda, Syed Nazreen & Saqlain Haider. (2015) Design, synthesis and biological evaluation of piperic acid triazolyl derivatives as potent anti-inflammatory agents. European Journal of Medicinal Chemistry 92, pages 490-500.
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Jeganathan Manivannan, Thangarasu Silambarasan, Rajendran Kadarkarairaj & Boobalan Raja. (2015) Systems pharmacology and molecular docking strategies prioritize natural molecules as cardioprotective agents. RSC Advances 5:94, pages 77042-77055.
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Neeraj Gilhotra & Dinesh Dhingra. (2014) Possible involvement of GABAergic and nitriergic systems for antianxiety-like activity of piperine in unstressed and stressed mice. Pharmacological Reports 66:5, pages 885-891.
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Mukesh Kumar YadavJune ChoiJae-Jun Song. (2014) Protective Effect of Hexane and Ethanol Extract of Piper Longum L. on Gentamicin-Induced Hair Cell Loss in Neonatal Cultures . Clinical and Experimental Otorhinolaryngology 7:1, pages 13.
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Muzamal Iqbal, Robert Verpoorte, Henrie A. A. J. Korthout & Natali Rianika Mustafa. (2012) Phytochemicals as a potential source for TNF-α inhibitors. Phytochemistry Reviews 12:1, pages 65-93.
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Paul B. Yaffe, Carolyn D. Doucette, Mark Walsh & David W. Hoskin. (2013) Piperine impairs cell cycle progression and causes reactive oxygen species-dependent apoptosis in rectal cancer cells. Experimental and Molecular Pathology 94:1, pages 109-114.
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Carolyn D. Doucette, Ashley L. Hilchie, Robert Liwski & David W. Hoskin. (2013) Piperine, a dietary phytochemical, inhibits angiogenesis. The Journal of Nutritional Biochemistry 24:1, pages 231-239.
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Christophe Wiart. 2013. Lead Compounds from Medicinal Plants for the Treatment of Cancer. Lead Compounds from Medicinal Plants for the Treatment of Cancer 1 95 .
Gi-Sang Bae, Jong-Jin Kim, Kyoung-Chel Park, Bon Soon Koo, Il-Joo Jo, Sun Bok Choi, Chang Hyuk Lee, Won-Seok Jung, Jung-Hee Cho, Seung-Heon Hong, Ho-Joon Song, Yong Kook Shin & Sung-Joo Park. (2012) Piperine Inhibits Lipopolysaccharide-induced Maturation of Bone-marrow-derived Dendritic Cells Through Inhibition of ERK and JNK Activation. Phytotherapy Research 26:12, pages 1893-1897.
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Hyung Gyun Kim, Eun Hee Han, Woo-Seok Jang, Jae Ho Choi, Tilak Khanal, Bong Hwan Park, Thu Phuong Tran, Young Chul Chung & Hye Gwang Jeong. (2012) Piperine inhibits PMA-induced cyclooxygenase-2 expression through downregulating NF-κB, C/EBP and AP-1 signaling pathways in murine macrophages. Food and Chemical Toxicology 50:7, pages 2342-2348.
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T. K. LimT. K. Lim. 2012. Edible Medicinal And Non-Medicinal Plants. Edible Medicinal And Non-Medicinal Plants 322 350 .
Denys J. CharlesDenys J. Charles. 2013. Antioxidant Properties of Spices, Herbs and Other Sources. Antioxidant Properties of Spices, Herbs and Other Sources 459 467 .
C. Ferreira, D.C. Soares, C.B. Barreto-Junior, M.T. Nascimento, L. Freire-de-Lima, J.C. Delorenzi, M.E.F. Lima, G.C. Atella, E. Folly, T.M.U. Carvalho, E.M. Saraiva & L.H. Pinto-da-Silva. (2011) Leishmanicidal effects of piperine, its derivatives, and analogues on Leishmania amazonensis. Phytochemistry 72:17, pages 2155-2164.
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V.S. Cardoso, I.S. Castro, C.A.R. Lima, M.E.F Lima, L.E.G. Dorneles, G.M. Direito & M.G.M. Danelli. (2011) Efficacy of piperine in reducing the effects of aflatoxin intoxication in broiler chickens: a preliminary report. Arquivo Brasileiro de Medicina Veterinária e Zootecnia 63:2, pages 495-498.
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Gi-Sang Bae, Min-Sun Kim, Won-Seok Jung, Sang-Wan Seo, Seung-Won Yun, Sung Gyu Kim, Rae-Kil Park, Eun-Cheol Kim, Ho-Joon Song & Sung-Joo Park. (2010) Inhibition of lipopolysaccharide-induced inflammatory responses by piperine. European Journal of Pharmacology 642:1-3, pages 154-162.
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Leonardo Freire-de-Lima, Tatiana Santana Ribeiro, Gustavo Miranda Rocha, Bruno Alves Brandão, Alexandre Romeiro, Lucia Mendonça-Previato, José Osvaldo Previato, Marco Edilson Freire de Lima, Técia Maria Ulisses de Carvalho & Norton Heise. (2008) The toxic effects of piperine against Trypanosoma cruzi: ultrastructural alterations and reversible blockage of cytokinesis in epimastigote forms. Parasitology Research 102:5, pages 1059-1067.
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Byung-Min Choi, Sung-Min Kim, Tae-Kwang Park, Guang Li, Sung-Jae Hong, Raekil Park, Hun-Taeg Chung & Bok-Ryang Kim. (2007) Piperine protects cisplatin-induced apoptosis via heme oxygenase-1 induction in auditory cells. The Journal of Nutritional Biochemistry 18:9, pages 615-622.
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Punathil Thejass & Girija Kuttan. (2007) Allyl isothiocyanate (AITC) and phenyl isothiocyanate (PITC) inhibit tumour-specific angiogenesis by downregulating nitric oxide (NO) and tumour necrosis factor-α (TNF-α) production. Nitric Oxide 16:2, pages 247-257.
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D.P. Bezerra, F.O. Castro, A.P.N.N. Alves, C. Pessoa, M.O. Moraes, E.R. Silveira, M.A.S. Lima, F.J.M. Elmiro & L.V. Costa-Lotufo. (2006) In vivo growth-inhibition of Sarcoma 180 by piplartine and piperine, two alkaloid amides from Piper. Brazilian Journal of Medical and Biological Research 39:6, pages 801-807.
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C.R. Pradeep & G. Kuttan. (2004) Piperine is a potent inhibitor of nuclear factor-κB (NF-κB), c-Fos, CREB, ATF-2 and proinflammatory cytokine gene expression in B16F-10 melanoma cells. International Immunopharmacology 4:14, pages 1795-1803.
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