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Research Article

Molecular Specificity of 5-Androstenediol as a Systemic Radioprotectant in Mice

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Pages 15-32 | Published online: 08 Oct 2008

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Vijay K Singh, Victoria L Newman, Patricia LP Romaine, Stephen Y Wise & Thomas M Seed. (2014) Radiation countermeasure agents: an update (2011 – 2014). Expert Opinion on Therapeutic Patents 24:11, pages 1229-1255.
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Vijay K. Singh, Elizabeth J. Ducey, Darren S. Brown & Mark H. Whitnall. (2012) A review of radiation countermeasure work ongoing at the Armed Forces Radiobiology Research Institute. International Journal of Radiation Biology 88:4, pages 296-310.
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Articles from other publishers (25)

Vijay K. Singh & Thomas M Seed. (2022) Armed Forces Radiobiology Research Institute/Uniformed Services University of the Health Sciences perspective on space radiation countermeasure discovery. Life Sciences in Space Research 35, pages 20-29.
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Mayuri Bandekar, Dharmendra K. Maurya, Deepak Sharma, Rahul Checker, Vikram Gota, Nigamananda Mishra & Santosh K. Sandur. (2020) Xenogeneic transplantation of human WJ-MSCs rescues mice from acute radiation syndrome via Nrf-2-dependent regeneration of damaged tissues. American Journal of Transplantation 20:8, pages 2044-2057.
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Tiancong Wu, Wen Liu, Ting Fan, Haiqing Zhong, Han Zhou, Wenjie Guo & Xixu Zhu. (2020) 5-Androstenediol prevents radiation injury in mice by promoting NF-κB signaling and inhibiting AIM2 inflammasome activation. Biomedicine & Pharmacotherapy 121, pages 109597.
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A. N. Grebenyuk & V. D. Gladkikh. (2020) Modern Condition and Prospects for the Development of Medicines towards Prevention and Early Treatment of Radiation Damage. Biology Bulletin 46:11, pages 1540-1555.
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Nataliya Uzlenkova. (2019) New pharmacological means of radiation protection (literature review). JOURNAL OF THE NATIONAL ACADEMY OF MEDICAL SCIENCES OF UKRAINE.
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Fan Bai, Limei Wang, Zhongtang Li, Lirong Yi, Zongchao Zuo, Cheng Zhang, Yajun Shan, Chao Yang, Renjun Peng, Rifang Yang, Zuyin Yu & Yuwen Cong. (2019) 17α-Ethinyl-androst-5-ene-3β, 17β-diol, a Novel Potent Oral Radioprotective Agent, Confers Radioprotection of Hematopoietic Stem and Progenitor Cells in a Granulocyte Colony-Stimulating Factor–Independent Manner. International Journal of Radiation Oncology*Biology*Physics 103:1, pages 217-228.
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Virginia Wotring. 2019. Principles of Clinical Medicine for Space Flight. Principles of Clinical Medicine for Space Flight 815 840 .
Gil-Im Mun, Seoyoung Kim, Eun Choi, Cha Soon Kim & Yun-Sil Lee. (2018) Pharmacology of natural radioprotectors. Archives of Pharmacal Research 41:11, pages 1033-1050.
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Michal Hofer, Zuzana Hoferová & Martin Falk. (2017) Pharmacological Modulation of Radiation Damage. Does It Exist a Chance for Other Substances than Hematopoietic Growth Factors and Cytokines?. International Journal of Molecular Sciences 18:7, pages 1385.
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Yiwei Zhang, Jian Li, Zhiyun Meng, Xiaoxia Zhu, Hui Gan, Ruolan Gu, Zhuona Wu, Ying Zheng, Jinbin Wei & Guifang Dou. (2017) A sharp, robust, and quantitative method by liquid chromatography tandem mass spectrometry for the measurement of EAD for acute radiation syndrome and its application. Journal of Chromatography B 1055-1056, pages 45-50.
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Mohammad Zahid Kamran, Atul Ranjan, Navrinder Kaur, Souvik Sur & Vibha Tandon. (2016) Radioprotective Agents: Strategies and Translational Advances. Medicinal Research Reviews 36:3, pages 461-493.
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Vijay K. Singh, Patricia L.P. Romaine & Thomas M. Seed. (2015) Medical Countermeasures for Radiation Exposure and Related Injuries. Health Physics 108:6, pages 607-630.
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Joong Sun Kim, Won Suk Jang, Sunjoo Lee, Yeonghoon Son, Sunhoo Park & Seung Sook Lee. (2014) A study of the effect of sequential injection of 5-androstenediol on irradiation-induced myelosuppression in mice. Archives of Pharmacal Research 38:6, pages 1213-1222.
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Yu. N. Morozov, A. Yu. Utekhina, V. P. Shabatin, V. V. Chernyshev & G. B. Sergeev. (2014) Cryosynthesis of nanosized drug substances. Russian Journal of General Chemistry 84:5, pages 1010-1017.
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Marcy B. Grace, Vijay K. Singh, Juong G. Rhee, William E. JacksonIIIIII, Tzu-Cheg Kao & Mark H. Whitnall. (2012) 5-AED enhances survival of irradiated mice in a G-CSF-dependent manner, stimulates innate immune cell function, reduces radiation-induced DNA damage and induces genes that modulate cell cycle progression and apoptosis. Journal of Radiation Research 53:6, pages 840-853.
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Fatima S.F. Aerts-Kaya, Trudi P. Visser, Shazia Arshad, James Frincke, Dwight R. Stickney, Chris L. Reading & Gerard Wagemaker. (2012) 5-Androstene-3β,17β-diol Promotes Recovery of Immature Hematopoietic Cells Following Myelosuppressive Radiation and Synergizes With Thrombopoietin. International Journal of Radiation Oncology*Biology*Physics 84:3, pages e401-e407.
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Virginia E. WotringVirginia E. Wotring. 2012. Space Pharmacology. Space Pharmacology 71 82 .
Merriline Satyamitra, Eric Lombardini, John Graves, Conor Mullaney, Patrick Ney, Jeffrey Hunter, Krista Johnson, Paul Tamburini, Yi Wang, Jeremy P. Springhorn & Venkataraman Srinivasan. (2011) A TPO Receptor Agonist, ALXN4100TPO, Mitigates Radiation-Induced Lethality and Stimulates Hematopoiesis in CD2F1 Mice. Radiation Research 175:6, pages 746.
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Joong-Sun KimSeung-Sook LeeWon-Suk JangSun-Joo LeeSunhoo ParkSoo-Youn ChoChangjong MoonSung-Ho KimMi-Sook Kim. (2010) Protective Effects of 5-Androstendiol (5-AED) on Radiation-induced Intestinal Injury. The Journal of the Korean Society for Therapeutic Radiology and Oncology 28:3, pages 141.
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Cong Liu, Jianguo Cui, Quan Sun & Jianming Cai. (2010) Hydrogen therapy may be an effective and specific novel treatment for acute radiation syndrome. Medical Hypotheses 74:1, pages 145-146.
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John G. VoellerTerry C. Pellmar. 2008. Wiley Handbook of Science and Technology for Homeland Security. Wiley Handbook of Science and Technology for Homeland Security.
Nicole H. Urban, Brett Chamberlin, Samuel Ramage, Zachary Roberts, Roger M. Loria & Matthew J. Beckman. (2008) Effects of α/β-androstenediol immune regulating hormones on bone remodeling and apoptosis in osteoblasts. The Journal of Steroid Biochemistry and Molecular Biology 110:3-5, pages 223-229.
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V.K. Singh, M.B. Grace, K.O. Jacobsen, C-M. Chang, V.I. Parekh, C.E. Inal, R.L. Shafran, A.D. Whitnall, T-C. Kao, W.E. JacksonIIIIII & M.H. Whitnall. (2008) Administration of 5-androstenediol to mice: Pharmacokinetics and cytokine gene expression. Experimental and Molecular Pathology 84:2, pages 178-188.
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Mang Xiao, Cynthia E. Inal, Vaishali I. Parekh, Cheng-Min Chang & Mark H. Whitnall. (2007) 5-Androstenediol Promotes Survival of γ-Irradiated Human Hematopoietic Progenitors through Induction of Nuclear Factor-κB Activation and Granulocyte Colony-Stimulating Factor Expression. Molecular Pharmacology 72:2, pages 370-379.
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Juliann G. Kiang, Russell M. Peckham, Leah E. Duke, Tomoharu Shimizu, Irshad H. Chaudry & George C. Tsokos. (2007) Androstenediol inhibits the trauma-hemorrhage-induced increase in caspase-3 by downregulating the inducible nitric oxide synthase pathway. Journal of Applied Physiology 102:3, pages 933-941.
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