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Immunopharmacology and Immunotoxicology Volume 27, 2005 - Issue 1
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Research Article

Effects of Antioxidants Coenzyme Q10 and Lipoic Acid on Interleukin-1β-Mediated Inhibition of Glucose-Stimulated Insulin Release from Cultured Mouse Pancreatic Islets

Michelle M. Schroeder Department of Medicinal and Biological Chemistry, College of Pharmacy, University of Toledo, Toledo, OhioUSA; Department of Pharmacology, College of Pharmacy, University of Toledo, 2801 W. Bancroft St., Toledo, Ohio, 43606-3390, USA
,
Robert J. Belloto Jr. Department of Medicinal and Biological Chemistry, College of Pharmacy, University of Toledo, Toledo, OhioUSA; Department of Pharmacology, College of Pharmacy, University of Toledo, 2801 W. Bancroft St., Toledo, Ohio, 43606-3390, USA
,
Richard A. Hudson Department of Medicinal and Biological Chemistry, College of Pharmacy, University of Toledo, Toledo, OhioUSA; Department of Pharmacology, College of Pharmacy, University of Toledo, 2801 W. Bancroft St., Toledo, Ohio, 43606-3390, USA
&
Dr. Marcia F. McInerney Department of Medicinal and Biological Chemistry, College of Pharmacy, University of Toledo, Toledo, OhioUSA; Department of Pharmacology, College of Pharmacy, University of Toledo, 2801 W. Bancroft St., Toledo, Ohio, 43606-3390, USA; Department of Medicinal and Biological Chemistry, College of Pharmacy, University of Toledo, BO 2833, MS# 606, 2801 W. Bancroft Street, Toledo, Ohio, 43606-3390, USA
Pages 109-122 | Published online: 08 Oct 2008

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Jiaqi Zhang, Chuan Xing, Han Zhao & Bing He. (2021) The effectiveness of coenzyme Q10, vitamin E, inositols, and vitamin D in improving the endocrine and metabolic profiles in women with polycystic ovary syndrome: a network Meta-analysis. Gynecological Endocrinology 37:12, pages 1063-1071.
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Articles from other publishers (20)

Tianqing Zhang, Qi He, Hao Xiu, ZiZhu Zhang, Yao Liu, Zhenrong Chen & Hengjing Hu. (2022) Efficacy and Safety of Coenzyme Q10 Supplementation in the Treatment of Polycystic Ovary Syndrome: a Systematic Review and Meta-analysis. Reproductive Sciences 30:4, pages 1033-1048.
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Umberto Capece, Simona Moffa, Ilaria Improta, Gianfranco Di Giuseppe, Enrico Celestino Nista, Chiara M. A. Cefalo, Francesca Cinti, Alfredo Pontecorvi, Antonio Gasbarrini, Andrea Giaccari & Teresa Mezza. (2022) Alpha-Lipoic Acid and Glucose Metabolism: A Comprehensive Update on Biochemical and Therapeutic Features. Nutrients 15:1, pages 18.
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Mohamed Ibrahim Mohamed Fahmy, Rabab Hamed Sayed, Muhammad Farag El-Yamany, Reham El-Naggar & Hesham A. Eliwa. (2022) Rosuvastatin and co-enzyme Q10 improve high-fat and high-fructose diet-induced metabolic syndrome in rats via ameliorating inflammatory and oxidative burden. Biomedicine & Pharmacotherapy 153, pages 113526.
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Silvia Lai, Luigi Petramala, Maurizio Muscaritoli, Rosario Cianci, Sandro Mazzaferro, Anna Paola Mitterhofer, Marzia Pasquali, Viola D'Ambrosio, Maria Carta, Matteo Ansuini, Cesarina Ramaccini, Alessandro Galani, Maria Ida Amabile, Alessio Molfino & Claudio Letizia. (2020) α-lipoic acid in patients with autosomal dominant polycystic kidney disease. Nutrition 71, pages 110594.
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Min Liu, Hongqiu Zhu, Xiaodan Hu, Ying Zhu & Haiyan Chen. (2020) Efficacy of coenzyme Q10 supplementation on glucose metabolism, lipid profiles, and biomarkers of inflammation in women with polycystic ovary syndrome. Medicine 99:46, pages e23130.
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Xia Wang, Qingjuan Meng, Cheng Qiu, Peng Li, Ruize Qu, Wenhan Wang, Yan Wang, Long Liu & Yunpeng Zhao. (2018) Potential therapeutic role of Co-Q10 in alleviating intervertebral disc degeneration and suppressing IL-1β-mediated inflammatory reaction in NP cells. International Immunopharmacology 64, pages 424-431.
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Marko Stojanović & Miroslav Radenković. (2017) A meta-analysis of randomized and placebo-controlled clinical trials suggests that coenzyme Q10 at low dose improves glucose and HbA1c levels. Nutrition Research 38, pages 1-12.
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Dick C. Chan, Jing Pang & Gerald F. Watts. (2014) Pathogenesis and Management of the Diabetogenic Effect of Statins: a Role for Adiponectin and Coenzyme Q10?. Current Atherosclerosis Reports 17:1.
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Ma Antonia Jiménez-Santos, Isela E Juárez-Rojop, Carlos A Tovilla-Zárate, María Teresa Espinosa-García, Marco A Juárez-Oropeza, Teresa Ramón-Frías, Deysi Y Bermúdez-Ocaña & Juan C Díaz-Zagoya. (2014) Coenzyme Q10 supplementation improves metabolic parameters, liver function and mitochondrial respiration in rats with high doses of atorvastatin and a cholesterol-rich diet. Lipids in Health and Disease 13:1.
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Hoda Zahedi, Shahryar Eghtesadi, Soroush Seifirad, Neshat Rezaee, Farzad Shidfar, Iraj Heydari, Banafsheh Golestan & Shima Jazayeri. (2014) Effects of CoQ10 Supplementation on Lipid Profiles and Glycemic Control in Patients with Type 2 Diabetes: a randomized, double blind, placebo-controlled trial. Journal of Diabetes & Metabolic Disorders 13:1.
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Udayakumar KarunakaranKeun-Gyu Park. (2013) A Systematic Review of Oxidative Stress and Safety of Antioxidants in Diabetes: Focus on Islets and Their Defense. Diabetes & Metabolism Journal 37:2, pages 106.
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Florence M Sohet & Nathalie M Delzenne. (2012) Is there a place for coenzyme Q in the management of metabolic disorders associated with obesity?. Nutrition Reviews 70:11, pages 631-641.
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YUFAN WANG, WEIPING DONG, XIAOYING DING, FENG WANG, YUFEI WANG, XINYA CHEN, LONG YU, XIAOHUA LI, AIFANG ZHANG & YONGDE PENG. (2012) Protective effect of α-lipoic acid on islet cells co-cultured with 3T3L1 adipocytes. Experimental and Therapeutic Medicine 4:3, pages 469-474.
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Jennifer E. BRUIN, Amanda K. WOYNILLOWICZ, Bart P. HETTINGA, Mark A. TARNOPOLSKY, Katherine M. MORRISON, Hertzel C. GERSTEIN & Alison C. HOLLOWAY. (2012) Maternal antioxidants prevent β-cell apoptosis and promote formation of dual hormone-expressing endocrine cells in male offspring following fetal and neonatal nicotine exposure. Journal of Diabetes 4:3, pages 297-306.
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Changting Xiao, Adria Giacca & Gary F. Lewis. (2011) Short-term oral α-lipoic acid does not prevent lipid-induced dysregulation of glucose homeostasis in obese and overweight nondiabetic men. American Journal of Physiology-Endocrinology and Metabolism 301:4, pages E736-E741.
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Mohammed A. Kandeil, Kamal A. Amin, Kamel A. Hassanin, Kalid M. Ali & Eman T. Mohammed. (2011) Role of lipoic acid on insulin resistance and leptin in experimentally diabetic rats. Journal of Diabetes and its Complications 25:1, pages 31-38.
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Gisela Drews, Peter Krippeit-Drews & Martina Düfer. (2010) Oxidative stress and beta-cell dysfunction. Pflügers Archiv - European Journal of Physiology 460:4, pages 703-718.
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Ki-Up Lee, Eun Hee Koh, Min-Seon Kim, Joong-Yeol Park & Eun Hee Cho. 2008. Lipoic Acid. Lipoic Acid.
Cristina M. Sena, Elsa Nunes, Aline Gomes, Maria S. Santos, Teresa Proença, Maria I. Martins & Raquel M. Seiça. (2008) Supplementation of coenzyme Q10 and α-tocopherol lowers glycated hemoglobin level and lipid peroxidation in pancreas of diabetic rats. Nutrition Research 28:2, pages 113-121.
Crossref
Bryan Fuller, Dustin Smith, Amber Howerton & Dale Kern. (2006) Anti-inflammatory effects of CoQ10 and colorless carotenoids. Journal of Cosmetic Dermatology 5:1, pages 30-38.
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