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Journal of Liquid Chromatography & Related Technologies Volume 26, 2003 - Issue 3
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Original Articles

Purification of HTOS Libraries by Supercritical Fluid Chromatography

Jill Hochlowski Medicinal Chemistry Technologies, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, Illinois, 60064, USACorrespondence[email protected]
,
Jeff Olson Medicinal Chemistry Technologies, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, Illinois, 60064, USA
,
Jeff Pan Medicinal Chemistry Technologies, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, Illinois, 60064, USA
,
Daryl Sauer Medicinal Chemistry Technologies, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, Illinois, 60064, USA
,
Philip Searle Medicinal Chemistry Technologies, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, Illinois, 60064, USA
&
Thomas Sowin Medicinal Chemistry Technologies, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, Illinois, 60064, USA
Pages 333-354 | Received 02 Sep 2002, Accepted 30 Sep 2002, Published online: 24 Jun 2011

Citations (14)

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Read on this site (3)

WilliamP. Farrell, ChristineM. Aurigemma & DavidF. Masters-Moore. (2009) Advances in High Throughput Supercritical Fluid Chromatography. Journal of Liquid Chromatography & Related Technologies 32:11-12, pages 1689-1710.
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RayT. McClain, Anna Dudkina, James Barrow, George Hartman & ChristopherJ. Welch. (2009) Evaluation and Implementation of a Commercially Available Mass-Guided SFC Purification Platform in a High Throughput Purification Laboratory in Drug Discovery. Journal of Liquid Chromatography & Related Technologies 32:4, pages 483-499.
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Yan Wu. (2004) Retention Mechanism Studies on Packed Column Supercritical Fluid Chromatography (pSFC) and Related Unified Chromatography Techniques. Journal of Liquid Chromatography & Related Technologies 27:7-9, pages 1203-1236.
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Articles from other publishers (11)

Mark JonesRoss L. Goodyear. (2023) High-Throughput Purification in Drug Discovery: Scaling New Heights of Productivity. ACS Medicinal Chemistry Letters 14:7, pages 916-919.
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Alexander S. Kaplitz, Terry A. Berger, Blair K. Berger & Kevin A. Schug. (2022) A review of fraction collection technology for supercritical fluid chromatography. TrAC Trends in Analytical Chemistry 151, pages 116588.
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Jeffrey Y. Pan. (2019) Engineering Chemistry Innovation. ACS Medicinal Chemistry Letters 10:5, pages 703-707.
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E.R. Francotte. 2017. Supercritical Fluid Chromatography. Supercritical Fluid Chromatography 275 315 .
Thomas C. Maier & Werngard Czechtizky. 2015. Small Molecule Medicinal Chemistry. Small Molecule Medicinal Chemistry 323 351 .
Yinong Zhang, Lu Zeng, Catherine Pham & Rongda Xu. (2014) Preparative two-dimensional liquid chromatography/mass spectrometry for the purification of complex pharmaceutical samples. Journal of Chromatography A 1324, pages 86-95.
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Katalin Ebinger, Harold N. Weller, Jeffrey Kiplinger & Paul Lefebvre. (2011) Evaluation of a New Preparative Supercritical Fluid Chromatography System for Compound Library Purification: The TharSFC SFC-MS Prep-100 System . JALA: Journal of the Association for Laboratory Automation 16:3, pages 241-249.
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John Isbell. (2008) Changing Requirements of Purification as Drug Discovery Programs Evolve from Hit Discovery. Journal of Combinatorial Chemistry 10:2, pages 150-157.
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Xu Zhang, Marc H. Towle, Christine E. Felice, James H. Flament & Wolfgang K. Goetzinger. (2006) Development of a Mass-Directed Preparative Supercritical Fluid Chromatography Purification System. Journal of Combinatorial Chemistry 8:5, pages 705-714.
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Marcus Koppitz & Knut Eis. (2006) Automated medicinal chemistry. Drug Discovery Today 11:11-12, pages 561-568.
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Philip A. Searle, Keithney A. Glass & Jill E. Hochlowski. (2003) Comparison of Preparative HPLC/MS and Preparative SFC Techniques for the High-Throughput Purification of Compound Libraries. Journal of Combinatorial Chemistry 6:2, pages 175-180.
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