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Journal of Liquid Chromatography & Related Technologies Volume 28, 2005 - Issue 5
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Original Articles

Preparative Separation of Indole Alkaloids from the Rind of Picralima nitida (Stapf) T. Durand & H. Durand by pH‐Zone‐Refining Countercurrent Chromatography

Chris O. Okunji International Center for Ethnomedicine and Drug Development (InterCEDD), Nsukka Nigeria; Bioresources Development & Conservation Programme, Silver Spring, Maryland, USA; Division of Experimental Therapeutics, Department of Medicinal Chemistry, Walter Reed Army Institute of Research, Washington DC, USA
,
Maurice M. Iwu International Center for Ethnomedicine and Drug Development (InterCEDD), Nsukka Nigeria; Bioresources Development & Conservation Programme, Silver Spring, Maryland, USA; Division of Experimental Therapeutics, Department of Medicinal Chemistry, Walter Reed Army Institute of Research, Washington DC, USA
,
Yoichiro Ito Center of Biochemistry and Biophysics, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USACorrespondence[email protected]
&
Philip L. Smith Division of Experimental Therapeutics, Department of Medicinal Chemistry, Walter Reed Army Institute of Research, Washington DC, USA
Pages 775-783 | Accepted 30 Oct 2004, Published online: 06 Feb 2007

Citations (29)

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Yuanjiang Pan & Yanbin Lu. (2007) Recent Progress in Countercurrent Chromatography. Journal of Liquid Chromatography & Related Technologies 30:5-7, pages 649-679.
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Articles from other publishers (28)

Justice Allotey Pappoe, Jerry Opoku-Ansah, Charles Lloyd Yeboah Amuah, Peter Osei-Wusu Adueming, Samuel Sonko Sackey, Rabbi Boateng, Justice Kwaku Addo, Moses Jojo Eghan, Patrick Mensah-Amoah & Benjamin Anderson. (2023) Automatic Classification of Antimalarial Herbal Drugs Exposed to Ultraviolet Radiation from Unexposed Ones Using Laser-Induced Autofluorescence with Chemometric Techniques. Journal of Fluorescence.
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Akinlade Ololade, Fredrick Anowi, Ajaghaku Anwuchaepe & Ejiofor IfedibaluChukwu. (2023) Pharmacognostic Study and Hepatoprotective Activity of the Methanolic Extract and Fractions of Leaves of Picralima nitida Apocyanaceae. Sciences of Phytochemistry 2:1, pages 114-127.
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Priya Chaudhary, Rohit Sharma, Sonam Rawat & Pracheta Janmeda. (2023) Antipyretic Medicinal Plants, Phytocompounds, and Green Nanoparticles: An Updated Review. Current Pharmaceutical Biotechnology 24:1, pages 23-49.
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Femi Olawale, Tomi Lois Adetunji, Ademola Emmanuel Adetunji, Opeyemi Iwaloye & Ibukun Mary Folorunso. (2023) The therapeutic value of alstonine: An updated review. South African Journal of Botany 152, pages 288-295.
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Emmanuel O. Adeyoju, Clement O. Ajayi, Awodayo O. Adepiti & Anthony A. Elujoba. (2022) Comparative in vivo antimalarial activities of aqueous and methanol extracts of MAMA powder - A herbal antimalarial preparation. Journal of Ethnopharmacology 283, pages 114686.
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Agnès Aubouy, Aissata Camara & Mohamed Haddad. 2022. Medicinal Plants as Anti-Infectives. Medicinal Plants as Anti-Infectives 267 306 .
Erwin Osiele Onyekachukwu, Aishat Mary Osagie, Sylvia Oghogho Omage, Kingsley Omage & Marshall Arebojie Azeke. (2021) Picralima nitida protects against hepatotoxicity and oxidative stress in alloxan-induced diabetic rats. Comparative Clinical Pathology 30:6, pages 981-993.
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M.S.J. Arnold, J.R. Macdonald, R.J. Quinn, T.S. Skinner-Adams, K.T. Andrews & G.M. Fisher. (2021) Antiplasmodial activity of the natural product compounds alstonine and himbeline. International Journal for Parasitology: Drugs and Drug Resistance 16, pages 17-22.
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Simone M. Creed, Anna M. Gutridge, Malaika D. Argade, Madeline R. Hennessy, J. Brent Friesen, Guido F. Pauli, Richard M. van Rijn & Andrew P. Riley. (2020) Isolation and Pharmacological Characterization of Six Opioidergic Picralima nitida Alkaloids . Journal of Natural Products 84:1, pages 71-80.
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Marzuq A. Ungogo, Godwin U. Ebiloma, Nahandoo Ichoron, John O. Igoli, Harry P. de Koning & Emmanuel O. Balogun. (2020) A Review of the Antimalarial, Antitrypanosomal, and Antileishmanial Activities of Natural Compounds Isolated From Nigerian Flora. Frontiers in Chemistry 8.
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Ramesh Subramani, Mathivanan Narayanasamy & Klaus-D. Feussner. (2017) Plant-derived antimicrobials to fight against multi-drug-resistant human pathogens. 3 Biotech 7:3.
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Ali Bakiri, Jane Hubert, Romain Reynaud, Sylvie Lanthony, Dominique Harakat, Jean-Hugues Renault & Jean-Marc Nuzillard. (2017) Computer-Aided 13 C NMR Chemical Profiling of Crude Natural Extracts without Fractionation . Journal of Natural Products 80:5, pages 1387-1396.
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Idensi Bajin ba Ndob, Line Edwige Mengome, Henri-Paul Bourobou Bourobou, Yvon Lossangoye Banfora & Francis Bivigou. (2016) Ethnobotanical survey of medicinal plants used as anthelmintic remedies in Gabon. Journal of Ethnopharmacology 191, pages 360-371.
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Viviane M. Linck, Marcelo Ganzella, Ana P. Herrmann, Christopher O. Okunji, Diogo O. Souza, Marta C. Antonelli & Elaine Elisabetsky. (2015) Original mechanisms of antipsychotic action by the indole alkaloid alstonine (Picralima nitida). Phytomedicine 22:1, pages 52-55.
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Udoamaka F. Ezuruike & Jose M. Prieto. (2014) The use of plants in the traditional management of diabetes in Nigeria: Pharmacological and toxicological considerations. Journal of Ethnopharmacology 155:2, pages 857-924.
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John A. Beutler, Gordon M. Cragg, Maurice Iwu, David J. Newman & Christopher Okunji. 2014. Novel Plant Bioresources. Novel Plant Bioresources 131 149 .
Pascal Amoa Onguéné, Fidele Ntie-Kang, Lydia Likowo Lifongo, Jean Claude Ndom, Wolfgang Sippl & Luc Meva’a Mbaze. (2013) The potential of anti-malarial compounds derived from African medicinal plants. Part I: A pharmacological evaluation of alkaloids and terpenoids. Malaria Journal 12:1.
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Ana P. Herrmann, Paula Lunardi, Luísa Klaus Pilz, Ana C. Tramontina, Viviane M. Linck, Christopher O. Okunji, Carlos A. Gonçalves & Elaine Elisabetsky. (2012) Effects of the putative antipsychotic alstonine on glutamate uptake in acute hippocampal slices. Neurochemistry International 61:7, pages 1144-1150.
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V.M. Linck, M.M. Bessa, A.P. Herrmann, M.M. Iwu, C.O. Okunji & E. Elisabetsky. (2012) 5-HT2A/C receptors mediate the antipsychotic-like effects of alstonine. Progress in Neuro-Psychopharmacology and Biological Psychiatry 36:1, pages 29-33.
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Lei Fang, Yuqin Liu, Bin Yang, Xiao Wang & Luqi Huang. (2011) Separation of alkaloids from herbs using high‐speed counter‐current chromatography. Journal of Separation Science 34:19, pages 2545-2558.
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Qing Yu, Shengqiang Tong, Jizhong Yan, Chaoqun Hong, Wenfeng Zhai & Yaqin Li. (2011) Preparative separation of quaternary ammonium alkaloids from Corydalis yanhusuo W. T. Wang by pH-zone-refining counter-current chromatography . Journal of Separation Science 34:3, pages 278-285.
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Viviane M. Linck, Ana P. Herrmann, Ângelo L. Piato, Bernardo C. Detanico, Micheli Figueiró, Jorge Flório, Maurice M. Iwu, Christopher O. Okunji, Mirna B. Leal & Elaine Elisabetsky. (2011) Alstonine as an Antipsychotic: Effects on Brain Amines and Metabolic Changes. Evidence-Based Complementary and Alternative Medicine 2011, pages 1-7.
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J.O. Adebayo & A.U. Krettli. (2011) Potential antimalarials from Nigerian plants: A review. Journal of Ethnopharmacology 133:2, pages 289-302.
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Gerhard Laus & Klaus Wurst. (2008) Crystal Structure of Akuammigine Picrate Hydrate. Helvetica Chimica Acta 91:5, pages 831-837.
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Otto Sticher. (2008) Natural product isolation. Natural Product Reports 25:3, pages 517.
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Alix Toribio, Eldra Delannay, Bernard Richard, Karen Plé, Monique Zèches-Hanrot, Jean-Marc Nuzillard & Jean-Hugues Renault. (2007) Preparative isolation of huperzines A and B from Huperzia serrata by displacement centrifugal partition chromatography. Journal of Chromatography A 1140:1-2, pages 101-106.
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S.I. Inya-Agha .S.C. Ezea .O.A. Odukoya .. (2006) Evaluation of Picralima nitida: Hypoglycemic Activity, Toxicity and Analytical Standards. International Journal of Pharmacology 2:5, pages 576-580.
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. (2005) Current Awareness in Phytochemical Analysis. Phytochemical Analysis 16:6, pages 486-493.
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