SYNTHESIS OF 1-(2-DEOXY-β-D-RIBOFURANOSYL)-2,4-DIFLUORO-5-SUBSTITUTED-BENZENES^*: “THYMINE REPLACEMENT” ANALOGS OF THYMIDINE FOR EVALUATION AS ANTICANCER AND ANTIVIRAL AGENTS

Zhi-Xian Wang Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB, T6G 2N8, Canada

Weili Duan Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB, T6G 2N8, Canada

Leonard I. Wiebe Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB, T6G 2N8, Canada

Jan Balzarini Rega Institute for Medical Research, Minderbroedersstraat 10, Leuven, B-3000, Belgium

Erik De Clercq Rega Institute for Medical Research, Minderbroedersstraat 10, Leuven, B-3000, Belgium

Edward E. Knaus Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB, T6G 2N8, CanadaCorrespondence[email protected]

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Andri P. Schütz, Sho Osawa, Jennifer Mathis, Anna K. H. Hirsch, Bruno Bernet, Boris Illarionov, Markus Fischer, Adelbert Bacher & François Diederich. (2012) Exploring the Ribose Sub-Pocket of the Substrate-Binding Site in Escherichia coli IspE: Structure-Based Design, Synthesis, and Biological Evaluation of Cytosines and Cytosine Analogues. European Journal of Organic Chemistry 2012:17, pages 3278-3287.
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Sarah K. Jarchow-Choy, Elena Sjuvarsson, Herman O. Sintim, Staffan Eriksson & Eric T. Kool. (2009) Nonpolar Nucleoside Mimics as Active Substrates for Human Thymidine Kinases. Journal of the American Chemical Society 131:15, pages 5488-5494.
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Anke Stahlschmidt, Hans-Jürgen Machulla, Gerald Reischl, Edward E. Knaus & Leonard I. Wiebe. (2008) Radioiodination of 1-(2-deoxy-β-d-ribofuranosyl)-2,4-difluoro-5-iodobenzene (dRFIB), a putative thymidine mimic nucleoside for cell proliferation studies. Applied Radiation and Isotopes 66:9, pages 1221-1228.
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Panteha Khalili, Ebrahim Naimi, Wei Yan Sun, Edward E. Knaus & Leonard I. Wiebe. (2003) Dose‐dependent pharmacokinetics of 1‐(2‐Deoxy‐ β ‐ D ‐ ribofuranosyl)‐2,4‐difluoro‐5‐iodobenzene: A potential mimic of 5‐iodo‐2′‐deoxyuridine . Biopharmaceutics & Drug Disposition 24:9, pages 385-395.
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Panteha Khalili, Ebrahim Naimi, Edward E. Knaus & Leonard I. Wiebe. (2002) Pharmacokinetics and metabolism of the novel synthetic C ‐nucleoside, 1‐(2‐deoxy‐ β ‐D‐ribofuranosyl)‐2,4‐difluoro‐ 5‐iodobenzene: a potential mimic of 5‐iodo‐2′‐deoxyuridine . Biopharmaceutics & Drug Disposition 23:3, pages 105-113.
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Zhi‐Xian Wang, Weili Duan, Leonard I. Wiebe, Jan Balzarini, Erik De Clercq & Edward E. Knaus. (2010) ChemInform Abstract: Synthesis of 1‐(2‐Deoxy‐β‐D‐ribofuranosyl)‐2,4‐difluoro‐5‐substituted‐benzenes: “Thymine Replacement” Analogues of Thymidine for Evaluation as Anticancer and Antiviral Agents.. ChemInform 32:31.
Crossref

Ebrahim Naimi, Leonard I. Wiebe, Jan Balzarini, Erik De Clercq & Edward E. Knaus. (2001) Synthesis of 1‐(2‐deoxy‐β‐ D ‐ribofuranosyl)‐2,4‐ difluoro‐5‐(2‐halo‐1‐hydroxyethyl)benzenes and related derivatives: “thymine replacement” analogs of deoxythymidine for evaluation as antiviral and anticancer agents . Drug Development Research 52:3, pages 492-499.
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SYNTHESIS OF 1-(2-DEOXY-β-D-RIBOFURANOSYL)-2,4-DIFLUORO-5-SUBSTITUTED-BENZENES^*: “THYMINE REPLACEMENT” ANALOGS OF THYMIDINE FOR EVALUATION AS ANTICANCER AND ANTIVIRAL AGENTS

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SYNTHESIS OF 1-(2-DEOXY-β-D-RIBOFURANOSYL)-2,4-DIFLUORO-5-SUBSTITUTED-BENZENES*: “THYMINE REPLACEMENT” ANALOGS OF THYMIDINE FOR EVALUATION AS ANTICANCER AND ANTIVIRAL AGENTS

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SYNTHESIS OF 1-(2-DEOXY-β-D-RIBOFURANOSYL)-2,4-DIFLUORO-5-SUBSTITUTED-BENZENES^*: “THYMINE REPLACEMENT” ANALOGS OF THYMIDINE FOR EVALUATION AS ANTICANCER AND ANTIVIRAL AGENTS