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Original Articles

SYNTHESIS AND IN VITRO ANTIBACTERIAL ACTIVITY OF NOVEL 5′-O-ANALOG DERIVATIVES OF ZIDOVUDINE AS POTENTIAL PRODRUGS

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Pages 231-241 | Received 30 May 2001, Accepted 27 Dec 2001, Published online: 17 Aug 2006

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Fabrizio Pertusati, Elisa Pileggi, Jennifer Richards, Mandy Wootton, Thijs Van Leemputte, Leentje Persoons, David De Coster, Xabier Villanueva, Dirk Daelemans, Hans Steenackers, Christopher McGuigan & Michaela Serpi. (2020) Drug repurposing: phosphate prodrugs of anticancer and antiviral FDA-approved nucleosides as novel antimicrobials. Journal of Antimicrobial Chemotherapy 75:10, pages 2864-2878.
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Jessica M. Thomson & Iain L. Lamont. (2019) Nucleoside Analogues as Antibacterial Agents. Frontiers in Microbiology 10.
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Esteban M. Schenfeld, Sergio R. Ribone & Mario A. Quevedo. (2018) Stability and plasmatic protein binding of novel zidovudine prodrugs: Targeting site ii of human serum albumin. European Journal of Pharmaceutical Sciences 115, pages 109-118.
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Michaela Serpi, Valentina Ferrari & Fabrizio Pertusati. (2016) Nucleoside Derived Antibiotics to Fight Microbial Drug Resistance: New Utilities for an Established Class of Drugs?. Journal of Medicinal Chemistry 59:23, pages 10343-10382.
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Kathleen M. Powis, Laura Smeaton, Michael D. Hughes, Esther A. Tumbare, Sajini Souda, Jennifer Jao, Kathleen E. Wirth, Joseph Makhema, Shahin Lockman, Wafaie Fawzi, Max Essex & Roger L. Shapiro. (2016) In-utero triple antiretroviral exposure associated with decreased growth among HIV-exposed uninfected infants in Botswana. AIDS 30:2, pages 211-220.
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Sergio R. Ribone, Esteban M. Schenfeld, Marcela Madrid, Adriana B. Pierini & Mario A. Quevedo. (2016) Evaluation and synthesis of AZT prodrugs with optimized chemical stabilities: experimental and theoretical analyses. New J. Chem. 40:3, pages 2383-2392.
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Soledad Ravetti, Cristian A. De Candia, María S. Gualdesi, Sandra Pampuro, Gabriela Turk, Mario A. Quevedo & Margarita C. Briñón. (2014) Biological evaluation and molecular modelling of didanosine derivatives. Med. Chem. Commun. 5:5, pages 622-631.
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Mónica A. Raviolo, Josep Esteve-Romero & Margarita C. Briñón. (2011) Stability-indicating micellar liquid chromatography method for three novel derivatives of zidovudine in aqueous and simulated gastric and intestinal fluids matrices. Journal of Chromatography A 1218:18, pages 2540-2545.
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Mónica A. Raviolo, Patricia A.M. Williams, Susana B. Etcheverry, Oscar E. Piro, Eduardo E. Castellano, Maria S. Gualdesi & Margarita C. Briñón. (2010) Synthesis, molecular structure and physicochemical properties of bis(3′-azido-3′-deoxythymidin-5′-yl) carbonate. Journal of Molecular Structure 970:1-3, pages 59-65.
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Mario Alfredo Quevedo & Margarita Cristina Briñón. (2009) In vitro and in vivo pharmacokinetic characterization of two novel prodrugs of zidovudine. Antiviral Research 83:2, pages 103-111.
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Mónica A. Raviolo, Julieta M. Sanchez, Margarita C. Briñón & María A. Perillo. (2008) Determination of liposome permeability of ionizable carbamates of zidovudine by steady state fluorescence spectroscopy. Colloids and Surfaces B: Biointerfaces 61:2, pages 188-198.
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Gabriela Turk, Guillermo Moroni, Sandra Pampuro, Margarita C Briñón & Horacio Salomón. (2002) Antiretroviral activity and cytotoxicity of novel zidovudine (AZT) derivatives and the relation to their chemical structure. International Journal of Antimicrobial Agents 20:4, pages 282-288.
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Guillermo N. Moroni, Patricia M. Bogdanov & Margarita C. Brinon. (2010) ChemInform Abstract: Synthesis and in vitro Antibacterial Activity of Novel 5′‐O‐Analogue Derivatives of Zidovudine as Potential Prodrugs.. ChemInform 33:35.
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