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Nucleosides, Nucleotides & Nucleic Acids Volume 23, 2004 - Issue 1-2
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Original Articles

Intercalating Nucleic Acids: The Influence of Linker Length and Intercalator Type on Their Duplex Stabilities

Ulf B. Christensen Nucleic Acid Center, Department of Chemistry, University of Southern Denmark, Campusvej 55, DK‐5230, Odense, Denmark; Unest A/S, Lille Tornbjerg Vej 24 B, DK‐5220, Odense SØ, Denmark
,
Michael Wamberg Nucleic Acid Center, Department of Chemistry, University of Southern Denmark, Campusvej 55, DK‐5230, Odense, DenmarkCorrespondence[email protected]
,
Farag A. G. El‐Essawy Nucleic Acid Center, Department of Chemistry, University of Southern Denmark, Campusvej 55, DK‐5230, Odense, Denmark
,
Abd El‐Hamid Ismail Nucleic Acid Center, Department of Chemistry, University of Southern Denmark, Campusvej 55, DK‐5230, Odense, Denmark
,
Christina B. Nielsen Nucleic Acid Center, Department of Chemistry, University of Southern Denmark, Campusvej 55, DK‐5230, Odense, Denmark
,
Vyacheslav V. Filichev Nucleic Acid Center, Department of Chemistry, University of Southern Denmark, Campusvej 55, DK‐5230, Odense, Denmark
,
Carsten H. Jessen Nucleic Acid Center, Department of Chemistry, University of Southern Denmark, Campusvej 55, DK‐5230, Odense, Denmark
,
Michael Petersen Nucleic Acid Center, Department of Chemistry, University of Southern Denmark, Campusvej 55, DK‐5230, Odense, Denmark
&
Erik B. Pedersen Nucleic Acid Center, Department of Chemistry, University of Southern Denmark, Campusvej 55, DK‐5230, Odense, Denmark
 show all
Pages 207-225 | Received 26 Aug 2003, Accepted 06 Oct 2003, Published online: 01 Jun 2007

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Larysa Dubey, Olga Ryazanova, Victor Zozulya, Dmytro Fedoryak & Igor Dubey. (2011) Postsynthetic Modification of Oligonucleotides with Imidazophenazine Dye and its Effect on Duplex Stability. Nucleosides, Nucleotides & Nucleic Acids 30:7-8, pages 585-596.
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MichaelE. Østergaard, MichaelC. Wamberg & ErikB. Pedersen. (2011) PYRENE INTERCALATING NUCLEIC ACIDS WITH A CARBON LINKER. Nucleosides, Nucleotides & Nucleic Acids 30:3, pages 210-226.
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HatemM. Gaber, SherifM. Sherif & FathiA. Abu-Shanab. (2005) Studies on heterocyclic β-enaminonitriles: Synthesis of new condensed thieno[2,3-b]pyridines containing N-heterocyclic moieties. Journal of Sulfur Chemistry 26:4-5, pages 393-403.
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Farag A. El-Essawy. (2005) Synthesis of Novel Acyclonucleosides Analogs of Pyridothienopyrimidine as Antiviral Agents. Nucleosides, Nucleotides & Nucleic Acids 24:8, pages 1265-1276.
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WagnatW. Wardakhan, HatemM. Gaber, SalamaA. Ouf & SherifM. Sherif. (2005) Studies on 2-Aminothiophenes: Synthesis, Transformations, and Biological Evaluation of Functionally-Substituted Thiophenes and Their Fused Derivatives. Phosphorus, Sulfur, and Silicon and the Related Elements 180:2, pages 601-618.
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Articles from other publishers (23)

Asmaa Abdelrahman, Mette-Marie Wendelboe Nielsen, Mette Halkjær Stage & Eva Christensen Arnspang. (2023) Nuclear envelope morphology change upon repetitive treatment with modified antisense oligonucleotides targeting Hutchinson-Gilford Progeria Syndrome. Biochemistry and Biophysics Reports 33, pages 101411.
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Imrich Géci, Maha I. Fatthalla, Maike Heintz, Per T. Jørgensen & Erik B. Pedersen. (2022) Hoogsteen triplexes stabilized through ethynyl-linked pyrene-indole synthesized by high-temperature Sonogashira coupling. Organic & Biomolecular Chemistry 20:45, pages 8873-8884.
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Rabia Asghar, Madiha Rasheed, Jalees ul Hassan, Mohsin Rafique, Mashooq Khan & Yulin Deng. (2022) Advancements in Testing Strategies for COVID-19. Biosensors 12:6, pages 410.
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Mohsen Mohammadniaei, Ming Zhang, Jon Ashley, Ulf Bech Christensen, Lennart Jan Friis-Hansen, Rasmus Gregersen, Jan Gorm Lisby, Thomas Lars Benfield, Finn Erland Nielsen, Jens Henning Rasmussen, Ellen Bøtker Pedersen, Anne Christine Rye Olinger, Lærke Tørring Kolding, Maryam Naseri, Tao Zheng, Wentao Wang, Jan Gorodkin & Yi Sun. (2021) A non-enzymatic, isothermal strand displacement and amplification assay for rapid detection of SARS-CoV-2 RNA. Nature Communications 12:1.
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Steffen Grann Jensen, Samantha Epistolio, Cesilie Lind Madsen, Majbritt Hauge Kyneb, Alice Riva, Alessia Paganotti, Jessica Barizzi, Rasmus Koefoed Petersen, Michael Børgesen, Francesca Molinari, Renzo Boldorini, Jan Lorenzen, Erik Sørensen, Ulf Bech Christensen, Estrid Høgdall & Milo Frattini. (2021) A new sensitive and fast assay for the detection of EGFR mutations in liquid biopsies. PLOS ONE 16:6, pages e0253687.
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Maha I. Fatthalla & Erik B. Pedersen. (2020) Evaluation of the Base‐Pairing Properties of 5‐(5‐Indolylethynyl) and 5‐(5‐Indolyl)‐2′‐deoxyuridine Modified Triplex and Duplex. ChemistrySelect 5:32, pages 10067-10071.
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Alice Riva, Michael BØrgesen, Mariann Guldmann-Christensen, Majbritt Hauge Kyneb, Kirsten Voogd, Christina Andersen, Samantha Epistolio, Elisabetta Merlo, Tine Yding Wolff, Stephen Hamilton-Dutoit, Jan Lorenzen, Ulf Bech Christensen & Milo Frattini. (2017) SensiScreen® KRAS exon 2-sensitive simplex and multiplex real-time PCR-based assays for detection of KRAS exon 2 mutations. PLOS ONE 12:6, pages e0178027.
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Marta Szumilak, Anna Merecz, Malgorzata Strek, Andrzej Stanczak, Tadeusz Inglot & Boleslaw Karwowski. (2016) DNA Interaction Studies of Selected Polyamine Conjugates. International Journal of Molecular Sciences 17:9, pages 1560.
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Maha I. Fatthalla & Erik B. Pedersen. (2016) Unexpected Hydration of a Triple Bond During DNA Synthesis: Conjugating 3‐(Pyren‐1‐ylethynyl)indole to DNA for Triplex Studies. European Journal of Organic Chemistry 2016:21, pages 3528-3535.
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David A. Rusling & Keith R. Fox. 2012. DNA Conjugates and Sensors. DNA Conjugates and Sensors 75 102 .
Uffe V. Schneider, Imrich Géci, Nina Jøhnk, Nikolaj D. Mikkelsen, Erik B. Pedersen & Gorm Lisby. (2011) Increasing the Analytical Sensitivity by Oligonucleotides Modified with Para- and Ortho-Twisted Intercalating Nucleic Acids – TINA. PLoS ONE 6:6, pages e20565.
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F. A. El-Essawy, M. A. Hawatta, A. E.-S. Abdel-Megied & D. A. El-Sherbeny. (2010) Synthesis of some fused heterocycles based on thieno[2,3-b]pyridine and their antimicrobial activity. Chemistry of Heterocyclic Compounds 46:3, pages 325-333.
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Vyacheslav V. Filichev, Irina V. Astakhova, Andrei D. Malakhov, Vladimir A. Korshun & Erik B. Pedersen. (2008) 1-, 2-, and 4-Ethynylpyrenes in the Structure of Twisted Intercalating Nucleic Acids: Structure, Thermal Stability, and Fluorescence Relationship. Chemistry - A European Journal 14:32, pages 9968-9980.
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Tadhg P. BegleyVyacheslav V. Filichev & Erik B. Pedersen. 2007. Wiley Encyclopedia of Chemical Biology. Wiley Encyclopedia of Chemical Biology 1 32 .
Nicolas Bouquin, Vladimir L. Malinovskii & Robert Häner. (2008) Anthraquinones as Artificial DNA Building Blocks. European Journal of Organic Chemistry 2008:13, pages 2213-2219.
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Michael C. Wamberg, Allam A. Hassan, Andrew D. Bond & Erik B. Pedersen. (2006) Intercalating nucleic acids (INAs) containing insertions of 6H-indolo[2,3-b]quinoxaline. Tetrahedron 62:48, pages 11187-11199.
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Youssef Lotfy Aly, Michael Wamberg & Erik B. Pedersen. (2005) Intercalating Nucleic Acids with Insertion of 5‐[(Pyren‐1‐yl)methylidene]hydantoin‐Substituted Butane‐1,2‐diol. Helvetica Chimica Acta 88:12, pages 3137-3144.
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Ahmed F. Khattab & Farag A. El-Essawy. (2019) Formation of Novel Pyrido[3′,2′:4,5]Thieno [2,3-e][1,2,4]Triazolo[4,3-c] Pyrimidines and their Acyclic C-Nucleosides Analogues: Synthesis of 3-(Alditol-1-yl)Pyridothienotriazolopyrimidines. Journal of Chemical Research 2005:11, pages 736-740.
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Vyacheslav V. Filichev & Erik B. Pedersen. (2005) Stable and Selective Formation of Hoogsteen-Type Triplexes and Duplexes Using Twisted Intercalating Nucleic Acids (TINA) Prepared via Postsynthetic Sonogashira Solid-Phase Coupling Reactions. Journal of the American Chemical Society 127:42, pages 14849-14858.
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Hatem M. Gaber, Galal E. H. Elgemeie, Salama A. Ouf & Sherif M. Sherif. (2005) Heterocyclic synthesis with 4-hydrazinopyridothienopyrimidines: Synthesis of pyridothienotriazolopyrimidines and heterocyclylpyridothienopyrimidines with biological interest. Heteroatom Chemistry 16:4, pages 298-307.
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Damian Ackermann & Robert Häner. (2004) Nonnucleosidic Base Surrogates: The Effect of 1,2-Disubstituted Phenanthrenes on DNA Duplex Stability. Helvetica Chimica Acta 87:11, pages 2790-2804.
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Vyacheslav V Filichev, Khalid M.H Hilmy, Ulf B Christensen & Erik B Pedersen. (2004) Intercalating nucleic acids: The inversion of the stereocenter in 1-O-(pyren-1-ylmethyl)glycerol from R to S. Thermal stability towards ssDNA, ssRNA and its own type of oligodeoxynucleotides. Tetrahedron Letters 45:25, pages 4907-4910.
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Asmaa Abdelrahman, Mette-Marie Wendelboe Nielsen, Mette Halkjær Stage & Eva Christensen Arnspang. (2022) Modified Antisense Oligonucleotides Targeting Hutchinson-Gilford Progeria Syndrome Using an Optimized Delivery Strategy. SSRN Electronic Journal.
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