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Pharmaceutical Development and Technology Volume 5, 2000 - Issue 1
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Research Article

Assessment of the Myotoxicity of Pharmaceutical Buffers Using an In Vitro Muscle Model: Effect of pH, Capacity, Tonicity, and Buffer Type

Jintana Napaporn Department of Pharmaceutics, College of Pharmacy, University of Florida, Box 100494 JHMHC, Gainesville, Florida, 32610, U.S.A.
,
Maike Thomas Department of Pharmaceutics, College of Pharmacy, University of Florida, Box 100494 JHMHC, Gainesville, Florida, 32610, U.S.A.
,
Kari A. Svetic Department of Pharmaceutics, College of Pharmacy, University of Florida, Box 100494 JHMHC, Gainesville, Florida, 32610, U.S.A.
,
Zahra Shahrokh Department of Pharmaceutical R&D, Genentech Inc., 1 DNA Way, South San Francisco, California, 94080, U.S.A.
&
Gayle A. Brazeau Department of Pharmaceutics, College of Pharmacy, University of Florida, Box 100494 JHMHC, Gainesville, Florida, 32610, U.S.A.
Pages 123-130 | Received 01 Mar 1999, Accepted 04 Aug 1999, Published online: 18 Jan 2000

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Gayle Brazeau, Shauna L. Sauberan, Larry Gatlin, Peter Wisniecki & Jaymin Shah. (2011) Effect of particle size of parenteral suspensions on in vitro muscle damage. Pharmaceutical Development and Technology 16:6, pages 591-598.
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Katsutoshi Nakamura, Keiichi Tokihiro, Yukihisa Motomura, Satoshi Nishide & Shigeharu Yokohama. (2003) Potential Use of Cyclodextrins to Enhance the Solubility of YM466 in Aqueous Solution. Drug Development and Industrial Pharmacy 29:8, pages 903-908.
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Articles from other publishers (12)

Adam McCartan, Julia Mackay, David Curran & Randall J Mrsny. (2022) Modelling intramuscular drug fate in vitro with tissue-relevant biomimetic hydrogels. International Journal of Pharmaceutics: X 4, pages 100125.
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Adam J.S. McCartan, David W. Curran & Randall J. Mrsny. (2021) Evaluating parameters affecting drug fate at the intramuscular injection site. Journal of Controlled Release 336, pages 322-335.
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Yajie Zhang, Daniel A. Davis, Khaled AboulFotouh, Jieliang Wang, Donna Williams, Akhilesh Bhambhani, Michael Zakrewsky, Mohammed Maniruzzaman, Zhengrong Cui & Robert O. WilliamsIIIIII. (2021) Novel formulations and drug delivery systems to administer biological solids. Advanced Drug Delivery Reviews 172, pages 183-210.
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Yajie Zhang, Hairui Zhang, Debadyuti Ghosh & Robert O. WilliamsIIIIII. (2020) Just how prevalent are peptide therapeutic products? A critical review. International Journal of Pharmaceutics 587, pages 119491.
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Teddy J. Zbacnik, Ryan E. Holcomb, Derrick S. Katayama, Brian M. Murphy, Robert W. Payne, Richard C. Coccaro, Gabriel J. Evans, James E. Matsuura, Charles S. Henry & Mark Cornell Manning. (2017) Role of Buffers in Protein Formulations. Journal of Pharmaceutical Sciences 106:3, pages 713-733.
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Utpal U. Shah & Matthew Roberts. 2014. Pediatric Formulations. Pediatric Formulations 239 252 .
Gayle Brazeau, Jessica Klapa & Pramod Gupta. 2012. Pharmaceutical Dosage Forms - Parenteral Medications. Pharmaceutical Dosage Forms - Parenteral Medications 135 147 .
Leonid (Leo) Kirkovsky & Anup Zutshi. 2011. ADMET for Medicinal Chemists. ADMET for Medicinal Chemists 201 285 .
ZAHRA SHAHROKH. 2007. Solvent Systems and Their Selection in Pharmaceutics and Biopharmaceutics. Solvent Systems and Their Selection in Pharmaceutics and Biopharmaceutics 341 357 .
Gayle Brazeau. 2005. Injectable Dispersed Systems. Injectable Dispersed Systems 527 542 .
Monique WJ den Brok, Bastiaan Nuijen, Remko Harms, Josie N Buluran, Michael D Harvey, Charles K Grieshaber & Jos H Beijnen. (2016) Compatibility and stability of the novel anti-cancer agent C1311 in infusion devices and its in vitro biocompatibility. Journal of Oncology Pharmacy Practice 11:1, pages 13-19.
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CHRISTOPHER C. McGUIGAN, GILLIAN M. PENRICE, LAURENCE GRUER, SYED AHMED, DAVID GOLDBERG, MARJORIE BLACK, JANE E. SALMON & JOHN HOOD. (2002) Lethal outbreak of infection with Clostridium novyi type A and other spore-forming organisms in Scottish injecting drug users. Journal of Medical Microbiology 51:11, pages 971-977.
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