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Pharmaceutical Development and Technology Volume 5, 2000 - Issue 1
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Research Article

Influence of Drying Temperature and Granulation Liquid Viscosity on the Inter- and Intragranular Drug Migration in Tray-Dried Granules and Compacts

Filip Kiekens Laboratory of Pharmaceutical Technology, University of Gent, Gent, Harelbekestraat 72, B-9000, Belgium
,
Romána Zelkó Pharmaceutical Institute, Semmelweis University of Medicine, H-1092 Budapest, 7 Högyes E. StreetHungary
&
Jean Paul Remon Laboratory of Pharmaceutical Technology, University of Gent, Gent, Harelbekestraat 72, B-9000, Belgium
Pages 131-137 | Received 08 Mar 1999, Accepted 04 Aug 1999, Published online: 18 Jan 2000

Citations (12)

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K. Giry, M. Genty, M. Viana, P. Wuthrich & D. Chulia. (2006) Multiphase versus Single Pot Granulation Process: Influence of Process and Granulation Parameters on Granules Properties. Drug Development and Industrial Pharmacy 32:5, pages 509-530.
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Articles from other publishers (11)

Bingwei Wang, Jianping Liu, Zhenghua Li, Yulong Xia, Shuangshuang Zhang & Ziyi Li. (2021) The Potential Migrated Mechanism of Water-Soluble Components in Pellets Prepared by Wet Extrusion/Spheronization: Effect of Drying Rate. Current Drug Delivery 18:6, pages 712-720.
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Anjali Kataria, Sarang Oka, David Smrčka, Zdenek Grof, František Štěpánek & Rohit Ramachandran. (2018) A quantitative analysis of drug migration during granule drying. Chemical Engineering Research and Design 136, pages 199-206.
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Sarang Oka, David Smrčka, Anjali Kataria, Heather Emady, Fernando Muzzio, František Štěpánek & Rohit Ramachandran. (2017) Analysis of the origins of content non-uniformity in high-shear wet granulation. International Journal of Pharmaceutics 528:1-2, pages 578-585.
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S. Schrank, B. Kann, E. Saurugger, M. Hainschitz, M. Windbergs, B.J. Glasser, J. Khinast & E. Roblegg. (2015) The effect of the drying temperature on the properties of wet-extruded calcium stearate pellets: Pellet microstructure, drug distribution, solid state and drug dissolution. International Journal of Pharmaceutics 478:2, pages 779-787.
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S. Schrank, B. Kann, E. Saurugger, H. Ehmann, O. Werzer, M. Windbergs, B. J. Glasser, A. Zimmer, J. Khinast & E. Roblegg. (2014) Impact of Drying on Solid State Modifications and Drug Distribution in Ibuprofen-Loaded Calcium Stearate Pellets. Molecular Pharmaceutics 11:2, pages 599-609.
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Simone Schrank, Birthe Kann, Maike Windbergs, Benjamin J. Glasser, Andreas Zimmer, Johannes Khinast & Eva Roblegg. (2013) Microstructure of Calcium Stearate Matrix Pellets: A Function of the Drying Process. Journal of Pharmaceutical Sciences 102:11, pages 3987-3997.
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Simone Schrank, Aden Hodzic, Andreas Zimmer, Benjamin J. Glasser, Johannes Khinast & Eva Roblegg. (2012) Ibuprofen-Loaded Calcium Stearate Pellets: Drying-Induced Variations in Dosage Form Properties. AAPS PharmSciTech 13:2, pages 686-698.
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Sami Poutiainen, Marko Honkanen, Johanna Becker, Dominique Nachtweide, Kristiina Järvinen & Jarkko Ketolainen. (2012) X-Ray Microtomography Analysis of Intragranular Drug Migration During Fluidized Bed and Oven Tray Drying. Journal of Pharmaceutical Sciences 101:4, pages 1587-1598.
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L. C. Mendes, R. C. Rodrigues & E. P. Silva. (2010) Thermal, structural and morphological assessment of PVP/HA composites. Journal of Thermal Analysis and Calorimetry 101:3, pages 899-905.
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Makoto YokoyamaMartine Tourigny, Kenji MoroshimaJunsuke SuzukiMiyako SakaiKiyoshi IwamotoHirofumi Takeuchi. (2010) A Novel Rapid Quantitative Analysis of Drug Migration on Tablets Using Laser Induced Breakdown Spectroscopy. Chemical and Pharmaceutical Bulletin 58:11, pages 1521-1524.
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Theodora Kapsidou, I Nikolakakis & S Malamataris. (2001) Agglomeration state and migration of drugs in wet granulations during drying. International Journal of Pharmaceutics 227:1-2, pages 97-112.
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