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Pharmaceutical Development and Technology Volume 4, 1999 - Issue 2
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Research Article

Capsule Filling Machine Simulation. I. Low-Force Powder Compression Physics Relevant to Plug Formation

Pavan K. Heda Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, Maryland, 21201, U.S.A.
,
Francis X. Muller
&
Larry L. Augsburger Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, Maryland, 21201, U.S.A.
Pages 209-219 | Received 23 Feb 1998, Accepted 15 Aug 1998, Published online: 22 Apr 1999

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Read on this site (4)

Eva Faulhammer, Julia Kruisz, Otto Scheibelhofer, Jakob Rehrl, Andreas Witschnigg & Johannes G. Khinast. (2020) Filling of lactose-based formulations in a tamping-pin capsule filler. Drug Development and Industrial Pharmacy 46:5, pages 775-787.
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Vikas Moolchandani, Larry L. Augsburger, Abhay Gupta, Mansoor A. Khan, John Langridge & Stephen W. Hoag. (2016) To investigate the influence of machine operating variables on formulations derived from lactose types in capsule filling: part 2. Drug Development and Industrial Pharmacy 42:4, pages 624-635.
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Vikas Moolchandani, Larry L. Augsburger, Abhay Gupta, Mansoor Khan, John Langridge & Stephen W. Hoag. (2015) Characterization and selection of suitable grades of lactose as functional fillers for capsule filling: part 1. Drug Development and Industrial Pharmacy 41:9, pages 1452-1463.
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Arne Hagsten Sørensen, Jørn Møller Sonnergaard & Lars Hovgaard. (2005) Bulk Characterization of Pharmaceutical Powders by Low-Pressure Compression. Pharmaceutical Development and Technology 10:2, pages 197-209.
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Articles from other publishers (10)

David Barona, Abouzar Shamsaddini, Maximilian Aisenstat, Kyrre Thalberg, David Lechuga-Ballesteros, Behzad Damadzadeh & Reinhard Vehring. (2021) Modulated Uniaxial Compression Analysis of Respirable Pharmaceutical Powders. KONA Powder and Particle Journal 38:0, pages 209-225.
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S.W. Hoag. 2017. Developing Solid Oral Dosage Forms. Developing Solid Oral Dosage Forms 723 747 .
. 2016. Pharmaceutical Dosage Forms - Tablets. Pharmaceutical Dosage Forms - Tablets 659 664 .
Marcos Llusa, Eva Faulhammer, Stefano Biserni, Vittorio Calzolari, Simon Lawrence, Massimo Bresciani & Johannes Khinast. (2014) The effects of powder compressibility, speed of capsule filling and pre-compression on plug densification. International Journal of Pharmaceutics 471:1-2, pages 182-188.
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Ammar Khawam. (2011) Modeling powder encapsulation in dosator-based machines: I. Theory. International Journal of Pharmaceutics 421:2, pages 203-209.
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Ian J Hardy & Walter G Cook. (2003) Predictive and correlative techniques for the design, optimisation and manufacture of solid dosage forms. Journal of Pharmacy and Pharmacology 55:1, pages 3-18.
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Andrey V. Zinchuk, Matthew P. Mullarney & Bruno C. Hancock. (2004) Simulation of roller compaction using a laboratory scale compaction simulator. International Journal of Pharmaceutics 269:2, pages 403-415.
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Mintong Guo, Francis X Muller & Larry L Augsburger. (2002) Evaluation of the plug formation process of silicified microcrystalline cellulose. International Journal of Pharmaceutics 233:1-2, pages 99-109.
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Susan H. Kopleman, Larry L. Augsburger, Agnes NguyenPho, William S. Zito & Fran X. Muller. (2015) Selected physical and chemical properties of commercial Hypericum perforatum extracts relevant for formulated product quality and performance. AAPS PharmSci 3:4, pages 1-18.
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Brian E Jones. (2001) The filling of powders into two-piece hard capsules. International Journal of Pharmaceutics 227:1-2, pages 5-26.
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