408
Views
69
CrossRef citations to date
0
Altmetric
Research Article

Enhanced Drug Dissolution and Bulk Properties of Solid Dispersions Granulated with a Surface Adsorbent

, , &
Pages 563-572 | Received 10 Jan 2001, Accepted 14 Mar 2001, Published online: 04 Apr 2002

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (9)

Ashok Mahajan, Naazneen Surti & Pooja Koladiya. (2018) Solid dispersion adsorbate technique for improved dissolution and flow properties of lurasidone hydrochloride: characterization using 32 factorial design. Drug Development and Industrial Pharmacy 44:3, pages 463-471.
Read now
Pawel Grobelny, Irina Kazakevich, Dan Zhang & Robin Bogner. (2015) Amorphization of itraconazole by inorganic pharmaceutical excipients: comparison of excipients and processing methods. Pharmaceutical Development and Technology 20:1, pages 118-127.
Read now
Kwang-Ho Cha, Kyung-Jin Cho, Min-Soo Kim, Jeong-Soo Kim, Hee Jun Park, Junsung Park, Wonkyung Cho, Jeong-Sook Park & Sung-Joo Hwang. (2012) Enhancement of the dissolution rate and bioavailability of fenofibrate by a melt-adsorption method using supercritical carbon dioxide. International Journal of Nanomedicine 7, pages 5565-5575.
Read now
Zhi Hui Loh, Dawn ZL Er, Lai Wah Chan, Celine V Liew & Paul WS Heng. (2011) Spray granulation for drug formulation. Expert Opinion on Drug Delivery 8:12, pages 1645-1661.
Read now
Myung Joo Kang, Soo Young Jung, Woo Heon Song, Jun Sang Park, Sung-Up Choi, Kyung Taek Oh, Hyung-Kyoon Choi, Young Wook Choi, Jaehwi Lee, Beom-Jin Lee & Sang-Cheol Chi. (2011) Immediate release of ibuprofen from Fujicalin®-based fast-dissolving self-emulsifying tablets. Drug Development and Industrial Pharmacy 37:11, pages 1298-1305.
Read now
Dali Shukla, Subhashis Chakraborty, Sanjay Singh & Brahmeshwar Mishra. (2011) Lipid-based oral multiparticulate formulations – advantages, technological advances and industrial applications. Expert Opinion on Drug Delivery 8:2, pages 207-224.
Read now
Subrata Mallick, Satyanarayan Pattnaik, Kalpana Swain, Pintu K. De, Arindam Saha, Pushpen Mazumdar & Gaurisankar Ghoshal. (2008) Physicochemical Characterization of Interaction of Ibuprofen by Solid-State Milling with Aluminum Hydroxide. Drug Development and Industrial Pharmacy 34:7, pages 726-734.
Read now
Harpreet K. Sandhu, Ashish Chatterji, Navnit H. Shah, A. Waseem Malick, Dipen Desai & Hossein Zia. (2007) Effect of Formulation and Processing Variables on the Granulation Kinetics of Hot Melt Granulation (HMG) Process. Pharmaceutical Development and Technology 12:2, pages 145-151.
Read now
Manish K. Gupta, Robin H. Bogner, David Goldman & Yin-Chao Tseng. (2002) Mechanism for Further Enhancement in Drug Dissolution from Solid-Dispersion Granules upon Storage. Pharmaceutical Development and Technology 7:1, pages 103-112.
Read now

Articles from other publishers (60)

Maryam Farzan, Roger Roth, Joachim Schoelkopf, Jörg Huwyler & Maxim Puchkov. (2023) The processes behind drug loading and release in porous drug delivery systems. European Journal of Pharmaceutics and Biopharmaceutics 189, pages 133-151.
Crossref
Taek-Seon Yun, Minwoo Jung, Ki-Hyun Bang, Hong-Ki Lee, Minki Jin, Hyelim Yoo, Jong-Hee Won, Bomin Song, Yu-Rim Hwang, Jong-Suep Baek & Cheong-Weon Cho. (2023) An economically advantageous amorphous solid dispersion of the fixed combination of lopinavir and ritonavir. Journal of Pharmaceutical Investigation 53:4, pages 549-561.
Crossref
Zhixing Lin, Kai Zheng, Mohammad A. Azad & Rajesh N. Davé. (2023) Preparation of Free-Flowing Spray-Dried Amorphous Composites Using Neusilin®. AAPS PharmSciTech 24:1.
Crossref
Pranav J. Shah, Milan P. Patel, Jigar Shah, Anroop B. Nair, Sabna Kotta & Bhavin Vyas. (2022) Amalgamation of solid dispersion and melt adsorption techniques for augmentation of oral bioavailability of novel anticoagulant rivaroxaban. Drug Delivery and Translational Research 12:12, pages 3029-3046.
Crossref
Qianyu Ye, Meilai Ding, Ping Zhang, Peng Wu, Yong Wang, Cordelia Selomulya & Xiao Dong Chen. (2022) Visual Monitoring of Disintegration of Solid Oral Dosage Forms in Simulated Gastric Fluids Using Low-Field NMR Imaging. AAPS PharmSciTech 23:7.
Crossref
Shaveta Sharma. (2022) The Role of Excipients in Liquisolid Technology. CGC International Journal of Contemporary Technology and Research 4:2, pages 296-299.
Crossref
Muhammad Usman Munir, Mahnoor Ikraam, Muhammad Nadeem, Syed Haroon Khalid, Sajid Asghar, Ikrima Khalid, Muhammad Irfan, Nayyer Islam, Nyla Ajaz & Ikram Ullah Khan. (2022) Fabrication, In Vitro and In Vivo Evaluation of Non-Ordered Mesoporous Silica-Based Ternary Solid Dispersions for Enhanced Solubility of Flurbiprofen. Pharmaceuticals 15:7, pages 856.
Crossref
Mukesh Yadav, Jayant Sarolia, Bhavin Vyas, Manisha Lalan, Shubhada Mangrulkar & Pranav Shah. (2021) Amalgamation of Solid Dispersion and Melt Adsorption Technique: Improved In Vitro and In Vivo Performance of Ticagrelor Tablets. AAPS PharmSciTech 22:8.
Crossref
Sonal V. Bhujbal, Biplob Mitra, Uday Jain, Yuchuan Gong, Anjali Agrawal, Shyam Karki, Lynne S. Taylor, Sumit Kumar & Qi (Tony) Zhou. (2021) Pharmaceutical amorphous solid dispersion: A review of manufacturing strategies. Acta Pharmaceutica Sinica B 11:8, pages 2505-2536.
Crossref
Sandeep Sarabu, Venkata Raman Kallakunta, Arun Butreddy, Karthik Yadav Janga, Srinivas Ajjarapu, Suresh Bandari, Feng Zhang, S. Narasimha Murthy & Michael A. Repka. (2021) A One-Step Twin-Screw Melt Granulation with Gelucire 48/16 and Surface Adsorbent to Improve the Solubility of Poorly Soluble Drugs: Effect of Formulation Variables on Dissolution and Stability. AAPS PharmSciTech 22:3.
Crossref
Matthew Lam, Kofi Asare-Addo & Ali Nokhodchi. (2021) Liqui-Tablet: the Innovative Oral Dosage Form Using the Newly Developed Liqui-Mass Technology. AAPS PharmSciTech 22:3.
Crossref
Pavlína Komínová, Lukáš Kulaviak & Petr Zámostný. (2021) Stress-Dependent Particle Interactions of Magnesium Aluminometasilicates as Their Performance Factor in Powder Flow and Compaction Applications. Materials 14:4, pages 900.
Crossref
Reena Siwach, Parijat Pandey & Harish Dureja. (2020) Formulation and Characterization of Glimepiride Nanoparticles for Dissolution Enhancement. Nanoscience & Nanotechnology-Asia 10:5, pages 649-663.
Crossref
Durgesh K. Jha, Devanshi S. Shah & Purnima D. Amin. (2020) Thermodynamic aspects of the preparation of amorphous solid dispersions of Naringenin with enhanced dissolution rate. International Journal of Pharmaceutics 583, pages 119363.
Crossref
Khaled AboulFotouh, Ayat A. Allam & Mahmoud El-Badry. 2020. Current and Future Aspects of Nanomedicine. Current and Future Aspects of Nanomedicine.
Xin Feng, Ahmed Zidan, Nahid S. Kamal, Xiaoming Xu, Dajun Sun, Ross Walenga, Heather Boyce, Celia N. Cruz & Muhammad Ashraf. (2020) Assessing Drug Release from Manipulated Abuse Deterrent Formulations. AAPS PharmSciTech 21:2.
Crossref
Sabitri Bindhani, S. Mohapatra & R.K. Kar. (2019) Self Emulsifying Drug Delivery System: A Recent Approach. Asian Journal of Chemistry 31:4, pages 751-759.
Crossref
Shigeru Itai. (2019) Development of Novel Functional Formulations Based on Pharmaceutical Technologies製剤技術を基盤とした新規機能性製剤の開発. YAKUGAKU ZASSHI 139:3, pages 419-435.
Crossref
Kapilkumar Vithani, Vincent Jannin, Colin W. Pouton & Ben J. Boyd. (2019) Colloidal aspects of dispersion and digestion of self-dispersing lipid-based formulations for poorly water-soluble drugs. Advanced Drug Delivery Reviews 142, pages 16-34.
Crossref
Paul Joyce, Tahnee J. Dening, Tahlia R. Meola, Hayley B. Schultz, René Holm, Nicky Thomas & Clive A. Prestidge. (2019) Solidification to improve the biopharmaceutical performance of SEDDS: Opportunities and challenges. Advanced Drug Delivery Reviews 142, pages 102-117.
Crossref
Tanja Vojinović, Djordje Medarević, Edina Vranić, Zorica Potpara, Marko Krstić, Jelena Djuriš & Svetlana Ibrić. (2018) Development of ternary solid dispersions with hydrophilic polymer and surface adsorbent for improving dissolution rate of carbamazepine. Saudi Pharmaceutical Journal 26:5, pages 725-732.
Crossref
Cheol-Hee Cho, Jin-Hong Min, Kyu-Mok Hwang & Eun-Seok Park. (2018) Development of sustained-release microparticles containing tamsulosin HCl for orally disintegrating tablet using melt-adsorption method. Drug Delivery and Translational Research 8:3, pages 552-564.
Crossref
Mohammad Azad, Jacqueline Moreno & Rajesh Davé. (2018) Stable and Fast-Dissolving Amorphous Drug Composites Preparation via Impregnation of Neusilin® UFL2. Journal of Pharmaceutical Sciences 107:1, pages 170-182.
Crossref
Yotsanan Weerapol, Sontaya Limmatvapirat, Jurairat Nunthanid, Srisuda Konthong, Supakij Suttiruengwong & Pornsak Sriamornsak. (2017) Development and characterization of nifedipine-amino methacrylate copolymer solid dispersion powders with various adsorbents. Asian Journal of Pharmaceutical Sciences 12:4, pages 335-343.
Crossref
Kapilkumar Vithani, Adrian Hawley, Vincent Jannin, Colin Pouton & Ben J. Boyd. (2017) Inclusion of Digestible Surfactants in Solid SMEDDS Formulation Removes Lag Time and Influences the Formation of Structured Particles During Digestion. The AAPS Journal 19:3, pages 754-764.
Crossref
Qionghua Wei, Cornelia M. Keck & Rainer H. Müller. (2017) Preparation and tableting of long-term stable amorphous rutin using porous silica. European Journal of Pharmaceutics and Biopharmaceutics 113, pages 97-107.
Crossref
Qionghua Wei, Cornelia M. Keck & Rainer H. Müller. (2017) Oral hesperidin—Amorphization and improved dissolution properties by controlled loading onto porous silica. International Journal of Pharmaceutics 518:1-2, pages 253-263.
Crossref
Kai Shiino, Yukari Fujinami, Shin-ichiro Kimura, Yasunori Iwao, Shuji Noguchi & Shigeru Itai. (2017) Melt Adsorption as a Manufacturing Method for Fine Particles of Wax Matrices without Any Agglomerates. CHEMICAL & PHARMACEUTICAL BULLETIN Chemical and Pharmaceutical Bulletin 65:8, pages 726-731.
Crossref
Li Liu, Jia Li, Mei-hui Zhao, Hui Xu, Lin-sen Li & Shao-ning Wang. (2016) Loading of tacrolimus containing lipid based drug delivery systems into mesoporous silica for extended release. Asian Journal of Pharmaceutical Sciences 11:6, pages 751-759.
Crossref
Roberta Censi, Maria Rosa Gigliobianco, Alessandra Dubbini, Ladjan Malaj & Piera Di Martino. (2015) New Nanometric Solid Dispersions of Glibenclamide in Neusilin® UFL2. AAPS PharmSciTech 17:5, pages 1204-1212.
Crossref
M. El Hadri, A. Achahbar, J. El Khamkhami, B. Khelifa, V. Faivre, O. Abbas & S. Bresson. (2016) Lyotropic behavior of Gelucire 50/13 by XRD, Raman and IR spectroscopies according to hydration. Chemistry and Physics of Lipids 200, pages 11-23.
Crossref
Teófilo Vasconcelos, Sara Marques, José das Neves & Bruno Sarmento. (2016) Amorphous solid dispersions: Rational selection of a manufacturing process. Advanced Drug Delivery Reviews 100, pages 85-101.
Crossref
Riccardo Rascioni, Roberta Censi, Ledjan Malaj & Piera Di Martino. (2015) Effect of particle size reduction and crystalline form on dissolution behaviour of nimesulide. Journal of Thermal Analysis and Calorimetry 123:3, pages 2213-2223.
Crossref
Dae Ro Lee, Young Han Kim, Keun Won Park, Myoung Jin Ho, Hyuck Jun Jung, Ha Ra Cho, Jun Seo Park, Yong Seok Choi, Dong Woo Yeom, Young Wook Choi & Myung Joo Kang. (2015) Fujicalin®-based solid supersaturable self-emulsifying drug delivery system (S-SEDDS) of tacrolimus for enhanced dissolution rate and oral absorption. Journal of Pharmaceutical Investigation 45:7, pages 651-658.
Crossref
B. Démuth, Z.K. Nagy, A. Balogh, T. Vigh, G. Marosi, G. Verreck, I. Van Assche & M.E. Brewster. (2015) Downstream processing of polymer-based amorphous solid dispersions to generate tablet formulations. International Journal of Pharmaceutics 486:1-2, pages 268-286.
Crossref
Ankita Shah & Abu T.M. Serajuddin. (2015) Conversion of solid dispersion prepared by acid–base interaction into free-flowing and tabletable powder by using Neusilin® US2. International Journal of Pharmaceutics 484:1-2, pages 172-180.
Crossref
Roshan Pradhan, Tuan Hiep Tran, Ju Yeon Choi, Im Soon Choi, Han-Gon Choi, Chul Soon Yong & Jong Oh Kim. (2014) Development of a rebamipide solid dispersion system with improved dissolution and oral bioavailability. Archives of Pharmacal Research 38:4, pages 522-533.
Crossref
Radhika Pandya, Tejal Mehta & Mukesh Gohel. (2014) Amalgamation of solid dispersion and adsorption technique. Journal of Thermal Analysis and Calorimetry 120:1, pages 699-709.
Crossref
Thanh-Huyen Tran, Chulhun Park, Taehee Kang, Young-Joon Park, Euichaul Oh & Beom-Jin Lee. (2015) Micromeritic properties and instrumental analysis of physical mixtures and solid dispersions with adsorbent containing losartan: Comparison of dissolution-differentiating factors. Powder Technology 272, pages 269-275.
Crossref
M. El Hadri, A. Achahbar, J. El Khamkhami, B. Khelifa, C. Tran Le Tuyet, V. Faivre, O. Abbas, M. El Marssi, F. Bougrioua & S. Bresson. (2015) Vibrational behavior of Gelucire 50/13 by Raman and IR spectroscopies: A focus on the 1800–1000cm−1 spectral range according to temperature and degree of hydration. Journal of Molecular Structure 1083, pages 441-449.
Crossref
Hesham M. Tawfeek, Imran Y. Saleem & Matthew Roberts. (2014) Dissolution Enhancement and Formulation of Rapid-Release Lornoxicam Mini-Tablets. Journal of Pharmaceutical Sciences 103:8, pages 2470-2483.
Crossref
Tarique Meer, Ritesh Fule, Deepak Khanna & Purnima Amin. (2013) Solubility modulation of bicalutamide using porous silica. Journal of Pharmaceutical Investigation 43:4, pages 279-285.
Crossref
Vaibhav I. Patel & Rutesh H. Dave. (2013) Evaluation of Colloidal Solid Dispersions: Physiochemical Considerations and In Vitro Release Profile. AAPS PharmSciTech 14:2, pages 620-628.
Crossref
Hywel D. Williams, Natalie L. Trevaskis, Susan A. Charman, Ravi M. Shanker, William N. Charman, Colin W. Pouton & Christopher J. H. Porter. (2013) Strategies to Address Low Drug Solubility in Discovery and Development. Pharmacological Reviews 65:1, pages 315-499.
Crossref
Tin Wui Wong & Nafisah Musa. (2012) Centrifugal air-assisted melt agglomeration for fast-release “granulet” design. International Journal of Pharmaceutics 430:1-2, pages 184-196.
Crossref
Huyen Thi Thanh Tran, Jun Bom Park, Ki-Hyuk Hong, Han-Gon Choi, Hyo-Kyung Han, Jaehwi Lee, Kyung Taek Oh & Beom-Jin Lee. (2011) Preparation and characterization of pH-independent sustained release tablet containing solid dispersion granules of a poorly water-soluble drug. International Journal of Pharmaceutics 415:1-2, pages 83-88.
Crossref
Ken K. Qian & Robin H. Bogner. (2011) Spontaneous Crystalline-to-Amorphous Phase Transformation of Organic or Medicinal Compounds in the Presence of Porous Media, Part 1: Thermodynamics of Spontaneous Amorphization. Journal of Pharmaceutical Sciences 100:7, pages 2801-2815.
Crossref
Subrata Mallick, Saroj Kumar Pradhan, Muronia Chandran, Manoj Acharya, Tanmayee Digdarsini & Rajaram Mohapatra. (2011) Study of particle rearrangement, compression behavior and dissolution properties after melt dispersion of ibuprofen, Avicel and Aerosil. Results in Pharma Sciences 1:1, pages 1-10.
Crossref
Subhashis Chakraborty, Dali Shukla, Parameswara Rao Vuddanda, Brahmeshwar Mishra & Sanjay Singh. (2010) Utilization of adsorption technique in the development of oral delivery system of lipid based nanoparticles. Colloids and Surfaces B: Biointerfaces 81:2, pages 563-569.
Crossref
L. HU, C. LIU, C. SHANG, X. YANG & J. YANG. (2010) Pharmacokinetics and improved bioavailability of toltrazuril after oral administration to rabbits. Journal of Veterinary Pharmacology and Therapeutics 33:5, pages 503-506.
Crossref
Bernard Van Eerdenbrugh, Michiel Van Speybroeck, Raf Mols, Kristof Houthoofd, Johan A. Martens, Ludo Froyen, Jan Van Humbeeck, Patrick Augustijns & Guy Van den Mooter. (2009) Itraconazole/TPGS/Aerosil®200 solid dispersions. European Journal of Pharmaceutical Sciences 38:3, pages 270-278.
Crossref
Subhashis Chakraborty, Dali Shukla, Brahmeshwar Mishra & Sanjay Singh. (2009) Lipid – An emerging platform for oral delivery of drugs with poor bioavailability. European Journal of Pharmaceutics and Biopharmaceutics 73:1, pages 1-15.
Crossref
Ambarish H. Vadher, Jolly R. Parikh, Rajesh H. Parikh & Ajay B. Solanki. (2009) Preparation and Characterization of Co-Grinded Mixtures of Aceclofenac and Neusilin US2 for Dissolution Enhancement of Aceclofenac. AAPS PharmSciTech 10:2, pages 606-614.
Crossref
Bo Tang, Gang Cheng, Jian-Chun Gu & Cai-Hong Xu. (2008) Development of solid self-emulsifying drug delivery systems: preparation techniques and dosage forms. Drug Discovery Today 13:13-14, pages 606-612.
Crossref
V. Jannin, J. Musakhanian & D. Marchaud. (2008) Approaches for the development of solid and semi-solid lipid-based formulations. Advanced Drug Delivery Reviews 60:6, pages 734-746.
Crossref
Subrata Mallick, Satyanarayan Pattnaik, Kalpana Swain, Pintu K. De, Arindam Saha, Gaurisankar Ghoshal & Arijit Mondal. (2008) Formation of physically stable amorphous phase of ibuprofen by solid state milling with kaolin. European Journal of Pharmaceutics and Biopharmaceutics 68:2, pages 346-351.
Crossref
Xiaohong Pan, Thomas Julian & Larry Augsburger. (2017) Quantitative measurement of indomethacin crystallinity in indomethacin-silica gel binary system using differential scanning calorimetry and X-ray powder diffractometry. AAPS PharmSciTech 7:1, pages E72-E78.
Crossref
Yukako Ito, Tomohiro Kusawake, Makoto Ishida, Riichi Tawa, Nobuhito Shibata & Kanji Takada. (2005) Oral solid gentamicin preparation using emulsifier and adsorbent. Journal of Controlled Release 105:1-2, pages 23-31.
Crossref
A Svensson, C Neves & B Cabane. (2004) Hydration of an amphiphilic excipient, Gelucire® 44/14. International Journal of Pharmaceutics 281:1-2, pages 107-118.
Crossref
Manish K. Gupta, Adam Vanwert & Robin H. Bogner. (2003) Formation of Physically Stable Amorphous Drugs by Milling with Neusilin. Journal of Pharmaceutical Sciences 92:3, pages 536-551.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.