1,070
Views
45
CrossRef citations to date
0
Altmetric
Research Article

Amlodipine Besylate–Excipients Interaction in Solid Dosage Form

, , &
Pages 15-24 | Received 17 Jul 2002, Accepted 12 Apr 2003, Published online: 02 Apr 2004

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (6)

Daniel Zakowiecki, Tobias Hess, Krzysztof Cal, Barbara Mikolaszek, Grzegorz Garbacz & Dorota Haznar-Garbacz. (2022) Directly compressible formulation of immediate release rosuvastatin calcium tablets stabilized with tribasic calcium phosphate. Pharmaceutical Development and Technology 27:4, pages 425-434.
Read now
Ummarah Kanwal, Shahid Mukhtar, Muzzamil Waheed, Arifa Mehreen, Nasir Abbas, Rahat Shamim, Khalid Hussain, Fatima Rasool, Amjad Hussain & Nadeem Irfan Bukhari. (2021) Fixed Dose Single Tablet Formulation with Differential Release of Amlodipine Besylate and Simvastatin and Its Pharmacokinetic Profile: QbD and Risk Assessment Approach. Drug Design, Development and Therapy 15, pages 2193-2210.
Read now
Š. Hadžidedić, A. Uzunović, S. Šehić Jazić & S. Kocova El-Arini. (2014) The impact of chirality on the development of robust and stable tablet formulation of (S-) amlodipine besylate. Pharmaceutical Development and Technology 19:8, pages 930-941.
Read now
Dipak D. Patil & Chandragouda R. Patil. (2013) Modification of pharmacological activity of nebivolol due to Maillard reaction. Pharmaceutical Development and Technology 18:4, pages 844-851.
Read now
Naseem Ahmad Charoo & Areeg Anwer Ali. (2013) Quality risk management in pharmaceutical development. Drug Development and Industrial Pharmacy 39:7, pages 947-960.
Read now
MohamedM. Hefnawy, Maha Sultan & Haya Al-Johar. (2009) Development of Capillary Electrophoresis Technique for Simultaneous Measurement of Amlodipine and Atorvastatin from Their Combination Drug Formulations. Journal of Liquid Chromatography & Related Technologies 32:20, pages 2923-2942.
Read now

Articles from other publishers (39)

Paweł Gumułka, Monika Dąbrowska & Małgorzata Starek. (2023) Stability Study of Selected Coxibs Used in the Treatment of Rheumatoid Diseases in Various Drug Combinations. Processes 11:9, pages 2605.
Crossref
Paula Soria-Chacartegui, Pablo Zubiaur, Dolores Ochoa, Gonzalo Villapalos-García, Manuel Román, Miriam Matas, Laura Figueiredo-Tor, Gina Mejía-Abril, Sofía Calleja, Alejandro de Miguel, Marcos Navares-Gómez, Samuel Martín-Vilchez & Francisco Abad-Santos. (2023) Genetic Variation in CYP2D6 and SLC22A1 Affects Amlodipine Pharmacokinetics and Safety. Pharmaceutics 15:2, pages 404.
Crossref
Xiaohong Lai, Xiang Chen, Min Li, Yan Zhou & Bing Xia. (2022) Purification and mass spectrometry study of Maillard reaction impurities in five acyclic nucleoside antiviral drugs. Journal of Pharmaceutical and Biomedical Analysis 212, pages 114637.
Crossref
Zhiyue Zhao, Yinghong Li, Jilei Wu, Zhenyu Shi, Peiqing Zhao, Hui Su, Qinghai Wang & Lili Jin. (2022) Nanofiber orodispersible films based on carboxymethyl curdlan and PEO: New delivery system for amlodipine besylate. Colloids and Surfaces A: Physicochemical and Engineering Aspects 635, pages 128096.
Crossref
Craig F. Steven, Elisabetta Chiarparin, Alison N. Hulme & Valerie G. Brunton. 2022. Stimulated Raman Scattering Microscopy. Stimulated Raman Scattering Microscopy 403 419 .
Jia Xiang, Fenglin Liu, Bo Wang, Lin Chen, Wenjie Liu & Songwen Tan. (2021) A Literature Review on Maillard Reaction Based on Milk Proteins and Carbohydrates in Food and Pharmaceutical Products: Advantages, Disadvantages, and Avoidance Strategies. Foods 10:9, pages 1998.
Crossref
Trusha J. Purohit, Sachin S. Thakur, Jonathan Carruth, Farhan Dean, Darin Kim, Seunghyun Lee, Colin Liu, Manisha Sharma & Sara M. Hanning. (2021) Formulation and stability evaluation of an extemporaneously prepared baclofen suspension (1 mg/mL). Journal of Pharmacy Practice and Research 51:4, pages 314-320.
Crossref
Thamer Alzoubi, Gary P. Martin, David J. Barlow & Paul G. Royall. (2021) Stability of α-lactose monohydrate: The discovery of dehydration triggered solid-state epimerization. International Journal of Pharmaceutics 604, pages 120715.
Crossref
Shaolan Wang, Jinsheng Lin, Dan Li, Tianpei Huang, Wenquan Zhu, Wenbin Chen, Min Li & Weiyang Shen. (2021) Study of the isomeric Maillard degradants, glycosylamine and Amadori rearrangement products, and their differentiation via MS 2 fingerprinting from collision‐induced decomposition of protonated ions . Rapid Communications in Mass Spectrometry 35:9.
Crossref
Philippe-Henri Secretan, Marie Antignac, Najet Yagoubi, Mélisande Bernard, Marie Cécile Perier, Jean Laurent Takombe, Dadhi Balde, Roland N'Guetta, Méo Stéphane Ikama, Patrice Zabsonre, Abdallahi Sidi Aly, Xavier Jouven & Bernard Do. (2020) Post hoc study to investigate the potential causes of poor quality of cardiovascular medicines collected in sub-Saharan countries. BMJ Open 10:11, pages e039252.
Crossref
Petr Gibala, Michal Douša, Aneta Kalužíková, Marcela Tkadlecová, Martin Štefko, Stanislav Kalášek & Jiří Břicháč. (2019) Identification and structure elucidation of a new degradation impurity in the multi-component tablets of amlodipine besylate. Journal of Pharmaceutical and Biomedical Analysis 162, pages 112-116.
Crossref
Mohammad Reaz Siahi, Soma Rahimi & Farnaz Monajjemzadeh. (2018) Analytical Investigation of the Possible Chemical Interaction of Methyldopa with Some Reducing Carbohydrates Used as Pharmaceutical Excipients. Advanced Pharmaceutical Bulletin 8:4, pages 657-666.
Crossref
Isabel Lozoya-Agullo, Isabel González-Álvarez, Matilde Merino-Sanjuán, Marival Bermejo & Marta González-Álvarez. (2018) Preclinical models for colonic absorption, application to controlled release formulation development. European Journal of Pharmaceutics and Biopharmaceutics 130, pages 247-259.
Crossref
Dipak K. Chowdhury, Haripada Sarker & Paul Schwartz. (2017) Regulatory Notes on Impact of Excipients on Drug Products and the Maillard Reaction. AAPS PharmSciTech 19:2, pages 965-969.
Crossref
J. Madeira do O, F. Mastrotto, N. Francini, S. Allen, C. F. van der Walle, S. Stolnik & G. Mantovani. (2018) Synthetic glycopolymers as modulators of protein aggregation: influences of chemical composition, topology and concentration. Journal of Materials Chemistry B 6:7, pages 1044-1054.
Crossref
Tarun Handa, Shalu Jhajra, Shweta Bhagat, P.V. Bharatam, Asit K. Chakraborti & Saranjit Singh. (2017) Molecular insight into atypical instability behavior of fixed-dose combination containing amlodipine besylate and losartan potassium. Journal of Pharmaceutical and Biomedical Analysis 136, pages 66-80.
Crossref
A. S Dukhanin. (2016) Actual questions of clinical pharmacology by amlodipine: should we prefer the original or a generic drug?. CardioSomatics 7:3-4, pages 104-109.
Crossref
Mohammad Reza Siahi Shadbad, Faranak Ghaderi, Leila Hatami & Farnaz Monajjemzadeh. (2016) Investigation of Possible Maillard Reaction Between Acyclovir and Dextrose upon Dilution Prior to Parenteral Administration. AAPS PharmSciTech 17:6, pages 1491-1499.
Crossref
Hamzah M. Maswadeh. (2015) Incompatibility study of ibuprofen in ternary interactive mixture by using differential scanning calorimetry. Journal of Thermal Analysis and Calorimetry 123:3, pages 1963-1971.
Crossref
Kishore Kumar Hotha, Swapan Roychowdhury & Veerappan Subramanian. (2016) Drug-Excipient Interactions: Case Studies and Overview of Drug Degradation Pathways. American Journal of Analytical Chemistry 07:01, pages 107-140.
Crossref
Ajit S. Narang, Divyakant Desai & Sherif Badawy. 2015. Excipient Applications in Formulation Design and Drug Delivery. Excipient Applications in Formulation Design and Drug Delivery 93 137 .
Erik Sjögren, Bertil Abrahamsson, Patrick Augustijns, Dieter Becker, Michael B. Bolger, Marcus Brewster, Joachim Brouwers, Talia Flanagan, Matthew Harwood, Christian Heinen, René Holm, Hans-Paul Juretschke, Marlies Kubbinga, Anders Lindahl, Viera Lukacova, Uwe Münster, Sibylle Neuhoff, Mai Anh Nguyen, Achiel van Peer, Christos Reppas, Amin Rostami Hodjegan, Christer Tannergren, Werner Weitschies, Clive Wilson, Patricia Zane, Hans Lennernäs & Peter Langguth. (2014) In vivo methods for drug absorption – Comparative physiologies, model selection, correlations with in vitro methods (IVIVC), and applications for formulation/API/excipient characterization including food effects. European Journal of Pharmaceutical Sciences 57, pages 99-151.
Crossref
Barbara Rojek, Marek Wesolowski & Bogdan Suchacz. (2013) Detection of compatibility between baclofen and excipients with aid of infrared spectroscopy and chemometry. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 116, pages 532-538.
Crossref
Z.Z. Stoiljković, V.M. Jovanović, D.Ž. Mijin, V. Nikolić, L. Nikolić, S.D. Petrović & M.L. Avramov Ivić. (2013) The Electrochemical Investigation of Inclusion Complexes of Nifedipine and Amlodipine with β-Cyclodextrin and (2-Hydroxypropyl)-β-Cyclodextrin. International Journal of Electrochemical Science 8:7, pages 9543-9557.
Crossref
Xin Yu, Alexei V. Buevich, Min Li, Xin Wang & Abu M. Rustum. (2013) A Compatibility Study of a Secondary Amine Active Pharmaceutical Ingredient with Starch: Identification of a Novel Degradant Formed Between Desloratadine and a Starch Impurity Using LC–MSn and NMR Spectroscopy. Journal of Pharmaceutical Sciences 102:2, pages 717-731.
Crossref
Ajit S. Narang, Divyakant Desai & Sherif Badawy. (2012) Impact of Excipient Interactions on Solid Dosage Form Stability. Pharmaceutical Research 29:10, pages 2660-2683.
Crossref
Min Li. 2012. Organic Chemistry of Drug Degradation. Organic Chemistry of Drug Degradation 150 164 .
Gennady Ananchenko, Jasmina Novakovic & Johnathan Lewis. 2012. 31 77 .
Nidal Daraghmeh, Iyad Rashid, Mahmoud M. H. Al Omari, Stephen A. Leharne, Babur Z. Chowdhry & Adnan Badwan. (2010) Preparation and Characterization of a Novel Co-processed Excipient of Chitin and Crystalline Mannitol. AAPS PharmSciTech 11:4, pages 1558-1571.
Crossref
Farnaz Monajjemzadeh, Davoud Hassanzadeh, Hadi Valizadeh, Mohammad R. Siahi-Shadbad, Javid Shahbazi Mojarrad, Thomas A. Robertson & Michael S. Roberts. (2009) Compatibility studies of acyclovir and lactose in physical mixtures and commercial tablets. European Journal of Pharmaceutics and Biopharmaceutics 73:3, pages 404-413.
Crossref
A. L. Huidobro & C. Barbas. (2008) Analytical study proving alprazolam degradation to its main impurity triazolaminoquinoleine through Maillard reaction. Analytical and Bioanalytical Chemistry 394:5, pages 1349-1359.
Crossref
Farnaz Monajjemzadeh, Davoud Hassanzadeh, Hadi Valizadeh, Mohammad R. Siahi-Shadbad, Javid Shahbazi Mojarrad, Thomas Robertson & Michael S. Roberts. (2009) Assessment of Feasibility of Maillard Reaction between Baclofen and Lactose by Liquid Chromatography and Tandem Mass Spectrometry, Application to Pre Formulation Studies. AAPS PharmSciTech 10:2, pages 649-659.
Crossref
Sanjeeva Yarkala, Sivakumar Amaravadi, Vinay U. Rao, Vijaykumar V, Sameer G. Navalgund & Balasubramaniam Jagdish. (2009) Role of Excipients on N-Oxide Raloxifene Generation from Raloxifene-Excipients Binary Mixtures. Chemical and Pharmaceutical Bulletin 57:10, pages 1174-1177.
Crossref
Ali Reza Fakhari, Saeed Nojavan, Soheila Haghgoo & Ali Mohammadi. (2008) Development of a stability-indicating CE assay for the determination of amlodipine enantiomers in commercial tablets. ELECTROPHORESIS 29:22, pages 4583-4592.
Crossref
Tomonori Murakami, Naoto Fukutsu, Junichi Kondo, Takao Kawasaki & Fumiyo Kusu. (2008) Application of liquid chromatography-two-dimensional nuclear magnetic resonance spectroscopy using pre-concentration column trapping and liquid chromatography–mass spectrometry for the identification of degradation products in stressed commercial amlodipine maleate tablets. Journal of Chromatography A 1181:1-2, pages 67-76.
Crossref
Sajjan Aryal & Nataša Škalko-Basnet. (2008) Stability of amlodipine besylate and atenolol in multi-component tablets of mono-layer and bi-layer types. Acta Pharmaceutica 58:3.
Crossref
David P. Elder. 2007. Analysis of Drug Impurities. Analysis of Drug Impurities 21 46 .
Zhigang Hao, Chih-Ying (Joey) Lu, Baiming Xiao, Naidong Weng, Barry Parker, Michael Knapp & Chi-Tang Ho. (2007) Separation of amino acids, peptides and corresponding Amadori compounds on a silica column at elevated temperature. Journal of Chromatography A 1147:2, pages 165-171.
Crossref
A. Mohammadi, N. Rezanour, M. Ansari Dogaheh, F. Ghorbani Bidkorbeh, M. Hashem & R.B. Walker. (2007) A stability-indicating high performance liquid chromatographic (HPLC) assay for the simultaneous determination of atorvastatin and amlodipine in commercial tablets. Journal of Chromatography B 846:1-2, pages 215-221.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.