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Research Article

A Study of the Impact of Freezing on the Lyophilization of a Concentrated Formulation with a High Fill Depth

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Pages 261-272 | Received 12 Apr 2004, Accepted 27 Sep 2004, Published online: 07 Oct 2008

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Read on this site (14)

Kyuya Nakagawa, Daiki Morishita, Tetsuo Suzuki & Noriaki Sano. (2023) Experimental and computational evaluation of the degree of micro-collapse formations in freeze-dried cakes. Drying Technology 41:3, pages 406-418.
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Alex Juckers, Petra Knerr, Frank Harms & Jochen Strube. (2023) Effect of the Freezing Step on Primary Drying Experiments and Simulation of Lyophilization Processes. Processes 11:5, pages 1404.
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Xiaofeng Lu, Shreya S. Kulkarni, Hanmin Dong, Yongan Tang, Li Yi & Supriya Gupta. (2023) Freezing process influences cake appearance of a lyophilized amorphous protein formulation with low solid content and high fill configuration. International Journal of Pharmaceutics 636, pages 122803.
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Yue Sang, Jian Wang, Yongxiang Zhang, Haina Gao, Shaoyang Ge, Haihong Feng, Yan Zhang, Fazheng Ren, Pengcheng Wen & Ran Wang. (2023) Influence of Temperature during Freeze-Drying Process on the Viability of Bifidobacterium longum BB68S. Microorganisms 11:1, pages 181.
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Seema Thakral, Jayesh Sonje, Bhushan Munjal, Bakul Bhatnagar & Raj Suryanarayanan. (2023) Mannitol as an Excipient for Lyophilized Injectable Formulations. Journal of Pharmaceutical Sciences 112:1, pages 19-35.
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Andrea Arsiccio & Roberto Pisano. (2020) The Ice-Water Interface and Protein Stability: A Review. Journal of Pharmaceutical Sciences 109:7, pages 2116-2130.
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Hungyen Lee, Dahai Jiang & William M. Pardridge. (2020) Lyoprotectant Optimization for the Freeze-Drying of Receptor-Targeted Trojan Horse Liposomes for Plasmid DNA Delivery. Molecular Pharmaceutics 17:6, pages 2165-2174.
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Hidenori Kawasaki, Toshinori Shimanouchi, Hiroyuki Sawada, Hiroshi Hosomi, Yuta Hamabe & Yukitaka Kimura. (2019) Temperature Measurement by Sublimation Rate as a Process Analytical Technology Tool in Lyophilization. Journal of Pharmaceutical Sciences 108:7, pages 2305-2314.
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Getachew Assegehegn, Edmundo Brito-de la Fuente, José M. Franco & Críspulo Gallegos. (2019) The Importance of Understanding the Freezing Step and Its Impact on Freeze-Drying Process Performance. Journal of Pharmaceutical Sciences 108:4, pages 1378-1395.
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Reza Esfandiary, Shravan K. Gattu, John M. Stewart & Sajal M. Patel. (2016) Effect of Freezing on Lyophilization Process Performance and Drug Product Cake Appearance. Journal of Pharmaceutical Sciences 105:4, pages 1427-1433.
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Yen-Hsiang Tseng, Chin-Chi Cheng, Hong-Ping Cheng & Dasheng Lee. (2015) Novel Real-Time Diagnosis of the Freezing Process Using an Ultrasonic Transducer. Sensors 15:5, pages 10332-10349.
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Geoff Smith, Muhammad Sohail Arshad, Eugene Polygalov & Irina Ermolina. (2013) Factors Affecting the Use of Impedance Spectroscopy in the Characterisation of the Freezing Stage of the Lyophilisation Process: the Impact of Liquid Fill Height in Relation to Electrode Geometry. AAPS PharmSciTech 15:2, pages 261-269.
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