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Journal of Receptors and Signal Transduction Volume 22, 2002 - Issue 1-4
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Research Article

TETRAETHYLAMMONIUM BINDING TO THE OUTER MOUTH OF THE KcsA POTASSIUM CHANNEL: IMPLICATIONS FOR ION PERMEATION

Leonardo Guidoni INFM-Democritos Center for Molecular Simulations, International School for Advanced Studies (SISSA), Via Beirut 4, Trieste, I-34014, Italy; Institute of Inorganic Chemistry, ETH-Zentrum, Universitätsstrasse 6, Zürich, CH-8092, Switzerland
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Paolo Carloni INFM-Democritos Center for Molecular Simulations, International School for Advanced Studies (SISSA), Via Beirut 4, Trieste, I-34014, Italy; School of Basic Sciences, Institutes of Molecular and Biological Chemistry, Swiss Federal Institute of Technology of Lausanne (EPFL), Lausanne, CH-1015, Switzerland
Pages 315-331 | Published online: 11 Nov 2002

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Guillaume Lamoureux & EsamA. Orabi. (2012) Molecular modelling of cation–π interactions. Molecular Simulation 38:8-9, pages 704-722.
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Articles from other publishers (16)

Lin Huang, Qing-Yu Huang & He-Qing Huang. (2014) The Evidence of HeLa Cell Apoptosis Induced with Tetraethylammonium Using Proteomics and Various Analytical Methods. Journal of Biological Chemistry 289:4, pages 2217-2229.
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Jiahua Li, Min Zhuo, Lei Pei & Alan S.L. Yu. (2013) Conserved Aromatic Residue Confers Cation Selectivity in Claudin-2 and Claudin-10b. Journal of Biological Chemistry 288:31, pages 22790-22797.
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Dan Gordon, Rong Chen & Shin-Ho Chung. (2013) Computational Methods of Studying the Binding of Toxins From Venomous Animals to Biological Ion Channels: Theory and Applications. Physiological Reviews 93:2, pages 767-802.
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Sébastien Dilly, Fabian Philippart, Cédric Lamy, Sylvie Poncin, Dirk Snyders, Vincent Seutin & Jean-François Liégeois. (2013) The interactions of apamin and tetraethylammonium are differentially affected by single mutations in the pore mouth of small conductance calcium-activated potassium (SK) channels. Biochemical Pharmacology 85:4, pages 560-569.
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Ping Li, Hai-feng Sun, Ping-zheng Zhou, Chao-ying Ma, Guo-yuan Hu, Hua-liang Jiang, Min Li, Hong Liu & Zhao-bing Gao. (2012) Comparison of the effects of DC031050, a class III antiarrhythmic agent, on hERG channel and three neuronal potassium channels. Acta Pharmacologica Sinica 33:6, pages 728-736.
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Qiulin Tan, Brandon Ritzo, Kai Tian & Li-Qun Gu. (2012) Tuning the tetraethylammonium sensitivity of potassium channel Kcv by subunit combination. Journal of General Physiology 139:4, pages 295-304.
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Sébastien Dilly, Cédric Lamy, Neil V. Marrion, Jean‐François Liégeois & Vincent Seutin. (2011) Ion‐Channel Modulators: More Diversity Than Previously Thought. ChemBioChem 12:12, pages 1808-1812.
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Wojtek Iwo Babiaczyk, Sara Bonella, Leonardo Guidoni & Giovanni Ciccotti. (2010) Hydration Structure of the Quaternary Ammonium Cations. The Journal of Physical Chemistry B 114:46, pages 15018-15028.
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Mobeen Raja & Elisabeth Vales. (2009) Mutations in the K+-Channel KcsA Toward Kir Channels Alter Salt-Induced Clusterization and Blockade by Quaternary Alkylammonium Ions. Journal of Membrane Biology 233:1-3, pages 43-50.
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Maurizio Recanatini, Andrea Cavalli & Matteo Masetti. (2008) Modeling hERG and its Interactions with Drugs: Recent Advances in Light of Current Potassium Channel Simulations. ChemMedChem 3:4, pages 523-535.
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Benoît Roux. (2006) Extracellular Blockade of Potassium Channels by TEA+: The Tip of the Iceberg?. The Journal of General Physiology 128:6, pages 635-636.
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Christopher A. Ahern, Amy L. Eastwood, Henry A. Lester, Dennis A. Dougherty & Richard Horn. (2006) A Cation–π Interaction between Extracellular TEA and an Aromatic Residue in Potassium Channels. The Journal of General Physiology 128:6, pages 649-657.
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Vicenta Salvador-Recatala, Yonjung Kim, Elena Zaks-Makhina & Edwin S. Levitan. (2006) Voltage-Gated K + Channel Block by Catechol Derivatives: Defining Nonselective and Selective Pharmacophores . Journal of Pharmacology and Experimental Therapeutics 319:2, pages 758-764.
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Michael J Lenaeus, Magdalini Vamvouka, Pamela J Focia & Adrian Gross. (2005) Structural basis of TEA blockade in a model potassium channel. Nature Structural & Molecular Biology 12:5, pages 454-459.
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Payam Andalib, Joseph F. Consiglio, Josef G. Trapani & Stephen J. Korn. (2004) The External TEA Binding Site and C-Type Inactivation in Voltage-Gated Potassium Channels. Biophysical Journal 87:5, pages 3148-3161.
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Victor B Luzhkov, Fredrik Österberg & Johan Åqvist. (2003) Structure-activity relationship for extracellular block of K + channels by tetraalkylammonium ions . FEBS Letters 554:1-2, pages 159-164.
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