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Journal of Receptors and Signal Transduction Volume 25, 2005 - Issue 1
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Research Article

Comparison of Elisa-Based Tyrosine Kinase Assays for Screening EGFR Inhibitors

EDIT VARKONDI Rational Drug Design Laboratory CRC, Semmelweis University, BudapestHungary
,
ESZTER SCHÄFER Rational Drug Design Laboratory CRC, Semmelweis University, BudapestHungary; Department of Gastroenterology MÁV Hospital, BudapestHungary
,
GYÖRGYI BÖKÖNYI Peptide-Biochemistry Research Group, Hungarian Academy of Sciences, BudapestHungary
,
TIBOR GYÖKERES Department of Gastroenterology MÁV Hospital, BudapestHungary
,
LASZLO ÖRFI Rational Drug Design Laboratory CRC, Semmelweis University, BudapestHungary
,
ISTVAN PETAK Rational Drug Design Laboratory CRC, Semmelweis University, BudapestHungary; First Institute of Pathology and Experimental Cancer Research, Semmelweis University, BudapestHungary
,
AKOS PAP Rational Drug Design Laboratory CRC, Semmelweis University, BudapestHungary; Department of Gastroenterology MÁV Hospital, BudapestHungary
,
ORSOLYA SZOKOLOCZI Rational Drug Design Laboratory CRC, Semmelweis University, BudapestHungary
,
GYÖRGY KERI Rational Drug Design Laboratory CRC, Semmelweis University, BudapestHungary; Peptide-Biochemistry Research Group, Hungarian Academy of Sciences, BudapestHungary
&
RICHARD SCHWAB Rational Drug Design Laboratory CRC, Semmelweis University, BudapestHungary; Department of Gastroenterology MÁV Hospital, BudapestHungary
 show all
Pages 45-56 | Published online: 10 Oct 2008

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Yakup Kolcuoglu, Olcay Bekircan, Hilal Fazli, Emine Sahin, Aslı Ture, Atilla Akdemir & Senay Hamarat Sanlier. (2023) Design and synthesis of new heterocyclic compounds containing 5-[(1H-1,2,4-triazol-1-yl)methyl]-3H-1,2,4-triazole-3-thione structure as potent hEGFR inhibitors. Journal of Biomolecular Structure and Dynamics 41:22, pages 12753-12767.
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Ibrahim H. Eissa, Reda G. Yousef, Hazem Elkady, Eslam B. Elkaeed, Dalal Z. Husein, Ibrahim M. Ibrahim, Bshra A. Alsfouk, Ahmed S. Doghish, Hesham A. El-Mahdy, Ahmed M. Kenawy, Nehal El-Deeb & Ahmed M. Metwaly. (2023) New theobromine derivative as apoptotic anti-triple-negative breast cancer targeting EGFR protein: CADD story. Journal of Molecular Structure 1294, pages 136336.
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Ibrahim H Eissa, Reda G Yousef, Eslam B Elkaeed, Aisha A Alsfouk, Dalal Z Husein, Ibrahim M Ibrahim, Hesham A El-Mahdy, Hazem Elkady & Ahmed M Metwaly. (2023) Computer-Assisted Drug Discovery of a Novel Theobromine Derivative as an EGFR Protein-Targeted Apoptosis Inducer. Evolutionary Bioinformatics 19.
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Juan Gao, Jingyi Jian, Zhengjin Jiang & Ann Van Schepdael. (2023) Screening assays for tyrosine kinase inhibitors: A review. Journal of Pharmaceutical and Biomedical Analysis 223, pages 115166.
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Kshipra S. Karnik, Aniket P. Sarkate, Shailee V. Tiwari, Rajaram Azad & Pravin S. Wakte. (2022) Design, synthesis, biological evaluation and in silico studies of EGFR inhibitors based on 4-oxo-chromane scaffold targeting resistance in non-small cell lung cancer (NSCLC). Medicinal Chemistry Research 31:9, pages 1500-1516.
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Yu Tang, Yingjiang Hu, Weihao Liu, Lin Chen, Yan Zhao, Huan Ma, Jijun Yang, Yuanyou Yang, Jiali Liao, Jiming Cai, Yue Chen & Ning Liu. (2019) A radiopharmaceutical [89Zr]Zr-DFO-nimotuzumab for immunoPET with epidermal growth factor receptor expression in vivo. Nuclear Medicine and Biology 70, pages 23-31.
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Laura J. Marholz, Nicholas A. Zeringo, Hua Jane Lou, Benjamin E. Turk & Laurie L. Parker. (2018) In Silico Design and in Vitro Characterization of Universal Tyrosine Kinase Peptide Substrates . Biochemistry 57:12, pages 1847-1851.
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Alicia Berard, Andrea Kroeker, Peter McQueen & Kevin M. Coombs. (2018) Methods and approaches to disease mechanisms using systems kinomics. Synthetic and Systems Biotechnology 3:1, pages 34-43.
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Tiffany M. Scharadin, Wei He, Yianni Yiannakou, Alexey A. Tomilov, Matthew Saldana, Gino A. Cortopassi, Kermit L. Carraway, Matthew A. Coleman & Paul T. Henderson. (2017) Synthesis and biochemical characterization of EGF receptor in a water-soluble membrane model system. PLOS ONE 12:6, pages e0177761.
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Marcelina Starok, Pascal Preira, Muriel Vayssade, Karsten Haupt, Laurence Salomé & Claire Rossi. (2015) EGFR Inhibition by Curcumin in Cancer Cells: A Dual Mode of Action. Biomacromolecules 16:5, pages 1634-1642.
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Bo-Rui Kang, Ai-Lin Shan, Yi-Ping Li, Jing Xu, She-Min Lu & San-Qi Zhang. (2013) Discovery of 2-aryl-8-hydroxy (or methoxy)-isoquinolin-1(2H)-ones as novel EGFR inhibitor by scaffold hopping. Bioorganic & Medicinal Chemistry 21:22, pages 6956-6964.
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Samah Doumiati, Karsten Haupt & Claire Rossi. (2012) Autophosphorylation activation and inhibition by curcumin of the epidermal growth factor receptor reconstituted in liposomes. Journal of Molecular Recognition 25:11, pages 623-629.
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Miao Zuo, Yue-Wen Zheng, She-Min Lu, Yan Li & San-Qi Zhang. (2012) Synthesis and biological evaluation of N-aryl salicylamides with a hydroxamic acid moiety at 5-position as novel HDAC–EGFR dual inhibitors. Bioorganic & Medicinal Chemistry 20:14, pages 4405-4412.
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Hui Du, Jing Ren, Sicen Wang & Langchong He. (2011) Cell membrane chromatography competitive binding analysis for characterization of α1A adrenoreceptor binding interactions. Analytical and Bioanalytical Chemistry 400:10, pages 3625-3633.
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Ya-Jun Lin & Yong-Su Zhen. (2009) Rhein lysinate suppresses the growth of breast cancer cells and potentiates the inhibitory effect of Taxol in athymic mice. Anti-Cancer Drugs 20:1, pages 65-72.
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. 2009. Class 2 Transferases. Class 2 Transferases 341 440 .
Alessandra Antonello, Andrea Tarozzi, Fabiana Morroni, Andrea Cavalli, Michela Rosini, Patrizia Hrelia, Maria Laura Bolognesi & Carlo Melchiorre. (2006) Multitarget-Directed Drug Design Strategy:  A Novel Molecule Designed To Block Epidermal Growth Factor Receptor (EGFR) and To Exert Proapoptotic Effects. Journal of Medicinal Chemistry 49:23, pages 6642-6645.
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