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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 32, 2002 - Issue 2
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Original Articles

POTENTIAL PURINE ANALOGUE ANTAGONISTS: SYNTHESIS OF NOVEL CYCLOALKANE RING-FUSED PYRAZOLO[1,5-A]PYRIMIDINES

Galal H. Elgemeie Chemistry Department, Faculty of Science, Helwan University, Ain-Helwan, Cairo, Egypt
&
Hany A. Ali Chemistry Department, Faculty of Science, Helwan University, Ain-Helwan, Cairo, Egypt
Pages 253-264 | Received 16 Oct 2000, Published online: 16 Aug 2006

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Elsherbiny H. El-Sayed & Khaled S. Mohamed. (2021) Synthesis and Anti-inflammatory Evaluation of Some New Pyrazole, Pyrimidine, Pyrazolo[1,5-a]Pyrimidine, Imidazo[1,2-b]Pyrazole and Pyrazolo[5,1-b]Quinazoline Derivatives Containing Indane Moiety. Polycyclic Aromatic Compounds 41:5, pages 1077-1093.
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Amira EM Abdallah & Galal H Elgemeie. (2018) Design, synthesis, docking, and antimicrobial evaluation of some novel pyrazolo[1,5-a] pyrimidines and their corresponding cycloalkane ring-fused derivatives as purine analogs. Drug Design, Development and Therapy 12, pages 1785-1798.
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Galal H. Elgemeie, Ahmed H. Elghandour & Ahmed M. Hussein. (2004) Amino Acids in Heterocyclic Synthesis: Novel Synthesis of Pyrano[2,3‐c]pyrazoles, Pyrazolo[3,4‐b]pyridine, and Pyrido[1,2‐a]benzimidazoles. Synthetic Communications 34:18, pages 3293-3302.
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Articles from other publishers (25)

Amira E. M. Abdallah & Galal H. Elgemeie. (2022) New Route to the Synthesis of Novel Pyrazolo[1,5-a]pyrimidines and Evaluation of their Antimicrobial Activity as RNA Polymerase Inhibitors. Medicinal Chemistry 18:9, pages 926-948.
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Galal H. Elgemeie, Rasha A. Azzam, Wafaa A. Zaghary, Mohammed A. Khedr & Gihad E. Elsherif. (2022) Medicinal Chemistry of Pyrazolopyrimidine Scaffolds Substituted with Different Heterocyclic Nuclei. Current Pharmaceutical Design 28:41, pages 3374-3403.
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Felipe S. Stefanello, Yuri G. Kappenberg, Juliane N. Araújo, Steffany Z. Franceschini, Marcos A.P. Martins, Nilo Zanatta, Bernardo A. Iglesias & Helio G. Bonacorso. (2022) Trifluoromethyl-substituted aryldiazenyl-pyrazolo[1,5-a]pyrimidin-2-amines: Regioselective synthesis, structure, and optical properties. Journal of Fluorine Chemistry 255-256, pages 109967.
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Galal H. Elgemeie & Reham A. Mohamed-Ezzat. 2022. New Strategies Targeting Cancer Metabolism. New Strategies Targeting Cancer Metabolism 547 611 .
Susma Das, Shilpika Khanikar, Shunan Kaping, Jayanti Datta Roy, Arnab Sen, Philippe Helissey & Jai Narain Vishwakarma. (2020) Efficient synthesis of diversely substituted pyrazolo[1,5-a]pyrimidine derivatives promoted by ultrasound irradiation in water and their antibacterial activities. European Journal of Chemistry 11:4, pages 304-313.
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Ali M. S. Hebishy, Hagar T. Salama & Galal H. Elgemeie. (2020) New Route to the Synthesis of Benzamide-Based 5-Aminopyrazoles and Their Fused Heterocycles Showing Remarkable Antiavian Influenza Virus Activity. ACS Omega 5:39, pages 25104-25112.
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Lanlan Yu, Shilong Xing, Kai Zheng & Seyed Mohsen Sadeghzadeh. (2020) Synthesis of pyrazolopyrimidines in mild conditions by gold nanoparticles supported on magnetic ionic gelation in aqueous solution. Applied Organometallic Chemistry 34:7.
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Khaled M. Elattar, Başak Doğru Mert, M. Monier & Ahmed El-Mekabaty. (2020) Advances in the chemical and biological diversity of heterocyclic systems incorporating pyrimido[1,6- a ]pyrimidine and pyrimido[1,6- c ]pyrimidine scaffolds . RSC Advances 10:26, pages 15461-15492.
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Mukta Singsardar, Rajib Sarkar, Koushik Majhi, Subrata Sinha & Alakananda Hajra. (2018) Brønsted Acidic Ionic Liquid-Catalyzed Regioselective Synthesis of Pyrazolopyrimidines and Their Photophysical Properties. ChemistrySelect 3:5, pages 1404-1410.
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Samir Bondock, Abd El-Gaber Tarhoni & Ahmed A. Fadda. (2015) Regioselective Synthesis of Some New Pyrazolo[1,5- a ]pyrimidines, Pyrazolo[1,5- a ]quinazoline and Pyrimido[4′,5′:3,4]pyrazolo[1,5- a ] pyrimidines Containing Thiazole Moiety . Journal of Heterocyclic Chemistry 52:6, pages 1792-1799.
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Ranjana Aggarwal, Eakta Masan, Pawan Kaushik, Dhirender Kaushik, Chetan Sharma & K.R. Aneja. (2014) Synthesis and biological evaluation of 7-trifluoromethylpyrazolo[1,5- a ]pyrimidines as anti-inflammatory and antimicrobial agents. Journal of Fluorine Chemistry 168, pages 16-24.
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A. A. Petrov & A. N. Kasatochkin. (2014) Convenient synthesis of 6,7-dihydroazolo[5,1-b]quinazolin-8(5H)-one derivatives. Russian Journal of Organic Chemistry 50:10, pages 1485-1495.
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Monika Chauhan & Raj Kumar. (2013) Medicinal attributes of pyrazolo[3,4-d]pyrimidines: A review. Bioorganic & Medicinal Chemistry 21:18, pages 5657-5668.
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Sobhi M. Gomha & Hassan M. Abdel-Aziz. (2013) An Efficient Synthesis of Functionalised 2-(heteroaryl)-3 H -benzo[f] Chromen-3-ones and Antibacterial Evaluation . Journal of Chemical Research 37:5, pages 298-303.
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A. A. Petrov, A. N. Kasatochkin & E. E. Emelina. (2012) Study of regioselectivity of reactions between 3(5)-aminopyrazoles and 2-acetylcycloalkanones. Russian Journal of Organic Chemistry 48:8, pages 1111-1120.
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Ahmed M. Hussein. (2012) Novel synthesis of some new pyrimido[1,6-a]pyrimidine and pyrazolo[1,5-a]pyrimidine derivatives. Journal of Heterocyclic Chemistry 49:2, pages 446-451.
Crossref
Jaime Portilla, Jairo Quiroga, Manuel Nogueras & Justo Cobo. (2012) Regioselective synthesis of fused pyrazolo[1,5-a]pyrimidines by reaction of 5-amino-1H-pyrazoles and β-dicarbonyl compounds containing five-membered rings. Tetrahedron 68:4, pages 988-994.
Crossref
Ahmed M. Hussein & Osama M. Ahmed. (2010) Regioselective one-pot synthesis and anti-proliferative and apoptotic effects of some novel tetrazolo[1,5-a]pyrimidine derivatives. Bioorganic & Medicinal Chemistry 18:7, pages 2639-2644.
Crossref
Ahmed M. Hussein. (2010) Synthesis of some new purine-related compounds: Regioselective one-pot synthesis of new tetrazolo[1,5-a]pyrimidine, pyrazolo[1,5-a]pyrimidine and pyrimido[1,6-a]pyrimidine derivatives. Journal of Saudi Chemical Society 14:1, pages 61-68.
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. (2009) Acetate-Promoted Aldol-Type Reaction: Scope and Reactivity of Acetates and Aldehydes. Bulletin of the Korean Chemical Society 30:4, pages 797-802.
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Xiaochun Tao, Ruzhang Liu, Qinghua Meng, Yinyan Zhao, Yongbin Zhou & Jiling Huang. (2005) The reaction of ketones with benzaldehyde catalyzed by TiCl4·2THF. Journal of Molecular Catalysis A: Chemical 225:2, pages 239-243.
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Rafik Gharbi, Anis Romdhane, Zine Mighri & Marie-Thérèse Martin. (2005) A convenient synthesis of a novel fused tetracyclic heterocoumarin. Journal of Heterocyclic Chemistry 42:1, pages 169-172.
Crossref
Tarek M. Abu Elmaati & Fathi M. El‐Taweel. (2009) New trends in the chemistry of 5‐aminopyrazoles. Journal of Heterocyclic Chemistry 41:2, pages 109-134.
Crossref
Larry Yet. 2003. A critical review of the 2002 fiterature preceded by three chapters on current heterocyclic topics. A critical review of the 2002 fiterature preceded by three chapters on current heterocyclic topics 206 229 .
Galal H. Elgemeie & Hany A. Ali. (2010) ChemInform Abstract: Potential Purine Analogue Antagonists: Synthesis of Novel Cycloalkane Ring‐Fused Pyrazolo[1,5‐a]pyrimidines.. ChemInform 33:25.
Crossref

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