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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 32, 2002 - Issue 3
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Original Articles

SELECTIVE N-ALKYLATION OF PRIMARY AMINES WITH CHLOROACETAMIDES UNDER pH-CONTROLLED AQUEOUS CONDITIONS

Eric Loeser Process R&D, Chemical and Analytical Development, Novartis Pharmaceuticals Corporation, 59 Route 10, East Hanover, NJ, 07936, U.S.A.
,
Kapa Prasad Process R&D, Chemical and Analytical Development, Novartis Pharmaceuticals Corporation, 59 Route 10, East Hanover, NJ, 07936, U.S.A.
&
Oljan Repic Process R&D, Chemical and Analytical Development, Novartis Pharmaceuticals Corporation, 59 Route 10, East Hanover, NJ, 07936, U.S.A.
Pages 403-409 | Received 19 Mar 2001, Published online: 16 Aug 2006

Citations (10)

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Read on this site (3)

B. S. Balaji & Neha Dalal. (2018) An expedient and rapid green chemical synthesis of N-chloroacetanilides and amides using acid chlorides under metal-free neutral conditions. Green Chemistry Letters and Reviews 11:4, pages 552-558.
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B. S. Balaji & Neha Dalal. (2018) An expedient, chemoselective N-chloroacetylation of aminoalcohols under metal-free bio-compatible conditions. Green Chemistry Letters and Reviews 11:4, pages 534-543.
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Qosay A Al-Balas, Munia F Sowaileh, Mohammad A Hassan, Amjad M Qandil, Karem H Alzoubi, Nizar M Mhaidat, Ammar M Almaaytah & Omar F Khabour. (2014) Novel N-substituted aminobenzamide scaffold derivatives targeting the dipeptidyl peptidase-IV enzyme. Drug Design, Development and Therapy 8, pages 129-163.
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Articles from other publishers (7)

Fabiana Gomes Nascimento Soares, Gabriela Göethel, Luciano Porto Kagami, Gustavo Machado das Neves, Elisa Sauer, Estefania Birriel, Javier Varela, Itamar Luís Gonçalves, Gilsane Von Poser, Mercedes González, Daniel Fábio Kawano, Fávero Reisdorfer Paula, Eduardo Borges de Melo, Solange Cristina Garcia, Hugo Cerecetto & Vera Lucia Eifler-Lima. (2019) Novel coumarins active against Trypanosoma cruzi and toxicity assessment using the animal model Caenorhabditis elegans. BMC Pharmacology and Toxicology 20:S1.
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Amjad M. Qandil & Lara I. Fakhouri. (2012) a-Anilinoketones, Esters and Amides: A Chemical Study. Pharmaceuticals 5:6, pages 591-612.
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Neal G. Anderson. 2012. Practical Process Research and Development. Practical Process Research and Development 237 260 .
Zerong Wang. 2010. Comprehensive Organic Name Reactions and Reagents. Comprehensive Organic Name Reactions and Reagents 1060 1063 .
Zerong Wang. 2010. Comprehensive Organic Name Reactions and Reagents. Comprehensive Organic Name Reactions and Reagents 1046 1050 .
St?phane P. Roche, Marie-Laure Teyssot & Arnaud Gautier. (2010) Synthesis of 1,2 diamines under environmentally benign conditions: application for the preparation of imidazolidiniums. Tetrahedron Letters 51:9, pages 1265-1268.
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Eric Loeser, Kapa Prasad & Oljan Repic. (2010) ChemInform Abstract: Selective N‐Alkylation of Primary Amines with Chloroacetamides under pH‐Controlled Aqueous Conditions.. ChemInform 33:26.
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