Advanced search
Publication Cover
Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 33, 2003 - Issue 12
Submit an article Journal homepage
1,279
Views
21
CrossRef citations to date
0
Altmetric
Original Articles

Novel Synthesis of 1-(1,2,3,5,6,7-Hexahydro- s-indacen-4-yl)-3-[4-(1-hydroxy-1-methyl-ethyl)-furan-2-sulfonyl]urea, an Anti-inflammatory Agent

Frank J. Urban Pfizer Global Research and Development, Chemical Research and Development, Groton, Connecticut, USACorrespondence[email protected]
,
V. John Jasys Pfizer Global Research and Development, Chemical Research and Development, Groton, Connecticut, USA
,
Jeffrey W. Raggon Pfizer Global Research and Development, Chemical Research and Development, Groton, Connecticut, USA
,
Richard A. Buzon Pfizer Global Research and Development, Chemical Research and Development, Groton, Connecticut, USA
,
Paul D. Hill Pfizer Global Research and Development, Chemical Research and Development, Groton, Connecticut, USA
,
James F. Eggler Pfizer Global Research and Development, Chemical Research and Development, Groton, Connecticut, USA
&
John D. Weaver Pfizer Global Research and Development, Chemical Research and Development, Groton, Connecticut, USA
 show all
Pages 2029-2043 | Received 17 Oct 2002, Published online: 17 Aug 2006

Citations (21)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (1)

Weike Su, Weihui Zhong, Gaofeng Bian, Xiangjun Shi & Jianping Zhang. (2004) RECENT ADVANCES IN THE CHEMISTRY OF TRICHLOROMETHYL CHLOROFORMATE AND bis-(TRICHLOROMETHYL) CARBONATE. Organic Preparations and Procedures International 36:6, pages 499-547.
Read now

Articles from other publishers (20)

Zhuoyue Li, Yiming Chen, Xiaolin Jiang, Penghui Lu, Chengli Wang, Zhimin Li, Xinyue Yu, Zixuan Yang, Shumin Ma, Shanshan Du, Zhengfu Tai, Xiaoyang Li, Siqi Zhang, Yuqi Jiang & Chong Qin. (2023) Novel Sulfonylurea-Based NLRP3 Inflammasome Inhibitor for Efficient Treatment of Nonalcoholic Steatohepatitis, Endotoxic Shock, and Colitis. Journal of Medicinal Chemistry.
Crossref
Pritam Thapa, Sunil P. Upadhyay, Vikas Singh, Varun C. Boinpelly, Jianping Zhou, David K. Johnson, Prajwal Gurung, Eung Seok Lee, Ram Sharma & Mukut Sharma. (2023) Chalcone: A potential scaffold for NLRP3 inflammasome inhibitors. European Journal of Medicinal Chemistry Reports 7, pages 100100.
Crossref
Christopher McBride, Lynnie Trzoss, Davide Povero, Milos Lazic, Geza Ambrus-Aikelin, Angelina Santini, Rama Pranadinata, Gretchen Bain, Ryan Stansfield, Jeffrey A. Stafford, James Veal, Ryan Takahashi, Justin Ly, Shu Chen, Liling Liu, Marika Nespi, Robert Blake, Arna Katewa, Tracy Kleinheinz, Swathi Sujatha-Bhaskar, Nandhini Ramamoorthi, Jessica Sims, Brent McKenzie, Mark Chen, Mark Ultsch, Matthew Johnson, Jeremy Murray, Claudio Ciferri, Steven T. Staben, Michael J. Townsend & Craig E. Stivala. (2022) Overcoming Preclinical Safety Obstacles to Discover ( S )- N -((1,2,3,5,6,7-Hexahydro- s -indacen-4-yl)carbamoyl)-6-(methylamino)-6,7-dihydro-5 H -pyrazolo[5,1- b ][1,3]oxazine-3-sulfonamide (GDC-2394): A Potent and Selective NLRP3 Inhibitor . Journal of Medicinal Chemistry 65:21, pages 14721-14739.
Crossref
Paloma Narros-Fernández, Mourad Chioua, Sonia A. Petcu, Daniel Diez-Iriepa, Laura Cerrada-Gálvez, Céline Decouty-Pérez, Alejandra Palomino-Antolín, Eva Ramos, Víctor Farré-Alins, Ana Belén López-Rodríguez, Alejandro Romero, José Marco-Contelles & Javier Egea. (2022) Synthesis and Pharmacological Evaluation of New N -Sulfonylureas as NLRP3 Inflammasome Inhibitors: Identification of a Hit Compound to Treat Gout . Journal of Medicinal Chemistry 65:8, pages 6250-6260.
Crossref
Tim Keuler, Dominic Ferber, Michael Marleaux, Matthias Geyer & Michael Gütschow. (2022) Structure–Stability Relationship of NLRP3 Inflammasome-Inhibiting Sulfonylureas. ACS Omega 7:9, pages 8158-8162.
Crossref
Tiziano De Ventura & Vinicio Zanirato. (2021) Recent Advances in the Synthesis of Sulfonylureas. European Journal of Organic Chemistry 2021:8, pages 1201-1214.
Crossref
Sameer Agarwal, Jignesh P. Pethani, Hardik A. Shah, Vismit Vyas, Santosh Sasane, Harsh Bhavsar, Debdutta Bandyopadhyay, Poonam Giri, Kasinath Viswanathan, Mukul R. Jain & Rajiv Sharma. (2020) Identification of a novel orally bioavailable NLRP3 inflammasome inhibitor. Bioorganic & Medicinal Chemistry Letters 30:21, pages 127571.
Crossref
Sameer Agarwal, Santosh Sasane, Hardik A. Shah, Jignesh P. Pethani, Prashant Deshmukh, Vismit Vyas, Pravin Iyer, Harsh Bhavsar, Kasinath Viswanathan, Debdutta Bandyopadhyay, Poonam Giri, Jogeswar Mahapatra, Abhijit Chatterjee, Mukul R. Jain & Rajiv Sharma. (2020) Discovery of N -Cyano-sulfoximineurea Derivatives as Potent and Orally Bioavailable NLRP3 Inflammasome Inhibitors . ACS Medicinal Chemistry Letters 11:4, pages 414-418.
Crossref
Vandana Deora, John D. Lee, Eduardo A. Albornoz, Luke McAlary, Cyril J. Jagaraj, Avril A. B. Robertson, Julie D. Atkin, Matthew A. Cooper, Kate Schroder, Justin J. Yerbury, Richard Gordon & Trent M. Woodruff. (2019) The microglial NLRP3 inflammasome is activated by amyotrophic lateral sclerosis proteins. Glia 68:2, pages 407-421.
Crossref
Sara J Thygesen, Karli E Takizawa, Avril A B Robertson, David P Sester & Katryn J Stacey. (2018) Compromised NLRP 3 and AIM 2 inflammasome function in autoimmune NZB /W F1 mouse macrophages . Immunology & Cell Biology 97:1, pages 17-28.
Crossref
Manohar Salla, Mark S. Butler, Nicholas L. Massey, Janet C. Reid, Matthew A. Cooper & Avril A.B. Robertson. (2018) Synthesis of deuterium-labelled analogues of NLRP3 inflammasome inhibitor MCC950. Bioorganic & Medicinal Chemistry Letters 28:4, pages 793-795.
Crossref
Manohar Salla, Mark S. Butler, Ruby Pelingon, Geraldine Kaeslin, Daniel E. Croker, Janet C. Reid, Jong Min Baek, Paul V. Bernhardt, Elizabeth M. J. Gillam, Matthew A. Cooper & Avril A. B. Robertson. (2016) Identification, Synthesis, and Biological Evaluation of the Major Human Metabolite of NLRP3 Inflammasome Inhibitor MCC950. ACS Medicinal Chemistry Letters 7:12, pages 1034-1038.
Crossref
Michael J. Primiano, Bruce A. Lefker, Michael R. Bowman, Andrea G. Bree, Cedric Hubeau, Paul D. Bonin, Matthew Mangan, Ken Dower, Brian G. Monks, Leah Cushing, Stephen Wang, Julia Guzova, Aiping Jiao, Lih-Ling Lin, Eicke Latz, David Hepworth & J. Perry Hall. (2016) Efficacy and Pharmacology of the NLRP3 Inflammasome Inhibitor CP-456,773 (CRID3) in Murine Models of Dermal and Pulmonary Inflammation. The Journal of Immunology 197:6, pages 2421-2433.
Crossref
Roman D. Savka & Herbert Plenio. (2012) A hexahydro-s-indacene based NHC ligand for olefin metathesis catalysts. Journal of Organometallic Chemistry 710, pages 68-74.
Crossref
John A. Brailsford, Ryan Lauchli & Kenneth J. Shea. (2009) Synthesis of the Bicyclic Welwitindolinone Core via an Alkylation/Cyclization Cascade Reaction. Organic Letters 11:22, pages 5330-5333.
Crossref
Gregory S. Basarab, Pamela J. Hill, Abdullah Rastagar & Peter J.H. Webborn. (2008) Design of Helicobacter pylori glutamate racemase inhibitors as selective antibacterial agents: A novel pro-drug approach to increase exposure. Bioorganic & Medicinal Chemistry Letters 18:16, pages 4716-4722.
Crossref
Kenneth C. Waterman, Anthony J. Carella, Michael J. Gumkowski, Patrick Lukulay, Bruce C. MacDonald, Michael C. Roy & Sheri L. Shamblin. (2007) Improved Protocol and Data Analysis for Accelerated Shelf-Life Estimation of Solid Dosage Forms. Pharmaceutical Research 24:4, pages 780-790.
Crossref
Sonia Macho, Daniel Miguel, Teresa Gómez, Teresa Rodríguez & Tomás Torroba. (2005) From Cyclopentanone Oximes to Bis[1,2,3]dithiazolo- s -indacenes, Cyclopenta[ c ][1,2]thiazine, Pentathiepino-, Tetrathiino-, and Thienocyclopenta[1,2,3]dithiazoles as a Rich Source of New Materials . The Journal of Organic Chemistry 70:23, pages 9314-9325.
Crossref
Karen M. Alsante, Peter Boutros, Michel A. Couturier, Robert C. Friedmann, Jeffrey W. Harwood, George J. Horan, Andrew J. Jensen, Qicai Liu, Linda L. Lohr, Ronald Morris, Jeffrey W. Raggon, George L. Reid, Dinos P. Santafianos, Thomas R. Sharp, John L. Tucker & Glenn E. Wilcox. (2004) Pharmaceutical impurity identification: A case study using a multidisciplinary approach. Journal of Pharmaceutical Sciences 93:9, pages 2296-2309.
Crossref
Frank J. Urban, V. John Jasys, Jeffrey W. Raggon, Richard A. Buzon, Paul D. Hill, James F. Eggler & John D. Weaver. (2003) Novel Synthesis of 1‐(1,2,3,5,6,7‐Hexahydro‐s‐indacen‐4‐yl)‐3‐ [4‐(1‐hydroxy‐1‐methyl‐ethyl)‐furan‐2‐sulfonyl]urea, an Antiinflammatory Agent.. ChemInform 34:43.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.