Search in:

Synthetic Communications

An International Journal for Rapid Communication of Synthetic Organic Chemistry

Volume 33, 2003 - Issue 13

Submit an article Journal homepage

384

Views

CrossRef citations to date

Altmetric

Original Articles

A New Way to tert-Butyl [(4R,6R)-6-Aminoethyl-2,2-dimethyl-1,3-dioxan-4-yl]acetate, a Key Intermediate of Atorvastatin Synthesis

Stanislav Rádl Research Institute of Pharmacy and Biochemistry, Dolni, Mecholupy Prague, Czech RepublicCorrespondence[email protected]

Pages 2275-2283 | Received 01 Oct 2002, Published online: 17 Aug 2006

Cite this article
https://doi.org/10.1081/SCC-120021507

Full Article
Figures & data
References
Citations
Metrics
Reprints & Permissions

Citations (20)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Articles from other publishers (20)

Naresh Vempala, Anireddy Jaya Shree, Srikanth Reddy Narra & Somnath Dasgupta. (2022) An Efficient Enantioselective Total Synthesis of Atorvastatin Calcium. Synlett 34:03, pages 283-287.
Crossref

Raj Kumar Tak, Hidetoshi Noda & Masakatsu Shibasaki. (2019) Cyanomethylation of β‐Alkoxyaldehydes: Toward a Short Synthesis of Atorvastatin. Asian Journal of Organic Chemistry 9:1, pages 57-60.
Crossref

Juanjuan Feng, Tianyu Li, Jiaxin Zhang & Peng Jiao. (2019) Application of chiral 2-isoxazoline for the synthesis of syn -1,3-diol analogs . Beilstein Journal of Organic Chemistry 15, pages 1840-1847.
Crossref

Guanxin Huang, Minjie Liu, Fangjun Xiong, Ge Meng, Yuan Tao, Yan Wu, Haihui Peng & Fener Chen. (2018) Chiral Syn-1,3-diol Derivatives via a One-Pot Diastereoselective Carboxylation/ Bromocyclization of Homoallylic Alcohols. iScience 9, pages 513-520.
Crossref

Ruben Vardanyan & Victor Hruby. 2016. Synthesis of Best-Seller Drugs. Synthesis of Best-Seller Drugs 285 315 .

Fang-Jun Xiong, Jie Li, Xiao-Fei Chen, Wen-Xue Chen & Fen-Er Chen. (2014) An improved process for chiron synthesis of the atorvastatin side chain. Tetrahedron: Asymmetry 25:16-17, pages 1205-1208.
Crossref

Yuji Kawato , Sandeep Chaudhary, Naoya Kumagai & Masakatsu Shibasaki . (2013) Streamlined Catalytic Asymmetric Synthesis of Atorvastatin. Chemistry – A European Journal 19:12, pages 3802-3806.
Crossref

Lemeng Hu, Fangjun Xiong, Xiaofei Chen, Wenxue Chen, Qiuqin He & Fener Chen. (2013) Synthetic studies on statins. Part 1: a short and cyanide-free synthesis of atorvastatin calcium via an enantioselective aldol strategy. Tetrahedron: Asymmetry 24:4, pages 207-211.
Crossref

Yuji Kawato, Mitsutaka Iwata, Ryo Yazaki, Naoya Kumagai & Masakatsu Shibasaki. (2011) A simplified catalytic system for direct catalytic asymmetric aldol reaction of thioamides; application to an enantioselective synthesis of atorvastatin. Tetrahedron 67:35, pages 6539-6546.
Crossref

Jian Gao, Yang Hui Guo, Ya Ping Wang, Xiang Jing Wang & Wen Sheng Xiang. (2011) A novel and efficient route for the preparation of atorvastatin. Chinese Chemical Letters.
Crossref

Daniel M. Bowles, David C. Boyles, Chulho Choi, Jeffrey A. Pfefferkorn, Stephanie Schuyler & Edward J. Hessler. (2010) Development of an Early Enabling Synthesis for PF-03052334-02: A Novel Hepatoselective HMG-CoA Reductase Inhibitor. Organic Process Research & Development 15:1, pages 148-157.
Crossref

Pramod Sawant & Martin E. Maier. (2010) A novel strategy towards the atorvastatin lactone. Tetrahedron 66:51, pages 9738-9744.
Crossref

Jan Stach, Jaroslav Havlíček, Lukáš Plaček & Stanislav Rádl. (2008) Synthesis of Some Impurities and/or Degradation Products of Atorvastatin. Collection of Czechoslovak Chemical Communications 73:2, pages 229-246.
Crossref

Jeffrey A. Pfefferkorn, Chulho Choi, Scott D. Larsen, Bruce Auerbach, Richard Hutchings, William Park, Valerie Askew, Lisa Dillon, Jeffrey C. Hanselman, Zhiwu Lin, Gina H. Lu, Andrew Robertson, Catherine Sekerke, Melissa S. Harris, Alexander Pavlovsky, Graeme Bainbridge, Nicole Caspers, Mark Kowala & Bradley D. Tait. (2007) Substituted Pyrazoles as Hepatoselective HMG-CoA Reductase Inhibitors: Discovery of (3 R ,5 R )-7-[2-(4-Fluoro-phenyl)-4-isopropyl-5-(4-methyl-benzylcarbamoyl)-2 H -pyrazol-3-yl]-3,5-dihydroxyheptanoic Acid (PF-3052334) as a Candidate for the Treatment of Hypercholesterolemia . Journal of Medicinal Chemistry 51:1, pages 31-45.
Crossref

Shyla George & Arumugam Sudalai. (2007) An efficient organocatalytic route to the atorvastatin side-chain. Tetrahedron Letters 48:48, pages 8544-8546.
Crossref

Jeffrey A. Pfefferkorn, Daniel M. Bowles, William Kissel, David C. Boyles, Chulho Choi, Scott D. Larsen, Yuntao Song, Kuai-Lin Sun, Steven R. Miller & Bharat K. Trivedi. (2007) Development of a practical synthesis of novel, pyrrole-based HMG-CoA reductase inhibitors. Tetrahedron 63:34, pages 8124-8134.
Crossref

Jeffrey A. Pfefferkorn, Chulho Choi, Yuntao Song, Bharat K. Trivedi, Scott D. Larsen, Valerie Askew, Lisa Dillon, Jeffrey C. Hanselman, Zhiwu Lin, Gina Lu, Andrew Robertson, Catherine Sekerke, Bruce Auerbach, Alexander Pavlovsky, Melissa S. Harris, Graeme Bainbridge & Nicole Caspers. (2007) Design and synthesis of novel, conformationally restricted HMG-CoA reductase inhibitors. Bioorganic & Medicinal Chemistry Letters 17:16, pages 4531-4537.
Crossref

Larry D. Bratton, Bruce Auerbach, Chulho Choi, Lisa Dillon, Jeffrey C. Hanselman, Scott D. Larsen, Gina Lu, Karl Olsen, Jeffrey A. Pfefferkorn, Andrew Robertson, Catherine Sekerke, Bharat K. Trivedi & Paul C. Unangst. (2007) Discovery of pyrrole-based hepatoselective ligands as potent inhibitors of HMG-CoA reductase. Bioorganic & Medicinal Chemistry 15:16, pages 5576-5589.
Crossref

Junjie Liu, Che-Chang Hsu & Chi-Huey Wong. (2004) Sequential aldol condensation catalyzed by DERA mutant Ser238Asp and a formal total synthesis of atorvastatin. Tetrahedron Letters 45:11, pages 2439-2441.
Crossref

Stanislav Radl. (2003) A New Way to tert‐Butyl [(4,6R)‐6‐Aminoethyl‐2,2‐dimethyl‐1,3‐dioxan‐4‐yl]acetate, a Key Intermediate of Atorvastatin Synthesis.. ChemInform 34:42.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Share icon
Back to Top

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.

People also read
Recommended articles
Cited by

To cite this article:

Reference style: APA Chicago Harvard

Citation copied to clipboard

Reference styles above use APA (6th edition), Chicago (16th edition) & Harvard (10th edition)

Download citation

Download a citation file in RIS format that can be imported by citation management software including EndNote, ProCite, RefWorks and Reference Manager.

Choose format: RIS BibTex RefWorks Direct Export

Choose options: Citation Citation & abstract Citation & references

A New Way to tert-Butyl [(4R,6R)-6-Aminoethyl-2,2-dimethyl-1,3-dioxan-4-yl]acetate, a Key Intermediate of Atorvastatin Synthesis

Articles from other publishers (20)

Information for

Open access

Opportunities

Help and information

Your download is now in progress and you may close this window

Login or register to access this feature

A New Way to tert-Butyl [(4R,6R)-6-Aminoethyl-2,2-dimethyl-1,3-dioxan-4-yl]acetate, a Key Intermediate of Atorvastatin Synthesis

Citations (20)

Articles from other publishers (20)

Reprints and Corporate Permissions

Academic Permissions

Related research

To cite this article:

Download citation

Information for

Open access

Opportunities

Help and information

Keep up to date