Advanced search
Publication Cover
Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 33, 2003 - Issue 18
Submit an article Journal homepage
54
Views
17
CrossRef citations to date
0
Altmetric
Original Articles

Synthesis of a First Estradiol-Adenosine Hybrid Compound

Dr. Donald Poirier Medicinal Chemistry Division, Oncology and Molecular Endocrinology Research Center and University Laval, Centre Hospitalier Universitaire de Québec (CHUQ), Pavillon CHUL, Québec, CanadaCorrespondence[email protected]
,
Roch P. Boivin Medicinal Chemistry Division, Oncology and Molecular Endocrinology Research Center and University Laval, Centre Hospitalier Universitaire de Québec (CHUQ), Pavillon CHUL, Québec, Canada
,
Marie Bérubé Medicinal Chemistry Division, Oncology and Molecular Endocrinology Research Center and University Laval, Centre Hospitalier Universitaire de Québec (CHUQ), Pavillon CHUL, Québec, Canada
&
Sheng-Xiang Lin Medicinal Chemistry Division, Oncology and Molecular Endocrinology Research Center and University Laval, Centre Hospitalier Universitaire de Québec (CHUQ), Pavillon CHUL, Québec, Canada
Pages 3183-3192 | Received 11 Dec 2002, Published online: 17 Aug 2006

Citations (17)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (1)

Marie Bérubé & Donald Poirier. (2009) Improved synthesis of EM-1745, preparation of its C17-ketone analogue and comparison of their inhibitory potency on 17β-hydroxysteroid dehydrogenase type 1. Journal of Enzyme Inhibition and Medicinal Chemistry 24:3, pages 832-843.
Read now

Articles from other publishers (16)

Hui Han, Jean-François Thériault, Guang Chen & Sheng-Xiang Lin. (2017) Substrate inhibition of 17β-HSD1 in living cells and regulation of 17β-HSD7 by 17β-HSD1 knockdown. The Journal of Steroid Biochemistry and Molecular Biology 172, pages 36-45.
Crossref
Wanhong He, Misra Gauri, Tang Li, Ruixuan Wang & Sheng-Xiang Lin. (2016) Current knowledge of the multifunctional 17β-hydroxysteroid dehydrogenase type 1 (HSD17B1). Gene 588:1, pages 54-61.
Crossref
Donald Poirier. (2011) Contribution to the development of inhibitors of 17β-hydroxysteroid dehydrogenase types 1 and 7: Key tools for studying and treating estrogen-dependent diseases. The Journal of Steroid Biochemistry and Molecular Biology 125:1-2, pages 83-94.
Crossref
Marie Bérubé, Florian Delagoutte & Donald Poirier. (2010) Preparation of 16β-Estradiol Derivative Libraries as Bisubstrate Inhibitors of 17β-Hydroxysteroid Dehydrogenase Type 1 Using the Multidetachable Sulfamate Linker. Molecules 15:3, pages 1590-1631.
Crossref
Annamaria Lilienkampf, Sampo Karkola, Sari Alho-Richmond, Pasi Koskimies, Nina Johansson, Kaisa Huhtinen, Kimmo Vihko & Kristiina Wähälä. (2009) Synthesis and Biological Evaluation of 17β-Hydroxysteroid Dehydrogenase Type 1 (17β-HSD1) Inhibitors Based on a Thieno[2,3- d ]pyrimidin-4(3 H )-one Core . Journal of Medicinal Chemistry 52:21, pages 6660-6671.
Crossref
Marie BérubéDonald Poirier. (2009) Design, chemical synthesis, and in vitro biological evaluation of simplified estradiol–adenosine hybrids as inhibitors of 17β-hydroxysteroid dehydrogenase type 1. Canadian Journal of Chemistry 87:8, pages 1180-1199.
Crossref
D. Fournier, D. Poirier, M. Mazumdar & S.-X. Lin. (2008) Design and synthesis of bisubstrate inhibitors of type 1 17β-hydroxysteroid dehydrogenase: Overview and perspectives. European Journal of Medicinal Chemistry 43:11, pages 2298-2306.
Crossref
Gillian M. Allan, Nigel Vicker, Harshani R. Lawrence, Helena J. Tutill, Joanna M. Day, Marion Huchet, Eric Ferrandis, Michael J. Reed, Atul Purohit & Barry V.L. Potter. (2008) Novel inhibitors of 17β-hydroxysteroid dehydrogenase type 1: Templates for design. Bioorganic & Medicinal Chemistry 16:8, pages 4438-4456.
Crossref
Sampo Karkola, Annamaria Lilienkampf & Kristiina Wähälä. (2008) A 3D QSAR Model of 17β-HSD1 Inhibitors Based on a Thieno[2,3-d]pyrimidin-4(3H)-one Core Applying Molecular Dynamics Simulations and Ligand–Protein Docking. ChemMedChem 3:3, pages 461-472.
Crossref
Nigel Vicker, Harshani R. Lawrence, Gillian M. Allan, Christian Bubert, Andrew Smith, Helena J. Tutill, Atul Purohit, Joanna M. Day, Mary F. Mahon, Michael J. Reed & Barry V. L. Potter. (2006) Focused Libraries of 16-Substituted Estrone Derivatives and Modified E-Ring Steroids: Inhibitors of 17ß-Hydroxysteroid Dehydrogenase Type 1. ChemMedChem 1:4, pages 464-481.
Crossref
Gillian M. Allan, Harshani R. Lawrence, Josephine Cornet, Christian Bubert, Delphine S. Fischer, Nigel Vicker, Andrew Smith, Helena J. Tutill, Atul Purohit, Joanna M. Day, Mary F. Mahon, Michael J. Reed & Barry V. L. Potter. (2006) Modification of Estrone at the 6, 16, and 17 Positions:  Novel Potent Inhibitors of 17β-Hydroxysteroid Dehydrogenase Type 1. Journal of Medicinal Chemistry 49:4, pages 1325-1345.
Crossref
Donald Poirier, Roch P. Boivin, Martin R. Tremblay, Marie Bérubé,, Wei Qiu & Sheng-Xiang Lin. (2005) Estradiol−Adenosine Hybrid Compounds Designed to Inhibit Type 1 17β-Hydroxysteroid Dehydrogenase. Journal of Medicinal Chemistry 48:26, pages 8134-8147.
Crossref
Harshani R. LawrenceNigel VickerGillian M. AllanAndrew SmithMary F. MahonHelena J. TutillAtul PurohitMichael J. ReedBarry V. L. Potter. (2005) Novel and Potent 17β-Hydroxysteroid Dehydrogenase Type 1 Inhibitors. Journal of Medicinal Chemistry 48:8, pages 2759-2762.
Crossref
James R. Hanson. (2005) Steroids: reactions and partial synthesis. Natural Product Reports 22:1, pages 104.
Crossref
Marie Bérubé & Donald Poirier. (2004) Synthesis of Simplified Hybrid Inhibitors of Type 1 17β-Hydroxysteroid Dehydrogenase via Cross-Metathesis and Sonogashira Coupling Reactions. Organic Letters 6:18, pages 3127-3130.
Crossref
Donald Poirier, Roch P. Boivin, Marie Berube & Sheng‐Xiang Lin. (2003) Synthesis of a First Estradiol‐Adenosine Hybrid Compound.. ChemInform 35:1.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.